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953 Results Found

  • Review
  • Open Access
18 Citations
23,549 Views
25 Pages

Examining the Landscape of Cognitive Fatigue Detection: A Comprehensive Survey

  • Enamul Karim,
  • Hamza Reza Pavel,
  • Sama Nikanfar,
  • Aref Hebri,
  • Ayon Roy,
  • Harish Ram Nambiappan,
  • Ashish Jaiswal,
  • Glenn R. Wylie and
  • Fillia Makedon

Cognitive fatigue, a state of reduced mental capacity arising from prolonged cognitive activity, poses significant challenges in various domains, from road safety to workplace productivity. Accurately detecting and mitigating cognitive fatigue is cru...

  • Communication
  • Open Access
5 Citations
3,923 Views
10 Pages

Assessment of Cognitive Fatigue from Gait Cycle Analysis

  • Hamza Reza Pavel,
  • Enamul Karim,
  • Ashish Jaiswal,
  • Sneh Acharya,
  • Gaurav Nale,
  • Michail Theofanidis and
  • Fillia Makedon

Cognitive Fatigue (CF) is the decline in cognitive abilities due to prolonged exposure to mentally demanding tasks. In this paper, we used gait cycle analysis, a biometric method related to human locomotion to identify cognitive fatigue in individual...

  • Article
  • Open Access
12 Citations
4,482 Views
11 Pages

Lowering the Sampling Rate: Heart Rate Response during Cognitive Fatigue

  • Kar Fye Alvin Lee,
  • Elliot Chan,
  • Josip Car,
  • Woon-Seng Gan and
  • Georgios Christopoulos

10 May 2022

Cognitive fatigue is a mental state characterised by feelings of tiredness and impaired cognitive functioning due to sustained cognitive demands. Frequency-domain heart rate variability (HRV) features have been found to vary as a function of cognitiv...

  • Review
  • Open Access
118 Citations
10,098 Views
20 Pages

Long-Term Fatigue and Cognitive Disorders in Breast Cancer Survivors

  • Florence Joly,
  • Marie Lange,
  • Melanie Dos Santos,
  • Ines Vaz-Luis and
  • Antonio Di Meglio

28 November 2019

Survivors of early-stage breast cancer may report treatment-related side effects that persist for several years after the end of primary treatment. Among these, fatigue and cognitive disorders are frequent complaints and can negatively impact quality...

  • Article
  • Open Access
21 Citations
10,536 Views
19 Pages

CogBeacon: A Multi-Modal Dataset and Data-Collection Platform for Modeling Cognitive Fatigue

  • Michalis Papakostas,
  • Akilesh Rajavenkatanarayanan and
  • Fillia Makedon

In this work, we present CogBeacon, a multi-modal dataset designed to target the effects of cognitive fatigue in human performance. The dataset consists of 76 sessions collected from 19 male and female users performing different versions of a cogniti...

  • Article
  • Open Access
2,136 Views
20 Pages

Cognitive Fatigue Disrupts Explosive Performance and Vigilance in Trained Individuals

  • Andreas Stafylidis,
  • Walter Staiano,
  • Athanasios Mandroukas,
  • Yiannis Michailidis,
  • Lluis Raimon Salazar Bonet,
  • Angelos E. Kyranoudis,
  • Marco Romagnoli,
  • Ana Ferri-Caruana and
  • Thomas I. Metaxas

4 November 2025

This study examined the effects of cognitive fatigue on repeated sprint ability (RSA), neuromuscular performance, and vigilance in physically active young adults (N = 28, 16 males, 12 females; mean age = 20.6 ± 1.4 years). Participants were ra...

  • Article
  • Open Access
2 Citations
3,855 Views
27 Pages

This study examines the interaction between cognitive demands and generative artificial intelligence (GenAI) technologies in shaping the quality and influence of academic research. While GenAI tools such as ChatGPT and Elicit are increasingly adopted...

