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107 Results Found

  • Article
  • Open Access
24 Citations
4,793 Views
13 Pages

Arsenic Speciation of Contaminated Soils/Solid Wastes and Relative Oral Bioavailability in Swine and Mice

  • Brooke N. Stevens,
  • Aaron R. Betts,
  • Bradley W. Miller,
  • Kirk G. Scheckel,
  • Richard H. Anderson,
  • Karen D. Bradham,
  • Stan W. Casteel,
  • David J. Thomas and
  • Nicholas T. Basta

Arsenic (As) is one of the most widespread, toxic elements in the environment, and human activities have resulted in a large number of contaminated areas. However abundant, the potential of As toxicity from exposure to contaminated soils is limited t...

  • Article
  • Open Access
316 Views
16 Pages

Study on the Bioavailability of Arsenic in the Rice–Crayfish Farming System

  • Kelei Zhang,
  • Shoudong Zhang,
  • Longjun Deng,
  • Tiancai Li,
  • Li Liu,
  • Wei Luo,
  • Yibo Zhang,
  • Yongyao Guo,
  • Dan Liu and
  • Zongjun Du
  • + 3 authors

15 December 2025

Rice–fishery integrated farming has expanded rapidly in China, yet its implications for arsenic (As) accumulation remain insufficiently understood. This study evaluated As bioavailability and enrichment in a rice–crayfish farming system (...

  • Article
  • Open Access
9 Citations
4,923 Views
10 Pages

A Pooled Data Analysis to Determine the Relationship between Selected Metals and Arsenic Bioavailability in Soil

  • Kaihong Yan,
  • Ravi Naidu,
  • Yanju Liu,
  • Ayanka Wijayawardena,
  • Luchun Duan and
  • Zhaomin Dong

Chronic exposure to arsenic (As) is a global concern due to worldwide exposure and adverse effects, and the importance of incorporating bioavailability in the exposure assessment and risk assessment of As is increasing acknowledged. The bioavailabili...

  • Article
  • Open Access
1 Citations
4,444 Views
17 Pages

Evaluation of the Bioavailability of Iodine and Arsenic in Raw and Cooked Saccharina japonica Based on Simulated Digestion/Caco-2 Cell Model

  • Na Li,
  • Zhaomeng Geng,
  • Yingying Guo,
  • Xinyue Dai,
  • Wenjia Zhu,
  • Lin Yao,
  • Yanhua Jiang,
  • Xiaojuan Wang,
  • Hao Dong and
  • Lianzhu Wang
  • + 1 author

10 September 2024

Kelp is a traditional healthy food due to its high nutritional content; however, its relatively high contents of iodine and arsenic have raised concerns about its edible safety. This study explored the effects of different cooking treatments on the c...

  • Article
  • Open Access
2 Citations
2,092 Views
18 Pages

Arsenic in a Karstic Paddy Soil with a High Geochemical Background in Guangxi, China: Its Bioavailability and Controlling Factors

  • Xuezhen Li,
  • Xudong Ma,
  • Qingye Hou,
  • Xueqi Xia,
  • Bo Li,
  • Kun Lin,
  • Xu Liu,
  • Zhiliang Wu,
  • Wenbing Ji and
  • Zhongfang Yang
  • + 2 authors

8 February 2024

Arsenic (As) is of widespread concern, as its elevated contents in soil and water have a serious impact on the ecological environment and human health. Soils in karst regions are characterized by a high geochemical background of As. However, the bioa...

  • Article
  • Open Access
7 Citations
6,143 Views
17 Pages

Iodine Bioavailability and Accumulation of Arsenic and Cadmium in Rats Fed Sugar Kelp (Saccharina latissima)

  • Even Fjære,
  • Rikke Poulsen,
  • Arne Duinker,
  • Bjørn Liaset,
  • Martin Hansen,
  • Lise Madsen and
  • Lene Secher Myrmel

7 December 2022

Suboptimal iodine status is a prominent public health issue in several European coun-tries. Brown algae have a high iodine content that, upon intake, may exceed the recommended dietary intake level, but iodine bioavailability has been reported to be...

  • Feature Paper
  • Article
  • Open Access
8 Citations
4,729 Views
19 Pages

3 February 2021

Fish consumption is the main exposure pathway of the neurotoxicant methylmercury (MeHg) in humans. The risk associated with exposure to MeHg may be modified by its interactions with selenium (Se) and arsenic (As). In vitro bioaccessibility studies ha...

