Objectives: The sample sizes of phase I trials are typically small; some designs may lead to inaccurate estimation of the maximum tolerated dose (MTD). The objective of this study was to propose a metric assessing whether the MTD decision is sensitiv...
Background: The effectiveness of corticosteroids in acute respiratory distress syndrome (ARDS) and COVID-19 still remains uncertain. Since ARDS is due to a hyperinflammatory response to a direct injury, we decided to perform a meta-analysis and an ev...
Aftershock fragility is usually calculated conditioned on a range of potential post-mainshock damage states. The post-mainshock damage can be identified using damage indices, the latter being frequently associated with displacement-based parameters s...
In regions exposed to floods followed by cold weather, brick masonry as a structural basis of the building envelope can be damaged due to the accompanying phenomenon of freezing and thawing. The main purpose of the article is the development of a mat...
As an important component in seismic isolation bridges, steel dampers should have excellent low-cycle fatigue performance. This paper performs destructive tests of two types of steel dampers to accurately evaluate the fatigue damage of steel dampers...
Background: Risk factors, including Joint Index Vector (JIV), a new disease activity indicator based on three-axis coordinates, and a pain score using a visual analog scale (PS-VAS), were evaluated for incident bone fragility fractures (inc-BFF) in p...
Inhibition of the renin-angiotensin-aldosterone system (RAAS) is broadly recommended in many nephrological guidelines to prevent chronic kidney disease (CKD) progression. This work aimed to analyze the robustness of randomized controlled trials (RCTs...
Data suggest inadequacy of common statistical techniques for reporting outcomes in clinical trials. The Fragility Index can measure how many events the statistical significance hinges on, and may facilitate better interpretation of trial results. Thi...
This study analyzes the applicability of different damage indexes for bearings, focusing on the time-dependent deterioration of materials and the time-dependent bond-slip behavior between steel and concrete caused by chloride erosion. First, the meth...
The p-value has long been the standard for statistical significance in scientific research, but this binary approach often fails to consider the nuances of statistical power and the potential for large sample sizes to show statistical significance de...
Introduction: High-quality evidence regarding the use of endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO) has been provided by recently completed randomized controlled clinical trials (RCTs). Methods: We conducted a...
With the popularity of network and the continuous development of multimedia technology, saving of network bandwidth and copyright protection of multimedia content have gradually attracted people’s attention. The fragile watermark for integrity authen...
As a measure of the sustainability of a country, a state’s fragility is attributed to numerous elements. Meanwhile, climate change is a potential global threat in the 21st century, which may further aggravate the fragility of countries. Concern...
15 June 2022
Background: Hip fragility fractures are becoming one of the main health care problems in countries with an aging population. This study aimed to evaluate the clinical characteristics and the usefulness of bone turnover markers in patients with a hip...
This paper summarises the evolution of the Water Poverty Index (WPI) application at different scales since its emergence. The review captures the main milestones and remarkable developments around the world. It sets the foundation for identifying the...
In this paper, the seismic response of a five-story reinforced concrete (RC) frame system building is analysed through fragility analysis. The structure is designed in accordance with structural Eurocodes EN1990, EN1991, EN1992 and EN1998, as a high-...
This paper presents a copula technique for developing seismic fragility curves for an RC (reinforced concrete) isolated continuous girder bridge, by considering earthquake damage indicators such as bridge piers, isolated bearing components, and the m...
Recent studies in the Romanian Western Carpathians have revealed increasing socio-demographic fragility in rural areas and small towns, driven by depopulation, population aging, and declining living standards. These trends stem from the legacy of for...
Traditional risk models often fail to capture extreme losses in interconnected global stock markets. This study introduces a novel approach, Expectile Regression Neural Network with Modified LASSO regularization (ERNN-mLASSO), to model nonlinear syst...
In recent years, policymakers have increasingly focused on environmental quality and economic growth. While various factors influence green growth, two important factors that have been overlooked in research are the global innovation index and the fr...
Stored red blood cells (RBCs) undergo oxidative stress that induces deleterious metabolic, structural, biochemical, and molecular changes collectively referred to as “storage lesions”. We hypothesized that vitamin C (VitC, reduced or oxidized) would...
Road networks are considered as one of the most important transport infrastructure systems, since they attain the economic and social prosperity of modern societies. For this reason, it is vital to improve the resiliency of road networks in order to...
The mainshock (MS) is often accompanied by a number of aftershocks (AS). The existence of AS may cause the seismic demand to be greater than the MS. In order to better evaluate the impact of AS, this paper takes RC columns as the research object and...
Background/Objectives: Pathological vertebral fragility (path-VF) increases the risk of osteoporotic fractures and pedicle screw loosening (PSL) after posterior instrumented spinal fusion (PISF). While WHO body mass index (BMI) categories broadly ide...
Considering the development of urban transportation systems and the importance of highway bridges in a city’s resilience against earthquakes, it is critical to pay special attention to the seismic risk evaluation of highway bridges. The most si...
