Menaquinone (MK) has an important role in human metabolism as an essential vitamin (VK2), which is mainly produced through the fermentation of microorganisms. MK8(H2) was identified to be the main menaquinone from Rhodococcus sp. B7740, a bacterium i...
The role of histamine H3 receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer’s disease (AD), is well-accepted. Therefore, the procognitive effects of acute...
Successful islet isolation is the key to successful islet transplantation. Our group recently modified the islet isolation protocol to include pancreatic ductal injection of the preservation solution, pancreas storage in modified extracellular-type t...
Ion exchange membranes covered with layers of polyelectrolytes of alternating charges are characterized by very high monovalent selectivity. This allows the use of such membranes for electrodialytic fractionation of multicomponent solutions. However,...
MAPKAPK2 (MK2) is an important regulator of the p38 mitogen-activated protein kinase (p38 MAPK) pathway, which is involved in a plethora of cellular processes concluding the development of gamete cells in meiosis and resisting pathogenic bacterial in...
Several studies have explored the antimicrobial properties of manuka honey (MkH). However, the data available regarding antibacterial action mechanisms are scarcer. The aim of this study was to scrutinize and characterize primary effects of manuka ho...
Glutamate-mediated excitotoxicity is a major cause of ischemic brain damage. MK-801 confers neuroprotection by attenuating the activation of the N-methyl-d-aspartate (NMDA) receptor, but it failed in clinical use due to the short therapeutic window....
Pregnane X receptor (PXR) is a nuclear receptor activated by various compounds, including prescribed drugs and dietary ingredients. Ligand-specific activation of PXR alters drug metabolism and affects many other physiological conditions. Species-spec...
Menaquinone-7 (MK-7) plays a crucial role in preventing fractures and certain cardiovascular diseases and is one of the essential vitamins in the human body. In this study, a strain of Bacillus subtilis that produces MK-7 was isolated from commercial...
Over the past few decades, ultrahigh-performance concrete (UHPC) has been widely studied and applied because of its outstanding mechanical properties, such as its high strength and notable durability. However, because of its high cost and easy shrink...
Vitamin K is involved many biological processes, such as the regulation of blood coagulation, prevention of vascular calcification, bone metabolism and modulation of cell proliferation. Menaquinones (MK) and phylloquinone vary in biological activity,...
The mitogen-activated protein kinase-activated protein kinase MK5 is a substrate of the mitogen-activated protein kinases p38, ERK3 and ERK4. Cell culture and animal studies have demonstrated that MK5 is involved in tumour suppression and promotion,...
A novel coagulase-negative Staphylococcus strain (H164T) was isolated from soymilk in Taiwan. Comparative sequence analysis of the 16S rRNA gene revealed that the H164T strain is a member of the genus Staphylococcus. We used multilocus sequence analy...
The influence of dietary sodium and potassium on blood pressure (BP) has been extensively studied, however their impact on endothelial function, particularly any interactive effects, has received less attention. The purpose of this study was to deter...
Aberrant neurogenesis in the subventricular zone (SVZ) and hippocampus (HIP) contributes to schizophrenia pathogenesis. Haloperidol (HAL) and olanzapine (OLA), commonly prescribed antipsychotics for schizophrenia treatment, affect neurogenesis too. T...
In an effort to further understand the challenges facing in vivo imaging probe development for the N-methyl-D-aspartate (NMDA) receptor ion channel, we have evaluated the effect of glutamate on the Alzheimer’s disease (AD) brain. Human post-mor...
Five alkali-activated analcime (ANA) sorbents (ANA-MK 1, ANA 2, ANA 3, ANA-MK 4, and ANA-MK 5) were developed for ammonium (NH4+) ion removal. Acid treatment and calcination were used as pre-treatments for analcime, and metakaolin (MK) was used as a...
This study compares the structural, microstructural, thermal, and mechanical properties of geopolymer pastes (GPs) created through traditional methods and those derived from ready-to-use powders for geopolymer (RUPG) materials. The metakaolin (MK) pr...
Ceramic membrane technology plays an important role in water and wastewater treatment. Strategic sourcing of various natural mineral resources has contributed to developing low-cost ceramic membranes. The combination with calcination of inorganic and...
Introduction. The proline-rich decapeptide 10c (Bj-PRO-10c; ENWPHPQIPP) from the Bothrops jararaca snake modulates argininosuccinate synthetase (AsS) activity to stimulate L-arginine metabolite production and neuroprotection in the SH-SY5Y cell line....
Water transport is vital for the durability of ultra-high performance concrete (UHPC) in engineering, but its absorption behavior requires further comprehension. This study investigates the impact of silica fume (SF) and metakaolin (MK) on water abso...
The rising antimicrobial resistance is particularly alarming for Acinetobacter baumannii, calling for the discovery and evaluation of alternatives to treat A. baumannii infections. Some bacteriophages produce a structural protein that depolymerizes c...
Background: Vestibular compensation (VC) after unilateral labyrinthectomy (UL) consists of the initial and late processes. These processes can be evaluated based on the decline in the frequency of spontaneous nystagmus (SN) and the number of MK801-in...
Tryptamine derivatives (Ts) were found to inhibit the binding of [3H]MK-801, [3H]ketanserin and [3H]8-OH-DPAT to rat brain membranes. [3H]MK-801 labels the NMDA (N-methyl-D-aspartate) receptor, a ionotropic glutamate receptor which controls synaptic...
Dual specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A), a phosphorylation kinase, is localized within the central nervous system and is linked to hyperphosphorylation of Tau. Imaging of DYRK1A may provide an earlier biomarker for Tauo...
