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324 Results Found

  • Article
  • Open Access
7 Citations
4,838 Views
14 Pages

Gene Flow Patterns among Aedes aegypti (Diptera: Culicidae) Populations in Sri Lanka

  • H.S.D. Fernando,
  • Menaka Hapugoda,
  • Rushika Perera,
  • William C. Black IV and
  • B.G.D.N.K. De Silva

6 March 2020

In Sri Lanka, dengue is the most serious arboviral disease. Recent increases in dengue cases suggest a higher infection rate and spread of the disease to new areas. The present study explores gene flow patterns of Ae. aegypti, the main vector of deng...

  • Article
  • Open Access
1 Citations
2,570 Views
21 Pages

Gene Flow and Recruitment Patterns among Disjunct Populations of Allocasuarina verticillata (Lam.) L.A.S. Johnson

  • Yong Zhang,
  • Nigel England,
  • Linda Broadhurst,
  • Lan Li,
  • Chonglu Zhong and
  • David Bush

21 July 2022

Allocasuarina verticillata (Lam.) L.A.S. Johnson is a widespread species in south-eastern Australia providing vegetation cover, protecting fragile soils and providing food for birds. Understanding the effects of gene flow on the recruitment patterns,...

  • Article
  • Open Access
408 Views
19 Pages

13 December 2025

Calcareous tropical green macroalgae of the genus Halimeda are key reef-builders, yet the drivers of their diversification and population dynamics remain poorly understood. This study analyzed the species diversity of Halimeda in the Xisha (Paracel)...

  • Article
  • Open Access
1 Citations
1,793 Views
22 Pages

Genetic Diversity, Population Structure, and Historical Gene Flow Patterns of Nine Indigenous Greek Sheep Breeds

  • Sofia Michailidou,
  • Maria Kyritsi,
  • Eleftherios Pavlou,
  • Antiopi Tsoureki and
  • Anagnostis Argiriou

10 July 2025

Ιn this study, we evaluated the genetic resources of nine Greek sheep breeds. The genotyping data of 292 animals were acquired from Illumina’s OvineSNP50 Genotyping BeadChip. The genetic diversity and inbreeding levels were evaluated using...

  • Article
  • Open Access
12 Citations
9,814 Views
13 Pages

An Unstructured Phylogeographic Pattern with Extensive Gene Flow in an Endemic Bird of South China: Collared Finchbill (Spizixos semitorques)

  • Bin Gao,
  • Lijiang Yu,
  • Yanhua Qu,
  • Gang Song,
  • Chuanyin Dai,
  • Ruiying Zhang,
  • Zuohua Yin,
  • Kaifeng Wang,
  • Xuebin Gao and
  • Fumin Lei
  • + 1 author

7 June 2011

Recent phylogeographical studies indicated that glacial oscillations played a key role on the phylogeographic pattern of extant species. As most studies have previously been carried out on heavily ice-covered regions, such as in European and North Am...

  • Article
  • Open Access
4 Citations
4,572 Views
14 Pages

Genetic Structure and Gene Flow in Red Foxes (Vulpes vulpes) in Scandinavia: Implications for the Potential Future Spread of Echinococcus multilocularis Tapeworm

  • Mari Hagenlund,
  • Arne Linløkken,
  • Kjartan Østbye,
  • Zea Walton,
  • Morten Odden,
  • Gustaf Samelius,
  • Tomas Willebrand and
  • Robert Wilson

4 December 2019

Knowledge about the dispersal and gene flow patterns in wild animals are important for our understanding of population ecology and the connectedness of populations. It is also important for management relating to disease control and the transmission...

  • Article
  • Open Access
1 Citations
2,651 Views
11 Pages

The Correlation Between Abnormal Uterine Artery Flow in the First Trimester and Genetic Thrombophilic Alteration: A Prospective Case-Controlled Pilot Study

  • Natalija Vedmedovska,
  • Diana Bokucava,
  • Anda Kivite-Urtane,
  • Vita Rovite,
  • Liene Zake-Nikitina,
  • Janis Klovins,
  • Violeta Fodina and
  • Gilbert G. G. Donders

Introduction. Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. A genotype, making women prone to microthrombi. constitutes the main known susceptibility factor for anomalous development o...

