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Article

The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients—A Large Population-Based Study

1
Heart Center, Kaplan Medical Center, Rehovot, Hebrew University of Jerusalem, Jerusalem 91905, Israel
2
Research Authority, Rehovot, Hebrew University of Jerusalem, Jerusalem 91905, Israel
3
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
4
General Management, The Chaim Sheba Medical Centre, Tel Hashomer, Ramat-Gan 52621, Israel
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Andrea Frustaci
J. Clin. Med. 2022, 11(8), 2219; https://doi.org/10.3390/jcm11082219
Received: 25 March 2022 / Revised: 11 April 2022 / Accepted: 12 April 2022 / Published: 15 April 2022
(This article belongs to the Section Cardiology)
Myocarditis and pericarditis are potential post-acute cardiac sequelae of COVID-19 infection, arising from adaptive immune responses. We aimed to study the incidence of post-acute COVID-19 myocarditis and pericarditis. Retrospective cohort study of 196,992 adults after COVID-19 infection in Clalit Health Services members in Israel between March 2020 and January 2021. Inpatient myocarditis and pericarditis diagnoses were retrieved from day 10 after positive PCR. Follow-up was censored on 28 February 2021, with minimum observation of 18 days. The control cohort of 590,976 adults with at least one negative PCR and no positive PCR were age- and sex-matched. Since the Israeli vaccination program was initiated on 20 December 2020, the time-period matching of the control cohort was calculated backward from 15 December 2020. Nine post-COVID-19 patients developed myocarditis (0.0046%), and eleven patients were diagnosed with pericarditis (0.0056%). In the control cohort, 27 patients had myocarditis (0.0046%) and 52 had pericarditis (0.0088%). Age (adjusted hazard ratio [aHR] 0.96, 95% confidence interval [CI]; 0.93 to 1.00) and male sex (aHR 4.42; 95% CI, 1.64 to 11.96) were associated with myocarditis. Male sex (aHR 1.93; 95% CI 1.09 to 3.41) and peripheral vascular disease (aHR 4.20; 95% CI 1.50 to 11.72) were associated with pericarditis. Post COVID-19 infection was not associated with either myocarditis (aHR 1.08; 95% CI 0.45 to 2.56) or pericarditis (aHR 0.53; 95% CI 0.25 to 1.13). We did not observe an increased incidence of neither pericarditis nor myocarditis in adult patients recovering from COVID-19 infection. View Full-Text
Keywords: COVID-19; myocarditis; pericarditis COVID-19; myocarditis; pericarditis
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MDPI and ACS Style

Tuvali, O.; Tshori, S.; Derazne, E.; Hannuna, R.R.; Afek, A.; Haberman, D.; Sella, G.; George, J. The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients—A Large Population-Based Study. J. Clin. Med. 2022, 11, 2219. https://doi.org/10.3390/jcm11082219

AMA Style

Tuvali O, Tshori S, Derazne E, Hannuna RR, Afek A, Haberman D, Sella G, George J. The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients—A Large Population-Based Study. Journal of Clinical Medicine. 2022; 11(8):2219. https://doi.org/10.3390/jcm11082219

Chicago/Turabian Style

Tuvali, Ortal, Sagi Tshori, Estela Derazne, Rebecca Regina Hannuna, Arnon Afek, Dan Haberman, Gal Sella, and Jacob George. 2022. "The Incidence of Myocarditis and Pericarditis in Post COVID-19 Unvaccinated Patients—A Large Population-Based Study" Journal of Clinical Medicine 11, no. 8: 2219. https://doi.org/10.3390/jcm11082219

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