Bacterial wilt of tomato is a destructive disease caused by Ralstonia solanacearum throughout the world. An endophytic actinomycete with antagonistic activity, designated strain LD120T, was isolated from moss (Physcomitrium sphaericum (Ludw) Fuernr)....
An isolated bacterium from soil that highly hydrolyzes cellulose was identified as Paenibacillus peoriae and named P. peoriae MK1. The cellulase from P. peoriae MK1 was cloned and expressed in Escherichia coli. The purified recombinant cellulase, a s...
P-glycoprotein (P-gp), which is encoded by the ATP-binding cassette (ABC) transporter subfamily B member 1 (ABCB1) gene, is one of the most pivotal ABC transporters that transport its substrates across the cell membrane. Its overexpression is one of...
This study evaluated the genetic parameters for growth and Vibrio parahaemolyticus (VpAHPND) resistance in both the introduced MK strain and the self-constructed GK strain of Penaeus vannamei, investigating the impact of genotyped female parents on t...
The influence of aluminosilicate pozzolanic waste, specifically spent fluid catalytic cracking waste (FCCW) and metakaolin waste (MK) from the expanded glass industry, on the properties of hardened Portland cement paste were analysed. The study invol...
Bombesin receptor subtype-3 (BRS-3) is a type 1 G-protein-coupled receptor (GPCR). BRS-3 is an orphan GPCR that is structurally related to neuromedin B and gastrin-releasing peptide receptors. When activated, BRS-3 causes phosphatidylinositol turnove...
Background and Objectives: The influence of montelukast (MK), an antagonist of cysLT1 leukotriene receptors, on lung lesions caused by experimental diabetes was studied. Materials and Methods: The study was conducted on four groups of six adult male...
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to be a global threat due to its ability to evolve and generate new subvariants, leading to new waves of infection. Additionally, other coronaviruses like Middle East respira...
Monascus pigments (MPs) and monacolin K (MK) are important secondary metabolites produced by Monascus spp. This study aimed to investigate the effect of soybean protein isolate (SPI) on the biosynthesis of MPs and MK based on the analysis of physiolo...
Cadmium (Cd) and lead (Pb) are global environmental pollutants. In this study, Nostoc sp. MK-11 was used as an environmentally safe, economical, and efficient biosorbent for the removal of Cd and Pb ions from synthetic aqueous solutions. Nostoc sp. M...
MK-801, also called dizocilpine, is an N-methyl-D-aspartate (NMDA) receptor antagonist widely used in animal research to model schizophrenia-like phenotypes. Although its effects in rodents are well characterised, little is known about the outcomes o...
A novel endophytic actinomycete strain GKU 173T isolated from the roots of Acacia mangium Willd. showed potential plant growth promoting (PGP) activity. Phylogenetic analysis, based on 16S rRNA gene, indicated that strain GKU 173T was the most closel...
A novel Gram staining positive, aerobic bacterium NEAU-HV1T that exhibits antifungal activity against Exserohilum turcicum was isolated from a soil collected from Gama, Hadjer lamis, Chad. It was grown at 10–45 °C (optimum 30 °C), pH 5&...
To provide the theoretical basis for the engineering application of metakaolin as aluminum-rich pozzolanic ash materials, the promoting effect of metakaolin on the macro- and micro-mechanical properties of composite cement-based composite materials w...
In this study, fourteen sustainable concrete mixes containing metakaolin (MK) as supplementary cement material (SCM) and magnetized water (MW) as concrete mixing water were designed, prepared, tested, analyzed, and compared. The MK was used as a part...
Mitogen-activated protein kinase-activated protein kinase 2 (MK-2) has been identified as a drug target for the treatment of inflammatory diseases. Currently, a series of thiourea analogs as potent MK-2 inhibitors were studied using comprehensive com...
Raw goat milk-derived Lactococcus lactis MK1/3 (CCM 9209) was studied to show its potential for use in the dairy industry. Finding an innovative strain indicates having a new safe, original additive for functional food. The strain has been shown to b...
A novel actinomycete producing heliquinomycin and 9’-methoxy-heliquinomycin, designated strain jys28T, was isolated from rhizosphere soil of Pinus yunnanensis and characterized using a polyphasic approach. The strain had morphological character...
The construction industry generates large amounts of waste and high CO2 emissions, especially from cement production. Sustainable alternatives, such as geopolymers, help reduce these impacts by promoting eco-friendly materials. This study aimed to de...
Monascus is used widely in Asian countries and produces various biologically active metabolites, such as Monascus pigments (MPs) and monacolin K (MK). In this study, the effect of γ-heptalactone on secondary metabolites and mycelial growth duri...
The basidiomycete Pleurotus sapidus produced a dye-decolorizing peroxidase (PsaPOX) with alkene cleavage activity, implying potential as a biocatalyst for the fragrance and flavor industry. To increase the activity, a daughter-generation of 101 basid...
In this study, the role of two reactive fillers, specifically a sand from a clay washing process as an alternative to waste glass powder and a commercial metakaolin (MK), into the geopolymerization process of waste clay-based materials was assessed....
This study focuses on using spodumene flotation tailings (SFT) to prepare phosphoric acid-activated metakaolin geopolymer, in which the replacement of metakaolin (MK) by a high percentage (up to 75 wt.%) of tailings was achieved. The compressive stre...
New carbonized biomass–metakaolin (PSD/MK_Fe) granular composite catalyst materials were manufactured for the catalytic wet air oxidation (CWAO) of bisphenol A (BPA). These catalysts were characterized using different analytical and spectroscopic tec...
A comprehensive study of the polyaniline influence on mineral scaling on the surface of the heterogeneous MK-40 sulfocationite membrane under electrodialysis has been conducted. Current-voltage curves and chronopotentiograms have been obtained and an...
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