  • Article
  • Open Access
8 Citations
3,549 Views
19 Pages

CYP6P9-Driven Signatures of Selective Sweep of Metabolic Resistance to Pyrethroids in the Malaria Vector Anopheles funestus Reveal Contemporary Barriers to Gene Flow

  • Delia Doreen Djuicy,
  • Jack Hearn,
  • Magellan Tchouakui,
  • Murielle J. Wondji,
  • Helen Irving,
  • Fredros O. Okumu and
  • Charles S. Wondji

5 November 2020

Pyrethroid resistance in major malaria vectors such as Anopheles funestus threatens malaria control efforts in Africa. Cytochrome P450-mediated metabolic resistance is best understood for CYP6P9 genes in southern Africa in An. funestus. However, we d...

  • Abstract
  • Open Access
1,124 Views
2 Pages

Evidence of High Levels of Gene Flow in a Widely Distributed Catadromous Species: The Thin-Lippedgrey Mullet

  • Esmeralda Pereira,
  • Catarina Sofia Mateus,
  • Maria Judite Alves,
  • Rita Almeida,
  • Joana Pereira,
  • Bernardo Ruivo Quintella and
  • Pedro Raposo de Almeida

The thin-lipped grey mullet Chelon ramada (Risso, 1827) is a catadromous species that is distributed along the Northeast Atlantic, from the Norwegian coastline down to Mauritania, on the African coast (20–60° N, 18° E–42° W),...

  • Article
  • Open Access
25 Citations
5,191 Views
15 Pages

15 January 2021

There is growing attention given to gene flow between crops and the wild relatives as global landscapes have been rapidly converted into agricultural farm fields over the past century. Crop-to-wild introgression may advance the extinction risks of ra...

  • Article
  • Open Access
24 Citations
5,249 Views
26 Pages

Transitions from Single- to Multi-Locus Processes during Speciation with Gene Flow

  • Martin P. Schilling,
  • Sean P. Mullen,
  • Marcus Kronforst,
  • Rebecca J. Safran,
  • Patrik Nosil,
  • Jeffrey L. Feder,
  • Zachariah Gompert and
  • Samuel M. Flaxman

24 May 2018

During speciation-with-gene-flow, a transition from single-locus to multi-locus processes can occur, as strong coupling of multiple loci creates a barrier to gene flow. Testing predictions about such transitions with empirical data requires building...

  • Feature Paper
  • Review
  • Open Access
13 Citations
7,399 Views
12 Pages

Vertebrate Left-Right Asymmetry: What Can Nodal Cascade Gene Expression Patterns Tell Us?

  • Axel Schweickert,
  • Tim Ott,
  • Sabrina Kurz,
  • Melanie Tingler,
  • Markus Maerker,
  • Franziska Fuhl and
  • Martin Blum

Laterality of inner organs is a wide-spread characteristic of vertebrates and beyond. It is ultimately controlled by the left-asymmetric activation of the Nodal signaling cascade in the lateral plate mesoderm of the neurula stage embryo, which result...

  • Article
  • Open Access
20 Citations
4,218 Views
26 Pages

7 July 2019

Liriodendron chinense (Hemsl.), a Tertiary relic tree, is mainly distributed in subtropical China. The causes of the geographical distribution pattern of this species are poorly understood. In this study, we inferred historical dispersal routes and g...

  • Article
  • Open Access
11 Citations
2,908 Views
19 Pages

1 November 2019

Gene introgression usually results from natural hybridization occurring among closely related species in sympatric populations. In this study, we discussed two rare and frequent gene flow phenomena between three species of Juglans plants and analyzed...

  • Article
  • Open Access
5 Citations
4,165 Views
17 Pages

20 January 2022

Anthropogenic activities cause loss and fragmentation of natural habitats and have strong effects on population maintenance by increasing their isolation. Pond ecosystems are scattered waterbodies that can interact as a network connected by dispersal...

  • Article
  • Open Access
6 Citations
3,986 Views
17 Pages

7 April 2021

Setaria viridis (L.) Beauv., or green foxtail, is native to Eurasia and is the putative ancestor of foxtail millet. Due to the advantageous genetic characteristics of S. viridis, it is a model species for C4 plants. However, S. viridis has seriously...

  • Article
  • Open Access
8 Citations
3,652 Views
16 Pages

15 April 2021

Speciation mechanisms, including the role of interspecific gene flow and introgression in the emergence of new species, are the major focus of evolutionary studies. Inference of taxonomic relationship between closely related species may be challenged...