  • Review
  • Open Access
20 Citations
7,265 Views
16 Pages

2 June 2021

Cognitive fatigue is a psychological state characterised by feelings of tiredness and impaired cognitive functioning arising from high cognitive demands. This paper examines the recent research progress on the assessment of cognitive fatigue and prov...

  • Review
  • Open Access
75 Citations
13,572 Views
23 Pages

Cognitive fatigue is one of the most frequent symptoms in multiple sclerosis (MS), associated with significant impairment in daily functioning and quality of life. Despite its clinical significance, progress in understanding and treating fatigue is s...

  • Article
  • Open Access
29 Citations
7,333 Views
14 Pages

Automatic Cognitive Fatigue Detection Using Wearable fNIRS and Machine Learning

  • Rui Varandas,
  • Rodrigo Lima,
  • Sergi Bermúdez I Badia,
  • Hugo Silva and
  • Hugo Gamboa

25 May 2022

Wearable sensors have increasingly been applied in healthcare to generate data and monitor patients unobtrusively. Their application for Brain–Computer Interfaces (BCI) allows for unobtrusively monitoring one’s cognitive state over time....

  • Article
  • Open Access
11 Citations
2,892 Views
11 Pages

Lowered Delta Activity in Post-COVID-19 Patients with Fatigue and Cognitive Impairment

  • Paola Ortelli,
  • Angelica Quercia,
  • Antonio Cerasa,
  • Sabrina Dezi,
  • Davide Ferrazzoli,
  • Luca Sebastianelli,
  • Leopold Saltuari,
  • Viviana Versace and
  • Angelo Quartarone

In post-COVID-19 syndrome (PCS), neurocognitive symptoms and fatigue are often associated with alterations in electroencephalographic (EEG) activity. The present study investigates the brain source activity at rest in PCS patients (PCS-pts) perceivin...

  • Article
  • Open Access
39 Citations
4,431 Views
9 Pages

Fatigue and Cognitive Dysfunction Are Associated with Occupational Status in Post-COVID Syndrome

  • Cristina Delgado-Alonso,
  • Constanza Cuevas,
  • Silvia Oliver-Mas,
  • María Díez-Cirarda,
  • Alfonso Delgado-Álvarez,
  • María José Gil-Moreno,
  • Jorge Matías-Guiu and
  • Jordi A. Matias-Guiu

Post-COVID syndrome (PCS) is a medical condition characterized by the persistence of a wide range of symptoms after acute infection by SARS-CoV-2. The work capacity consequences of this disorder have scarcely been studied. We aimed to analyze the fac...

  • Article
  • Open Access
19 Citations
5,407 Views
12 Pages

Mental Fatigue Is Associated with Subjective Cognitive Decline among Older Adults

  • Qianqian Zhang,
  • McKenna Angela Sun,
  • Qiuzi Sun,
  • Hua Mei,
  • Hengyi Rao and
  • Jianghong Liu

21 February 2023

Both Subjective Cognitive Decline (SCD) and mental fatigue are becoming increasingly prevalent as global demographics shifts indicate our aging populations. SCD is a reversible precursor for Alzheimer’s disease, and early identification is impo...

  • Article
  • Open Access
3 Citations
8,316 Views
17 Pages

Sleep Fragmentation Modulates the Neurophysiological Correlates of Cognitive Fatigue

  • Oumaïma Benkirane,
  • Peter Simor,
  • Olivier Mairesse and
  • Philippe Peigneux

22 October 2024

Cognitive fatigue (CF) is a critical factor affecting performance and well-being. It can be altered in suboptimal sleep quality conditions, e.g., in patients suffering from obstructive sleep apnea who experience both intermittent hypoxia and sleep fr...

  • Review
  • Open Access
903 Views
25 Pages

Golexanolone Attenuates Neuroinflammation, Fatigue, and Cognitive and Motor Impairment in Diverse Neuroinflammatory Disorders

  • Marta Llansola,
  • Gergana Mincheva,
  • Yaiza M. Arenas,
  • Paula Izquierdo-Altarejos,
  • Maria A. Pedrosa,
  • Thomas P. Blackburn,
  • Torbjörn Bäckström,
  • Bruce F. Scharschmidt,
  • Magnus Doverskog and
  • Vicente Felipo

18 November 2025

Background and Objectives: Neuroinflammation plays a significant role in liver and neurological disorders via its disruption of neurotransmission, which alters cerebral function, resulting in cognitive and motor impairment, fatigue, anxiety, and depr...

