17,292 Results Found

Attenuating the expression of immediate early (IE) proteins is essential for controlling the lytic replication of human cytomegalovirus (HCMV). The human microRNAs (hsa-miRs), miR-200b-3p and miR-200c-3p, have been identified to bind the 3′-unt...

As p300-mediated RelA/p65 hyperacetylation by signal transducers and activators of transcription 3 (STAT3) is critical for NF-κB activation, in the current study, the apoptotic mechanism of lambertianic acid (LA) was explored in relation to STA...

The second messenger, cAMP has potent immunosuppressive and anti-inflammatory actions. These have been attributed, in part, to the ability of cAMP-induced signals to interfere with the function of the proinflammatory transcription factor Nuclear Fact...

Background: The development of non-small cell lung cancer (NSCLC) involves the progressive accumulation of genetic and epigenetic changes. These include somatic oncogenic KRAS and EGFR mutations and inactivating TP53 tumour suppressor mutations, lead...

The Nuclear Factor Kappa B (NF-κB) transcription factor family consists of five members: RelA (p65), RelB, c-Rel, p50 (p105/NF-κB1), and p52 (p100/NF-κB2). This family is considered a master regulator of classical biochemical pathwa...

Transcription Factors (TFs) are the main regulators of gene expression, controlling among others cell homeostasis, identity, and fate. TFs may either act synergistically or antagonistically on nearby regulatory elements and their interplay may activa...

The NFκB transcription factors are major regulators of innate immune responses, and NFκB signal pathway dysregulation is linked to inflammatory disease. Here, we utilised bone marrow-derived macrophages from the p65-DsRedxp/IκB&alph...

In-box LOCA was identified as one of the worst accidental scenarios for the HCLL TBS (Helium Cooled Lithium-Lead Test Blanket System). Aiming to experimentally analyze the consequences of this transient, ENEA designed and built THALLIUM (Test HAmmer...

Relapsing–remitting experimental autoimmune encephalomyelitis (rEAE) in mice is a model that closely resembles relapsing–remitting multiple sclerosis in humans. This study aims to investigate a new approach to modulation of the inflammato...

Magnetohydrodynamic (MHD) phenomena, due to the interaction between a magnetic field and a moving electro-conductive fluid, are crucial for the design of magnetic-confinement fusion reactors and, specifically, for the design of the breeding blanket c...

The RELAP5 code is a computational tool designed for transient simulations of light water reactor coolant systems under hypothesized accident conditions. The original wall drag partition model in the RELAP5 code has a problem in that the bubble veloc...

The molten salt reactor (MSR) is a prominent Generation IV nuclear reactor concept that offers substantial advantages over conventional solid-fueled systems, including enhanced fuel utilization, inherent passive safety features, and significant reduc...

Background: Glioblastoma (GBM) harbors significant genetic heterogeneity, high infiltrative capacity, and patterns of relapse following many therapies. The expression of nuclear factor kappa-B (NF-κB p65 (RelA)) and signaling pathways is consti...

Inflammation plays a crucial role in tumorigenesis, primarily mediated by NF-κB. RhoA GTPases are instrumental in regulating the activation of NF-κB. Specifically, the phosphorylation of Tyrosine 42 on RhoA ensures the activation of NF-&k...

Our main goal of this research is to present the theory of points for relatively cyclic and relatively relatively noncyclic p-contractions in complete locally K -convex spaces by providing basic conditions to ensure the existence and uniqueness...

The safety performance of nuclear power plants (NPPs) is a very important factor in evaluating nuclear energy sustainability. Safety analysis of passive and active safety systems have a positive influence on reactor transient mitigation. One of the c...

In this paper, p-topologicalness (a relative topologicalness) in ⊤-convergence spaces are studied through two equivalent approaches. One approach generalizes the Fischer’s diagonal condition, the other approach extends the Gähler’s n...

The evolving understanding of asthma and COPD pathomechanisms led to this study examining chronic obstructive lung diseases’ impact on cognitive decline—a growing concern in aging populations. We explored whether subunits of key inflammat...

Penitrem A, an indole–diterpenoid neurotoxin, is produced by several species of Penicillium on cereal grains, meat, dairy products, and fruits. Penicillium crustosum is a well-known penitrem A producer, but much is unknown about physiological c...

The present work deals with simulations carried out at the University of Pisa by using the System Thermal Hydraulics code RELAP5/Mod3.3 to support the experimental campaign conducted at the ENEA (Energia Nucleare ed Energie Alternative) Brasimone Res...

The in-box LOCA (Loss of Coolant Accident) represents a major safety concern to be addressed in the design of the WCLL-BB (water-cooled lead-lithium breeding blanket). Research activities are ongoing to master the phenomena and processes that occur d...

MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their mRNA sequences’ 3′ untranslated regions (3′UTR). Interleukin-6 (IL-6) is known to promote cancer progression and treatment resistance. In this...

One of the biggest experimental programs helping to improve nuclear installation safety is PHEBUS, an international cooperative research program that provides data for validating computer codes dedicated to the analysis of severe accidents and their...

Recent R&D activities in nuclear fusion have identified the DEMO reactor as the ITER successor, aiming at demonstrating the technical feasibility of fusion plants, along with their commercial exploitation. However, the pulsed operation of the mac...

The development and the validation of old and new software in relevant DEMO reactor conditions have been exploited in the latest years within the EUROfusion Consortium. The aim was to use—if possible—the software already validated for fis...

