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Photobiomodulation—Underlying Mechanism and Clinical Applications

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The School of Medicine, Medical Sciences and Nutrition, Aberdeen University, Aberdeen AB25 2ZD, UK
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Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznań, Poland
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Laser Laboratory at Dental Surgery Department, Medical University of Wroclaw, 50-425 Wroclaw, Poland
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Department of Periodontics, School of Dentistry Virginia Commonwealth University, VCU, Richmond, VA 23298, USA
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Department of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, Poland
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Physiology Graduate Program, North Carolina State University, Raleigh, NC 27695, USA
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Department of Periodontology and Oral Implantology, University of Guarulhos, Guarulhos 07030-010, Brazil
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Centre for Craniofacial and Regenerative Biology, Dental Institute, King’s College London, London WC2R2LS, UK
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Center of Assisted Reproduction, Department of Obstetrics and Gynecology, University Hospital and Masaryk University, 601 77 Brno, Czech Republic
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Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
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Department of Biomaterials and Experimental Dentistry, Poznan University of Medical Sciences, 61-701 Poznan, Poland
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Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(6), 1724; https://doi.org/10.3390/jcm9061724
Received: 6 April 2020 / Revised: 14 May 2020 / Accepted: 1 June 2020 / Published: 3 June 2020
(This article belongs to the Section Clinical Cytology)
The purpose of this study is to explore the possibilities for the application of laser therapy in medicine and dentistry by analyzing lasers’ underlying mechanism of action on different cells, with a special focus on stem cells and mechanisms of repair. The interest in the application of laser therapy in medicine and dentistry has remarkably increased in the last decade. There are different types of lasers available and their usage is well defined by different parameters, such as: wavelength, energy density, power output, and duration of radiation. Laser irradiation can induce a photobiomodulatory (PBM) effect on cells and tissues, contributing to a directed modulation of cell behaviors, enhancing the processes of tissue repair. Photobiomodulation (PBM), also known as low-level laser therapy (LLLT), can induce cell proliferation and enhance stem cell differentiation. Laser therapy is a non-invasive method that contributes to pain relief and reduces inflammation, parallel to the enhanced healing and tissue repair processes. The application of these properties was employed and observed in the treatment of various diseases and conditions, such as diabetes, brain injury, spinal cord damage, dermatological conditions, oral irritation, and in different areas of dentistry. View Full-Text
Keywords: laser; low-level laser therapy; photobiomodulation; stem cells; tissue regeneration laser; low-level laser therapy; photobiomodulation; stem cells; tissue regeneration
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MDPI and ACS Style

Dompe, C.; Moncrieff, L.; Matys, J.; Grzech-Leśniak, K.; Kocherova, I.; Bryja, A.; Bruska, M.; Dominiak, M.; Mozdziak, P.; Skiba, T.H.I.; Shibli, J.A.; Angelova Volponi, A.; Kempisty, B.; Dyszkiewicz-Konwińska, M. Photobiomodulation—Underlying Mechanism and Clinical Applications. J. Clin. Med. 2020, 9, 1724. https://doi.org/10.3390/jcm9061724

AMA Style

Dompe C, Moncrieff L, Matys J, Grzech-Leśniak K, Kocherova I, Bryja A, Bruska M, Dominiak M, Mozdziak P, Skiba THI, Shibli JA, Angelova Volponi A, Kempisty B, Dyszkiewicz-Konwińska M. Photobiomodulation—Underlying Mechanism and Clinical Applications. Journal of Clinical Medicine. 2020; 9(6):1724. https://doi.org/10.3390/jcm9061724

Chicago/Turabian Style

Dompe, Claudia, Lisa Moncrieff, Jacek Matys, Kinga Grzech-Leśniak, Ievgeniia Kocherova, Artur Bryja, Małgorzata Bruska, Marzena Dominiak, Paul Mozdziak, Tarcio H.I. Skiba, Jamil A. Shibli, Ana Angelova Volponi, Bartosz Kempisty, and Marta Dyszkiewicz-Konwińska. 2020. "Photobiomodulation—Underlying Mechanism and Clinical Applications" Journal of Clinical Medicine 9, no. 6: 1724. https://doi.org/10.3390/jcm9061724

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