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8,192 Results Found

  • Case Report
  • Open Access
9 Citations
17,518 Views
9 Pages

Three Cases of Severe ME/CFS in Adults

  • Leah R. Williams and
  • Carol Isaacson-Barash

16 February 2021

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, only partially understood multi-system disease whose onset and severity vary widely. Symptoms include overwhelming fatigue, post-exertional malaise, sleep disruptions, gastroin...

(This article belongs to the Special Issue ME/CFS – the Severely and Very Severely Affected)
  • Article
  • Open Access
28 Citations
24,331 Views
19 Pages

A Comprehensive Examination of Severely Ill ME/CFS Patients

  • Chia-Jung Chang,
  • Li-Yuan Hung,
  • Andreas M. Kogelnik,
  • David Kaufman,
  • Raeka S. Aiyar,
  • Angela M. Chu,
  • Julie Wilhelmy,
  • Peng Li,
  • Linda Tannenbaum and
  • Ronald W. Davis
  • + 1 author

29 September 2021

One in four myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients are estimated to be severely affected by the disease, and these house-bound or bedbound patients are currently understudied. Here, we report a comprehensive examination...

(This article belongs to the Special Issue ME/CFS – the Severely and Very Severely Affected)
  • Feature Paper
  • Article
  • Open Access
5 Citations
9,328 Views
16 Pages

The German Multicenter Registry for ME/CFS (MECFS-R)

  • Hannah Hieber,
  • Rafael Pricoco,
  • Katrin Gerrer,
  • Cornelia Heindrich,
  • Katharina Wiehler,
  • Lorenz L. Mihatsch,
  • Matthias Haegele,
  • Daniela Schindler,
  • Quirin Donath and
  • Uta Behrends
  • + 14 authors

28 May 2024

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystemic disease characterized by a complex, incompletely understood etiology. Methods: To facilitate future clinical and translational research, a multice...

(This article belongs to the Special Issue Clinical Aspects of Infectious Diseases)
  • Viewpoint
  • Open Access
19 Citations
53,612 Views
23 Pages

A personal account from an Extremely Severe Bedridden ME/CFS patient about the experience of living with extremely severe ME/CFS. Illness progression, medical history, description of various aspects of extremely severe ME/CFS and various essays on sp...

(This article belongs to the Special Issue ME/CFS – the Severely and Very Severely Affected)
  • Article
  • Open Access
3 Citations
4,064 Views
16 Pages

Evaluation of a Webinar to Increase Health Professionals’ Knowledge about Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

  • Laura Froehlich,
  • Jasmin Niedrich,
  • Daniel B. R. Hattesohl,
  • Uta Behrends,
  • Claudia Kedor,
  • Johannes-Peter Haas,
  • Michael Stingl and
  • Carmen Scheibenbogen

2 August 2023

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic illness and patients with ME/CFS are often medically underserved in Germany and other countries. One contributing factor is health professionals’ lack of knowledge...

(This article belongs to the Section Digital Health Technologies)
  • Opinion
  • Open Access
28 Citations
11,931 Views
5 Pages

Our Evolving Understanding of ME/CFS

  • Kenneth J. Friedman,
  • Modra Murovska,
  • Derek F. H. Pheby and
  • Paweł Zalewski

26 February 2021

The potential benefits of the scientific insights gleaned from years of treating ME/CFS for the emerging symptoms of COVID-19, and in particular Longhaul- or Longhauler-COVID-19 are discussed in this opinion article. Longhaul COVID-19 is the current...

(This article belongs to the Special Issue ME/CFS: Causes, Clinical Features and Diagnosis)
  • Article
  • Open Access
23 Citations
7,289 Views
11 Pages

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE)

  • John Cullinan,
  • Derek F. H. Pheby,
  • Diana Araja,
  • Uldis Berkis,
  • Elenka Brenna,
  • Jean-Dominique de Korwin,
  • Lara Gitto,
  • Dyfrig A. Hughes,
  • Rachael M. Hunter and
  • Xia Wang-Steverding
  • + 1 author

26 February 2021

Background and Objectives: We have conducted a survey of academic and clinical experts who are participants in the European ME/CFS Research Network (EUROMENE) to elicit perceptions of general practitioner (GP) knowledge and understanding of myalgic e...