  • Article
  • Open Access
19 Citations
3,418 Views
18 Pages

21 November 2019

This research focuses on the effects of the composting process on oxytetracycline antibiotic degradation and the bioavailability of arsenic and copper. A compost experiment was conducted using cow and pig manure contaminated with oxytetracycline, and...

  • Article
  • Open Access
4 Citations
2,536 Views
12 Pages

Arsenic: A Perspective on Its Effect on Pioglitazone Bioavailability

  • María Cruz del Rocío Terrones-Gurrola,
  • Patricia Ponce-Peña,
  • José Manuel Salas-Pacheco,
  • Abelardo Camacho-Luis,
  • Amaury de Jesús Pozos-Guillén,
  • Guillermo Nieto-Delgado,
  • Olga Dania López-Guzmán and
  • Angel Antonio Vértiz-Hernández

Arsenic (As) is a common contaminant in drinking water in northeastern Mexico, which reduces the expression of cytochrome P450 (CYP 450). This enzyme group metabolizes numerous drugs, such as oral antidiabetic drugs such as pioglitazone (61% CYP 3A4,...

  • Article
  • Open Access
1 Citations
1,220 Views
13 Pages

The Effects of Straw-Returning Processes on the Formation of Fe-Mn (Hydr)oxide Colloids and Arsenic Bioavailability

  • Junhao Zheng,
  • Mei Jiang,
  • Qingzhu Li,
  • Zhihui Yang,
  • Qi Liao,
  • Mengying Si and
  • Weichun Yang

14 November 2024

The objective of this study was to investigate the effect of straw return on the formation of Fe-Mn colloids in arsenic-contaminated soils and its subsequent influence on arsenic behavior. It was observed that organic matter (SD) resulting from straw...

  • Article
  • Open Access
11 Citations
3,570 Views
12 Pages

Aspergillus niger Decreases Bioavailability of Arsenic(V) via Biotransformation of Manganese Oxide into Biogenic Oxalate Minerals

  • Bence Farkas,
  • Marek Kolenčík,
  • Miroslav Hain,
  • Edmund Dobročka,
  • Gabriela Kratošová,
  • Marek Bujdoš,
  • Huan Feng,
  • Yang Deng,
  • Qian Yu and
  • Martin Urík
  • + 4 authors

9 November 2020

The aim of this work was to evaluate the transformation of manganese oxide (hausmannite) by microscopic filamentous fungus Aspergillus niger and the effects of the transformation on mobility and bioavailability of arsenic. Our results showed that the...

  • Article
  • Open Access
18 Citations
5,810 Views
17 Pages

10 January 2019

A rapid and sensitive method was established for arsenic (As) speciation based on high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC-ICP-MS). This method was validated for the quantification of four a...

  • Article
  • Open Access
7 Citations
7,696 Views
17 Pages

Arsenic contamination in a large area of agricultural fields on the Guandu Plain of northern Taiwan was confirmed in a survey conducted in 2006, but research concerning the relationship between bioavailable As concentrations in contaminated soils and...

  • Article
  • Open Access
Toxics2026, 14(2), 112;https://doi.org/10.3390/toxics14020112 
(registering DOI)

24 January 2026

Arsenic (As) contamination in paddy soils poses a serious risk to rice safety and human health. To mitigate this issue, we developed a low-temperature, partially pyrolyzed Fe/Mn/Mg-modified biochar (FMM-BC) and evaluated its performance and mechanism...

  • Review
  • Open Access
40 Citations
5,566 Views
21 Pages

Current Advances of Nanomedicines Delivering Arsenic Trioxide for Enhanced Tumor Therapy

  • Mengzhen Yu,
  • Yanwen Zhang,
  • Meirong Fang,
  • Shah Jehan and
  • Wenhu Zhou

Arsenic trioxide (ATO) is one of the first-line chemotherapeutic drugs for acute promyelocytic leukemia. Its anti-cancer activities against various human neoplastic diseases have been extensively studied. However, the clinical use of ATO for solid tu...

