This work focused on the production of the MoAlB MAB phase through self-propagating, high-temperature synthesis in the thermal explosion mode. The influence of the method of a Mo-Al-B-powder reaction mixture preparation on the combustion temperature,...
Millimeter wave (mmWave), reconfigurable intelligent surface (RIS), and unmanned aerial vehicles (UAVs) are considered vital technologies of future six-generation (6G) communication networks. In this paper, various UAV mounted RIS are distributed to...
For XL-MIMO multi-user frequency division duplex systems, this paper proposes a near-field beam training scheme using a two-phase combinatorial multi-armed bandit (MAB) framework. This scheme leverages the MAB framework, integrating energy-aware user...
Nickel aluminum bronze (NAB) and manganese aluminum bronze (MAB) are widely used in propulsion and seawater handling systems in naval platforms due to their attractive combination of mechanical strength, toughness, and very low susceptibility to mari...
This review paper offers a comprehensive exploration of the many Artificial Intelligence (AI) applications in monoclonal antibody (mAb) manufacturing, covering a wide spectrum of topics, including upstream and downstream processes, process control, o...
Cr2AlB2 and Cr4AlB4 are members of the MAB phases that exhibit unique properties of both metals and ceramics. However, despite these unique characteristics, Cr2AlB2 and Cr4AlB4 phase coatings have not been widely investigated. In this study, Cr2AlB2...
Cardiovascular diseases, including thrombosis, are the leading cause of mortality worldwide. The generation of monoclonal antibodies (mAb) targeting specific coagulation factors could provide more targeted and safer anticoagulant therapies. Factor V...
The dramatic experience with SARS-CoV-2 has alerted the scientific community to be ready to face new epidemics/pandemics caused by new variants. Among the therapies against the pandemic SARS-CoV-2 virus, monoclonal Antibodies (mAbs) targeting the Spi...
Transforming growth factor β (TGF-β) signalling pathways are highly conserved across metazoa and play essential roles not only during development but also in adult tissue maintenance. Alterations of these pathways usually result in a pletho...
In the course of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), the infiltration of lymphocytes and other inflammatory cells across the blood–brain barrier is associated with interactions between...
HLA class-I (HLA-I) polyreactive monoclonal antibodies (mAbs) reacting to all HLA-I alleles were developed by immunizing mice with HLA-E monomeric, α-heavy chain (αHC) open conformers (OCs). Two mAbs (TFL-006 and TFL-007) were bound to the αHC’s coat...
Unconjugated anti-cancer IgG1 monoclonal antibodies (mAbs) activate antibody-dependent cellular cytotoxicity (ADCC) by natural killer (NK) cells and antibody-dependent cellular phagocytosis (ADCP) by macrophages, and these activities are thought to b...
Mycobacterium abscessus exhibits intrinsic resistance to conventional antibiotics, significantly limiting treatment options. Our previous studies established that MAB_2362 (SteA) is a key regulator of cell division that contributes to intrinsic resis...
Multi-armed bandit (MAB) models are a viable approach to describe the problem of best wireless network selection by a multi-Radio Access Technology (multi-RAT) device, with the goal of maximizing the quality perceived by the final user. The classical...
Monoclonal antibodies (mAbs) are often needed and applied in high concentration solutions, >100 mg/mL. Due to close intermolecular distances between mAbs at high concentrations (~10–20 nm at 200 mg/mL), intermolecular interactions between mA...
A series of studies have reported that monoclonal antibody 263 (Mab263), a monoclonal antibody against the growth hormone receptor (GHR), acts as an agonist in vitro and in vivo. However, the intracellular signaling pathways triggered by Mab263 have...
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by a higher mortality rate among breast cancer subtypes. Poly(ADP-ribose) polymerase (PARP) inhibitors are used in clinics to treat a subgroup of TNBC...
Mycobacterium tuberculosis, the pathogen that causes tuberculosis, is responsible for the death of 1.5 million people each year and the number of bacteria resistant to the standard regimen is constantly increasing. This highlights the need to discove...
Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common types of primary cutaneous T-cell lymphoma (CTCL). Proliferating cell nuclear antigen (PCNA) is expressed on the cell surface of cancer cells (csPCNA), but not on normal cells...
Mycobacterium abscessus is an opportunistic pathogen causing human diseases, especially in immunocompromised patients. M. abscessus strains with a rough morphotype are more virulent than those with a smooth morphotype. Morphotype switch may occur dur...
Cancer-specific monoclonal antibodies (CasMabs) that recognize cancer-specific antigens with in vivo antitumor efficacy are innovative therapeutic strategies for minimizing adverse effects. We previously established a cancer-specific anti-human epide...
Intracerebral hemorrhage (ICH) is recognized as a severe clinical problem lacking effective treatment. High mobility group box-1 (HMGB1) exhibits inflammatory cytokine-like activity once released into the extracellular space from the nuclei. We previ...
Background/Objective: Neurotoxic soluble amyloid-β (Aβ) oligomers are key drivers of Alzheimer’s pathology, with evidence suggesting that early targeting of these soluble forms may slow disease progression. Traditional intravenous (IV...
Traffic management is a critical task in software-defined IoT networks (SDN-IoTs) to efficiently manage network resources and ensure Quality of Service (QoS) for end-users. However, traditional traffic management approaches based on queuing theory or...
For the monitoring of chimeric antigen receptor (CAR) T-cell therapies, antigen-based CAR detection methods are usually applied. However, for each target-antigen, a separate detection system is required. Furthermore, when monitored CAR T-cells in the...
