- Article
Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA
- Rocio K. Finol-Urdaneta,
- Jeffrey R. McArthur,
- Vyacheslav S. Korkosh,
- Sun Huang,
- Denis McMaster,
- Robert Glavica,
- Denis B. Tikhonov,
- Boris S. Zhorov and
- Robert J. French
µ-Conotoxin PIIIA, in the sub-picomolar, range inhibits the archetypal bacterial sodium channel NaChBac (NavBh) in a voltage- and use-dependent manner. Peptide µ-conotoxins were first recognized as potent components of the venoms of fish-...