The liquid-fueled molten salt reactor (MSR) is one of the candidate reactors for the Generation IV advanced nuclear power systems, which utilizes flowing liquid molten salt as both fuel and coolant. In transients of liquid-fueled MSRs, the distributi...

The Breeding Blanket (BB) is one of the key components of the European Demonstration (EU-DEMO) fusion reactor. Its main subsystems, the Breeder Zone (BZ) and the First Wall (FW), are cooled by two independent cooling circuits, called Primary Heat Tra...

Chronic kidney disease (CKD) is associated with low-grade inflammation that activates nuclear factor–κB (NF–κB), which upregulates the expression of numerous NF–κB responsive genes, including the genes encoding IL-...

Mycobacterium tuberculosis is a human pathogen that can thrive inside the host immune cells for several years and cause tuberculosis. This is due to the propensity of M. tuberculosis to synthesize a sturdy cell wall, shift metabolism and growth, secr...

Background: Reduced LV longitudinal strain (GLS) and increased relative apical sparing (RELAPS) and increased wall thickness have been proposed as features for transthyretin cardiac amyloidosis (ATTR-CA). Myocardial work (MW) has recently been shown...

The nuclear factor-κB (NF-κB) transcription factor family consists of five related proteins, RelA (p65), c-Rel, RelB, p50/p105 (NF-κB1), and p52/p100 (NF-κB2). These proteins are important not only for inflammation and the imm...

The immune system consists of various cells, organs, and processes that interact in a sophisticated manner to defend against pathogens. Upon initial exposure to an invader, nonspecific mechanisms are raised through the activation of macrophages, mono...

Soluble phosphates are the most common sources currently used in crop production in tropical soils; however, they present low efficiency and are more expensive than natural rock phosphates. The objective was to develop new phosphate fertilizers with...

Humans are routinely exposed to complex mixtures such as polycyclic aromatic hydrocarbons (PAHs) rather than to single compounds, as are often assessed for hazards. Cytochrome P450 enzymes (CYPs) metabolize PAHs, and multiple PAHs found in mixtures c...

This paper reports an event–related potential (ERP) study examining the processing of “gapless” relative clauses (RCs), normal (“gapped”) RCs, attributive clauses, Subject–Verb–Object (SVO) forms and the morp...

Instant coffee powder is highly sensitive to environmental humidity, which can significantly affect its quality during storage. The objective of this study was to evaluate the storage stability of instant coffee by assessing the moisture uptake and m...

Preimplantation genetic testing for polygenic disease risk (PGT-P) represents a new tool to aid in embryo selection. Previous studies demonstrated the ability to obtain necessary genotypes in the embryo with accuracy equivalent to in adults. When app...

Following Smolin, we proceed to unification of general relativity and quantum theory by operating solely with events, i.e., without appealing to physical systems and space-time. The universe is modelled as a dendrogram (finite tree) expressing the hi...

DNA vaccine-induced immunity can be enhanced by the co-delivery of synthetic gene-encoding molecular adjuvants. Many of these adjuvants have included cytokines, chemokines or co-stimulatory molecules that have been demonstrated to enhance vaccine-ind...

In order to obtain high-quality images, the application of low-illumination image enhancement techniques plays a vital role in enhancing the overall visual appeal. However, it is particularly difficult to enhance an image while maintaining the origin...

Drought is one of the main environmental stress factors affecting plant growth and yield. The impact of different PEG concentrations on the photosynthetic performance of maize (Zea mays L. Mayflower) and sorghum (Sorghum bicolor L. Foehn) was investi...

Mast cells (MCs) are sentinel cells which represent an important part of the first line of defense of the immune system. MCs highly express receptors for danger-associated molecular patterns (DAMPs) such as the IL-33R and P2X7, making MCs to potentia...

Senescent cells secrete pro-inflammatory factors, and a hallmark feature of senescence is senescence-associated secretory phenotype (SASP). The aim of this study is to investigate the protein kinase CK2 (CK2) effects on SASP factors expression in cel...

In the present paper the humidity sensing properties of regioregular rr-P3HT (poly-3-hexylthiophene) polymer films is investigated by means of surface acoustic wave (SAW) based sensors implemented on LiNbO3 (1280 Y-X) and ST-quartz piezoelectric subs...

Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants. The aim was to explore the performance of a generic physiologically-based pharmacok...

The recent release of consumer-grade dual-frequency receivers sparked scientific interest into use of these cost-efficient devices for high precision positioning and tropospheric delay estimations. Previous analyses with low-cost single-frequency rec...

Image completion, which falls to a special type of inverse problems, is an important but challenging task. The difficulties lie in that (i) the datasets usually appear to be multi-dimensional; (ii) the unavailable or corrupted data entries are random...

This paper analyses the recent recurring dieback and growth decline of Black pine (P. nigra Arn. var austriaca) in the Keszthely mountains of south-west Hungary, and their relations to water deficits due to droughts. These relations were studied in f...

The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various cellular functions, including organization of the actin cytoskeleton, cell adhesion and migration. A pro-inflammatory lipid mediator, lysophosphatidic acid (LPA), i...

The potD gene, belonging to the well-conserved ABC (ATP-binding cassette) transport system potABCD, encodes the bacterial substrate-binding subunit of the polyamine transport system. In this study, we found PotD in Haemophilus (Glaesserella) parasuis...