(This article belongs to the Special Issue ME/CFS: Causes, Clinical Features and Diagnosis)
  • Editorial
  • Open Access
7 Citations
10,518 Views
9 Pages

Turning a Corner in ME/CFS Research

  • Derek F. H. Pheby,
  • Kenneth J. Friedman,
  • Modra Murovska and
  • Pawel Zalewski

25 September 2021

This collection of research papers addresses fundamental questions concerning the nature of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS), the problem of disbelief and lack of knowledge and understanding of the condition among many doc...

(This article belongs to the Special Issue ME/CFS: Causes, Clinical Features and Diagnosis)
  • Opinion
  • Open Access
8 Citations
27,021 Views
6 Pages

ME/CFS: Past, Present and Future

  • William Weir and
  • Nigel Speight

This review raises a number of compelling issues related to the condition of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Some historical perspective is necessary in order to highlight the nature of the controversy concerning its caus...

(This article belongs to the Special Issue ME/CFS – the Severely and Very Severely Affected)
  • Review
  • Open Access
36 Citations
8,369 Views
17 Pages

A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE)

  • Derek F. H. Pheby,
  • Diana Araja,
  • Uldis Berkis,
  • Elenka Brenna,
  • John Cullinan,
  • Jean-Dominique de Korwin,
  • Lara Gitto,
  • Dyfrig A. Hughes,
  • Rachael M. Hunter and
  • Xia Wang-Steverding
  • + 1 author

24 December 2020

Background and Objectives: The socioeconomic working group of the European myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Research Network (EUROMENE) has conducted a review of the literature pertaining to GPs’ knowledge and underst...

(This article belongs to the Special Issue ME/CFS: Causes, Clinical Features and Diagnosis)
  • Opinion
  • Open Access
9 Citations
5,887 Views
16 Pages

The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE)

  • Derek F. H. Pheby,
  • Diana Araja,
  • Uldis Berkis,
  • Elenka Brenna,
  • John Cullinan,
  • Jean-Dominique de Korwin,
  • Lara Gitto,
  • Dyfrig A. Hughes,
  • Rachael M. Hunter and
  • Xia Wang-Steverding
  • + 1 author

16 April 2021

This report addresses the extent to which there may be scope for preventive programmes for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), and, if so, what economic benefits may accrue from the implementation of such programmes. We consi...

(This article belongs to the Special Issue ME/CFS: Causes, Clinical Features and Diagnosis)
  • Review
  • Open Access
23 Citations
5,882 Views
7 Pages

21 July 2021

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term disabling illness accompanied by fatigue unsolved by rest. However, ME/CFS is a poorly understood illness that lacks a universally accepted pathophysiology and tre...

(This article belongs to the Special Issue Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: Diagnosis and Treatment)
  • Article
  • Open Access
7 Citations
11,674 Views
15 Pages

Autonomic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Findings from the Multi-Site Clinical Assessment of ME/CFS (MCAM) Study in the USA

  • Anindita Issa,
  • Jin-Mann S. Lin,
  • Yang Chen,
  • Jacob Attell,
  • Dana Brimmer,
  • Jeanne Bertolli,
  • Benjamin H. Natelson,
  • Charles W. Lapp,
  • Richard N. Podell and
  • Elizabeth R. Unger
  • + 4 authors

5 September 2025

Background/Objectives: Symptoms of autonomic dysfunction are common in infection-associated chronic conditions and illnesses (IACCIs), including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study aimed to evaluate autonomic sympt...

(This article belongs to the Special Issue POTS, ME/CFS and Long COVID: Recent Advances and Future Direction)
  • Feature Paper
  • Review
  • Open Access
41 Citations
12,888 Views
12 Pages

The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE)

  • Derek F.H. Pheby,
  • Diana Araja,
  • Uldis Berkis,
  • Elenka Brenna,
  • John Cullinan,
  • Jean-Dominique de Korwin,
  • Lara Gitto,
  • Dyfrig A Hughes,
  • Rachael M Hunter and
  • Xia Wang-Steverding
  • + 1 author

We have developed a Europe-wide approach to investigating the economic impact of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), facilitating acquisition of information on the economic burden of ME/CFS, and international comparisons of e...

(This article belongs to the Special Issue ME/CFS – the Severely and Very Severely Affected)
  • Article
  • Open Access
133 Citations
23,523 Views
11 Pages

20 December 2022

This study sought to ascertain the prevalence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) among a sample of 465 patients with Long COVID. The participants completed three questionnaires: (1) a new questionnaire measuring both the f...

  • Review
  • Open Access
20 Citations
17,974 Views
15 Pages

18 February 2022

For the last few decades, medical guidelines have recommended treating patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with graded exercise therapy (GET) and cognitive behavioural therapy (CBT). Moreover, doctors have questi...

  • Article
  • Open Access
42 Citations
12,933 Views
36 Pages

Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts

  • Daniel Missailidis,
  • Oana Sanislav,
  • Claire Y. Allan,
  • Paige K. Smith,
  • Sarah J. Annesley and
  • Paul R. Fisher

19 February 2021

Although understanding of the biomedical basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is growing, the underlying pathological mechanisms remain uncertain. We recently reported a reduction in the proportion of basal oxygen cons...

(This article belongs to the Special Issue Environmental Sensitivity Illnesses: Mechanisms and Molecular Signatures 2.0)
  • Review
  • Open Access
125 Citations
21,866 Views
22 Pages

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview

  • Undine-Sophie Deumer,
  • Angelica Varesi,
  • Valentina Floris,
  • Gabriele Savioli,
  • Elisa Mantovani,
  • Paulina López-Carrasco,
  • Gian Marco Rosati,
  • Sakshi Prasad and
  • Giovanni Ricevuti

19 October 2021

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic systemic disease that manifests via various symptoms such as chronic fatigue, post-exertional malaise, and cognitive impairment described as “brain fog”. These symptoms often pr...

(This article belongs to the Special Issue Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: Diagnosis and Treatment)
  • Review
  • Open Access
6 Citations
4,890 Views
18 Pages

31 December 2025

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling clinical condition, whose hallmark characteristic is post-exertional malaise (PEM). It can affect many organs and systems, leading to severe impairment of patients’ qual...

(This article belongs to the Special Issue 25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology)
  • Article
  • Open Access
8 Citations
14,797 Views
14 Pages

Serum Spike Protein Persistence Post COVID Is Not Associated with ME/CFS

  • Annick Fehrer,
  • Franziska Sotzny,
  • Laura Kim,
  • Claudia Kedor,
  • Helma Freitag,
  • Cornelia Heindrich,
  • Patricia Grabowski,
  • Nina Babel,
  • Carmen Scheibenbogen and
  • Kirsten Wittke

8 February 2025

Background/Objectives: According to the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC), an estimated 3–6% of people suffer from post-COVID condition or syndrome (PCS). A subset meets the diagnostic criteria...

(This article belongs to the Section Infectious Diseases)
  • Brief Report
  • Open Access
4,900 Views
8 Pages

Comparing Frequency and Severity Ratings for ME/CFS versus Controls

  • Leonard A. Jason,
  • Sage Benner and
  • Nicole Hansel

30 June 2023

Most questionnaires for somatic symptoms focus either on occurrence, frequency, or severity, and in doing so, they might not be able to comprehensively assess the burden that symptoms present to patients. For example, a symptom might occur at a high...

(This article belongs to the Special Issue Feature Papers in Psych)
  • Article
  • Open Access
5 Citations
3,433 Views
20 Pages

Research on the Simplified Method of Nonlinear Finite Element Analysis for CFS-SPR Connections

  • Ailin Zhang,
  • Zhiqiang Xie,
  • Leilei Shi,
  • Yanxia Zhang,
  • Daxing Zhou and
  • Xiangdong Zhang

8 November 2022

This study reviewed some simplified methods of finite element analysis (FEA) for connections in cold-formed steel (CFS) structure, and summarized eight simplified methods divided into three categories. Shear performance tests were performed for six g...