  • Article
  • Open Access
6 Citations
8,101 Views
17 Pages

Landscape Genomics of a Widely Distributed Snake, Dolichophis caspius (Gmelin, 1789) across Eastern Europe and Western Asia

  • Sarita Mahtani-Williams,
  • William Fulton,
  • Amelie Desvars-Larrive,
  • Sara Lado,
  • Jean Pierre Elbers,
  • Bálint Halpern,
  • Dávid Herczeg,
  • Gergely Babocsay,
  • Boris Lauš and
  • Pamela Anna Burger
  • + 5 authors

17 October 2020

Across the distribution of the Caspian whipsnake (Dolichophis caspius), populations have become increasingly disconnected due to habitat alteration. To understand population dynamics and this widespread but locally endangered snake’s adaptive p...

  • Article
  • Open Access
9 Citations
3,254 Views
19 Pages

24 March 2021

A panel of 387 durum wheat genotypes including Mediterranean landraces and modern cultivars was characterized with 46,161 diversity arrays technology (DArTseq) markers. Analysis of population structure uncovered the existence of five subpopulations (...

  • Article
  • Open Access
14 Citations
7,641 Views
15 Pages

22 November 2013

We used the mitochondria DNA COI (cytochrome c oxidase subunit I) sequence as a genetic marker to analyze the population genetic structure of two species of freshwater copepods, Neodiaptomus schmackeri (Poppe and Richard, 1892) and Mongolodiaptomus b...

  • Article
  • Open Access
2 Citations
3,294 Views
34 Pages

Genomic Signatures of Local Adaptation under High Gene Flow in Lumpfish—Implications for Broodstock Provenance Sourcing and Larval Production

  • Simo Njabulo Maduna,
  • Ólöf Dóra Bartels Jónsdóttir,
  • Albert Kjartan Dagbjartarson Imsland,
  • Davíð Gíslason,
  • Patrick Reynolds,
  • Lauri Kapari,
  • Thor Arne Hangstad,
  • Kristian Meier and
  • Snorre B. Hagen

26 September 2023

Aquaculture of the lumpfish (Cyclopterus lumpus L.) has become a large, lucrative industry owing to the escalating demand for “cleaner fish” to minimise sea lice infestations in Atlantic salmon mariculture farms. We used over 10K genome-w...

  • Brief Report
  • Open Access
1 Citations
1,927 Views
10 Pages

Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell Transcriptome

  • Amelia Meecham,
  • Sara McCurdy,
  • Eduardo Frias-Anaya,
  • Wenqing Li,
  • Helios Gallego-Gutierrez,
  • Phu Nguyen,
  • Yi-Shuan Li,
  • Shu Chien,
  • John Y.-J. Shyy and
  • Miguel Alejandro Lopez-Ramirez
  • + 1 author

Endothelial cells respond to forces generated by laminar blood flow with changes in vasodilation, anticoagulant, fibrinolytic, or anti-inflammatory functions which preserve vessel patency. These responses to flow shear stress are primarily mediated b...

  • Article
  • Open Access
2 Citations
3,549 Views
14 Pages

20 March 2022

Variation in population sex ratio is particularly pronounced in gynodioecious angiosperms. Extremely high female frequencies in gynodioecious populations cannot be readily explained by selective forces alone. To assess the contributions of drift and...

  • Article
  • Open Access
6 Citations
2,936 Views
16 Pages

A Bocage Landscape Restricts the Gene Flow of Pest Vole Populations

  • Aitor Somoano,
  • Cristiane Bastos-Silveira,
  • Jacint Ventura,
  • Marcos Miñarro and
  • Gerald Heckel

27 May 2022

The population dynamics of most animal species inhabiting agro-ecosystems may be determined by landscape characteristics, with agricultural intensification and the reduction of natural habitats influencing dispersal and hence limiting gene flow. Incr...

  • Article
  • Open Access
747 Views
22 Pages

8 September 2025

The present research investigates the fine-scale spatial genetic structure (SGS) and gene flow dynamics in the endangered relict tree Tetracentron sinense, a keystone species in China’s montane ecosystems facing severe habitat fragmentation and...

