61,925 Results Found

This is the first study outside of clinical trials (phase I–III) evaluating the ability of the Ad5-nCoV vaccine to generate neutralizing antibodies and the factors associated with optimal or suboptimal response. In a longitudinal assay, 346 people (1...

Oncolytic adenoviruses (Ad) are promising tools for cancer therapeutics. Most Ad-based therapies utilize species C serotypes, with Adenovirus type 5 (Ad5) most commonly employed. Prior clinical trials demonstrated low efficiency of oncolytic Ad5 vect...

Rabies is a zoonotic viral disease that is preventable through vaccination. Effective control strategies should follow the “One Health” concept, as targeting zoonotic pathogens at their animal source is the most effective and cost-efficie...

Background: Pre-existing adenovirus immunity restricts the utilization of adenovirus-vectored vaccines. The current study aims to conduct a pooled analysis of eight clinical trials to evaluate the influence of pre-existing Ad5 neutralizing antibodies...

SARS-CoV-2 has rapidly generated a pandemic. Vaccines are currently being rolled out to control the viral spread and prevent deaths. Emergency vaccines, using new platforms, have been approved. Their effectiveness, safety and immunogenicity in differ...

Mobile app ads pose a far greater security threat to users than adverts on computer browsers. This is because app developers must embed a Software Development Kit (SDK), called an ad library or ad lib for short, provided by ad networks (i.e., ad comp...

We derive the thermodynamic products, in particular the area (or entropy) products of ${\mathcal{H}}^{\pm }$ for a wide variety of black holes (BHs) in anti-de Sitter (AdS) space. We show by explicit and exact calculations that, for this class of BHs, more co...

We evaluated cellular immune responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in an immunized population based on HLA-E-restricted CD8⁺ T cell epitope identification. HLA-E-restricted SARS-CoV-2 CD8⁺ T cell n...

On YouTube, skippable in-stream advertisements (ads) are critical income for both YouTube and content creators. However, ads inevitably irritate viewers, and as a result, they tend to avoid ads. Thus, this study attempts to identify potential mitigat...

We analyze Hayward black holes (BHs) with a negative cosmological constant surrounded by a cloud of strings, which we designate Hayward–Letelier AdS BHs. These solutions can be obtained by coupling the Einstein equations with nonlinear electrod...

In this paper, the anti-cancer activity and molecular mechanisms of the isomers of AD-1 and AD-2 (20(R)-AD-1, 20(R)-AD-2, 20(S)-AD-1 and 20(S)-AD-2) were investigated. The results indicated that all of the four compounds obviously suppressed the viab...

Desmoglein 2 (DSG2) is overexpressed in many epithelial cancers and therefore represents a target receptor for oncolytic viruses, including Ad5/3-based viruses. For most Ad serotypes, the receptor-binding fiber is composed of tail, shaft, and knob do...

In this paper, we study the thermodynamic behavior of charged AdS black holes in higher-dimensional spacetimes within the framework of conformal holographic extended thermodynamics. This formalism is based on a novel AdS/CFT dictionary in which the c...

Determining the genetic variations of candidate genes in affected subjects will help identify early pathological biomarkers of Alzheimer’s disease (AD) and develop effective treatments. It has recently been found that some genes that are linked...

We give a systematic local description of invariant metrics and other invariant fields on a spacetime under the action of a (non-abelian) group. This includes the invariant fields in a neighbourhood of a principal and a special orbit. The constructio...

In this paper we explore a solenoid configuration involving a magnetic universe solution embedded in an empty Anti-de Sitter (AdS) spacetime. This requires a non-trivial surface current at the interface between the two spacetimes, which can be provid...

Under experimental conditions, pigs infected with Ebola Virus (EBOV) develop disease and can readily transmit the virus to non-human primates or pigs. In the event of accidental or intentional EBOV infection of domestic pigs, complex and time-consumi...

Education evaluation plays a key role in promoting education development. The sustainable concept of evaluation provides the basis for the sustainable development of education. Value-added evaluation makes up for the shortcomings of traditional evalu...

The main focuses of the Sino–US trade dispute are the issue of trade interests. If taking environmental costs into consideration, the trade interests are even more overestimated. There are different methods for measuring trade interests, and the resu...

Typically, an ad baculum argument is one where an arguer threatens a respondent in order to induce them to adopt a standpoint. It is a fallacy, a common account goes, because the power to impose a standpoint is irrelevant to its truth or acceptabilit...

High intake of added sugars is associated with excess energy intake and poorer diet quality. The objective of this cross-sectional study (n = 16,806) was to estimate usual intakes and the primary food sources of added sugars across the range of intak...

Corporations have engaged in cause-related marketing (CRM) based on consumer expectations toward ethical and sustainable corporate management. However, it is equally important to understand how to do so effectively. The role of cause proximity has be...

This paper initiates the study of the mathematical aspects of the ad-hoc Lanzhou index. If G is a graph with the vertex set $\{x_1,\dots ,x_n\}$, then the ad-hoc Lanzhou index of G is defined by $\widetilde{Lz}\left(G\right)={\sum }_{i=1}^n{d}_i{(n-1-d_i)}^2$, where $d_i$ rep...

Unlike uniform motion, when an object moves underwater with variable speed, it experiences additional resistance from the water, commonly referred to as added mass force. At present, several methods exist to solve this force, including theoretical, e...

