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156,345 Results Found

  • Article
  • Open Access
16 Citations
4,593 Views
12 Pages

Simultaneous Immunization with Omp25 and L7/L12 Provides Protection against Brucellosis in Mice

  • Sonal Gupta,
  • Surender Mohan,
  • Vikas Kumar Somani,
  • Somya Aggarwal and
  • Rakesh Bhatnagar

24 February 2020

Currently used Brucella vaccines, Brucella abortus strain 19 and RB51, comprises of live attenuated Brucella strains and prevent infection in animals. However, these vaccines pose potential risks to recipient animals such as attenuation reversal and...

  • Article
  • Open Access
9 Citations
3,619 Views
14 Pages

The Thermal Properties of L12 Phases in Aluminum Enhanced by Alloying Elements

  • Jihang Lan,
  • Zhaoqun Chen,
  • Linghong Liu,
  • Qingzhou Zhang,
  • Mengdong He,
  • Jianbo Li,
  • Xiaofang Peng and
  • Touwen Fan

8 September 2021

The L12 type trialuminide compounds Al3M possess outstanding mechanical properties, which enable them to be ideal for dispersed strengthening phases for the high-strength thermally stable Al based alloys. Ab-initio calculations based on the density f...

  • Article
  • Open Access
5 Citations
1,867 Views
14 Pages

Transformation from D022 to L12 in Al3Ti by Fe Addition for Enhanced Wear Resistance

  • Guijiang Diao,
  • Junfeng Yuan,
  • Anqiang He,
  • Dong Zhang,
  • Aakash Kumar,
  • Ranran Fang,
  • Anatoliy Vorobyev,
  • Wengang Chen and
  • Dongyang Li

19 November 2024

The addition of third elements may help transform brittle D022-structured lightweight Al3Ti to a relatively ductile L12-structured (Al, M)3Ti (where M represents the third elements), thus increasing the ductility at the expense of hardness. Such a tr...

  • Article
  • Open Access
3 Citations
1,368 Views
13 Pages

Theoretical Study of the Competition Mechanism of Alloying Elements in L12-(Nix1Crx2Cox3)3Al Precipitates

  • Yu Liu,
  • Lijun Wang,
  • Juangang Zhao,
  • Zhipeng Wang,
  • Touwen Fan,
  • Ruizhi Zhang,
  • Yuanzhi Wu,
  • Xiangjun Zhou,
  • Jie Zhou and
  • Pingying Tang

26 April 2024

The impact of variations in the content of single alloying element on the properties of alloy materials has been extensively discussed, but the influence of this change on the content of multiple alloying elements in the alloy materials has been disr...

  • Article
  • Open Access
10 Citations
6,332 Views
18 Pages

12 February 2018

The antiphase boundary energies of {111} and {010} planes in L1 2 intermetallics (Ni 3 Ge, Ni 3 Si, Al 3 Sc, Ni 3 Al, Ni 3 Ga and Al 3 Ti) under different pressure are presented using first-principle...

  • Article
  • Open Access
1 Citations
2,151 Views
17 Pages

Temperature-Dependent Mechanical Behaviors and Deformation Mechanisms in a Si-Added Medium-Entropy Superalloy with L12 Precipitation

  • Tuanwei Zhang,
  • Tianxiang Bai,
  • Renlong Xiong,
  • Shunhui Luo,
  • Hui Chang,
  • Shiyu Du,
  • Jinyao Ma,
  • Zhiming Jiao,
  • Shengguo Ma and
  • Zhihua Wang

25 June 2024

A novel Ni-Co-Cr-based medium-entropy superalloy with a high Si content (7.5 at%) strengthened by an L12 phase was developed. The pure L12 phase, characterized by an average size of 50 nm and a volume fraction of 46%, was precipitated within the FCC...

  • Article
  • Open Access
1 Citations
1,196 Views
13 Pages

27 June 2025

Aluminum alloys based on the eutectic Al–Ni system are a promising class of lightweight materials for applications at elevated temperatures owing to the thermal stability of the eutectic Al3Ni phase. In this study, the eutectic Al–Ni allo...

