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Hemodynamics in Cardiac Development

Department of Animal Sciences and Health, Institute of Biology, Sylvius Laboratory, University of Leiden, Sylviusweg 72, 2333BE Leiden, The Netherlands
Department of Cardiology, Leiden University Medical Center, Albinusdreef 20, 2300RC Leiden, The Netherlands
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2018, 5(4), 54;
Received: 17 September 2018 / Revised: 3 November 2018 / Accepted: 4 November 2018 / Published: 6 November 2018
The beating heart is subject to intrinsic mechanical factors, exerted by contraction of the myocardium (stretch and strain) and fluid forces of the enclosed blood (wall shear stress). The earliest contractions of the heart occur already in the 10-somite stage in the tubular as yet unsegmented heart. With development, the looping heart becomes asymmetric providing varying diameters and curvatures resulting in unequal flow profiles. These flow profiles exert various wall shear stresses and as a consequence different expression patterns of shear responsive genes. In this paper we investigate the morphological alterations of the heart after changing the blood flow by ligation of the right vitelline vein in a model chicken embryo and analyze the extended expression in the endocardial cushions of the shear responsive gene Tgfbeta receptor III. A major phenomenon is the diminished endocardial-mesenchymal transition resulting in hypoplastic (even absence of) atrioventricular and outflow tract endocardial cushions, which might be lethal in early phases. The surviving embryos exhibit several cardiac malformations including ventricular septal defects and malformed semilunar valves related to abnormal development of the aortopulmonary septal complex and the enclosed neural crest cells. We discuss the results in the light of the interactions between several shear stress responsive signaling pathways including an extended review of the involved Vegf, Notch, Pdgf, Klf2, eNos, Endothelin and Tgfβ/Bmp/Smad networks. View Full-Text
Keywords: cardiogenesis; endocardial cushions; neural crest; hemodynamics; shear stress; semilunar valve; outflow tract septum; Klf2; growth factors; TGF beta cardiogenesis; endocardial cushions; neural crest; hemodynamics; shear stress; semilunar valve; outflow tract septum; Klf2; growth factors; TGF beta
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MDPI and ACS Style

Poelmann, R.E.; Gittenberger-de Groot, A.C. Hemodynamics in Cardiac Development. J. Cardiovasc. Dev. Dis. 2018, 5, 54.

AMA Style

Poelmann RE, Gittenberger-de Groot AC. Hemodynamics in Cardiac Development. Journal of Cardiovascular Development and Disease. 2018; 5(4):54.

Chicago/Turabian Style

Poelmann, Robert E., and Adriana C. Gittenberger-de Groot. 2018. "Hemodynamics in Cardiac Development" Journal of Cardiovascular Development and Disease 5, no. 4: 54.

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