This paper proposes a MAC protocol for ad hoc networks using In-band Full-duplex (IBFD) wireless communications, which are named as AdHoc-FDMAC. To utilize IBFD communications in ad hoc networks, this protocol modifies a number of control frames in t...

Despite the rapidly growing expenditure on digital advertising, the effectiveness of the functioning of the digital advertising ecosystem is becoming less and less visible. This is related to the fact that only a small part of the expenditure incurre...

Unmanned aerial system (UAS) traffic management (UTM) requires each UAS to communicate with each other and to other stakeholders involved in the operation. In practice, there are two types of wireless communication systems established in the UAS comm...

Different methods for determining the effect of added sugars intake among children and adults on meeting recommended nutrient intakes were compared using 24 h dietary recall data from the National Health and Nutrition Examination Survey (NHANES) 2011...

We propose a geometry topological framework to analyze storm dynamics by coupling persistent homology with Anti-de Sitter (AdS)-inspired metrics. On radar images of a bow echo event, we compare Euclidean distance with three compressive AdS metrics ($\&$...

The antibody-dependent enhancement (ADE) effect of a PRRSV infection is that the preexisting sub- or non-neutralizing antibodies specific against PRRSV can facilitate the virus entry and replication, and it is likely to be a great obstacle for the se...

Internet-related electricity consumption is rising rapidly as global Internet users spend more than 6.5 h per day online. Open source ad blockers have the potential to reduce the time and thus electricity spent using computers by eliminating ads duri...

Autologous therapies using adipose-derived stromal vascular fraction (AD-SVFs) and adult adipose-derived mesenchymal stem cells (AD-MSCs) warrant careful preparation of the harvested adipose tissue. Currently, no standardized technique for this prepa...

All sports have their roots and connection in some way to the Olympic spirit, and therefore fall within the vision and mission of the Olympic Committee, which has a central aim of “building a better world”. This is a fundamental value of...

Purpose: The high intake of added sugars from foods or beverages increases the risk of obesity, hypertension, dyslipidemia, and cardiovascular disease. Because state-level data are lacking, we estimated dietary intake of added sugars by state and fac...

We review recent developments in the study of the AdS/CFT correspondence in lower dimensions. We start by summarising the classification of AdS${}_3\times {\mathrm{S}}^2$ solutions in massive type IIA supergravity with (0, 4) supersymmetries and the construction of their 2...

The context of Display Google ads and its components has significant importance to previous studies. However, the full understanding of the variables that influence both Display Google ads avoidance and intention to click has not been thoroughly ackn...

Automatic Dependent Surveillance-Broadcast is an Air Traffic Control system in which aircraft transmit their own information (identity, position, velocity, etc.) to ground sensors for surveillance purposes. This system has many advantages compared to...

The reduction of free or added sugar intake (sugars added to food and drinks as a sweetener) is almost universally recommended to reduce the risk of obesity-related diseases and dental caries. The World Health Organisation recommends intakes of free...

The skin is a natural barrier against the ultraviolet (UV) radiation of sunlight. The long-term and/or repetitive exposure to the sunlight and related UV radiation may change the skin structure, decreasing collagen production, promoting premature ski...

Automatic Dependent Surveillance-Broadcast (ADS-B) enables aircraft to periodically broadcast their flight states such as position and velocity. Compared to classical radar surveillance, it increases update rate and accuracy. Currently, Mode S Extend...

Amid a global effort in reducing the shipping ecologic impact, the study of the particular case of added resistance of high speed vessels cruising in a seaway has been approached by a very limited number of authors. In this study, we provide a compre...

Based on the voltage threshold adaptive memristor (VTEAM) model, this paper proposes a circuit design of a memristor-based A/D converter, which can achieve high-resolution conversion by simple configuration. For this A/D converter, there are the inpu...

The study investigates a predictive exchange rate effect on value-added trade flows on global value chains. We theoretically review the role of exchange rates on international trade based on insular, open, and global value chained economies. This pap...

The present Perspective analyzes the remarkable evolution of the Amyloid Cascade Hypothesis 2.0 (ACH2.0) theory of Alzheimer’s disease (AD) since its inception a few years ago, as reflected in the diminishing role of amyloid-beta (Aβ) in t...

This paper examines Croatian Regional Value Chains (RVCs). We use the value chain approach to study supply chains, examining data specifically for Croatia and its proximate trading partners in the European Union, as well as some other European countr...

In wireless ad hoc networks, security and communication challenges are frequently addressed by deploying a trust mechanism. A number of approaches for evaluating trust of ad hoc network nodes have been proposed, including the one that uses neural net...

An accurate diagnosis of Alzheimer’s disease (AD) currently stands as one of the most difficult and challenging in all of clinical neurology. AD is typically diagnosed using an integrated knowledge and assessment of multiple biomarkers and inte...

Research is limited on added sugars in school meals and children’s dietary intakes after the 2015–2020 Dietary Guidelines for Americans (DGA) recommended that added sugars be limited to less than 10% of total calories. This analysis uses data from th...

Since 2010, the contemporary worship scene has changed. New prominent church bands have emerged and streaming services have made worship music more accessible. While solo worship artists such as Chris Tomlin and Tim Hughes primarily released studio a...

The Adding-Doubling (AD) algorithm is a general analytical solution of the radiative transfer equation (RTE). AD offers a favorable balance between accuracy and computational efficiency, surpassing other RTE solutions, such as Monte Carlo (MC) simula...