  • Article
  • Open Access
17 Citations
8,712 Views
18 Pages

Introducing Simple Detection of Bioavailable Arsenic at Rafaela (Santa Fe Province, Argentina) Using the ARSOlux Biosensor

  • Konrad Siegfried,
  • Sonja Hahn-Tomer,
  • Andreas Koelsch,
  • Eva Osterwalder,
  • Juergen Mattusch,
  • Hans-Joachim Staerk,
  • Jorge M. Meichtry,
  • Graciela E. De Seta,
  • Fernando D. Reina and
  • Hauke Harms
  • + 2 authors

Numerous articles have reported the occurrence of arsenic in drinking water in Argentina, and the resulting health effects in severely affected regions of the country. Arsenic in drinking water in Argentina is largely naturally occurring due to eleva...

  • Article
  • Open Access
6 Citations
2,359 Views
12 Pages

14 August 2020

An incubation experiment was conducted to determine the effects of nanoscale drinking water treatment residuals (nWTRs) on arsenic (As) fractionation and speciation in agricultural soil amended with biosolids. The soils were treated with biosolids of...

  • Communication
  • Open Access
6 Citations
3,642 Views
8 Pages

12 June 2022

Soil acidification in the subtropical region reduces soil productivity and increases the bioavailability of heavy metal(loid)s in soil. Here 800 °C-calcined oyster shell and leonardite-derived humic substance were combined to form a Ca-humic comp...

  • Article
  • Open Access
26 Citations
4,783 Views
11 Pages

Zinc (Zn) is a key micronutrient affecting bio-functions of crops. Impacts of foliar application of three forms of Zn-containing agrichemicals on the physiology of rice seedlings and their uptake of heavy metal(loid)s and micronutrients from fully fl...

  • Article
  • Open Access
27 Citations
6,977 Views
17 Pages

Applicability of a Freundlich-Like Model for Plant Uptake at an Industrial Contaminated Site with a High Variable Arsenic Concentration

  • Francesca Pedron,
  • Martina Grifoni,
  • Meri Barbafieri,
  • Gianniantonio Petruzzelli,
  • Irene Rosellini,
  • Elisabetta Franchi,
  • Roberto Bagatin and
  • Marco Vocciante

Phytoextraction is a low-cost technology with negligible environmental impacts. A major issue at the field scale is the heterogeneity of contaminant concentration since the entire site needs to be treated evenly even though zones may need different i...

  • Review
  • Open Access
763 Citations
29,865 Views
45 Pages

Arsenic Uptake, Toxicity, Detoxification, and Speciation in Plants: Physiological, Biochemical, and Molecular Aspects

  • Ghulam Abbas,
  • Behzad Murtaza,
  • Irshad Bibi,
  • Muhammad Shahid,
  • Nabeel Khan Niazi,
  • Muhammad Imran Khan,
  • Muhammad Amjad,
  • Munawar Hussain and
  • Natasha

Environmental contamination with arsenic (As) is a global environmental, agricultural and health issue due to the highly toxic and carcinogenic nature of As. Exposure of plants to As, even at very low concentration, can cause many morphological, phys...

  • Article
  • Open Access
2 Citations
2,055 Views
16 Pages

Composting as a Sustainable Solution for the Management of Plant Biomass Contaminated with Hg and As from Puddles Generated by Small-Scale Gold Mining in the Municipality of Unión Panamericana, Colombian Pacific

  • Gysela Rengifo-Mosquera,
  • Manuel Salas-Moreno,
  • Harry Gutierréz-Palacios,
  • Yuber Palacios-Torres,
  • Allien Romaña-Palacios and
  • José Marrugo-Negrete

14 November 2024

ASGM in the Chocó region (Colombian Pacific) has generated abandoned puddles with concentrations of Hg; however, these sites can generate ecosystem services from contaminated biomass with a circular economy approach. (1) Background: The plant...

  • Proceeding Paper
  • Open Access
3 Citations
2,004 Views
4 Pages

Environmental Forensic Study and Remediation Feasibility in an Abandoned Industrial Site

  • Diego Baragaño,
  • Eduardo Rodríguez-Valdés,
  • Ana I. Peláez,
  • Carlos Boente,
  • Nora Matanzas,
  • Nerea García and
  • José Luis R. Gallego

6 November 2018

An environmental forensic study was developed in a former industrial area in southern Spain. Previous information about the site revealed arsenic and hydrocarbons affection exceeding soil screening levels. A full characterisation of arsenic affection...