(This article belongs to the Special Issue Steel Structures and Sustainable Building Structure System)
  • Review
  • Open Access
14 Citations
18,425 Views
15 Pages

The purpose of this article is to review the evidence of similar symptomatology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-acute sequelae of SARS-CoV-2 infection (PASC). Reanalysis of data from a study by Jason comparing...

(This article belongs to the Special Issue Feature Review Papers on Brain and Nervous Related Diseases)
  • Review
  • Open Access
14 Citations
6,767 Views
34 Pages

17 April 2024

The utilization of cold-formed steel (CFS) sections in construction has become widespread due to their favorable attributes, including their lightweight properties, high strength, recyclability, and ease of assembly. To ensure their continued safe an...

(This article belongs to the Section Building Structures)
  • Article
  • Open Access
12 Citations
4,564 Views
12 Pages

23 March 2021

Background and Objectives: A comparative survey of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients was carried out in three countries, with the aim of identifying appropriate policy measures designed to alleviate the burden of di...

(This article belongs to the Special Issue ME/CFS: Causes, Clinical Features and Diagnosis)
  • Article
  • Open Access
21 Citations
25,335 Views
29 Pages

Urine Metabolomics Exposes Anomalous Recovery after Maximal Exertion in Female ME/CFS Patients

  • Katherine A. Glass,
  • Arnaud Germain,
  • Yuhsin V. Huang and
  • Maureen R. Hanson

12 February 2023

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with unknown etiology or effective treatments. Post-exertional malaise (PEM) is a key symptom that distinguishes ME/CFS patients. Investigating changes in the urine...

(This article belongs to the Special Issue New Advances in Metabolic Syndrome)
  • Perspective
  • Open Access
13 Citations
14,016 Views
7 Pages

Many people with severe Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) commonly receive no care from healthcare professionals, while some have become distanced from all statutory medical services. Paradoxically, it is often the most serious...

(This article belongs to the Special Issue ME/CFS – the Severely and Very Severely Affected)
  • Article
  • Open Access
7 Citations
8,089 Views
13 Pages

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a multisystem chronic illness characterized by severe muscle fatigue, pain, dizziness, and brain fog. Many patients with ME/CFS experience orthostatic intolerance (OI), which is charac...

(This article belongs to the Special Issue Advances of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS))
  • Article
  • Open Access
77 Citations
22,576 Views
18 Pages

Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids

  • Arnaud Germain,
  • Dinesh K. Barupal,
  • Susan M. Levine and
  • Maureen R. Hanson

14 January 2020

The latest worldwide prevalence rate projects that over 65 million patients suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), an illness with known effects on the functioning of the immune and nervous systems. We performed an e...

  • Article
  • Open Access
60 Citations
29,134 Views
17 Pages

We have previously demonstrated that platelet-poor plasma (PPP) obtained from patients with Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is characterized by a hypercoagulable state and contains hyperactivated platelets and considerable numbers o...

(This article belongs to the Special Issue Anticoagulants and Antiplatelet Drugs)
  • Review
  • Open Access
21 Citations
8,228 Views
22 Pages

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Cancer-Related Fatigue (CRF) are syndromes with considerable overlap with respect to symptoms. There have been many studies that have compared the two conditions, and some of this resear...

(This article belongs to the Special Issue Molecular Research in Radiobiology)
  • Article
  • Open Access
9 Citations
4,264 Views
10 Pages

Potential of Activin B as a Clinical Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

  • Sabine Gravelsina,
  • Zaiga Nora-Krukle,
  • Anda Vilmane,
  • Simons Svirskis,
  • Katrine Vecvagare,
  • Angelika Krumina and
  • Modra Murovska

11 August 2021

Reliable serum biomarkers are of immense need for diagnostic purposes of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)—a disabling and complex disease for which diagnosis is mainly based on clinical symptoms. The aim of this study was t...

(This article belongs to the Section Chemical Biology)
  • Article
  • Open Access
4 Citations
10,282 Views
16 Pages

An In-Depth Exploration of the Autoantibody Immune Profile in ME/CFS Using Novel Antigen Profiling Techniques

  • Arnaud Germain,
  • Jillian R. Jaycox,
  • Christopher J. Emig,
  • Aaron M. Ring and
  • Maureen R. Hanson

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder characterized by serious physical and cognitive impairments. Recent research underscores the role of immune dysfunction, including the role of autoantibodies, in M...

