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38,315 Results Found

  • Review
  • Open Access
120 Citations
11,003 Views
18 Pages

On the Determination of Uncertainty and Limit of Detection in Label-Free Biosensors

  • Álvaro Lavín,
  • Jesús De Vicente,
  • Miguel Holgado,
  • María F. Laguna,
  • Rafael Casquel,
  • Beatriz Santamaría,
  • María Victoria Maigler,
  • Ana L. Hernández and
  • Yolanda Ramírez

26 June 2018

A significant amount of noteworthy articles reviewing different label-free biosensors are being published in the last years. Most of the times, the comparison among the different biosensors is limited by the procedure used of calculating the limit of...

  • Article
  • Open Access
13 Citations
4,825 Views
13 Pages

On the Performance of an Aerosol Electrometer with Enhanced Detection Limit

  • Yixin Yang,
  • Tongzhu Yu,
  • Jiaoshi Zhang,
  • Jian Wang,
  • Wenyu Wang,
  • Huaqiao Gui and
  • Jianguo Liu

12 November 2018

An aerosol electrometer with enhanced detection limit was developed for measuring the collected particles electrical current ranging from −50 pA to 50 pA with no range switching necessary. The detection limit was enhanced by suppressing the ele...

  • Article
  • Open Access
7 Citations
3,396 Views
20 Pages

Effect of UV Scattering on Detection Limit of SO2 Cameras

  • Kuijun Wu,
  • Zihao Zhang,
  • Jianjun Guo,
  • Xiangrui Hu,
  • Juan Li,
  • Faquan Li and
  • Weiwei He

25 January 2023

SO2 ultraviolet (UV) camera technology has been successfully applied to the accurate imaging detection of pollutant gas concentration; however, the actual detection ability of this technology has not been intensively studied, especially the detection...

  • Article
  • Open Access
54 Citations
7,911 Views
13 Pages

Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices

  • Jonas Leuermann,
  • Adrián Fernández-Gavela,
  • Antonia Torres-Cubillo,
  • Sergio Postigo,
  • Alejandro Sánchez-Postigo,
  • Laura M. Lechuga,
  • Robert Halir and
  • Íñigo Molina-Fernández

23 August 2019

Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suit...

  • Article
  • Open Access
1 Citations
1,506 Views
13 Pages

8 October 2024

In order to evaluate the tracking capability of optoelectric tracking for an orbital target, the limit magnitude detection performance calculation model and its calculation method are studied. Combining the optical signal characteristics of the track...

  • Article
  • Open Access
55 Citations
7,754 Views
11 Pages

A Simple Procedure to Assess Limit of Detection for Multisensor Systems

  • Ekaterina Oleneva,
  • Maria Khaydukova,
  • Julia Ashina,
  • Irina Yaroshenko,
  • Igor Jahatspanian,
  • Andrey Legin and
  • Dmitry Kirsanov

18 March 2019

Currently, there are no established procedures for limit of detection (LOD) evaluation in multisensor system studies, which complicates their correct comparison with other analytical techniques and hinders further development of the method. In this s...

  • Feature Paper
  • Article
  • Open Access
1,001 Views
24 Pages

12 April 2025

Processes in biotechnology are considered reliable if they produce samples satisfying regulatory benchmarks. For example, laboratories may be required to show that levels of an undesirable analyte rarely (e.g., in less than 5% of samples) exceed a to...

  • Article
  • Open Access
6 Citations
2,579 Views
32 Pages

30 January 2023

Community structure is one of the most important features of complex networks. Modularity-based methods for community detection typically rely on heuristic algorithms to optimize a specific community quality function. Such methods have two major limi...

  • Article
  • Open Access
16 Citations
5,942 Views
10 Pages

2 February 2018

Breath analysis is considered to be an effective method for point-of-care diagnosis due to its noninvasiveness, quickness and simplicity. Gas sensors for breath analysis require detection of low-concentration substances. In this paper, we propose tha...

  • Article
  • Open Access
1 Citations
1,373 Views
16 Pages

Determining the Minimum Detection Limit of Methane Hydrate Using Associated Alpha Particle Technique

  • Josip Batur,
  • Davorin Sudac,
  • Ilker Meric,
  • Vladivoj Valković,
  • Karlo Nađ and
  • Jasmina Obhođaš

Methane hydrate is a crystalline compound in which methane is trapped within a water lattice under high-pressure, low-temperature conditions. Its presence in oceanic and permafrost sediments makes it a promising alternative energy source, but also a...