  • Article
  • Open Access
1 Citations
2,670 Views
8 Pages

Magnetic Phase Transition, Elastic and Thermodynamic Properties of L12-(Ni,Cu)3(Al,Fe,Cr) in 3d High-Entropy Alloys

  • Li Ma,
  • Zhi-Peng Wang,
  • Guo-Hua Huang,
  • Jin-Li Huang,
  • Ping-Ying Tang and
  • Tou-Wen Fan

2 December 2020

The phase stability and elastic properties of paramagnetic (PM), ferromagnetic (FM) and antiferromagnetic (AFM) phases in L12-(Ni,Cu)3(Al,Fe,Cr) alloy are first investigated using the exact muffin-tin orbitals (EMTO) method in combination with the co...

  • Article
  • Open Access
3 Citations
1,785 Views
13 Pages

First-Principles Study of Atomic Diffusion by Vacancy Defect of the L12-Al3M (M = Sc, Zr, Er, Y) Phase

  • Shuai Liu,
  • Binbin Liao,
  • Baohua Nie,
  • Touwen Fan,
  • Dongchu Chen,
  • Jianglong Zhang and
  • Yu Song

21 September 2023

Atomic diffusion by the vacancy defect of L12-Al3M (M = Sc, Zr, Er, Y) was investigated based on a first-principles calculation. The point defect formation energies were firstly evaluated. Then, the migration energy for different diffusion paths was...

  • Article
  • Open Access
6 Citations
2,488 Views
10 Pages

First-Principle Investigation of the Interface Properties of the Core-Shelled L12-Al3M (M = Sc, Zr, Er, Y) Phase

  • Yu Song,
  • Songtao Zhan,
  • Baohua Nie,
  • Shuai Liu,
  • Haiying Qi,
  • Fangjun Liu,
  • Touwen Fan and
  • Dongchu Chen

28 February 2023

The interface structure and segregation behavior of L12-Al3M (M = Sc, Zr, Er, Y) phases were investigated based on first-principles calculations. The results showed that the order of the thermodynamically stable interface was Al3Zr/Al > Al3Sc/Al &...

  • Article
  • Open Access
7 Citations
2,244 Views
16 Pages

29 June 2023

The key parameters of growth and nucleation of Al3TM particles (TM = Sc-Zn, Y-Cd and Hf-Hg) have been calculated using the combination of the first principles calculations with the quasi-harmonic approximation (QHA). Herein, the diffusion rate Ds of...

  • Article
  • Open Access
21 Citations
5,768 Views
17 Pages

Heat Capacities of L-Cysteine, L-Serine, L-Threonine, L-Lysine, and L-Methionine

  • Václav Pokorný,
  • Vojtěch Štejfa,
  • Jakub Havlín,
  • Michal Fulem and
  • Květoslav Růžička

3 January 2023

In an effort to establish reliable thermodynamic data for amino acids, heat capacity and phase behavior are reported for L-cysteine (CAS RN: 52-90-4), L-serine (CAS RN: 56-45-1), L-threonine (CAS RN: 72-19-5), L-lysine (CAS RN: 56-87-1), and L-methio...

  • Article
  • Open Access
21 Citations
4,885 Views
12 Pages

Heat Capacities of l-Histidine, l-Phenylalanine, l-Proline, l-Tryptophan and l-Tyrosine

  • Václav Pokorný,
  • Vojtěch Štejfa,
  • Jakub Havlín,
  • Květoslav Růžička and
  • Michal Fulem

15 July 2021

In an effort to establish reliable thermodynamic data for proteinogenic amino acids, heat capacities for l-histidine (CAS RN: 71-00-1), l-phenylalanine (CAS RN: 63-91-2), l-proline (CAS RN: 147-85-3), l-tryptophan (CAS RN: 73-22-3), and l-tyrosine (C...

  • Article
  • Open Access
1 Citations
3,810 Views
27 Pages

The acquisition of determiners in French presents a significant challenge for both children in L1 and adults in L2. Research in L1 acquisition has found that French determiners, which are highly constrained, appear quite early relative to other langu...

  • Article
  • Open Access
57 Citations
4,343 Views
13 Pages

Deletion of the L7L-L11L Genes Attenuates ASFV and Induces Protection against Homologous Challenge

  • Jingyuan Zhang,
  • Yanyan Zhang,
  • Teng Chen,
  • Jinjin Yang,
  • Huixian Yue,
  • Lidong Wang,
  • Xintao Zhou,
  • Yu Qi,
  • Xun Han and
  • Rongliang Hu
  • + 7 authors

8 February 2021

African swine fever (ASF), caused by the African swine fever virus (ASFV), is a major epidemic disease endangering the swine industry. Although a number of vaccine candidates have been reported, none are commercially available yet. To explore the eff...

