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Pathways for Sensing and Responding to Hydrogen Peroxide at the Endoplasmic Reticulum

Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
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Author to whom correspondence should be addressed.
Cells 2020, 9(10), 2314; https://doi.org/10.3390/cells9102314
Received: 14 September 2020 / Revised: 14 October 2020 / Accepted: 15 October 2020 / Published: 18 October 2020
(This article belongs to the Special Issue Redox-dependent ER processes)
The endoplasmic reticulum (ER) has emerged as a source of hydrogen peroxide (H2O2) and a hub for peroxide-based signaling events. Here we outline cellular sources of ER-localized peroxide, including sources within and near the ER. Focusing on three ER-localized proteins—the molecular chaperone BiP, the transmembrane stress-sensor IRE1, and the calcium pump SERCA2—we discuss how post-translational modification of protein cysteines by H2O2 can alter ER activities. We review how changed activities for these three proteins upon oxidation can modulate signaling events, and also how cysteine oxidation can serve to limit the cellular damage that is most often associated with elevated peroxide levels. View Full-Text
Keywords: endoplasmic reticulum (ER); hydrogen peroxide; reactive oxygen species (ROS); redox signaling; cysteine oxidation; BiP; IRE1; SERCA2; unfolded protein response (UPR) endoplasmic reticulum (ER); hydrogen peroxide; reactive oxygen species (ROS); redox signaling; cysteine oxidation; BiP; IRE1; SERCA2; unfolded protein response (UPR)
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MDPI and ACS Style

Roscoe, J.M.; Sevier, C.S. Pathways for Sensing and Responding to Hydrogen Peroxide at the Endoplasmic Reticulum. Cells 2020, 9, 2314. https://doi.org/10.3390/cells9102314

AMA Style

Roscoe JM, Sevier CS. Pathways for Sensing and Responding to Hydrogen Peroxide at the Endoplasmic Reticulum. Cells. 2020; 9(10):2314. https://doi.org/10.3390/cells9102314

Chicago/Turabian Style

Roscoe, Jennifer M., and Carolyn S. Sevier 2020. "Pathways for Sensing and Responding to Hydrogen Peroxide at the Endoplasmic Reticulum" Cells 9, no. 10: 2314. https://doi.org/10.3390/cells9102314

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