  • Article
  • Open Access
1 Citations
741 Views
10 Pages

14 July 2025

Ammonia (NH3) is one of the characteristic gases used to detect food spoilage. In this study, the 10 wt% Ag-NiFe2O4 nanocomposite was synthesized via the hydrothermal method. Characterization results from SEM, XRD, and XPS analyzed the microstructure...

  • Article
  • Open Access
8 Citations
2,596 Views
20 Pages

28 November 2023

Existing transportation infrastructure and traffic control systems face increasing strain as a result of rising demand, resulting in frequent congestion. Expanding infrastructure is not a feasible solution for enhancing the capacity of the road. Henc...

  • Article
  • Open Access
6 Citations
6,072 Views
10 Pages

11 May 2016

A highly sensitive refractive index sensor with low detection limit based on an asymmetric optical microfiber coupler is proposed. It is composed of a silica optical microfiber and an As2Se3 optical microfiber. Due to the asymmetry of the microfiber...

  • Review
  • Open Access
11 Citations
6,439 Views
34 Pages

Emerging Low Detection Limit of Optically Activated Gas Sensors Based on 2D and Hybrid Nanostructures

  • Ambali Alade Odebowale,
  • Amer Abdulghani,
  • Andergachew Mekonnen Berhe,
  • Dinelka Somaweera,
  • Sanjida Akter,
  • Salah Abdo,
  • Khalil As’ham,
  • Reza Masoudian Saadabad,
  • Toan T. Tran and
  • Haroldo T. Hattori
  • + 3 authors

19 September 2024

Gas sensing is essential for detecting and measuring gas concentrations across various environments, with applications in environmental monitoring, industrial safety, and healthcare. The integration of two-dimensional (2D) materials, organic material...

  • Article
  • Open Access
2,023 Views
19 Pages

25 October 2024

Reference intervals are indispensable for the interpretation of medical laboratory results to distinguish “normal” from “pathological” values. Recently, indirect methods have been published, which estimate reference intervals...

  • Article
  • Open Access
12 Citations
3,670 Views
12 Pages

Double-Antibody Sandwich Immunoassay and Plasmonic Coupling Synergistically Improved Long-Range SPR Biosensor with Low Detection Limit

  • Jianying Jing,
  • Kun Liu,
  • Junfeng Jiang,
  • Tianhua Xu,
  • Shuang Wang,
  • Jinying Ma,
  • Zhao Zhang,
  • Wenlin Zhang and
  • Tiegen Liu

22 August 2021

A long-range surface plasmonic resonance (LR-SPR) biosensor modified with double-antibody sandwich immunoassay and plasmonic coupling is demonstrated for human-immunoglobulin G detection with a low limit of detection (LOD). The double-antibody sandwi...

  • Article
  • Open Access
2 Citations
1,855 Views
20 Pages

8 November 2024

Gas cloud imaging with uncooled infrared spectroscopy is influenced by ambient temperature, complicating the quantitative detection of gas concentrations in open environments. To solve the aforementioned challenges, the paper analyzes the main factor...

  • Article
  • Open Access
1,459 Views
12 Pages

11 July 2025

Wastewater-based epidemiology (WBE) has historically proven to be a powerful surveillance tool, particularly during the SARS-CoV-2 pandemic. Effective WBE depends on the sensitive detection of pathogens in wastewater. However, determining the process...

  • Article
  • Open Access
11 Citations
4,901 Views
17 Pages

There is growing scientific interest in identifying the multitude of chemical exposures related to human diseases through mixture analysis. In this paper, we address the issue of below detection limit (BDL) missing data in mixture analysis using Baye...

  • Article
  • Open Access
4 Citations
4,837 Views
9 Pages

Comparison of Analytical Sensitivity (Limit of Detection) of Xpert MTB/RIF and Xpert MTB/RIF Ultra for Non-Sputum Specimens

  • Marisa C. Nielsen,
  • Paula Clarner,
  • Ruchi Paroha,
  • Sunhee Lee,
  • Phyu M. Thwe and
  • Ping Ren

18 January 2023

Tuberculosis (TB) is a significant public health threat and has remained a leading cause of death in many parts of the world. Rapid and accurate testing and timely diagnosis can improve treatment efficacy and reduce new exposures. The Cepheid Xpert&r...