  • Article
  • Open Access
38 Citations
2,366 Views
16 Pages

24 October 2019

By means of the residual implication on a frame L, a degree approach to L-continuity and L-closedness for mappings between L-cotopological spaces are defined and their properties are investigated systematically. In addition, in the situation of L-top...

  • Article
  • Open Access
608 Views
20 Pages

18 July 2025

This paper introduces and investigates the fundamental properties of L-primals, a generalization of the primal concept within the framework of L-fuzzy sets and complete lattices. Building upon the established theories of L-topological spaces and L-pr...

  • Article
  • Open Access
5 Citations
4,190 Views
12 Pages

An Untargeted Metabolomic Analysis of Lacticaseibacillus (L.) rhamnosus, Lactobacillus (L.) acidophilus, Lactiplantibacillus (L.) plantarum and Limosilactobacillus (L.) reuteri Reveals an Upregulated Production of Inosine from L. rhamnosus

  • Luca Spaggiari,
  • Natalia Pedretti,
  • Francesco Ricchi,
  • Diego Pinetti,
  • Giuseppina Campisciano,
  • Francesco De Seta,
  • Manola Comar,
  • Samyr Kenno,
  • Andrea Ardizzoni and
  • Eva Pericolini

Lactic acid bacteria are considered an inexhaustible source of bioactive compounds; indeed, products from their metabolism are known to have immunomodulatory and anti-inflammatory activity. Recently, we demonstrated that Cell-Free Supernatants (CFS)...

  • Feature Paper
  • Article
  • Open Access
1 Citations
933 Views
21 Pages

Extending L-Topologies to Bipolar L-Fuzzy Topologies

  • Alexander Šostak and
  • Ingrīda Uļjane

27 August 2024

We develop a model that allows for the extension of an L-topology τ on a set X (i.e., τ⊆LX) to a bipolar L-fuzzy topology T on this set (i.e., T:LX→L). This model is based on the use of an additional algebraic structure on a complet...

  • Article
  • Open Access
3 Citations
2,690 Views
14 Pages

Heat Capacities of N-Acetyl Amides of Glycine, L-Alanine, L-Valine, L-Isoleucine, and L-Leucine

  • Vojtěch Štejfa,
  • Václav Pokorný,
  • Eliška Lieberzeitová,
  • Jakub Havlín,
  • Michal Fulem and
  • Květoslav Růžička

16 July 2023

As a follow-up to our effort to establish reliable thermodynamic data for amino acids, the heat capacity and phase behavior are reported for N-acetyl glycine amide (CAS RN: 2620-63-5), N-acetyl-L-alanine amide (CAS RN: 15962-47-7), N-acetyl-L-valine...

  • Article
  • Open Access
2 Citations
2,746 Views
17 Pages

15 February 2023

The revised version of the Speech Learning Model (SLM-r) regards full-time equivalent (FTE), which involves the amount of L2 use during the length of residence (LOR) in an L2 setting, as the main factor in L2 speech acquisition. Previous studiesshowe...

  • Article
  • Open Access
2 Citations
9,004 Views
11 Pages

In Vitro Metabolism of Dibenzo[a,l]pyrene, 2-Chlorodibenzo [a,l]pyrene and 10-Chlorodibenzo[a,l]pyrene - Effects of Chloro Substitution

  • Yuh-Shen Wu,
  • Guor-Cheng Fang,
  • Joanna Moody,
  • Linda S. Von Tungeln,
  • Peter P. Fu,
  • Huey-Min Hwang and
  • Hongtao Yu

30 September 2002

Stereoselective metabolism of dibenzo[a,l]pyrene (DB[a,l]P), 2-chlorodibenzo[a,l]pyrene (2-Cl-DB[a,l]P) and 10-chlorodibenzo[a,l]pyrene (10-Cl-DB[a,l]P) by rat liver microsomes was studied and effects of the chloro substituent on the metabolism were...

