- Article
Determination of Paracetamol and Orphenadrine Citrate in Tablets via a Novel RP-HPLC Method: Development Following Box–Behnken Design, Validation, Robustness Testing, and Greenness Assessment
- Dimitris Valatsos,
- Kostas Gkountanas and
- Yannis Dotsikas
Paracetamol (PAR) and orphenadrine citrate (ORPH) are two active substances commonly used in combination medicinal products, due to the analgesic effect of paracetamol and the muscle relaxant effect of orphenadrine, with a therapeutic indication of m...

