3,254 Results Found

More than four decades ago, the discovery of a companion protein of immunoglobulins in myeloma cells and soon after, of their ability to associate with heavy chains, made the term immunoglobulin binding protein (BiP) emerge, prompting a tremendous am...

The AB plant toxin ricin binds both glycoproteins and glycolipids at the cell surface via its B subunit. After binding, ricin is endocytosed and then transported retrogradely through the Golgi to the endoplasmic reticulum (ER). In the ER, the A subu...

In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS...

Background: Glucose-regulated protein 78/Binding immunoglobulin protein (GRP78/BiP) is a protein associated with endoplasmic reticulum stress and is upregulated by metabolic alterations at the tissue-level, such as hypoxia or glucose deprivation, and...

P-glycoprotein (P-gp, ABCB1 member of the ABC (ATP-binding cassette) transporter family) localized in leukemia cell plasma membranes is known to reduce cell sensitivity to a large but well-defined group of chemicals known as P-gp substrates. However,...

GRP78/BiP, a stress-induced protein and autoantigen in rheumatoid arthritis (RA), exhibits different expressions in various biological fluids and tissues, including blood, synovial fluid (SF), and synovium, all of which are pertinent to the disease a...

Organometallic ruthenium (Ru)(II)-cymene complexes display promising pharmacological properties and might represent alternative therapeutic agents in medical applications. Polyphenols, such as curcumin and curcuminoids, display beneficial properties...

The endoplasmic reticulum chaperone BiP (also known as GRP-78 or HSPA5) maintains protein folding to allow cell proliferation and survival and has been implicated in carcinogenesis, tumor progression, and therapy resistance. BiP’s association w...

Background: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children, and is associated with a poor prognosis in patients presenting with recurrent or metastatic disease. The unfolded protein response (UPR) plays pivotal roles in tum...

Cigarette smoking is a significant risk factor for the development and progression of oral cancer. Previous studies have reported an association between nicotine and malignancy in oral cancer. Recent studies have also demonstrated that nicotine can i...

Various drug-sensitivity markers are potentially responsible for tumor progression and chemotherapy resistance in cancer patients with both epithelial and sarcomatous components; however, the clinicopathological significance of drug-sensitivity marke...

Osteoblasts must acquire a considerable capacity for folding unfolded and misfolded proteins (MPs) to produce large amounts of extracellular matrix proteins and maintain bone homeostasis. MP accumulation contributes to cellular apoptosis and bone dis...

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in protein biogenesis, calcium (Ca²⁺) homeostasis, and signal transduction. Among the roughly one hundred components, which are involved in protein import and protein...

Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic and does not allow vicious circles causing disease development to break. Protein misfolding is considered the most important pathogenetic factor of neurodegenerative di...

A major limitation of current prostate cancer pharmacotherapy approaches is the inability of these compounds to target androgen receptor variants or mutants that develop during prostate cancer progression. The demand for novel therapeutics to prevent...

Human pluripotent stem cells (hPSCs), such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have a well-orchestrated program for differentiation and self-renewal. However, the structural features of unique proteostatic-maint...

The endoplasmic reticulum (ER) has emerged as a source of hydrogen peroxide (H₂O₂) and a hub for peroxide-based signaling events. Here we outline cellular sources of ER-localized peroxide, including sources within and near the ER. Focusing on three E...

Through kidney transplantation, ischemia/reperfusion is known to induce tissular injury due to cell energy shortage, oxidative stress, and endoplasmic reticulum (ER) stress. ER stress stems from an accumulation of unfolded or misfolded proteins in th...

Marinesco–Sjogren syndrome (MSS) is a rare multisystem pediatric disorder, caused by loss-of-function mutations in the gene encoding the endoplasmic reticulum cochaperone SIL1. SIL1 acts as a nucleotide exchange factor for BiP, which plays a central...

Our understanding of autophagy and lysosomal function has been greatly enhanced by the discovery of natural product structures that can serve as chemical probes to reveal new patterns of signal transduction in cells. Coibamide A is a cytotoxic marine...

The essential oils of the flowers, leaves and stems of Senecio polyanthemoides Sch. Bip. Samples collected from two different localities within the city of uMhlathuze, KwaZulu-Natal Province (South Africa) were isolated by hydrodistillation and analy...

Bidens pilosa L. var. radiata Sch. Bip. (BPr) had been found capable of excluding Cyperus rotundus L. (CR) from its vegetation in fallow fields. Both allelopathy and competition of BPr were able to limit the growth of CR, but this has not been extens...

Missense mutations are the most prevalent alterations in genetic disorders such as hemophilia A (HA), which results from coagulation factor VIII (FVIII) deficiencies. These mutations disrupt protein biosynthesis, folding, secretion, and function. Cur...

Chamomile (Matricaria chamomilla L.) and feverfew (Tanacetum parthenium L. Sch. Bip.), both members of the Asteraceae family, are widely distributed in Serbia and traditionally used for their medicinal properties. Chamomile is primarily known for its...

Exploiting excellent photocatalytic activity and stable heterostructure composites are of critical importance for environmental sustainability. The spherical Bi₂WO₆/Bi₂S₃/MoS₂ n-p heterojunction is first prepared via an in situ hydrothermal method us...

Novel heterojunction photocatalysts with remarkable photocatalytic capabilities and durability for degrading recalcitrant contaminants are extremely desired; however, their development still remains quite challenging. In this study, a series of flowe...

Mexico City Metropolitan Area children and young adults exposed to high concentrations of air pollutants including fine and ultrafine particulate matter (PM) vs. clean air controls, exhibit myocardial inflammation and inflammasome activation with a d...

