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Article

Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic

by 1,2,*,†, 2,3,†, 4, 1,2, 1,5,‡ and 1,2,‡
1
Department of Public Health, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
2
Czech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
3
Department of Nursing and Midwifery, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
4
Department of Oral and Maxillofacial Surgery, Justus-Liebig-University, Klinikstrasse 33, 35392 Giessen, Germany
5
Czech Clinical Research Infrastructure Network, Department of Pharmacology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Equal contribution as first authorship.
Equal contribution as senior authorship.
Academic Editor: Giovanni Gabutti
J. Clin. Med. 2021, 10(7), 1428; https://doi.org/10.3390/jcm10071428
Received: 9 March 2021 / Revised: 18 March 2021 / Accepted: 23 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Impact of COVID-19 on the Dental Community)
Background: COVID-19 vaccine side effects have a fundamental role in public confidence in the vaccine and its uptake process. Thus far, the evidence on vaccine safety has exclusively been obtained from the manufacturer-sponsored studies; therefore, this study was designed to provide independent evidence on Pfizer–BioNTech COVID-19 vaccine side effects. Methods: A cross-sectional survey-based study was carried out between January and February 2021 to collect data on the side effects following the COVID-19 vaccine among healthcare workers in the Czech Republic. The study used a validated questionnaire with twenty-eight multiple-choice items covering the participants’ demographic data, medical anamneses, COVID-19-related anamneses, general, oral, and skin-related side effects. Results: Injection site pain (89.8%), fatigue (62.2%), headache (45.6%), muscle pain (37.1%), and chills (33.9%) were the most commonly reported side effects. All the general side effects were more prevalent among the ≤43-year-old group, and their duration was mainly one day (45.1%) or three days (35.8%) following the vaccine. Antihistamines were the most common drugs associated with side effects, thus requiring further investigation. The people with two doses were generally associated with a higher frequency of side effects. Conclusions: The distribution of side effects among Czech healthcare workers was highly consistent with the manufacturer’s data, especially in terms of their association with the younger age group and the second dose. The overall prevalence of some local and systemic side effects was higher than the manufacturer’s report. Further independent studies on vaccine safety are strongly required to strengthen public confidence in the vaccine. View Full-Text
Keywords: adverse effects; BNT162 vaccine; cross-sectional studies; COVID-19; Czech Republic; drug-related side effects and adverse reactions; health personnel; mass vaccination; prevalence adverse effects; BNT162 vaccine; cross-sectional studies; COVID-19; Czech Republic; drug-related side effects and adverse reactions; health personnel; mass vaccination; prevalence
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MDPI and ACS Style

Riad, A.; Pokorná, A.; Attia, S.; Klugarová, J.; Koščík, M.; Klugar, M. Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic. J. Clin. Med. 2021, 10, 1428. https://doi.org/10.3390/jcm10071428

AMA Style

Riad A, Pokorná A, Attia S, Klugarová J, Koščík M, Klugar M. Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic. Journal of Clinical Medicine. 2021; 10(7):1428. https://doi.org/10.3390/jcm10071428

Chicago/Turabian Style

Riad, Abanoub, Andrea Pokorná, Sameh Attia, Jitka Klugarová, Michal Koščík, and Miloslav Klugar. 2021. "Prevalence of COVID-19 Vaccine Side Effects among Healthcare Workers in the Czech Republic" Journal of Clinical Medicine 10, no. 7: 1428. https://doi.org/10.3390/jcm10071428

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