  • Protocol
  • Open Access
6 Citations
3,031 Views
11 Pages

Social Cognition Impairments in Association to Clinical, Cognitive, Mood, and Fatigue Features in Multiple Sclerosis: A Study Protocol

  • Triantafyllos K. Doskas,
  • Foteini Christidi,
  • Kanellos C. Spiliopoulos,
  • Dimitrios Tsiptsios,
  • George D. Vavougios,
  • Anna Tsiakiri,
  • Theofanis Vorvolakos,
  • Christos Kokkotis,
  • Ioannis Iliopoulos and
  • Konstantinos Vadikolias
  • + 1 author

1 September 2023

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS), characterized by the diffuse grey and white matter damage. Cognitive impairment (CI) is a frequent clinical feature in patients with MS (PwMS) that can...

  • Review
  • Open Access
42 Citations
13,763 Views
13 Pages

8 February 2022

Fatigue caused by exercise or mentally demanding tasks can lead to an alteration in the cognitive functioning of athletes. Therefore, it is important to investigate whether and to what extent fatigue influences athletes cognitive performance in sport...

  • Article
  • Open Access
11 Citations
3,094 Views
9 Pages

The objective of this study is to explore the mediator role of cognitive fusion and chronic pain acceptance on the effects that the walking pattern, following an established clinical guideline for physical exercise, can have on fatigue (physical and...

  • Article
  • Open Access
15 Citations
4,840 Views
12 Pages

Combining HIIT Plus Cognitive Task Increased Mental Fatigue but Not Physical Workload in Tennis Players

  • Jesús Díaz-García,
  • Vicente Javier Clemente-Suárez,
  • Juan Pedro Fuentes-García and
  • Santos Villafaina

12 June 2023

Mental fatigue can significantly impair physical performance during sports practice. However, previous studies have not analyzed the impact of combining High-Intensity Interval Training (HIIT) with a cognitive task on physical performance. In this li...

  • Article
  • Open Access
796 Views
12 Pages

Fatigue Severity, Cognitive Strain, and Psychological Health in Long COVID: Untangling the Interconnected Aftermath from a Dedicated Long COVID Clinic

  • Ashish Bhargava,
  • Hemang Patel,
  • Susan Szpunar,
  • Mamta Sharma,
  • Michael Somero,
  • Shyam Moudgil and
  • Louis Saravolatz

27 November 2025

Post-acute sequelae of SARS-CoV-2 infection (PASC) frequently includes persistent fatigue and cognitive dysfunction, but the relationship between these symptoms remains poorly defined. In this prospective observational study at the Henry Ford St. Joh...

  • Review
  • Open Access
21 Citations
7,799 Views
15 Pages

Most people recover within months after a mild traumatic brain injury (TBI) or concussion, but some will suffer from long-term fatigue with a reduced quality of life and the inability to maintain their employment status or education. For many people,...

  • Review
  • Open Access
59 Citations
20,983 Views
17 Pages

11 December 2020

An increasing number of young and previously fit and healthy people who did not require hospitalisation continue to have symptoms months after mild cases of COVID-19. Rehabilitation clinics are already offering cognitive behavioural therapy (CBT) as...

  • Review
  • Open Access
4 Citations
12,732 Views
22 Pages

Cognitive Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome—Aetiology and Potential Treatments

  • Amolak Singh Bansal,
  • Katharine A. Seton,
  • Jonathan C. W. Brooks and
  • Simon R. Carding

22 February 2025

Systemic infection and inflammation impair mental function through a combination of altered attention and cognition. Here, we comprehensively review the relevant literature and report personal clinical observations to discuss the relationship between...