  • Proceeding Paper
  • Open Access
1,271 Views
12 Pages

Strategy of Phytoremediation for Sustainable Use of Arsenic-Rich Farmland

  • Chang-Chao Chen,
  • Min-Siou Lin,
  • Pei-Cheng Cheng,
  • Chin-Yuan Huang and
  • Shu-Fen Cheng

Arsenic-rich groundwater causes arsenic accumulation in arable soils for irrigation. For such arsenic-contaminated farmland, phytoremediation is a feasible method in terms of cost and maintenance of soil. We studied arsenic-rich farmland planted with...

  • Article
  • Open Access
4 Citations
2,449 Views
13 Pages

Effect of NaCl and EDDS on Heavy Metal Accumulation in Kosteletzkya pentacarpos in Polymetallic Polluted Soil

  • Mingxi Zhou,
  • Zahar Kiamarsi,
  • Ruiming Han,
  • Mohammad Kafi and
  • Stanley Lutts

14 April 2023

The ability of plants to accumulate heavy metals is a crucial factor in phytoremediation. This study investigated the effect of NaCl and S,S-ethylenediaminesuccinic acid (EDDS) on heavy metal accumulation in Kosteletzkya pentacarpos in soil polluted...

  • Review
  • Open Access
54 Citations
10,273 Views
41 Pages

5 December 2017

Arsenic is a potent cardiovascular toxicant associated with numerous biomarkers of cardiovascular diseases in exposed human populations. Arsenic is also a carcinogen, yet arsenic trioxide is used as a therapeutic agent in the treatment of acute promy...

  • Review
  • Open Access
17 Citations
5,630 Views
27 Pages

Significance of Shewanella Species for the Phytoavailability and Toxicity of Arsenic—A Review

  • Aminu Darma,
  • Jianjun Yang,
  • Peiman Zandi,
  • Jin Liu,
  • Katarzyna Możdżeń,
  • Xing Xia,
  • Ali Sani,
  • Yihao Wang and
  • Ewald Schnug

18 March 2022

The distribution of arsenic continues due to natural and anthropogenic activities, with varying degrees of impact on plants, animals, and the entire ecosystem. Interactions between iron (Fe) oxides, bacteria, and arsenic are significantly linked to c...

  • Article
  • Open Access
3 Citations
2,184 Views
15 Pages

Improvement of Arsenic Phytoextraction Using Indigenous Bacteria and Mobilizing Agents

  • Elisabetta Franchi,
  • Meri Barbafieri,
  • Gianniantonio Petruzzelli,
  • Sergio Ferro and
  • Marco Vocciante

9 September 2022

Among inorganic contaminants, arsenic (As) is known for its toxicity and the risks to the environment and human health that could derive from its presence. Phytoremediation represents an effective strategy for the removal of arsenic from contaminated...

  • Article
  • Open Access
3 Citations
2,819 Views
19 Pages

2 October 2023

The gradually increasing presence of arsenic, a highly toxic heavy metal, poses a significant threat to both soil environmental safety and human health. Pteris vittata has long been recognized as an efficient hyperaccumulator plant for arsenic pollut...

  • Article
  • Open Access
736 Views
19 Pages

Effectiveness and Remediation Mechanisms of Geo-Electrochemical Technology for Arsenic Removal in Paddy Soil from Northern Guangxi

  • Yuxiong Jiang,
  • Meilan Wen,
  • Yao Sun,
  • Panfeng Liu,
  • Yunxue Ma,
  • Caiyun Zhang and
  • Xiaohan Zhang

29 August 2025

Arsenic pollution in paddy soil is a major environmental issue, and its remediation has become a subject of broad interest. Geo-electrochemical technology has been shown to have significant potential for remediating heavy metal-contaminated soils in...

  • Article
  • Open Access
4 Citations
1,790 Views
16 Pages

Influence of Arsenate Competition on Tungstate Sorption by Soil

  • Francesca Pedron and
  • Gianniantonio Petruzzelli

28 October 2024

The green and digital transitions toward sustainable development will drive an increased demand for critical raw materials, among which tungsten plays a crucial role in emerging sustainable technologies. Understanding the sorption processes of tungst...