  • Article
  • Open Access
3 Citations
3,136 Views
13 Pages

21 April 2024

The Flinders Technology Associates (FTA) card, a cotton-based cellulose membrane impregnated with a chaotropic agent, effectively inactivates infectious microorganisms, lyses cellular material, and fixes nucleic acid. The aim of this study is to asse...

  • Article
  • Open Access
8 Citations
3,121 Views
12 Pages

16 August 2020

In a combustion reaction of hydrocarbon fuel, carbon monoxide (CO) is a gas species that is closely related to air pollution generation and combustion efficiency. It has a trade-off with nitrogen oxide and increases rapidly in case of incomplete comb...

  • Article
  • Open Access
9 Citations
13,139 Views
9 Pages

Material Limitations on the Detection Limit in Refractometry

  • Peder Skafte-Pedersen,
  • Pedro S. Nunes,
  • Sanshui Xiao and
  • Niels Asger Mortensen

26 October 2009

We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η with n + iη being the complex refractive index of the material under refractome...

  • Article
  • Open Access
30 Citations
6,416 Views
15 Pages

2 April 2022

Low-cost particle sensors are now used worldwide to monitor outdoor air quality. However, they have only been in wide use for a few years. Are they reliable? Does their performance deteriorate over time? Are the algorithms for calculating PM2.5 conce...

  • Review
  • Open Access
33 Citations
5,887 Views
23 Pages

Picomolar or beyond Limit of Detection Using Molecularly Imprinted Polymer-Based Electrochemical Sensors: A Review

  • Naheed Sidiq Shah,
  • Vandana Thotathil,
  • Shabi Abbas Zaidi,
  • Hanan Sheikh,
  • Maimoona Mohamed,
  • Ahmadyar Qureshi and
  • Kishor Kumar Sadasivuni

1 December 2022

Over the last decades, molecularly imprinted polymers (MIPs) have emerged as selective synthetic receptors that have a selective binding site for specific analytes/target molecules. MIPs are synthetic analogues to the natural biological antigen&ndash...

  • Article
  • Open Access
2 Citations
1,904 Views
11 Pages

Proposed Detection Limits for Radioactivity Concentrations in Water in the Decommissioning and Dismantling of Nuclear Facilities

  • Raquel Idoeta,
  • Susana Petisco-Ferrero,
  • Saroa Rozas,
  • Concepción Olondo and
  • Margarita Herranz

The Dismantling and Decommissioning (D&D) of nuclear facilities poses several challenges for radioactivity measurement laboratories involved in environmental radiation monitoring plans. One of them is the definition of the detection limits to be...

  • Review
  • Open Access
12 Citations
5,671 Views
24 Pages

Review of Detection Limits for Various Techniques for Bacterial Detection in Food Samples

  • Xinyi Zhao,
  • Abhijnan Bhat,
  • Christine O’Connor,
  • James Curtin,
  • Baljit Singh and
  • Furong Tian

Foodborne illnesses can be infectious and dangerous, and most of them are caused by bacteria. Some common food-related bacteria species exist widely in nature and pose a serious threat to both humans and animals; they can cause poisoning, diseases, d...

  • Article
  • Open Access
11 Citations
8,168 Views
24 Pages

A key enabler for Cognitive Radio (CR) is spectrum sensing, which is physically implemented by sensor and actuator networks typically using the popular energy detection method. The threshold of the binary hypothesis for energy detection is generally...

  • Article
  • Open Access
6 Citations
3,506 Views
16 Pages

Limits of Detection of Topically Applied Products in the Skin Using In Vivo Raman Spectroscopy

  • Cláudio Nico,
  • Tom C. Bakker Schut,
  • Peter J. Caspers and
  • Gerwin J. Puppels

We have developed a method to determine the limit of detection (LoD) for quantitative measurement of exogenous analytes in the outer layer of the human skin by in vivo confocal Raman spectroscopy. The method is in accordance with the guidelines of th...