  • Review
  • Open Access
6 Citations
5,672 Views
11 Pages

28 February 2023

This article is an attempt to conceptualise the possibility of two coexisting language learning motivational subsystems for an existing L2 (or L2s) and an L3 currently being learnt, which gives rise to a complex dynamic dual-motivational system. As i...

  • Article
  • Open Access
1 Citations
2,267 Views
30 Pages

27 January 2025

Prior research has shown that people can predict the syntactic features of an upcoming word during sentence comprehension. However, evidence for morphosyntactic predictive processing has been limited to gender or case marking in a small subset of Ind...

  • Article
  • Open Access
16 Citations
8,236 Views
23 Pages

Effect of L-Tryptophan and L-Glutamic Acid on Carrot Yield and Its Quality

  • Robert Rosa,
  • Larysa Hajko,
  • Jolanta Franczuk,
  • Anna Zaniewicz-Bajkowska,
  • Alena Andrejiová and
  • Ivana Mezeyová

15 February 2023

Positively affecting crop quality and yields, amino acids used as plant stimulants play a special role in ensuring global food security. L-tryptophan (L-Try) and L-glutamic acid (L-Glu) are important biostimulants that increase the yield of field cro...

  • Article
  • Open Access
4 Citations
4,088 Views
18 Pages

Until recently, research on language attitudes focused mainly on attitudes relating to speakers’ L1. However, with the increase in interest in multilingualism in a globalised world, there has been a renewed interest in language attitudes relati...

  • Article
  • Open Access
11 Citations
3,121 Views
14 Pages

25 November 2022

Adults commonly struggle with perceiving and recognizing the sounds and words of a second language (L2), especially when the L2 sounds do not have a counterpart in the learner’s first language (L1). We examined how L1 Mandarin L2 English speake...

  • Article
  • Open Access
2 Citations
3,039 Views
19 Pages

10 January 2024

This study presents evidence of second language (L2) influence on first language (L1) perception of alveolar stops. Sixty-one L1 Japanese late learners of L2 English (onset ~12 years old) in Japan (N = 31) and in the US (N = 30) participated. We exam...

  • Article
  • Open Access
30 Citations
6,503 Views
19 Pages

Comparative Assessment of the Phytochemical Composition and Biological Activity of Extracts of Flowering Plants of Centaurea cyanus L., Centaurea jacea L. and Centaurea scabiosa L.

  • Natalia Sharonova,
  • Evgeny Nikitin,
  • Dmitriy Terenzhev,
  • Anna Lyubina,
  • Syumbelya Amerhanova,
  • Kseniya Bushmeleva,
  • Adelya Rakhmaeva,
  • Igor Fitsev and
  • Kirill Sinyashin

23 June 2021

The data on the phytochemical composition and biological activity for flowering plant extracts of the genus Centaurea (Knapweed)—cornflower (Centaurea cyanus L.), brown knapweed (Centaurea jacea L.), and greater knapweed (Centaurea scabiosa L.), whic...

  • Article
  • Open Access
8 Citations
7,645 Views
15 Pages

The total melanin synthesis in the skin depends on various melanogenic factors, including the number of viable melanocytes, the level of melanogenic enzymes per cell, and the reaction rate of the enzymes. The purpose of this study is to examine the e...

  • Review
  • Open Access
17 Citations
5,158 Views
29 Pages

While promising, PD-L1 expression on tumor tissues as assessed by immunohistochemistry has been shown to be an imperfect biomarker that only applies to a limited number of cancers, whereas many patients with PD-L1-negative tumors still respond to ant...

  • Article
  • Open Access
5 Citations
3,039 Views
14 Pages

5 October 2023

L-ornithine and L-glutamine are amino acids used for ammonia and nitrogen transport in the human body. Novel biodegradable synthetic poly(lactic-co-glycolic acid) derivatives were synthesized via conjugation with L-ornithine or L-glutamine, which wer...

  • Communication
  • Open Access
19 Citations
4,243 Views
9 Pages

3 September 2020

ZSM-5 zeolites are commonly used as a heterogeneous catalyst for reactions. Four ZSM-5 catalysts (with various crystallite sizes and a similar ratio of Si/Al) and their ball-milling/surface-poisoning derivates were used to convert L-lactic acid to L,...