  • Article
  • Open Access
1 Citations
469 Views
16 Pages

22 December 2025

Volcanic eruptions can mobilize naturally occurring toxic elements such as arsenic into surrounding ecosystems, contaminating soil, water, and food webs. Despite increasing evidence of arsenic enrichment in volcanic regions, comprehensive exposure as...

  • Article
  • Open Access
106 Citations
8,100 Views
14 Pages

Heavy Metal Bioaccumulation in Rice from a High Geological Background Area in Guizhou Province, China

  • Xiangyu Kong,
  • Ting Liu,
  • Ziheng Yu,
  • Zhe Chen,
  • Da Lei,
  • Zhiwei Wang,
  • Hua Zhang,
  • Qiuhua Li and
  • Shanshan Zhang

Long-term exposure to high levels of heavy metals can lead to a variety of diseases. In recent years, researchers have paid more attention to mining and smelting areas, industrial areas, and so forth, but they have neglected to report on high geologi...

  • Article
  • Open Access
5 Citations
2,299 Views
23 Pages

26 July 2024

Mercury and arsenic are two highly toxic pollutants, and many researchers have explored the effects of the two substances on the environment. However, the research content of toxic substances in frozen periods is relatively small. To explore the spat...

  • Article
  • Open Access
2,696 Views
14 Pages

23 July 2021

Various types of organic and inorganic materials are widely examined and applied into the arsenic (As) contaminated soil to stabilize As bioavailability and to enhance soil quality as an amendment. This study deals with two types of amendments: bioch...

  • Review
  • Open Access
30 Citations
4,478 Views
37 Pages

24 October 2023

Invasive fungal infections present a significant risk to human health. The current arsenal of antifungal drugs is hindered by drug resistance, limited antifungal range, inadequate safety profiles, and low oral bioavailability. Consequently, there is...

  • Article
  • Open Access
6 Citations
3,031 Views
11 Pages

Arsenic (As) is a toxic semi-metallic element that is ubiquitous in the environment and poses serious human health risks. Phytoextraction by Pteris vittata is considered a low-cost and environmentally friendly approach to treat As-contaminated soil....

  • Article
  • Open Access
1 Citations
2,077 Views
15 Pages

Elements in Serum, Muscle, Liver, and Kidney of Rabbits Fed Macroalgae-Supplemented Diets

  • Sabela Al-Soufi,
  • Marta Miranda,
  • Javier García,
  • Antonio Muíños,
  • Eugenio Cegarra,
  • Nuria Nicodemus,
  • Carlos Herrero-Latorre and
  • Marta López-Alonso

7 June 2024

The addition of marine macroalgae to animal feed has garnered interest due to the demonstrated benefits of gut health in many livestock species. Most macroalgae have a higher mineral content than terrestrial vegetables, making them an attractive, sus...

  • Article
  • Open Access
9 Citations
3,297 Views
16 Pages

21 October 2022

Mercury (Hg) and arsenic (As) are toxic and harmful heavy metals, with exceedance rates of 1.6% and 2.7%, respectively, in soils across China. Compared to soils contaminated with Hg or As alone, co-contaminated soils pose complex environmental risks...

  • Review
  • Open Access
55 Citations
7,810 Views
23 Pages

In order to obtain a well understanding of the toxicity and ecological effects of trace elements in the environment, it is necessary to determine not only the total amount, but also their existing species. Speciation analysis has become increasingly...

  • Article
  • Open Access
3 Citations
2,098 Views
16 Pages

Fe3O4/Mulberry Stem Biochar as a Potential Amendment for Highly Arsenic-Contaminated Paddy Soil Remediation

  • Ziling Tang,
  • Meina Liang,
  • Yanmei Ding,
  • Chongmin Liu,
  • Qing Zhang,
  • Dunqiu Wang and
  • Xuehong Zhang

22 October 2024

Magnetite-loaded biochar has recently received attention owing to its ability to remove arsenic from contaminated soil. In this study, mulberry stem biochar (MBC) and Fe3O4-loaded mulberry stem biochar (Fe3O4@MBC) were produced and used in a 100-day...