  • Review
  • Open Access
379 Views
43 Pages

Challenges and Opportunities in Tomato Leaf Disease Detection with Limited and Multimodal Data: A Review

  • Yingbiao Hu,
  • Huinian Li,
  • Chengcheng Yang,
  • Ningxia Chen,
  • Zhenfu Pan and
  • Wei Ke

26 January 2026

Tomato leaf diseases cause substantial yield and quality losses worldwide, yet reliable detection in real fields remains challenging. Two practical bottlenecks dominate current research: (i) limited data, including small samples for rare diseases, cl...

  • Feature Paper
  • Article
  • Open Access
14 Citations
7,810 Views
16 Pages

2 August 2020

Ibuprofen is one of the best-known nonsteroidal anti-inflammatory and analgesic drugs. Following the previous work, the current study is focused on estimating the effect of different chromatographic conditions on the sensitivity of thin-layer chromat...

  • Article
  • Open Access
10 Citations
2,948 Views
19 Pages

Borrow from Source Models: Efficient Infrared Object Detection with Limited Examples

  • Ruimin Chen,
  • Shijian Liu,
  • Jing Mu,
  • Zhuang Miao and
  • Fanming Li

11 February 2022

Recent deep models trained on large-scale RGB datasets lead to considerable achievements in visual detection tasks. However, the training examples are often limited for an infrared detection task, which may deteriorate the performance of deep detecto...

  • Article
  • Open Access
38 Citations
7,714 Views
14 Pages

Calculating the Limits of Detection in Laser-Induced Breakdown Spectroscopy: Not as Easy as It Might Seem

  • Francesco Poggialini,
  • Stefano Legnaioli,
  • Beatrice Campanella,
  • Bruno Cocciaro,
  • Giulia Lorenzetti,
  • Simona Raneri and
  • Vincenzo Palleschi

13 March 2023

The objectives of this paper will be to discuss the issues related to the determination of the limits of detection (LOD) in laser-induced breakdown spectroscopy (LIBS) analytical applications. The derivation of the commonly used ‘3-sigma over s...

  • Article
  • Open Access
24 Citations
10,636 Views
13 Pages

It is necessary to determine the limit of detection when validating any analytical method. For methods with a linear response, a simple and low labor-consuming procedure is to use the linear regression parameters obtained in the calibration to estima...

  • Article
  • Open Access
1 Citations
2,416 Views
16 Pages

The main aim of this work is to define the limits of detection (LOD) and quantification (LOQ) for polyethylene (PE) particles using a pyrolysis and oxidation-based method, the thermal Rock-Eval® device, combined with a mathematical extrapolation...

  • Article
  • Open Access
11 Citations
2,660 Views
25 Pages

19 April 2024

Identifying the structural state without baseline data is an important engineering problem in the field of structural health monitoring, which is crucial for assessing the safety condition of structures. In the context of limited accelerometers avail...

  • Article
  • Open Access
33 Citations
5,982 Views
13 Pages

The detection of adenine molecules at very low concentrations is important for biological and medical research and applications. This paper reports a silver-based surface-enhanced Raman scattering (SERS) sensor with a very low detection limit for ade...

  • Proceeding Paper
  • Open Access
1 Citations
2,452 Views
8 Pages

26 September 2023

Smart, ultra-scaled, always-on wearable, and implantable (WI) sensors are an exciting frontier in personalized medicine. These sensors integrate sensing and actuation capabilities, enabling real-time analyte detection for on-demand drug delivery, aki...

  • Article
  • Open Access
8 Citations
3,866 Views
15 Pages

Shotgun proteomics has proven to be an attractive alternative for identifying a pathogen and characterizing the antimicrobial resistance genes it produces. Because of its performance, proteotyping of microorganisms by tandem mass spectrometry is expe...

  • Article
  • Open Access
2 Citations
2,776 Views
12 Pages

Comparison of Sub-Ppm Instrument Response Suggests Higher Detection Limits Could Be Used to Quantify Methane Emissions from Oil and Gas Infrastructure

  • Stuart N. Riddick,
  • Mercy Mbua,
  • Ryan Brouwer,
  • Ethan W. Emerson,
  • Abhinav Anand,
  • Elijah Kiplimo,
  • Seunfunmi Ojomu,
  • Jui-Hsiang Lo and
  • Daniel J. Zimmerle

25 May 2024

Quantifying and controlling fugitive methane emissions from oil and gas facilities remains essential for addressing climate goals, but the costs associated with monitoring millions of production sites remain prohibitively expensive. Current thinking,...