  • Article
  • Open Access
11 Citations
4,435 Views
10 Pages

Tribo-Behavior and Corrosion Properties of Welded 304L and 316L Stainless Steel

  • Hany S. Abdo,
  • Asiful H. Seikh,
  • Hamad F. Alharbi,
  • Jabair Ali Mohammed,
  • Mahmoud S. Soliman,
  • Ahmed Fouly and
  • Sameh A. Ragab

20 December 2021

The present study investigates the electrochemical corrosion response and tribo-behavior of 304L and 316L stainless steel welded by gas metal arc welding (GMAW), which offered a high deposition rate. During this research, the metallurgically prepared...

  • Review
  • Open Access
18 Citations
3,799 Views
16 Pages

Mutation Profile of HPV16 L1 and L2 Genes in Different Geographic Areas

  • Dimitris Tsakogiannis,
  • Marios Nikolaidis,
  • Flora Zagouri,
  • Eleni Zografos,
  • Christine Kottaridi,
  • Zaharoula Kyriakopoulou,
  • Lamprini Tzioga,
  • Panayotis Markoulatos,
  • Grigoris D. Amoutzias and
  • Garyfalia Bletsa

31 December 2022

The causal relationship between HPV and cervical cancer in association with the high prevalence of high risk HPV genotypes led to the design of HPV vaccines based on the major capsid L1 protein. In recent years, capsid protein L2 has also become a fo...

  • Feature Paper
  • Article
  • Open Access
6 Citations
3,204 Views
12 Pages

15 April 2022

l-Fucose isomerase (l-FucI)-mediated isomerization is a promising biotechnological approach for synthesizing various rare sugars of industrial significance, including l-fucose. Extremozymes that can retain their functional conformation under extreme...

  • Article
  • Open Access
28 Citations
4,920 Views
20 Pages

Non-Volatile and Volatile Bioactives of Salvia officinalis L., Thymus serpyllum L. and Laurus nobilis L. Extracts with Potential Use in the Development of Functional Beverages

  • Ivanka Maleš,
  • Verica Dragović-Uzelac,
  • Igor Jerković,
  • Zoran Zorić,
  • Sandra Pedisić,
  • Maja Repajić,
  • Ivona Elez Garofulić and
  • Ana Dobrinčić

Functional beverages based on herbal extracts are highly demanded products due to the presence of bioactives with promising health benefits and interesting and characteristic sensory properties. Mediterranean medicinal and aromatic herbs contain a wi...

  • Article
  • Open Access
8 Citations
3,844 Views
16 Pages

L0 and L1 Guidance and Path-Following Control for Airborne Wind Energy Systems

  • Manuel C. R. M. Fernandes,
  • Sérgio Vinha,
  • Luís Tiago Paiva and
  • Fernando A. C. C. Fontes

14 February 2022

For an efficient and reliable operation of an Airborne Wind Energy System, it is widely accepted that the kite should follow a pre-defined optimized path. In this article, we address the problem of designing a trajectory controller so that such path...

  • Article
  • Open Access
14 Citations
3,095 Views
15 Pages

Antifungal Activities of L-Methionine and L-Arginine Treatment In Vitro and In Vivo against Botrytis cinerea

  • Shengwang Li,
  • Youwei Yu,
  • Peng Xie,
  • Xianran Zhu,
  • Chao Yang,
  • Linjing Wang and
  • Shaoying Zhang

Gray mold caused by Botrytis cinerea is a common postharvest fungal disease in fruit and vegetables. The prevention and treatment of postharvest gray mold has been one of the hot research issues addressed by researchers. This study aimed to investiga...

  • Communication
  • Open Access
1 Citations
2,557 Views
7 Pages

Divergent Cellular Expression Patterns of PD-L1 and PD-L2 Proteins in Breast Cancer

  • Julie M. Jorns,
  • Yunguang Sun,
  • Sailaja Kamaraju,
  • Yee Chung Cheng,
  • Amanda Kong,
  • Tina Yen,
  • Caitlin R. Patten,
  • Chandler S. Cortina,
  • Christopher R. Chitambar and
  • Lubna N. Chaudhary

29 April 2024

PD-L1 immunohistochemistry (IHC) has become an established method for predicting cancer response to targeted anti-PD1 immunotherapies, including breast cancer (BC). The alternative PD-1 ligand, PD-L2, remains understudied but may be a complementary p...