  • Article
  • Open Access
3,060 Views
19 Pages

The Mental Fatigue Induced by Physical, Cognitive and Combined Effort in Amateur Soccer Players: A Comparative Study Using EEG

  • Ana Rubio-Morales,
  • Jesús Díaz-García,
  • Marika Berchicci,
  • Jesús Morenas-Martín,
  • Vicente Luis del Campo and
  • Tomás García-Calvo

Objective: Mental fatigue (MF) worsens soccer performance. Further knowledge is needed to understand MF’s effects on soccer players and its underlying mechanisms. Our aim was to analyze the subjective, objective, and neural MF-related outcomes...

  • Article
  • Open Access
487 Views
18 Pages

26 December 2025

This study investigates how digital lifestyles and cognitive fatigue influence sustainable behaviour and energy awareness among Generation Z. Drawing on environmental psychology and social science perspectives, it explores behavioural and cognitive m...

  • Article
  • Open Access
1,038 Views
21 Pages

27 November 2025

This study aimed to investigate the effects of acute exhaustion exercise on cognitive control in young men, a key higher cognitive function for goal-directed behavior. Although long-term regular exercise benefits cognition, the effects of acute exhau...

  • Article
  • Open Access
951 Views
22 Pages

5 October 2025

In our study, we examine how the temporal window shift—the step between consecutive analysis windows—affects EEG-based cognitive fatigue detection while keeping the window length fixed. Using a reference workload dataset and a pipeline th...

  • Article
  • Open Access
8 Citations
3,231 Views
10 Pages

Making Visible the Invisible: Automatically Measured Global and Regional Brain Volume Is Associated with Cognitive Impairment and Fatigue in Multiple Sclerosis

  • Stefano Ziccardi,
  • Francesca Benedetta Pizzini,
  • Maddalena Guandalini,
  • Agnese Tamanti,
  • Cecilia Cristofori and
  • Massimiliano Calabrese

In multiple sclerosis (MS), the transition from relapsing-remitting to the secondary-progressive phase is characterized by a progression independent of relapse activity (PIRA), resulting in physical disability accumulation and invisible symptoms, i.e...

  • Review
  • Open Access
78 Citations
42,915 Views
18 Pages

Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression

  • Stefan Markun,
  • Isaac Gravestock,
  • Levy Jäger,
  • Thomas Rosemann,
  • Giuseppe Pichierri and
  • Jakob M. Burgstaller

12 March 2021

Vitamin B12 is often used to improve cognitive function, depressive symptoms, and fatigue. In most cases, such complaints are not associated with overt vitamin B12 deficiency or advanced neurological disorders and the effectiveness of vitamin B12 sup...

  • Article
  • Open Access
26 Citations
11,508 Views
14 Pages

28 January 2021

Multiple studies suggest that genetic polymorphisms influence the neurocognitive effects of caffeine. Using data collected from a double-blinded, within-participants, randomized, cross-over design, this study examined the effects of trait (long-stand...

  • Article
  • Open Access
1,815 Views
9 Pages

The Cognitive Reserve May Influence Fatigue after Rehabilitation in Progressive Multiple Sclerosis: A Secondary Analysis of the RAGTIME Trial

  • Ambra Balzeri,
  • Nicola Lamberti,
  • Andrea Baroni,
  • Nino Basaglia,
  • Antonella Bergonzoni,
  • Franca Stablum,
  • Fabio Manfredini and
  • Sofia Straudi

29 May 2024

Cognitive reserve (CR) seems to be an ability to adapt cognitive processes in response to brain disease and may influence rehabilitation outcomes. This is a secondary analysis of the “Robot-Assisted Gait Training versus conventional therapy on...