  • Article
  • Open Access
4 Citations
4,065 Views
19 Pages

Strong Gene Flow Undermines Local Adaptations in a Host Parasite System

  • Perttu Seppä,
  • Mariaelena Bonelli,
  • Simon Dupont,
  • Sanja Maria Hakala,
  • Anne-Geneviève Bagnères and
  • Maria Cristina Lorenzi

1 September 2020

The co-evolutionary pathways followed by hosts and parasites strongly depend on the adaptive potential of antagonists and its underlying genetic architecture. Geographically structured populations of interacting species often experience local differe...

  • Article
  • Open Access
4 Citations
4,538 Views
27 Pages

The Build-Up of Population Genetic Divergence along the Speciation Continuum during a Recent Adaptive Radiation of Rhagoletis Flies

  • Thomas H. Q. Powell,
  • Glen Ray Hood,
  • Meredith M. Doellman,
  • Pheobe M. Deneen,
  • James J. Smith,
  • Stewart H. Berlocher and
  • Jeffrey L. Feder

30 January 2022

New species form through the evolution of genetic barriers to gene flow between previously interbreeding populations. The understanding of how speciation proceeds is hampered by our inability to follow cases of incipient speciation through time. Comp...

  • Article
  • Open Access
10 Citations
3,806 Views
15 Pages

Molecular Insights into the Centaurea Calocephala Complex (Compositae) from the Balkans—Does Phylogeny Match Systematics?

  • Jelica Novaković,
  • Pedja Janaćković,
  • Alfonso Susanna,
  • Maja Lazarević,
  • Igor Boršić,
  • Sretco Milanovici,
  • Dmitar Lakušić,
  • Bojan Zlatković,
  • Petar D. Marin and
  • Núria Garcia-Jacas

16 May 2022

Groups of recent speciation are characterized by high levels of introgression and gene flow, which often confounds delimitation of species on a DNA basis. We analyzed nuclear DNA sequences (ETS spacer and the AGT1 gene) obtained from a large sample o...

  • Article
  • Open Access
1 Citations
1,997 Views
9 Pages

Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2 Caused by a Novel PIGA Variant Not Associated with a Skewed X-Inactivation Pattern

  • Alba Gabaldon-Albero,
  • Lourdes Cordon,
  • Amparo Sempere,
  • Laia Pedrola,
  • Carla Martin-Grau,
  • Silvestre Oltra,
  • Sandra Monfort,
  • Alfonso Caro-Llopis,
  • Marta Dominguez-Martinez and
  • Francisco Martinez
  • + 3 authors

18 June 2024

Germline variants in the phosphatidylinositol glycan class A (PIGA) gene, which is involved in glycosylphosphatidylinositol (GPI) biosynthesis, cause multiple congenital anomalies-hypotonia-seizures syndrome 2 (MCAHS2) with X-linked recessive inherit...

  • Review
  • Open Access
6 Citations
3,743 Views
14 Pages

What Is the Spatial Extent of a Bemisia tabaci Population?

  • Michael S. Crossley and
  • William E. Snyder

18 November 2020

Effective pest management depends on basic knowledge about insect dispersal patterns and gene flow in agroecosystems. The globally invasive sweet potato whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) is considered a weak flier whose lif...

  • Article
  • Open Access
26 Citations
6,625 Views
11 Pages

Cloning and Functional Characterization of Two 4-Coumarate: CoA Ligase Genes from Selaginella moellendorffii

  • Xin-Yan Liu,
  • Ping-Ping Wang,
  • Yi-Feng Wu,
  • Ai-Xia Cheng and
  • Hong-Xiang Lou

Selaginella is an extant lycopodiophyte genus, which is representative of an ancient lineage of tracheophytes. The important evolutionary status makes it a valuable resource for the study of metabolic evolution in vascular plants. 4-coumarate: CoA li...

  • Review
  • Open Access
2 Citations
2,802 Views
18 Pages

20 December 2024

The formation of the embryonic left–right axis is a fundamental process in animals, which subsequently conditions both the shape and the correct positioning of internal organs. During vertebrate early development, a transient structure, known a...