(This article belongs to the Section Molecular Immunology)
  • Article
  • Open Access
6 Citations
13,389 Views
12 Pages

Systems Modeling Reveals Shared Metabolic Dysregulation and Potential Treatments in ME/CFS and Long COVID

  • Gong-Hua Li,
  • Fei-Fei Han,
  • Efthymios Kalafatis,
  • Qing-Peng Kong and
  • Wenzhong Xiao

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID are complex multisystem conditions that pose significant challenges in healthcare. Accumulated research evidence suggests that ME/CFS and Long COVID exhibit overlapping metabo...

(This article belongs to the Special Issue Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition)
  • Article
  • Open Access
7 Citations
4,424 Views
25 Pages

Good Practices of Food Banks in Spain: Contribution to Sustainable Development from the CFS-RAI Principles

  • María Leticia Acosta Mereles,
  • Carlos Mur Nuño,
  • Ricardo Rubén Stratta Fernández and
  • Manuel Enrique Chenet

23 January 2025

The Principles for Responsible Investment in Agriculture and Food Systems (CFS-RAI) are suitable standards for contributing to the Sustainable Development Goals (SDGs) in the area of sound consumption and sustainable food. In this context, food banks...

(This article belongs to the Special Issue Sustainable Rural Development Projects: Diversity and Opportunities from Principles of Responsible Investment in Agriculture and Food Systems)
  • Article
  • Open Access
4 Citations
2,336 Views
23 Pages

16 November 2022

A novel CFS composite wall filled with cement-based lightweight polymer material (CFS-CLPM composite wall) has been proposed and proven to have excellent architectural and mechanical performance. To promote its application in prefabricated concrete (...

(This article belongs to the Special Issue Sustainability and Resiliency of Building Materials and Structures)
  • Article
  • Open Access
22 Citations
7,704 Views
8 Pages

7 January 2021

Background and objectives: To explore the impacts that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has on the patient and their family members using the WHOQOL-BREF (Abbreviated World Health Organisation Quality of Life questionnaire)...

(This article belongs to the Special Issue ME/CFS: Causes, Clinical Features and Diagnosis)
  • Article
  • Open Access
3 Citations
1,437 Views
16 Pages

The Effect of Deep Cryogenic Treatment on the Electrocatalytic Performance of a Pd@CFs Catalyst for Methanol Oxidation

  • Chenxing Wang,
  • Jiahui Mo,
  • Haoting Wang,
  • Jia Liu,
  • Gege He,
  • Xinhai He and
  • Yanyan Song

22 February 2025

To enhance the electrocatalytic performance of a flexible Pd@CFs catalyst for methanol oxidation, deep cryogenic treatment in liquid nitrogen was introduced. The effects of the frequency and time of the deep cryogenic treatment on the surface crystal...

(This article belongs to the Special Issue Application of Nanomaterials in Efficient Energy Conversion and Storage)
  • Article
  • Open Access
25 Citations
15,284 Views
19 Pages

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling disease with worldwide prevalence and limited therapies exclusively aimed at treating symptoms. To gain insights into the molecular disruptions in ME/CFS, we utilized an aptam...

(This article belongs to the Special Issue Functional Proteomics 2020)
  • Article
  • Open Access
2 Citations
7,167 Views
18 Pages

Heat vs. Fatigue: Hyperthermia as a Possible Treatment Option for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

  • Barbara Hochecker,
  • Katja Matt,
  • Melanie Scherer,
  • Alica Meßmer,
  • Alexander von Ardenne and
  • Jörg Bergemann

The aetiology and pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have not yet been clarified. Its exact diagnosis is also difficult because it has no biomarkers. This lack of knowledge leads to difficulties in treating...

(This article belongs to the Special Issue Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome)
  • Article
  • Open Access
31 Citations
8,209 Views
17 Pages

6 July 2021

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a poorly understood, complex, multisystem disorder, with severe fatigue not alleviated by rest, and other symptoms, which lead to substantial reductions in functional activity...