The production of monoclonal antibodies (mAbs) plays a pivotal role in therapeutic treatments, and optimizing their production is crucial for minimizing costs and improving their accessibility to patients. One way of improving the production process...
A previously published, experimentally validated fed-batch reactor model for production of monoclonal antibodies (mAbs) via a fermentation process (which includes substrate consumption by cells, resulting in biomass growth and product formation) is e...
The cytotoxic T lymphocyte-antigen 4 (CTLA-4) has been considered an IC exclusively expressed on T cells, where it counteracts the co-stimulatory CD28 receptor, by competing for its binding to CD-80 and CD-86. We recently found that it is expressed a...
The distortions in the high-order structure of therapeutic monoclonal antibodies (mAbs) under different environmental conditions acutely affect mAb stability, resulting in altered safety, efficacy, and shelf-life profiles. The overall stability of mA...
Antibodies targeting Immune Checkpoints (IC) on tumor infiltrating lymphocytes improve immune responses against cancer. Recently, the expression of some ICs has also been reported on cancer cells. We used the clinically validated Ipilimumab and Nivol...
We examined the kinetics and mechanisms by which monoclonal antibodies (mAbs) utilize complement to rapidly kill targeted cancer cells. Based on results from flow cytometry, confocal microscopy and high-resolution digital imaging experiments, the gen...
UNESCO’s MAB Programme promotes a people-centered conservation strategy to strengthen the sustainability of social and ecological systems. However, there exist knowledge gaps regarding its implementation in specific contexts. For this study, a...
Natural killer (NK) cells hold a pivotal role in tumor-targeting monoclonal antibody (mAb)-based activity due to the expression of CD16, the low-affinity receptor for IgG. Indeed, beyond exerting cytotoxic function, activated NK cells also produce an...
Epidural and subdural hematomas are commonly associated with traumatic brain injury. While surgical removal is the primary intervention for these hematomas, it is also critical to prevent and reduce complications such as post-traumatic epilepsy, whic...
The effects such as warpage, dimensional instability and environmental stress corrosion, due to the presence of residual stresses in polymeric products, are strongly dependent on injection molding conditions. The holding time and holding pressure bel...
Foot-and-mouth disease (FMD) is a devastating infectious viral disease of cloven-hoofed animals. Differentiating FMD from other vesicular diseases is difficult based on only clinical symptoms, requiring an appropriate laboratory diagnostic test. The...
Background: Few studies compare the clinical effectiveness of the three anti-CGRP mAbs. Moreover, no studies compare their efficacy during suspension and reprisal. Our study aimed to compare the efficacy of migraine frequency, intensity, and symptoma...
Antibody-based cancer immunotherapy includes monoclonals against immune checkpoints (ICs), to modulate specific T cell responses against cancer. NK cells are a newly emerging target for immune checkpoint receptor inhibition in cancer immunotherapy, a...
New variants of SARS-CoV-2 continue to emerge and evade immunity. We isolated SARS-CoV-2 temporally across the pandemic starting with the first emergence of the virus in the western hemisphere and evaluated the immune escape among variants. A clinic-...
The clinical impact of anti-spike monoclonal antibodies (mAb) in Coronavirus Disease 2019 (COVID-19) breakthrough infections is unclear. We present the results of an observational prospective cohort study assessing and comparing COVID-19 progression...
Reducing the immunogenicity of animal-derived monoclonal antibodies (mAbs) for use in humans is critical to maximize therapeutic effectiveness and preclude potential adverse events. While traditional humanization methods have primarily focused on gra...
Heparanase is the only human enzyme responsible for heparan sulfate (HS) breakdown, an activity that remodels the extracellular matrix (ECM) and strongly drives cancer metastasis and angiogenesis. Compelling evidence implies that heparanase promotes...
Production of monoclonal antibodies (mAbs) is a well-known method used to synthesize a large number of identical antibodies, which are molecules of huge importance in medicine. Due to such reasons, intense efforts have been invested to maximize the m...
Single-phase center multiple azimuth beam (SPC MAB) mode is an effective method for high-resolution wide-swath (HRWS) SAR imaging. The traditional azimuth spectrum reconstruction method for SPC MAB mode is based on the combination scheme from which f...
Antibodies (mAbs) are attractive molecules for their application as a diagnostic and therapeutic agent for diseases of the central nervous system (CNS). mAbs can be generated to have high affinity and specificity to target molecules in the CNS. Unfor...
Monoclonal antibodies are among the most powerful therapeutics in modern medicine. Since the approval of the first therapeutic antibody in 1986, monoclonal antibodies keep holding great expectations for application in a range of clinical indications,...
The integration of real time release testing into an advanced process control (APC) concept in combination with digital twins accelerates the process towards autonomous operation. In order to implement this, on the one hand, measurement technology is...
In large systems, such as power plants or petrochemical plants, various equipment (e.g., compressors, pumps, turbines, etc.) are typically deployed. Each piece of equipment operates under generally harsh operating conditions, depending on its purpose...
Conventional path-planning strategies for GMA-WAAM may encounter challenges related to geometrical features when printing complex-shaped builds. One alternative to mitigate geometry-related flaws is to use algorithms that optimise trajectory choices&...
Abrin is a types II ribosome-inactivating protein (RIP) isolated from Abrus precatorious seeds, which comprises a catalytically active A chain and a lectin-like B chain linked by a disulfide bond. Four isotoxins of abrin have been reported with simil...
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