  • Article
  • Open Access
5 Citations
4,135 Views
28 Pages

Characterization of Aurintricarboxylic Acid (ATA) Interactions with Plasma Transporter Protein and SARS-CoV-2 Viral Targets: Correlation of Functional Activity and Binding Energetics

  • Conceição A. Minetti,
  • David P. Remeta,
  • Keiji Hashimoto,
  • Radha Bonala,
  • Rajesh Chennamshetti,
  • Xingyu Yin,
  • Miguel Garcia-Diaz,
  • Arthur P. Grollman,
  • Francis Johnson and
  • Viktoriya S. Sidorenko

10 June 2022

In an effort to identify functional-energetic correlations leading to the development of efficient anti-SARS-CoV-2 therapeutic agents, we have designed synthetic analogs of aurintricarboxylic acid (ATA), a heterogeneous polymeric mixture of structura...

  • Article
  • Open Access
2 Citations
2,224 Views
13 Pages

4 October 2022

Nitrogen (N) fertilizer affects the migration and transformation of arsenic (As) in soil and rice. We conducted pot experiments and studied the effects of 0.1, 0.2, and 0.4 g∙kg−1 N levels of NH4Cl, (NH4)2SO4, and NH4NO3 fertilizers on th...

  • Article
  • Open Access
10 Citations
2,501 Views
11 Pages

8 June 2020

Indiscriminate overuse of liquid fertilizer and arsenic (As) contaminated soil by abandoned mines is one of the important environmental issues in Korea. This study was carried out to solve these two problems. Amendments (limestone, red mud and acid m...

  • Article
  • Open Access
22 Citations
4,969 Views
18 Pages

Heavy metal abundance and potential environmental risks are reported for surface sediments (n = 21) from the Port of Koper area, Republic of Slovenia. The enrichment factor (EF) indicates minor enrichment in arsenic (As), cadmium (Cd), copper (Cu), m...

  • Article
  • Open Access
1 Citations
1,256 Views
12 Pages

Evaluation Study of the Passivation Effect of Arsenic-Contaminated Farmland Soil

  • Shuyue Liu,
  • Jikai Su,
  • Zhiyu Zhang,
  • Yajing Huang,
  • Xiaoyao Wang and
  • Xiaoyun Yi

8 December 2024

In situ passivation technology, by reducing the bioavailability of arsenic in soil, thereby reducing its uptake by crops, is currently the main remediation method for arsenic-contaminated farmland soil. However, applying stabilizing materials may als...

  • Review
  • Open Access
212 Citations
15,382 Views
20 Pages

Effects of Silicon and Silicon-Based Nanoparticles on Rhizosphere Microbiome, Plant Stress and Growth

  • Vishnu D. Rajput,
  • Tatiana Minkina,
  • Morteza Feizi,
  • Arpna Kumari,
  • Masudulla Khan,
  • Saglara Mandzhieva,
  • Svetlana Sushkova,
  • Hassan El-Ramady,
  • Krishan K. Verma and
  • Ravish Choudhary
  • + 4 authors

17 August 2021

Silicon (Si) is considered a non-essential element similar to cadmium, arsenic, lead, etc., for plants, yet Si is beneficial to plant growth, so it is also referred to as a quasi-essential element (similar to aluminum, cobalt, sodium and selenium). A...

  • Article
  • Open Access
15 Citations
3,129 Views
16 Pages

16 April 2022

Rice-crayfish system has been extensively promoted in China in recent years. However, the presence of toxic elements in soil may threaten the quality of agricultural products. In this study, eight toxic elements were determined in multi-medium includ...

  • Article
  • Open Access
2 Citations
1,210 Views
16 Pages

14 August 2025

Some soil heavy metal pollution, such as As (Arsenic) and Cd (cadmium), in the black shale areas of western Zhejiang, exhibits significant geological background characteristics, yet the migration patterns and bioavailability are unclear. This study s...

  • Review
  • Open Access
402 Views
26 Pages

Effects of Micronutrients and Heavy Metals on Endothelial Function and Cardiovascular Risk in the Face of Environmental Changes

  • Agata Doligalska-Dolina,
  • Marcin Dolina,
  • Amanda Zoń,
  • Emilia Główczewska-Siedlecka,
  • Karolina Osińska,
  • Gary Andrew Margossian,
  • Carla Liana Margossian and
  • Katarzyna Napiórkowska-Baran

Dynamic environmental changes significantly affect trace element balance and exposure to toxic metals, influencing vascular homeostasis. The endothelium, as a key regulator of vascular tone and inflammation, is highly sensitive to fluctuations in mic...

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