  • Article
  • Open Access
1 Citations
1,138 Views
19 Pages

Synthesis and Evaluation of [18F]AlF-NOTA-iPD-L1 as a Potential Theranostic Pair for [177Lu]Lu-DOTA-iPD-L1

  • Guillermina Ferro-Flores,
  • Myrna Luna-Gutiérrez,
  • Blanca Ocampo-García,
  • Nallely Jiménez-Mancilla,
  • Nancy Lara-Almazán,
  • Rigoberto Oros-Pantoja,
  • Clara Santos-Cuevas,
  • Erika Azorín-Vega and
  • Laura Meléndez-Alafort

Background/Objective: Programmed cell death ligand-1 (PD-L1), which is overexpressed in certain tumors, inhibits the body’s natural immune response by providing an “off” signal that enables cancer cells to evade the immune system. I...

  • Article
  • Open Access
7 Citations
3,758 Views
18 Pages

Mouse Papillomavirus L1 and L2 Are Dispensable for Viral Infection and Persistence at Both Cutaneous and Mucosal Tissues

  • Sarah Brendle,
  • Jingwei J. Li,
  • Nancy M. Cladel,
  • Debra A. Shearer,
  • Lynn R. Budgeon,
  • Karla K. Balogh,
  • Hannah Atkins,
  • Marina Costa-Fujishima,
  • Paul Lopez and
  • Jiafen Hu
  • + 2 authors

14 September 2021

Papillomavirus L1 and L2, the major and minor capsid proteins, play significant roles in viral assembly, entry, and propagation. In the current study, we investigate the impact of L1 and L2 on viral life cycle and tumor growth with a newly establishe...

  • Review
  • Open Access
12 Citations
5,645 Views
19 Pages

24 December 2021

Nucleic-acid-based small molecule and oligonucleotide therapies are attractive topics due to their potential for effective target of disease-related modules and specific control of disease gene expression. As the non-naturally occurring biomolecules,...

  • Article
  • Open Access
3 Citations
2,783 Views
18 Pages

Previous research points to a major role of L3 proficiency in L3 acquisition whereas language dominance and cognate status in bilinguals remain under-researched. The aim of this paper was to investigate the role of L3 proficiency, language dominance...

  • Article
  • Open Access
22 Citations
7,650 Views
24 Pages

L-Selectin/CD62L Is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men

  • Hannah K. Drescher,
  • Angela Schippers,
  • Stefanie Rosenhain,
  • Felix Gremse,
  • Laura Bongiovanni,
  • Alain de Bruin,
  • Sreepradha Eswaran,
  • Suchira U. Gallage,
  • Dominik Pfister and
  • Daniela C. Kroy
  • + 5 authors

29 April 2020

CD62L (L-Selectin) dependent lymphocyte infiltration is known to induce inflammatory bowel disease (IBD), while its function in the liver, especially in non-alcoholic steatohepatitis (NASH), remains unclear. We here investigated the functional role o...

  • Review
  • Open Access
18 Citations
5,047 Views
27 Pages

18 October 2021

Approximately 20% of breast cancer (BC) patients suffer from distant metastasis. The incidence and prevalence rates of metastatic BC have increased annually. Immune checkpoint inhibitors are an emerging area of treatment, especially for metastatic pa...

  • Article
  • Open Access
7 Citations
3,536 Views
14 Pages

Limits of Solid Solutions and Thermal Deformations in the L-Alanine–L-Serine Amino Acid System

  • Elena Kotelnikova,
  • Roman Sadovnichii,
  • Lyudmila Kryuchkova and
  • Heike Lorenz

16 July 2020

The limits of solid solutions and thermal deformations in the L-alanine–L-serine (L-ala–L-ser) amino acid system have been determined. Thirteen amino acid mixtures with various proportions of the components L-ser/L-ala were studied using...

  • Article
  • Open Access
14 Citations
7,363 Views
34 Pages

13 November 2018

The goals of this study were to investigate the developmental patterns of acquisition of the Spanish tap and trill by L1 Mandarin–L2 English–L3 Spanish speakers, and to examine the extent to which the L1 and the L2 influenced the L3 produ...

of 3,127