  • Article
  • Open Access
9 Citations
2,369 Views
16 Pages

29 July 2023

Wheat stripe rust (WSR) is an airborne disease that causes severe damage to wheat. The rapid and early detection of WSR is essential for the prevention and control of this disease. The minimum detection limit (MDL) is one of the most important charac...

  • Article
  • Open Access
1,181 Views
15 Pages

Electric Field-Enhanced SPR Sensors with AuNPs and CQDs for Rapid and Low-Detection-Limit Detection of Co2+

  • Xinyue Jing,
  • Minxuan Chen,
  • Xingye Ma,
  • Xinrui Xu,
  • Ning Wang,
  • Kunpeng Niu,
  • Xiaohan Chen,
  • Yihao Wang,
  • Jiayi Zhu and
  • Zhichao Wang
  • + 1 author

1 September 2025

As a vital transition metal species, cobalt ions (Co2+) play a critical role in industrial and medical fields. However, uncontrolled release into ecosystems via industrial effluents presents significant environmental risks. To address this, a prism-c...

  • Article
  • Open Access
9 Citations
4,908 Views
8 Pages

22 July 2019

We report on a novel optical microcavity sensing scheme by using the orthogonal demodulation Pound–Drever–Hall (PDH) technique. We found that larger sensitivity in a broad range of cavity quality factor (Q) could be obtained. Taking micro...

  • Article
  • Open Access
1 Citations
2,730 Views
9 Pages

30 August 2022

Fluorescence correlation spectroscopy (FCS) is an extremely versatile tool that has been widely used to measure chemical reaction rates, protein binding, nanoparticle-protein interactions, and biomolecular dynamics in vitro and in vivo. As an inheren...

  • Article
  • Open Access
14 Citations
10,190 Views
14 Pages

Fabrication of Stretchable Copper Coated Carbon Nanotube Conductor for Non-Enzymatic Glucose Detection Electrode with Low Detection Limit and Selectivity

  • Dawei Jiang,
  • Zhongsheng Liu,
  • Kunkun Wu,
  • Linlin Mou,
  • Raquel Ovalle-Robles,
  • Kanzan Inoue,
  • Yu Zhang,
  • Ningyi Yuan,
  • Jianning Ding and
  • Zunfeng Liu
  • + 2 authors

28 March 2018

The increasing demand for wearable glucose sensing has stimulated growing interest in stretchable electrodes. The development of the electrode materials having large stretchability, low detection limit, and good selectivity is the key component for c...

  • Article
  • Open Access
3 Citations
3,602 Views
14 Pages

Snow Surface Microbial Diversity at the Detection Limit within the Vicinity of the Concordia Station, Antarctica

  • Alessandro Napoli,
  • Claudia Coleine,
  • Nikea J. Ulrich,
  • Ralf Moeller,
  • Daniela Billi and
  • Laura Selbmann

30 December 2022

The Concordia Research Station provides a unique location for preparatory activities for future human journey to Mars, to explore microbial diversity at subzero temperatures, and monitor the dissemination of human-associated microorganisms within the...

  • Article
  • Open Access
5 Citations
2,892 Views
11 Pages

19 May 2022

In this study, nanoporous gold (NPG) was synthesized by free corrosion dealloying of an amorphous precursor, Au20Cu48Ag7Pd5Si20 (at. %), in a mixture of nitric and hydrofluoric acid, starting from amorphous melt-spun ribbons. NPG revealed a 3D nanopo...

  • Communication
  • Open Access
7 Citations
5,408 Views
7 Pages

27 November 2022

Rapid antigen tests (RATs) are widely used worldwide to detect SARS-CoV-2 since they are an easy-to-use kit and offer rapid results. The RAT detects the presence of the nucleocapsid protein, which is located inside the virus. However, the sensitivity...

  • Article
  • Open Access
20 Citations
9,440 Views
16 Pages

Improving the Detection Limit in a Capillary Raman System for In Situ Gas Analysis by Means of Fluorescence Reduction

  • Simone Rupp,
  • Andreas Off,
  • Hendrik Seitz-Moskaliuk,
  • Timothy M. James and
  • Helmut H. Telle

11 September 2015

Raman spectroscopy for low-pressure or trace gas analysis is rather challenging, in particular in process control applications requiring trace detection and real-time response; in general, enhancement techniques are required. One possible enhancement...

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