Many scholars are skeptical about the poverty reduction effect and the ecological effect of poverty alleviation resettlement (PAR). This study evaluates the spatial and temporal evolution of the ecological environment quality (EEQ) to analyze the eff...
The advancements in communication and information technologies have substantially enabled the extensive distribution and modification of high-resolution color images. Although this accessibility provides many advantages, it also presents risks relate...
During the 13th Five-Year Plan period (2015–2020), the Poverty alleviation relocation (PAR), led by the Chinese government in the karst regions of southwest China, aimed to cope with poverty and ameliorate the ecological environment. Neverthele...
Economic stability in emerging market economies is increasingly shaped by the interplay between global financial integration, domestic monetary dynamics, and asset price fluctuations. Yet, early detection of financial market disruptions remains a per...
Background: We investigated the spinopelvic parameters of lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt (PT) and sacral slope (SS) in patients with fragility fractures of the pelvis (FFPs). We hypothesized that these parameters differ from...
A methodology aiming to predict the vulnerability of masonry structures under seismic action is presented herein. Masonry structures, among which many are cultural heritage assets, present high vulnerability under earthquake. Reliable simulations of...
Poly(dimethylosiloxane) (PDMS) cross-linked by metal-ligand coordination has a potential functionality for electronic devices applications. In this work, the molecular dynamics of bipyridine (bpy)–PDMS-MeCl2 (Me: Mn2+, Fe2+, Ni2+, and Zn2+) are...
A time-domain wind-induced damage evaluation for the risk- and resilience-targeted design of building structures requires nonlinear dynamic analysis (NDA) solvers to handle long duration input loads. Moreover, post-construction damage identification...
This study investigates the seismic fragility of railway tunnels intersecting fractured geological zones using a nonlinear numerical approach. A series of dynamic analyses was performed on tunnel models subjected to multiple ground motions with varyi...
The Qinghai-Tibet Plateau serves as an important ecological security shelter in China and across Asia. During the past two decades, the patterns of land development and conservation on the Qinghai-Tibet Plateau have undergone significant changes unde...
Background: The cortical thickness index (CTI) is a measure of bone quality and it correlates with the risk of proximal femoral fractures. The purpose of this study was to investigate the CTI in femoral neck, trochanteric fractures and non-fractured...
Risk management for technological hazards mainly focuses on the consequences for human lives. Although technological risk analysis evaluates environmental vulnerability, it does not reflect the consequences of environmentally exposed elements. This p...
This study describes the methodology employed to construct a seismic fragility function based on a pre-existing numerical model tailored for underground stations. Employing a dynamic numerical model, a comprehensive analysis encompassing 110 distinct...
Assessing the fragility of intake towers using a single damage index does not allow for accurate evaluation of the potential for structural damage under seismic conditions. In this study, based on the probabilistic seismic demand analysis method, the...
Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and...
This study examines the longitudinal relationship and interactions among comprehensive water management, human development, and fragility. The seventeen Middle Eastern countries were examined for the period from 1996 to 2023. The Human Development In...
Background/Objectives: Comparative studies often use the p value to convey statistical significance, but fragility indices (FI) and fragility quotients (FQ) may better signify statistical strength. The use of aspirin as venous thromboembolism (VTE) c...
This paper validates the effectiveness of the modeling approach based on the finite element analysis of shaking table tests, establishing finite element models for both a base-isolated structure and a hybrid base-isolated structure designed to addres...
Bone strain Index (BSI) is an innovative index of bone strength that provides information about skeletal resistance to loads not considered by existing indexes (Bone Mineral Density, BMD. Trabecular Bone Score, TBS. Hip Structural Analysis, HSA. Hip...
As an important industry in ecologically fragile areas, the synergy of agricultural pollution control and carbon reduction is vital for the balanced development of industries and regional synergy. This paper aims to explore the synergistic result of...
In this article we present three instruments: (1) a social vulnerability to extreme heat index to identify the areas of a city (and populations thereof) more vulnerable to extreme heat due to climate change (heat islands); (2) a new overall fragility...
The Financial Lobster Bias describes how SMEs, driven by distorted liquidity perceptions, engage in aggressive expansion until financial breakdown occurs. Using data from 10,412 Spanish SMEs (2000–2024), this study shows that liquidity misperce...
The vulnerability of ecological environment threatens social and economic development. Recent studies failed to reveal the driving mechanism behind it, and there is little analysis on the spatial clustering characteristics of the vulnerability of urb...
The purpose of this research is to study the seismic performance of railway embankments through a probabilistic approach. Nonlinear response history analyses were conducted utilizing PLAXIS software. Three categories of railway embankments were selec...
A quantitative evaluation model is proposed to assess the seismic resilience of water supply systems. The water supply system is divided into three parts: water sources, aboveground infrastructures, and underground pipeline network, and importance fa...
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