Next Article in Journal
De Novo ACTG1 Variant Expands the Phenotype and Genotype of Partial Deafness and Baraitser–Winter Syndrome
Previous Article in Journal
The Effect of Tau and Taxol on Polymerization of MCF7 Microtubules In Vitro
Previous Article in Special Issue
Mutation Analysis of Radioresistant Early-Stage Cervical Cancer
Review

Commonalities in the Features of Cancer and Chronic Fatigue Syndrome (CFS): Evidence for Stress-Induced Phenotype Instability?

1
Department of Integrated Biomedical Engineering and Health Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada
2
Department of Biology, McMaster University, Hamilton, ON L8S 4L8, Canada
3
National CFIDS Foundation Inc., 103 Aletha Road, Needham, MA 02492, USA
*
Author to whom correspondence should be addressed.
Academic Editors: José L. Quiles and Luigi M. Bagella
Int. J. Mol. Sci. 2022, 23(2), 691; https://doi.org/10.3390/ijms23020691
Received: 30 November 2021 / Revised: 26 December 2021 / Accepted: 5 January 2022 / Published: 8 January 2022
(This article belongs to the Special Issue Molecular Research in Radiobiology)
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Cancer-Related Fatigue (CRF) are syndromes with considerable overlap with respect to symptoms. There have been many studies that have compared the two conditions, and some of this research suggests that the etiologies of the conditions are linked in some cases. In this narrative review, CFS/ME and cancer are introduced, along with their known and putative mechanistic connections to multiple stressors including ionizing radiation. Next, we summarize findings from the literature that suggest the involvement of HPA-axis dysfunction, the serotonergic system, cytokines and inflammation, metabolic insufficiency and mitochondrial dysfunction, and genetic changes in CRF and CFS/ME. We further suspect that the manifestation of fatigue in both diseases and its causes could indicate that CRF and CFS/ME lie on a continuum of potential biological effects which occur in response to stress. The response to this stress likely varies depending on predisposing factors such as genetic background. Finally, future research ideas are suggested with a focus on determining if common biomarkers exist in CFS/ME patients and those afflicted with CRF. Both CFS/ME and CRF are relatively heterogenous syndromes, however, it is our hope that this review assists in future research attempting to elucidate the commonalities between CRF and CFS/ME. View Full-Text
Keywords: chronic fatigue and immune dysfunction syndrome (CFIDS); myalgic encephalomyelitis/chronic fatigue syndrome (CFS/ME); cancer; radiation; mitochondria; non-targeted effects (NTE); metabolism; biomarkers chronic fatigue and immune dysfunction syndrome (CFIDS); myalgic encephalomyelitis/chronic fatigue syndrome (CFS/ME); cancer; radiation; mitochondria; non-targeted effects (NTE); metabolism; biomarkers
Show Figures

Figure 1

MDPI and ACS Style

Rusin, A.; Seymour, C.; Cocchetto, A.; Mothersill, C. Commonalities in the Features of Cancer and Chronic Fatigue Syndrome (CFS): Evidence for Stress-Induced Phenotype Instability? Int. J. Mol. Sci. 2022, 23, 691. https://doi.org/10.3390/ijms23020691

AMA Style

Rusin A, Seymour C, Cocchetto A, Mothersill C. Commonalities in the Features of Cancer and Chronic Fatigue Syndrome (CFS): Evidence for Stress-Induced Phenotype Instability? International Journal of Molecular Sciences. 2022; 23(2):691. https://doi.org/10.3390/ijms23020691

Chicago/Turabian Style

Rusin, Andrej, Colin Seymour, Alan Cocchetto, and Carmel Mothersill. 2022. "Commonalities in the Features of Cancer and Chronic Fatigue Syndrome (CFS): Evidence for Stress-Induced Phenotype Instability?" International Journal of Molecular Sciences 23, no. 2: 691. https://doi.org/10.3390/ijms23020691

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop