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Toxics, Volume 11, Issue 2

2023 February - 112 articles

Cover Story: European regulations require safe migration from food packaging, but evaluating the safety of non-intentionally added substances is difficult. Efforts are focused on combining data from analytics, bioassays, and in silico toxicology. Non-targeted screening approaches are key. A protocol was developed for chemical and biological screening of migrants from coated metal packaging, including guidance on sample preparation, migrant simulation, chemical analysis, and validated bioassays covering endocrine activity, genotoxicity and metabolism-related targets. An inter-laboratory study found acceptable consistency in chemical analysis and bioassay results, but technical differences led to different data interpretations. Suggestions for improvement that an aligned protocol for chemical and biological analyses is needed for packaging safety assessment to avoid inconsistent data interpretation. View this paper
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Articles (112)

  • Case Report
  • Open Access
27 Citations
6,673 Views
19 Pages

Heavy Metals Content in Selected Medicinal Plants Produced and Consumed in Serbia and Their Daily Intake in Herbal Infusions

  • Irina Kandić,
  • Milan Kragović,
  • Jelena Petrović,
  • Peđa Janaćković and ,
  • Milan Gavrilović,
  • Miloš Momčilović and
  • Marija Stojmenović
  • + 2 authors+ 0 author

20 February 2023

The heavy metals content (HMs) was investigated in 14 different medicinal plants collected from the three regions in Central Serbia, Zlatar, Sokobanja, and Kopaonik. The concentrations of Cd, Cr, Ni, Hg and Pb were determined: Cd (<0.03–2.72...

(This article belongs to the Section Metals and Radioactive Substances)
  • Feature Paper
  • Article
  • Open Access
9 Citations
4,106 Views
13 Pages

20 February 2023

With the widespread use of diethylstilbestrol (DES), it has become a common contaminant in the aquatic environment. It is toxic to a wide range of aquatic organisms, disrupting the water flea growth and further interfering with several ecosystem serv...

(This article belongs to the Section Emerging Contaminants)
  • Case Report
  • Open Access
4 Citations
5,568 Views
6 Pages

Successful Use of Continuous Veno-Venous Haemodialysis in a Case of Potential Lethal Caffeine Intoxication

  • Elles J. Reimerink,
  • Daan W. Huntjens,
  • Lindsey G. Pelkmans,
  • Jan-Willem H. J. Geerts and
  • Eric J. F. Franssen

20 February 2023

Here we describe the case of a potentially lethal caffeine intoxication after the reported ingestion of 10 g of caffeine. Due to hemodynamic instability with tachycardia and hypertension with an insufficient effect of continuous labetalol infusion, t...

(This article belongs to the Special Issue Clinical and Post-Mortem Toxicology)
  • Feature Paper
  • Article
  • Open Access
14 Citations
4,507 Views
22 Pages

Preliminary Toxicological Analysis in a Safe-by-Design and Adverse Outcome Pathway-Driven Approach on Different Silver Nanoparticles: Assessment of Acute Responses in A549 Cells

  • Giulia Motta,
  • Maurizio Gualtieri,
  • Melissa Saibene,
  • Rossella Bengalli and ,
  • Andrea Brigliadori,
  • Marie Carrière and
  • Paride Mantecca
  • + 2 authors+ 0 author

20 February 2023

Silver nanoparticles (Ag NPs) are among the most widely used metal-based nanomaterials (NMs) and their applications in different products, also as antibacterial additives, are increasing. In the present manuscript, according to an adverse outcome pat...

(This article belongs to the Special Issue Nano and Ultrafine Particle Toxicology and Exposure Assessment)
  • Feature Paper
  • Guidelines
  • Open Access
19 Citations
3,862 Views
12 Pages

Chinese Technical Guideline for Deriving Water Quality Criteria for Protection of Freshwater Organisms

  • Zhen-Guang Yan,
  • Xin Zheng,
  • Yi-Zhang Zhang,
  • Zhan-Hong Yang and ,
  • Quan Zhou,
  • Shu-Hui Men and
  • Jin-Zhe Du
  • + 2 authors+ 0 author

19 February 2023

In recent years, China has determined the national goal of “developing national environmental criteria”, thereby promoting the rapid development of environmental quality criteria research in China. In 2017, the Ministry of Ecology and Environment of...