In this study, Bi₂WO₆ was prepared by the hydrothermal method. The effects of reaction temperature (150/170/200 °C) and reaction time (6/12/24 h) were investigated. The role of strongly acidic pH (1 >) and the full range between 0.3 and 13.5 w...

For surveilling human health, industries, and the environment, pH monitoring is important. Numerous studies on fluorescent probes have been conducted to monitor various pH ranges. However, fluorescent probes that are capable of sensing alkaline regio...

Melioidosis is a severe disease caused by Burkholderia pseudomallei (B. pseudomallei), a Gram-negative environmental bacterium. It is endemic in Southeast Asia and Northern Australia, but it is underreported in many other countries. The principal rou...

The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins. Mutant proteins and environmental stresses can overwhelm the a...

In this study, fusiform bismuth (Bi) was synthesized, and its photocatalytic performance, degradation mechanism, and pathways for removing rhodamine B (RhB) at different pH levels were investigated. Additionally, the morphologies, structural characte...

p-BiOI nanosheets/n-TiO₂ nanofibers (p-BiOI/n-TiO₂ NFs) have been facilely prepared via the electrospinning technique combining successive ionic layer adsorption and reaction (SILAR). Dense BiOI nanosheets with good crystalline and width about 500 nm...

Background/Objectives: First row transition metal ions have recently regained attention in coordination chemistry as alternatives to gadolinium-based paramagnetic contrast agents, motivated by emerging safety concerns associated with certain Gd³⁺-bas...

Fe₂O₃-Bi₂O₃-B₂O₃ (FeBiB) glasses were developed as novel pH responsive hydrophobic glasses. The influence of the glass composition on the pH sensitivity of FeBiB glasses was investigated. The pH sensitivity drastically decreased with decreasing B₂O₃...

Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) associates a chloroplast- and a nucleus-encoded subunit (LSU and SSU). It constitutes the major entry point of inorganic carbon into the biosphere as it catalyzes photosynthetic CO₂ fixation....

Photocatalytic technology holds significant promise for sustainable development and environmental protection due to its ability to utilize renewable energy sources and degrade pollutants efficiently. In this study, BiOI nanosheets (NSs) were synthesi...

Introduction: The aim of the present study was to validate the Barratt Impulsiveness Scale (BIS-11th version) scale as well as the short version of the Impulsive Behavior Scale (UPPS-P) in a population of Greek young adults. Secondly, we aimed at val...

Environmental remediation in the presence of robust semiconductor photocatalysts by utilizing renewable energy sources is of keen interest among researchers. In this study, we synthesize a BiVO₄/P-g-C₃N₄ semiconductor heterojunction photocatalytic sy...

In current manuscript, using Laguerre polynomials and $(p-q)$-Wanas operator, we identify upper bounds $\left|a_2\right|$ and $\left|a_3\right|$ which are first two Taylor-Maclaurin coefficients for a specific bi-univalent functions classes ${\mathcal{W}}_{\sum }(\eta ,\delta ,\lambda ,\sigma$...

Subtilase cytotoxin (SubAB) is the prototype of a new AB₅ toxin family produced by a subset of Shiga toxigenic Escherichia coli (STEC) strains. Its A subunit is a subtilase-like serine protease and cytotoxicity for eukaryotic cells is due to a highly...

The photoelectrochemical (PEC) conversion of organic small molecules offers a dual benefit of synthesizing value-added chemicals and concurrently producing hydrogen (H₂). Ethylene glycol, with its dual hydroxyl groups, stands out as a versatile organ...

The development of efficient and novel p-n heterojunctions for photoelectrochemical (PEC) water splitting is still a challenging problem. We have demonstrated the complementary nature of (p-type) BiSbS₃ as a sensitizer when coupled with (n-type) TiO₂...

Making use of generalized bivariate Fibonacci polynomials, we propose two families of regular functions of the type $\varphi \left(\zeta \right)=\zeta +{\displaystyle \sum _{j=2}^{\infty }}{d}_j{\zeta }^j$, which are bi-univalent in the disc $\{\zeta \in \mathbb{C}:|\zeta |<1\}$ involving the (p, q)-...

Hyperbranched poly(methylene-bis-acrylamide), poly(bis(N,N-propyl acryl amide)) (HPNPAM) and poly(bis(N,N-butyl acryl amide)) were synthesized by reversible addition-fragmentation chain transfer polymerization. HPNPAMs showed lower critical solution...

In this study, the generalized $(p,q)$-derivative operator is used to define a novel class of bi-univalent functions. For this class, we define constraints on the coefficients up to $|{\ell }_5|$. The functions are analyzed using a suitable operational method,...

With the intensification of the energy crisis and the growing concern over environmental pollution, particularly the discharge of organic dye pollutants in industrial wastewater, photocatalytic degradation of these contaminants using solar energy has...

The motivation of the present article is to define the $(p-q)$-Wanas operator in geometric function theory by the symmetric nature of quantum calculus. We also initiate and explore certain new families of holormorphic and bi-univalent functions ${\mathcal{A}}_E(\lambda ,\sigma ,$...

In this study, electroless-plating of a nickel-phosphor (Ni–P) thin film on surface-controlled thermoelectric elements was developed to significantly increase the bonding strength between Bi–Te materials and copper (Cu) electrodes in ther...

P25 loaded few layered molybdenum disulfide (MoS₂) nanosheets (P25@MoS₂) are successfully synthesized through a facile one-step hydrothermal process. The bi-catalytic activities, i.e., photocatalytic and electrocatalytic activities, of the as-prepare...