  • Article
  • Open Access
1,134 Views
18 Pages

Oscillatory Disturbed Flow Enhances Inflammatory and Oxidative Stress Markers in Endothelial Cells

  • Maram Hasan,
  • Onur Mutlu,
  • Munshi Sajidul Islam,
  • Samar Shurbaji,
  • Ruba Sulaiman,
  • Yasmin Elsharabassi,
  • Abdelali Agouni and
  • Huseyin C. Yalcin

1 November 2025

Hemodynamics significantly impact the biology of endothelial cells (ECs) lining the blood vessels. ECs are exposed to various hemodynamic forces, particularly frictional shear stress from flowing blood. While physiological flows are critical for the...

  • Article
  • Open Access
3 Citations
2,923 Views
14 Pages

An Integrative Study of Aortic mRNA/miRNA Longitudinal Changes in Long-Term LVAD Support

  • Dana Dlouha,
  • Peter Ivak,
  • Ivan Netuka,
  • Sarka Benesova,
  • Zuzana Tucanova and
  • Jaroslav A. Hubacek

Studying the long-term impact of continuous-flow left ventricular assist device (CF-LVAD) offers an opportunity for a complex understanding of the pathophysiology of vascular changes in aortic tissue in response to a nonphysiological blood flow patte...

  • Article
  • Open Access
7 Citations
5,010 Views
16 Pages

Interactome Analysis of iPSC Secretome and Its Effect on Macrophages In Vitro

  • Luca Tamò,
  • Kleanthis Fytianos,
  • Fabienne Caldana,
  • Cedric Simillion,
  • Anis Feki,
  • Izabela Nita,
  • Manfred Heller,
  • Thomas Geiser and
  • Amiq Gazdhar

Induced pluripotent stem cell secretome (iPSC-CM) mitigate organ injury and help in repair. Macrophages play a critical role in tissue repair and regeneration and can be directed to promote tissue repair by iPSC-CM, although the exact mechanisms are...

  • Article
  • Open Access
14 Citations
5,294 Views
15 Pages

Genetic Diversity among Cowpea (Vigna unguiculata (L.) Walp.) Landraces Suggests Central Mozambique as an Important Hotspot of Variation

  • Ana Maria Figueira Gomes,
  • David Draper,
  • Pedro Talhinhas,
  • Paula Batista Santos,
  • Fernanda Simões,
  • Nascimento Nhantumbo,
  • Rafael Massinga,
  • José C. Ramalho,
  • Isabel Marques and
  • Ana I. Ribeiro-Barros

30 November 2020

Cowpea is a multiple-purpose drought-tolerant leguminous pulse crop grown in several dry tropical areas. Its domestication center is thought to be East or West Africa, where a high level of genetic diversity is apparently still found. However, detail...

  • Article
  • Open Access
3 Citations
3,233 Views
16 Pages

17 September 2023

The genetic structure and demographic history of marine organisms are influenced by biological and ecological features, oceanic currents, and the paleo-geological effects of sea-level fluctuations. In this study, we used mitochondrial COI + 16S gene...

  • Article
  • Open Access
8 Citations
2,625 Views
12 Pages

Prevalence of Bacterial Coinfections with Vibrio harveyi in the Industrialized Flow-through Aquaculture Systems in Hainan Province: A Neglected High-Risk Lethal Causative Agent to Hybrid Grouper

  • He Xu,
  • Yan-Hua Zeng,
  • Wen-Liang Yin,
  • Hong-Bin Lu,
  • Xiao-Xiao Gong,
  • Na Zhang,
  • Xiang Zhang,
  • Hao Long,
  • Wei Ren and
  • Zhen-Yu Xie
  • + 2 authors

1 October 2022

Vibrio harveyi is one of the most serious bacterial pathogens to aquatic animals worldwide. Evidence is mounting that coinfections caused by multiple pathogens are common in nature and can alter the severity of diseases in marine animals. However, ba...

  • Article
  • Open Access
19 Citations
5,499 Views
15 Pages

14 August 2019

Understanding the population genetic pattern and process of gene flow requires a detailed knowledge of how landscape characteristics structure populations. Although Cynodon dactylon (L.) Pers. (common bermudagrass) is widely distributed in the world,...

  • Article
  • Open Access
3 Citations
2,765 Views
12 Pages

28 June 2021

Salt tolerance is an important trait in soybean cultivation and breeding. Plant responses to salt stress include physiological and biochemical changes that affect the movement of water across the plasma membrane. Plasma membrane intrinsic proteins (P...

  • Review
  • Open Access
28 Citations
9,909 Views
18 Pages

Genomic Signatures of Reinforcement

  • Austin G. Garner,
  • Benjamin E. Goulet,
  • Matthew C. Farnitano,
  • Y. Franchesco Molina-Henao and
  • Robin Hopkins

3 April 2018

Reinforcement is the process by which selection against hybridization increases reproductive isolation between taxa. Much research has focused on demonstrating the existence of reinforcement, yet relatively little is known about the genetic basis of...

  • Article
  • Open Access
5 Citations
3,682 Views
14 Pages

17 July 2022

Spain is the leading producer of olives and olive oil. Ninety-five percent of world production originate from Spain and other regions of the Mediterranean Basin. However, these olive-growing countries face a major problem, the harmful fly Bactrocera...

  • Review
  • Open Access
21 Citations
9,227 Views
13 Pages

18 March 2011

Chromosomal rearrangements can alter the rate and patterns of gene flow within or between species through a reduction in the fitness of chromosomal hybrids or by reducing recombination rates in rearranged areas of the genome. This concept, together w...

  • Article
  • Open Access
35 Citations
6,444 Views
19 Pages

Hemodynamics in Cardiac Development

  • Robert E. Poelmann and
  • Adriana C. Gittenberger-de Groot

The beating heart is subject to intrinsic mechanical factors, exerted by contraction of the myocardium (stretch and strain) and fluid forces of the enclosed blood (wall shear stress). The earliest contractions of the heart occur already in the 10-som...

  • Article
  • Open Access
2 Citations
3,907 Views
16 Pages

16 February 2022

The genetic contribution with respect to autosomal genes has been widely used to evaluate the genetic diversity of a target population. Here, we developed a method to calculate the genetic contribution with respect to genes on sex chromosomes and mit...

  • Article
  • Open Access
1,413 Views
13 Pages

9 October 2025

Ammopiptanthus nanus is an endangered evergreen shrub endemic to the western Tianshan Mountains. Genetic diversity and population structure of this species were assessed using single-nucleotide polymorphism (SNP) loci identified via double-digest res...

  • Article
  • Open Access
4 Citations
4,007 Views
18 Pages

Contrasting Genetic Footprints among Saharan Olive Populations: Potential Causes and Conservation Implications

  • Guillaume Besnard,
  • Océane Gorrilliot,
  • Pauline Raimondeau,
  • Benoit Génot,
  • Ahmed El Bakkali,
  • Fabien Anthelme and
  • Djamel Baali-Cherif

14 June 2021

The Laperrine’s olive is endemic to the Saharan Mountains. Adapted to arid environments, it may constitute a valuable genetic resource to improve water-stress tolerance in the cultivated olive. However, limited natural regeneration coupled with human...

  • Article
  • Open Access
10 Citations
2,758 Views
14 Pages

Phylogeographic Structuring of the Kuroshio-Type Prawn Macrobrachium japonicum (Decapoda: Palaemonidae) in Taiwan and Ryukyu Islands

  • Chiao-Chuan Han,
  • Chien-Hung Lai,
  • Chi-Chun Huang,
  • I-Chen Wang,
  • Hung-Du Lin and
  • Wei-Kuang Wang

30 July 2022

Oceanic currents, biological traits, and geological evidence from historical climate change have shaped the distribution of genetic diversity and demographic history in Macrobrachium japonicum. In this study, we investigated the phylogeographic struc...

  • Article
  • Open Access
2 Citations
2,574 Views
16 Pages

11 May 2022

The mitochondrial genomes are generally considered non-recombining and homoplasmic in nature. However, our previous study provided the first evidence of extensive and stable mitochondrial heteroplasmy in natural populations of the basidiomycete fungu...

  • Review
  • Open Access
106 Citations
14,115 Views
15 Pages

Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia

  • Aaron Kruse,
  • Nour Abdel-Azim,
  • Hye Na Kim,
  • Yongsheng Ruan,
  • Valerie Phan,
  • Heather Ogana,
  • William Wang,
  • Rachel Lee,
  • Eun Ji Gang and
  • Yong-Mi Kim
  • + 1 author

5 February 2020

Minimal residual disease (MRD) refers to a chemotherapy/radiotherapy-surviving leukemia cell population that gives rise to relapse of the disease. The detection of MRD is critical for predicting the outcome and for selecting the intensity of further...

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