(This article belongs to the Section Emerging Contaminants)
  • Article
  • Open Access
18 Citations
5,394 Views
13 Pages

19 February 2023

Heavy metal toxicity is a major threat to the health of both humans and ecosystems. Toxic levels of heavy metals in food crops, such as grapes, can have devastating effects on plant health and the market value of the produce. Two important factors th...

(This article belongs to the Section Metals and Radioactive Substances)
  • Feature Paper
  • Review
  • Open Access
23 Citations
8,979 Views
20 Pages

Neurobehavioral Effects of Low-Dose Chronic Exposure to Insecticides: A Review

  • Laura Maria Antonangeli,
  • Saniya Kenzhebekova and
  • Claudio Colosio

19 February 2023

The modes of action of insecticides frequently involve a neurotoxic effect; therefore, the study of neurotoxic effects caused by long-term and low-dose insecticide exposure is of particular interest. This study looks at whether or not new studies con...

(This article belongs to the Section Neurotoxicity)
  • Article
  • Open Access
10 Citations
3,269 Views
14 Pages

18 February 2023

Methylmercury (MeHg) is a global pollutant with established toxic effects on the central nervous system (CNS). However, early events and early-warning biomarkers of CNS damage following exposure to low-dose MeHg are still lacking. This study aimed to...

(This article belongs to the Topic Environmental Toxicology and Human Health)
  • Systematic Review
  • Open Access
102 Citations
14,335 Views
13 Pages

Association of Dietary Nitrate, Nitrite, and N-Nitroso Compounds Intake and Gastrointestinal Cancers: A Systematic Review and Meta-Analysis

  • Monireh Sadat Seyyedsalehi,
  • Elham Mohebbi,
  • Fatemeh Tourang,
  • Bahareh Sasanfar and ,
  • Paolo Boffetta and
  • Kazem Zendehdel
  • + 1 author+ 0 author

17 February 2023

N-nitroso compounds (NOCs) are a class of chemical carcinogens found in various environmental sources such as food, drinking water, cigarette smoke, the work environment, and the indoor air population. We conducted a systematic review and meta-analys...

(This article belongs to the Topic Environmental Toxicology and Human Health)
  • Article
  • Open Access
11 Citations
3,921 Views
18 Pages

17 February 2023

The impact of exposure to multiple chemicals raises concerns for human and environmental health. The adverse outcome pathway method offers a framework to support mechanism-based assessment in environmental health starting by describing which mechanis...

(This article belongs to the Section Exposome Analysis and Risk Assessment)
  • Review
  • Open Access
29 Citations
8,427 Views
26 Pages

17 February 2023

Emerging and low-carbon technologies and innovations are driving a need for domestic sources, sustainable use, and availability of critical minerals (CMs)—those vital to the national and economic security of the United States. Understanding the...

(This article belongs to the Section Ecotoxicology)
  • Article
  • Open Access
3 Citations
3,551 Views
20 Pages

Complex Mixtures: Array PBPK Modeling of Jet Fuel Components

  • Teresa R. Sterner,
  • Tammie R. Covington and
  • David R. Mattie

17 February 2023

An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To predict internal dosimetry of jet fuel components simultaneously, an array PBPK model was coded...

(This article belongs to the Special Issue Toxic Mixtures Evaluation and Management)
  • Article
  • Open Access
8 Citations
3,110 Views
11 Pages

Estrogenic Effect Mechanism and Influencing Factors for Transformation Product Dimer Formed in Preservative Parabens Photolysis

  • Xiaolin Niu,
  • Guanhui Chen,
  • Yi Chen,
  • Na Luo and ,
  • Mei Wang,
  • Xinyi Hu,
  • Yanpeng Gao,
  • Yuemeng Ji and
  • Taicheng An
  • + 4 authors+ 0 author

17 February 2023

The environmental transformation and health effects of endocrine disruptors (EDCs) need urgent attention, particularly the formation of transformation products with higher toxicity than parent EDCs. In this paper, an important transformation product...

(This article belongs to the Section Emerging Contaminants)
  • Review
  • Open Access
75 Citations
12,872 Views
22 Pages

Antimicrobial and the Resistances in the Environment: Ecological and Health Risks, Influencing Factors, and Mitigation Strategies

  • Weitao Wang,
  • You Weng,
  • Ting Luo,
  • Qiang Wang and ,
  • Guiling Yang and
  • Yuanxiang Jin
  • + 1 author+ 0 author

16 February 2023

Antimicrobial contamination and antimicrobial resistance have become global environmental and health problems. A large number of antimicrobials are used in medical and animal husbandry, leading to the continuous release of residual antimicrobials int...