(This article belongs to the Special Issue Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: Diagnosis and Treatment)
  • Article
  • Open Access
2 Citations
7,452 Views
14 Pages

22 May 2025

Background/Objectives: Orthostatic intolerance is prevalent in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and is caused by an abnormal reduction in cerebral blood flow (CBF). In healthy controls (HCs), CBF is regulated...

(This article belongs to the Section Cardiology)
  • Hypothesis
  • Open Access
20 Citations
15,328 Views
11 Pages

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is often associated with various other syndromes or conditions including mast cell activation (MCA), dysmenorrhea and endometriosis, postural tachycardia (POTS) and small fiber neuropathy (S...

(This article belongs to the Special Issue Advances in ME/CFS Research and Clinical Care)
  • Article
  • Open Access
33 Citations
16,757 Views
16 Pages

Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study

  • Luis Nacul,
  • Barbara de Barros,
  • Caroline C. Kingdon,
  • Jacqueline M. Cliff,
  • Taane G. Clark,
  • Kathleen Mudie,
  • Hazel M. Dockrell and
  • Eliana M. Lacerda

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease presenting with extreme fatigue, post-exertional malaise, and other symptoms. In the absence of a diagnostic biomarker, ME/CFS is diagnosed clinically, although lab...

(This article belongs to the Special Issue Biomedical Insights that Inform the Diagnosis of ME/CFS)
  • Article
  • Open Access
7 Citations
6,711 Views
21 Pages

Investigating Antibody Reactivity to the Intestinal Microbiome in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Feasibility Study

  • Katharine A. Seton,
  • Marianne Defernez,
  • Andrea Telatin,
  • Sumeet K. Tiwari,
  • George M. Savva,
  • Antonietta Hayhoe,
  • Alistair Noble,
  • Ana L. S. de Carvalho-KoK,
  • Steve A. James and
  • Simon R. Carding
  • + 2 authors

18 October 2023

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic disease of unknown aetiology that is characterised by disabling chronic fatigue and involves both the immune and gastrointestinal (GI) systems. Patients display alteration...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Review
  • Open Access
362 Citations
35,456 Views
14 Pages

26 April 2021

Background and Objectives: Long COVID defines a series of chronic symptoms that patients may experience after resolution of acute COVID-19. Early reports from studies with patients with long COVID suggests a constellation of symptoms with similaritie...

(This article belongs to the Special Issue ME/CFS: Causes, Clinical Features and Diagnosis)
  • Article
  • Open Access
2,101 Views
23 Pages

28 February 2026

The rapid proliferation of small satellite missions demands flight software that combines reliability, reusability, and rapid development cycles. NASA’s Core Flight System (cFS), with its layered architecture and component-based design, offers...

  • Article
  • Open Access
15 Citations
2,705 Views
12 Pages

29 December 2020

In recent research activities, shake-table tests were revealed to be useful to investigate the seismic behavior of cold-formed steel (CFS) buildings. However, testing full-scale buildings or reduced-scale prototypes is not always possible; indeed, pr...

(This article belongs to the Special Issue Conventional vs. Innovative Materials, Tradition and Innovation)
  • Article
  • Open Access
2 Citations
8,769 Views
24 Pages

Performance of Novel U-Connector in CFS Truss-to-Column Bolted Connection under Axial Force

  • Lazar Lukačević,
  • Paulina Krolo,
  • Antonio Bakran and
  • Ivan Palijan

This paper presents an experimental and numerical investigation of the tensile and compressive behaviour of a novel U-connector in the cold-formed steel (CFS) truss-to-column connection. Tensile tests were performed on 12 specimens representing the t...

(This article belongs to the Section Building Structures)
  • Review
  • Open Access
57 Citations
14,105 Views
17 Pages

29 October 2021

The well-known symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are chronic pain, cognitive dysfunction, post-exertional malaise and severe fatigue. Another class of symptoms commonly reported in the context of ME/CFS are gastr...

(This article belongs to the Special Issue Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: Diagnosis and Treatment)

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