  • Study Protocol
  • Open Access
5 Citations
3,331 Views
12 Pages

Herbal Medicines for Post-Acute Sequelae (Fatigue or Cognitive Dysfunction) of SARS-CoV-2 Infection: A Phase 2 Pilot Clinical Study Protocol

  • Kyung Hwan Jegal,
  • Jiwon Yoon,
  • Sanghyun Kim,
  • Soobin Jang,
  • Young-Hee Jin,
  • Jun-Hwan Lee,
  • Sun-Mi Choi,
  • Tae Hun Kim and
  • Sunoh Kwon

22 September 2022

Long-term sequelae refer to persistent symptoms or signs for >6 months after SARS-CoV-2 infection. The most common symptoms of sequelae are fatigue and neuropsychiatric symptoms (concentration difficulty, amnesia, cognitive dysfunction, anxiety, a...

  • Article
  • Open Access
4 Citations
2,760 Views
17 Pages

29 November 2022

Intense exercise is reported to induce physical and cognitive fatigue, but few studies have focused on treatments to alleviate fatigue. We hypothesized that the oral supplementation of enzymatic porcine placenta hydrolysate (EPPH) prepared using prot...

  • Article
  • Open Access
973 Views
15 Pages

22 October 2025

Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which can lead to physical and cognitive disability, fatigue, depression, and sleep disturbance, all of which may impair quality of life (QoL). While...

  • Article
  • Open Access
1,062 Views
15 Pages

Elevated Plasma BDNF in Early Primary Biliary Cholangitis: Associations with Liver Fibrosis, IL-6, IL-18, Fatigue, and Cognitive Impairment

  • Magdalena Rogalska,
  • Sławomir Ławicki,
  • Agnieszka Błachnio-Zabielska,
  • Piotr Zabielski,
  • Kamila Roszczyc-Owsiejczuk,
  • Jacek Janica,
  • Dagmara Bogdanowska-Charkiewicz,
  • Aleksandra Andrzejuk,
  • Andrzej Dąbrowski and
  • Paweł Rogalski
  • + 1 author

Background and Aims: Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease frequently associated with fatigue and mild cognitive impairment. Brain-derived neurotrophic factor (BDNF) plays key roles in neuroplasticity, immune regulat...

  • Article
  • Open Access
3 Citations
4,586 Views
19 Pages

Objectives: With the advancement of modern society, people in cognitively demanding jobs are increasingly exposed to occupational stress. Prolonged and high-intensity cognitive activities are prone to inducing mental fatigue (MF), which adversely aff...

  • Review
  • Open Access
5 Citations
26,725 Views
16 Pages

11 August 2017

The Dutch Fatigue In Teenagers on the interNET (FITNET) study claimed that after 6 months, internet based cognitive behaviour therapy in adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), led to a 63% recovery rate compared...

  • Article
  • Open Access
13 Citations
3,781 Views
15 Pages

Magnetoencephalography and High-Density Electroencephalography Study of Acoustic Event Related Potentials in Early Stage of Multiple Sclerosis: A Pilot Study on Cognitive Impairment and Fatigue

  • Damiano Paolicelli,
  • Alessia Manni,
  • Antonio Iaffaldano,
  • Giusy Tancredi,
  • Katia Ricci,
  • Eleonora Gentile,
  • Rosa Gemma Viterbo,
  • Silvia Giovanna Quitadamo,
  • Marina de Tommaso and
  • Maria Trojano

Cognitive impairment (CI) is a common and disabling symptom of Multiple Sclerosis (MS) with a negative impact on daily living. In this pilot study, we applied magnetoencephalography (MEG) and high density (hd) electroencephalography (EEG) study to ev...

  • Article
  • Open Access
463 Views
18 Pages

12 December 2025

This study examines two primary research objectives: (1) to investigate the roles of work stress, logistics infrastructure, financial stress, and environmental stress as antecedent factors influencing the wellbeing of truck drivers in Thailand, and (...

  • Article
  • Open Access
47 Citations
10,423 Views
20 Pages

Impact of Sleep Fragmentation on Cognition and Fatigue

  • Oumaïma Benkirane,
  • Bérénice Delwiche,
  • Olivier Mairesse and
  • Philippe Peigneux

Sleep continuity and efficacy are essential for optimal cognitive functions. How sleep fragmentation (SF) impairs cognitive functioning, and especially cognitive fatigue (CF), remains elusive. We investigated the impact of induced SF on CF through th...