(This article belongs to the Section Drugs Toxicity)
  • Article
  • Open Access
21 Citations
4,396 Views
12 Pages

Multi-Omics Analyses Reveal the Mechanisms of Early Stage Kidney Toxicity by Diquat

  • Huazhong Zhang,
  • Jinsong Zhang,
  • Jinquan Li,
  • Zhengsheng Mao and ,
  • Jian Qian,
  • Cheng Zong,
  • Hao Sun and
  • Beilei Yuan
  • + 3 authors+ 0 author

16 February 2023

Diquat (DQ), a widely used bipyridyl herbicide, is associated with significantly higher rates of kidney injuries compared to other pesticides. However, the underlying molecular mechanisms are largely unknown. In this study, we identified the molecula...

(This article belongs to the Special Issue State-of-the-Art Environmental Chemicals Exposomics and Metabolomics)
  • Article
  • Open Access
9 Citations
6,690 Views
16 Pages

A Proposed Association between Improving Energy Metabolism of HepG2 Cells by Plant Extracts and Increasing Their Sensitivity to Doxorubicin

  • Tamer A. Al-Shafie,
  • Engy A. Mahrous,
  • Mustafa Shukry,
  • Mohammad Y. Alshahrani and ,
  • Samah F. Ibrahim,
  • Liana Fericean,
  • Afaf Abdelkader and
  • Mennatallah A. Ali
  • + 3 authors+ 0 author

16 February 2023

Increasing cancer cell sensitivity to chemotherapy by amending aberrant metabolism using plant extracts represents a promising strategy to lower chemotherapy doses while retaining the same therapeutic outcome. Here, we incubated HepG2 cells with four...

(This article belongs to the Section Novel Methods in Toxicology Research)
  • Correction
  • Open Access
1 Citations
1,689 Views
2 Pages

Correction: Lenarczyk et al. T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys. Toxics 2022, 10, 797

  • Marek Lenarczyk,
  • Ammar J. Alsheikh,
  • Eric P. Cohen,
  • Dörthe Schaue and ,
  • Amy Kronenberg,
  • Aron Geurts,
  • Slade Klawikowski,
  • David Mattson and
  • John E. Baker
  • + 4 authors+ 0 author

16 February 2023

In the original publication [...]

(This article belongs to the Section Metals and Radioactive Substances)
  • Feature Paper
  • Article
  • Open Access
17 Citations
4,242 Views
15 Pages

Differential Cell Metabolic Pathways in Gills and Liver of Fish (White Seabream Diplodus sargus) Coping with Dietary Methylmercury Exposure

  • Giuseppe De Marco,
  • Barbara Billè,
  • Fátima Brandão,
  • Mariachiara Galati and ,
  • Patrícia Pereira,
  • Tiziana Cappello and
  • Mário Pacheco
  • + 2 authors+ 0 author

16 February 2023

Mercury (Hg) is a dangerous and persistent trace element. Its organic and highly toxic form, methylmercury (MeHg), easily crosses biological membranes and accumulates in biota. Nevertheless, understanding the mechanisms of dietary MeHg toxicity in fi...

(This article belongs to the Section Ecotoxicology)
  • Article
  • Open Access
14 Citations
3,700 Views
16 Pages

Risk Assessment of Phthalate Esters in Baiyangdian Lake and Typical Rivers in China

  • Yin Hou,
  • Mengchen Tu,
  • Cheng Li,
  • Xinyu Liu and ,
  • Jing Wang,
  • Chao Wei,
  • Xin Zheng and
  • Yihong Wu
  • + 3 authors+ 0 author

15 February 2023

Phthalate esters (PAEs) are frequently tracked in water environments worldwide. As a typical class of endocrine disruptor chemicals (EDCs), PAEs posed adverse effects on aquatic organisms at low concentration. Thus, they have attracted wide attention...

(This article belongs to the Special Issue Effects of Environmental Organic Pollutants on Environment and Human Health: The Latest Updates)
  • Feature Paper
  • Article
  • Open Access
1 Citations
4,268 Views
16 Pages

Assessment and Management of Mercury Leaching from a Riverbank

  • Hasti Ziaei,
  • Balaji Rao,
  • Tea V. Wood,
  • Uriel Garza-Rubalcava and ,
  • Ashkan Alborzi,
  • Huayun Zhou,
  • Paul Bireta,
  • Nancy Grosso and
  • Danny Reible
  • + 4 authors+ 0 author

15 February 2023

The South River located in the city of Waynesboro, Virginia, contains mercury (Hg) contamination due to historical releases from an industrial facility operating between 1929 and 1950. In 2015, two sampling events were conducted in two of the contami...

(This article belongs to the Topic Removal of Hazardous Substances from Water Resources)
  • Feature Paper
  • Article
  • Open Access
39 Citations
6,129 Views
19 Pages

Sulfamethoxazole (SMX) Alters Immune and Apoptotic Endpoints in Developing Zebrafish (Danio rerio)

  • Nazish Iftikhar,
  • Isaac Konig,
  • Cole English,
  • Emma Ivantsova and ,
  • Christopher L. Souders,
  • Imran Hashmi and
  • Christopher J. Martyniuk
  • + 2 authors+ 0 author

14 February 2023

Sulfamethoxazole (SMX) is a broad-range bacteriostatic antibiotic widely used in animal and fish farming and is also employed in human medicine. These antibiotics can ultimately end up in the aquatic ecosystem and affect non-target organisms such as...

(This article belongs to the Section Ecotoxicology)
  • Article
  • Open Access
19 Citations
4,776 Views
17 Pages

Stage-Related Neurotoxicity of BPA in the Development of Zebrafish Embryos

  • Jianjun Liu,
  • Wenyu Kong,
  • Yuchen Liu,
  • Qiyao Ma and ,
  • Qi Shao,
  • Liwen Zeng,
  • Yu Chao,
  • Xiaoyao Song and
  • Jie Zhang
  • + 4 authors+ 0 author

14 February 2023

Bisphenol A (BPA) is one of the most widely produced chemicals in the world used in the production of epoxy resins and polycarbonate plastics. BPA is easily migrated from the outer packaging to the contents. Due to the lipophilic property, BPA is eas...

(This article belongs to the Special Issue State-of-the-Art Environmental Chemicals Exposomics and Metabolomics)
  • Review
  • Open Access
24 Citations
6,399 Views
17 Pages

14 February 2023

Cyanobacterial blooms have been recognized as a problem in fresh water for about 150 years. Over the past 50 years, experimental studies on the subject have gained importance considering the increasing need to control toxic cyanobacterial blooms. Thi...

(This article belongs to the Special Issue (Eco)Toxicology of Cyanobacteria and Cyanotoxins: From Environmental Dynamics to Adverse Effects)
  • Article
  • Open Access
6 Citations
3,045 Views
11 Pages

Preliminary Study on the Protective Effects and Molecular Mechanism of Procyanidins against PFOS-Induced Glucose-Stimulated Insulin Secretion Impairment in INS-1 Cells

  • Hai-Ming Xu,
  • Meng-Yu Wu,
  • Xin-Chen Shi,
  • Ke-Liang Liu and ,
  • Ying-Chi Zhang,
  • Yin-Feng Zhang and
  • Hong-Mei Li
  • + 2 authors+ 0 author

14 February 2023

This study aimed to investigate the effects of perfluorooctanesulfonic acid (PFOS) exposure on glucose-stimulated insulin secretion (GSIS) of rat insulinoma (INS-1) cells and the potential protective effects of procyanidins (PC). The effects of PFOS...

(This article belongs to the Special Issue Cellular, Molecular and Genetic Toxicity of Endocrine Disruptors)
  • Article
  • Open Access
5 Citations
3,028 Views
10 Pages

Potential Role of Lipase Activity on the Internal Exposure Assessment of Glycidol Released from Its Fatty Acid Esters

  • Yuko Shimamura,
  • Ryo Inagaki,
  • Minami Oike,
  • Yuri Wada and ,
  • Hiroshi Honda and
  • Shuichi Masuda
  • + 1 author+ 0 author

14 February 2023

Glycidyl fatty acid esters (GEs) can be found in food, and they can be converted into genotoxic animal carcinogen glycidol in vivo by the action of lipase. This study examined whether human ingestion of charbroiled pork containing high levels of GEs...

(This article belongs to the Special Issue Biological Risk Monitoring of Exposure to Chemical Pollutants and/or Physical Agents)
  • Article
  • Open Access
9 Citations
4,152 Views
10 Pages

Fishing Cat Scats as a Biomonitoring Tool for Toxic Heavy Metal Contamination in Aquatic Ecosystems

  • Thirupati Lakshmi Harika,
  • Khalid A. Al-Ghanim,
  • Mian Nadeem Riaz,
  • Kaliyamoorthy Krishnappa and ,
  • Jeganathan Pandiyan and
  • Marimuthu Govindarajan
  • + 1 author+ 0 author

13 February 2023

Mangrove forest is one of the productive ecosystems that provide essential habitats for various fauna as breeding and feeding drives. However, heavy metal pollution in the mangrove forest has led to severe health problems for several aquatic species....

(This article belongs to the Section Ecotoxicology)
  • Feature Paper
  • Article
  • Open Access
19 Citations
5,003 Views
17 Pages

Health Risk Assessment of PAHs from Estuarine Sediments in the South of Italy

  • Fabiana Di Duca,
  • Paolo Montuori,
  • Ugo Trama,
  • Armando Masucci and ,
  • Gennaro Maria Borrelli and
  • Maria Triassi
  • + 1 author+ 0 author

13 February 2023

Increased concerns about the toxicities of Polycyclic Aromatic Hydrocarbons (PAHs), ubiquitous and persistent compounds, as well as the associated ecotoxicology issue in estuarine sediments, have drawn attention worldwide in the last few years. The l...

(This article belongs to the Special Issue Advances in Water, Air and Soil Pollution Monitoring, Modeling and Restoration)
  • Communication
  • Open Access
31 Citations
7,226 Views
9 Pages

13 February 2023

Epidemiological studies have linked particulate matter (PM2.5) to gestational diabetes mellitus (GDM). However, the causality of this association has not been established; Mendelian randomization was carried out using summary data from genome-wide as...

(This article belongs to the Section Air Pollution and Health)
  • Article
  • Open Access
21 Citations
4,930 Views
13 Pages

Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

  • Çiğdem Sevim,
  • Erol Akpınar,
  • Emrah Hicazi Aksu,
  • Ali Doğan Ömür and ,
  • Serkan Yıldırım,
  • Mehtap Kara,
  • İsmail Bolat,
  • Aristides Tsatsakis,
  • Robin Mesnage and
  • Rabia Nilüfer Ersoylu
  • + 7 authors+ 2 authors

12 February 2023

The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic Saccharomy...

(This article belongs to the Special Issue Environmental Exposure and Reproductive Health)
  • Article
  • Open Access
6 Citations
2,702 Views
18 Pages

Mitigation Effect of Dense “Water Network” on Heavy PM2.5 Pollution: A Case Model of the Twain-Hu Basin, Central China

  • Yan Zhu,
  • Yongqing Bai,
  • Jie Xiong,
  • Tianliang Zhao and ,
  • Jiaping Xu,
  • Yue Zhou,
  • Kai Meng,
  • Chengzhen Meng,
  • Xiaoyun Sun and
  • Weiyang Hu
  • + 5 authors+ 0 author

10 February 2023

The influence of the underlying surface on the atmospheric environment over rivers and lakes is not fully understood. To improve our understanding, this study targeted the Twain-Hu Basin (THB) in central China, with a unique underlying surface compri...

(This article belongs to the Section Air Pollution and Health)
  • Editorial
  • Open Access
3 Citations
2,419 Views
4 Pages

10 February 2023

In most health risk assessment (HRA) frameworks for chemicals, the default approach for exposure assessment is to estimate the intake from different sources and different routes of exposure [...]

(This article belongs to the Special Issue Human Biomonitoring in Health Risk Assessment: Current Practices and Recommendations for the Future)
  • Article
  • Open Access
7 Citations
2,501 Views
16 Pages

9 February 2023

Cadmium is a component of ambient metal pollution, which is linked to diverse health issues globally, including male reproductive impairment. Assessments of the acute effects of cadmium on male reproduction systems, such as testes, tend to be based o...

(This article belongs to the Section Reproductive and Developmental Toxicity)
  • Article
  • Open Access
8 Citations
3,732 Views
13 Pages

9 February 2023

There is limited evidence concerning the association between air pollution and different outpatient visits in moderately polluted areas. This paper investigates the effects of moderate-level air pollution on outpatient visits associated with six cate...

(This article belongs to the Section Human Toxicology and Epidemiology)
  • Article
  • Open Access
29 Citations
5,053 Views
16 Pages

Substantial Changes in Selected Volatile Organic Compounds (VOCs) and Associations with Health Risk Assessments in Industrial Areas during the COVID-19 Pandemic

  • Bhupendra Pratap Singh,
  • Sayed Sartaj Sohrab,
  • Mohammad Athar,
  • Thamir A. Alandijany and ,
  • Saumya Kumari,
  • Arathi Nair,
  • Sweety Kumari,
  • Kriti Mehra,
  • Khyati Chowdhary and
  • Esam Ibraheem Azhar
  • + 6 authors+ 1 author

9 February 2023

During the COVID-19 pandemic, governments in many countries worldwide, including India, imposed several restriction measures, including lockdowns, to prevent the spread of the infection. COVID-19 lockdowns led to a reduction in gaseous and particulat...

(This article belongs to the Special Issue Effects of Environmental Organic Pollutants on Environment and Human Health: The Latest Updates)
  • Article
  • Open Access
4 Citations
2,550 Views
18 Pages

9 February 2023

Baoji is a medium-sized city in the Guanzhong Plain of northwest China. The compositions of three important organic groups, namely n-alkanes, polycyclic aromatic hydrocarbons (PAHs), and saccharides in atmospheric aerosol with different aerodynamic d...

(This article belongs to the Section Air Pollution and Health)
  • Review
  • Open Access
16 Citations
5,487 Views
20 Pages

A Scoping Assessment of Implemented Toxicokinetic Models of Per- and Polyfluoro-Alkyl Substances, with a Focus on One-Compartment Models

  • Alexander East,
  • Daniel E. Dawson,
  • Sydney Brady,
  • Daniel A. Vallero and
  • Rogelio Tornero-Velez

9 February 2023

Toxicokinetic (TK) models have been used for decades to estimate concentrations of per-and polyfluoroalkyl substances (PFAS) in serum. However, model complexity has varied across studies depending on the application and the state of the science. This...

(This article belongs to the Special Issue PFAS Toxicology and Metabolism)
  • Article
  • Open Access
5 Citations
3,385 Views
16 Pages

Downregulation of LncRNA GCLC-1 Promotes Microcystin-LR-Induced Malignant Transformation of Human Liver Cells by Regulating GCLC Expression

  • Xinglei Huang,
  • Zhaohui Su,
  • Jiangheng Li,
  • Junquan He and ,
  • Na Zhao,
  • Liyun Nie,
  • Bin Guan,
  • Qiuyue Huang,
  • Huiliu Zhao and
  • Qingqing Nong
  • + 6 authors+ 1 author

9 February 2023

Microcystin-LR (MCLR) is an aquatic toxin, which could lead to the development of hepatocellular carcinoma (HCC). Long non-coding RNAs (lncRNAs) are considered important regulatory elements in the occurrence and development of cancer. However, the ro...

(This article belongs to the Topic Environmental Toxicology and Human Health)
  • Article
  • Open Access
32 Citations
6,608 Views
15 Pages

9 February 2023

Per- and polyfluoroalkyl substances (PFASs) have received extensive attention due to their various harmful effects. In this study, the adsorptive removal of 10 legacy and emerging PFASs by four anion-exchange resins (including gel and macroreticular...

(This article belongs to the Special Issue Occurrence, Fate, Removal, and Effects of Per- and Polyfluoroalkyl Substances (PFASs))
  • Article
  • Open Access
33 Citations
4,519 Views
13 Pages

Melatonin Ameliorates Diquat-Induced Testicular Toxicity via Reducing Oxidative Stress, Inhibiting Apoptosis, and Maintaining the Integrity of Blood-Testis Barrier in Mice

  • Li Yang,
  • Jianyong Cheng,
  • Dejun Xu,
  • Zelin Zhang and ,
  • Rongmao Hua,
  • Huali Chen,
  • Jiaxin Duan,
  • Xiaoya Li and
  • Qingwang Li
  • + 4 authors+ 0 author

8 February 2023

Diquat is a fast, potent, and widely used bipyridine herbicide in agriculture and it induces oxidative stress in several animal models. However, its genotoxic effects on the male reproductive system remain unclear. Melatonin is an effective free-radi...