  • Article
  • Open Access
14 Citations
10,167 Views
16 Pages

28 December 2020

Recent dietary trends have prompted growing support for a variety of fasting paradigms involving extreme restriction or nil-caloric intake on fasting days. Some studies indicate that fasting may negatively influence factors including cognitive functi...

  • Article
  • Open Access
1,683 Views
21 Pages

tDCS and Cognitive Training for Fatigued and Cognitively Impaired People with Multiple Sclerosis: An SCED Study

  • Teresa L’Abbate,
  • Nefeli K. Dimitriou,
  • George Dimakopoulos,
  • Franca Tecchio and
  • Grigorios Nasios

Background/Objectives: Fatigue and cognitive impairment are common issues for People with Multiple Sclerosis (PwMS), affecting over 80% and 40–65%, respectively. The relationship between these two debilitating conditions is complex, with cognit...

  • Article
  • Open Access
2 Citations
2,802 Views
11 Pages

(1) Background: Emotional recognition (ER), the ability to read into others’ minds and recognize others’ emotional states, is important in social environment adaptation. Recently it has been found that ER difficulties affect patients with...

  • Review
  • Open Access
364 Citations
129,746 Views
35 Pages

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

  • Anne-Laure Tardy,
  • Etienne Pouteau,
  • Daniel Marquez,
  • Cansu Yilmaz and
  • Andrew Scholey

16 January 2020

Vitamins and minerals are essential to humans as they play essential roles in a variety of basic metabolic pathways that support fundamental cellular functions. In particular, their involvement in energy-yielding metabolism, DNA synthesis, oxygen tra...

  • Article
  • Open Access
6 Citations
6,444 Views
28 Pages

23 December 2024

Continued solicitation of cognitive resources eventually leads to cognitive fatigue (CF), i.e., a decrease in cognitive efficiency that develops during sustained cognitive demands in conditions of constrained processing time, independently of sleepin...

  • Review
  • Open Access
7 Citations
6,723 Views
24 Pages

16 January 2023

The German Institute for Quality and Efficiency in Healthcare (IQWiG) recently published its draft report to the government about myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The IQWiG concluded that graded exercise therapy (GET) and...

  • Article
  • Open Access
34 Citations
4,717 Views
22 Pages

10 November 2020

Cognitive fatigue is common and debilitating among persons with multiple sclerosis (pwMS). Neural mechanisms underlying fatigue are not well understood, which results in lack of adequate treatment. The current study examined cognitive fatigue-related...

  • Article
  • Open Access
2 Citations
3,336 Views
12 Pages

Circadian Rhythm and Physical Fatigue Separately Influence Cognitive and Physical Performance in Amateur Athletes

  • Panagiota Karanika,
  • Philip Gallardo,
  • Themistoklis Tsatalas,
  • Giannis Giakas and
  • Panagiotis V. Tsaklis

Background/Objectives: Circadian rhythm (CR) influences various physiological functions, including physical and cognitive performance, which fluctuate throughout the day. The present study aimed to investigate the combined and separate effects of CR...

  • Article
  • Open Access
4 Citations
2,339 Views
14 Pages

The Fatigue and Altered Cognition Scale among SARS-CoV-2 Survivors: Psychometric Properties and Item Correlations with Depression and Anxiety Symptoms

  • Yu-Yu Hsiao,
  • Timothy R. Elliott,
  • Julie Jaramillo,
  • Megan E. Douglas,
  • Mark B. Powers and
  • Ann Marie Warren

10 April 2024

Background/Objectives: This study examined the psychometric properties of the Fatigue and Altered Cognition Scale (FACs) among adult COVID-19 survivors and its unique ability to assess symptomology not accounted for by measures of depression and anxi...

  • Article
  • Open Access
1 Citations
3,714 Views
15 Pages

This study examined the nature, severity, and predictors of cognitive complaints in patients referred for suspected obstructive sleep apnea (OSA). The sample included 127 patients classified as no OSA (AHI, apnea/hypopnea index < 5, N = 32), mild...

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