(This article belongs to the Section Agrochemicals and Food Toxicology)
  • Article
  • Open Access
28 Citations
4,350 Views
19 Pages

Hypericum perforatum L. Nanoemulsion Mitigates Cisplatin-Induced Chemobrain via Reducing Neurobehavioral Alterations, Oxidative Stress, Neuroinflammation, and Apoptosis in Adult Rats

  • Heba M. A. Khalil,
  • Hanan M. A. El Henafy,
  • Islam A. Khalil,
  • Alaa F. Bakr and ,
  • Mohamed I. Fahmy,
  • Nancy S. Younis and
  • Riham A. El-Shiekh
  • + 2 authors+ 0 author

8 February 2023

Cisplatin (Cis) is a potent chemotherapeutic agent; however, it is linked with oxidative stress, inflammation, and apoptosis, which may harmfully affect the brain. Hypericum perforatum L. (HP L.) is a strong medicinal plant, but its hydrophobic polyp...

(This article belongs to the Section Neurotoxicity)
  • Review
  • Open Access
24 Citations
5,521 Views
14 Pages

Long Non-Coding RNA MEG3 in Metal Carcinogenesis

  • Zhuo Zhang,
  • Sophia Shi,
  • Jingxia Li and
  • Max Costa

7 February 2023

Most transcripts from human genomes are non-coding RNAs (ncRNAs) that are not translated into proteins. ncRNAs are divided into long (lncRNAs) and small non-coding RNAs (sncRNAs). LncRNAs regulate their target genes both transcriptionally and post-tr...

(This article belongs to the Section Metals and Radioactive Substances)
  • Review
  • Open Access
11 Citations
3,742 Views
17 Pages

7 February 2023

Heavy metal pollution creates environmental health concerns. Among these, iron (Fe), copper (Cu) and manganese (Mn) are commonly found in aquatic environments due to the release of wastewaters. Phytoremediation in hydroponics uses macrophytes to trea...

(This article belongs to the Special Issue New Lights on Phytoremediation)
  • Article
  • Open Access
12 Citations
6,896 Views
23 Pages

Interlaboratory Study to Evaluate a Testing Protocol for the Safety of Food Packaging Coatings

  • Maricel Marin-Kuan,
  • Vincent Pagnotti,
  • Amaury Patin,
  • Julie Moulin and ,
  • Helia Latado,
  • Jesús Varela,
  • Yves-Alexis Hammel,
  • Thomas Gude,
  • Heidi Moor and
  • David T. Szabo
  • + 11 authors+ 6 authors

7 February 2023

According to European regulations, migration from food packaging must be safe. However, currently, there is no consensus on how to evaluate its safety, especially for non-intentionally added substances (NIAS). The intensive and laborious approach, in...

(This article belongs to the Special Issue Risk Assessment of Food Contact Materials/Articles)
  • Article
  • Open Access
28 Citations
11,603 Views
17 Pages

Toxicological Assessment of Particulate and Metal Hazards Associated with Vaping Frequency and Device Age

  • Jennifer Jeon,
  • Qian Zhang,
  • Patrick S. Chepaitis,
  • Roby Greenwald and ,
  • Marilyn Black and
  • Christa Wright
  • + 1 author+ 0 author

7 February 2023

Electronic nicotine delivery systems (ENDS) aerosols are complex mixtures of chemicals, metals, and particles that may present inhalation hazards and adverse respiratory health risks. Despite being considered a safer alternative to tobacco cigarettes...

(This article belongs to the Special Issue Exposure to Indoor Hazardous Chemicals and Harmful Impacts on Human Body)
  • Systematic Review
  • Open Access
17 Citations
4,872 Views
13 Pages

A Systematic Review of Nano- and Microplastic (NMP) Influence on the Bioaccumulation of Environmental Contaminants: Part I—Soil Organisms

  • Paula S. Tourinho,
  • Susana Loureiro,
  • Maria D. Pavlaki,
  • Klará Anna Mocová and
  • Fabianne Ribeiro

7 February 2023

Nano- and microplastics (NMPs) are a group of contaminants that cause concern due to their abundance in the environment, high persistence, and interaction with other contaminants. This review aims to understand the role of NMP in the bioaccumulation...

(This article belongs to the Section Ecotoxicology)
  • Article
  • Open Access
16 Citations
4,837 Views
12 Pages

6 February 2023

Soils with high lead (Pb) levels can be decontaminated with the use of tolerant plants. Their effectiveness may be increased with added soil N due to boosted plant vigor, but such an agronomic practice has not been widely reported so far. In this wor...

(This article belongs to the Section Toxicity Reduction and Environmental Remediation)
  • Communication
  • Open Access
5 Citations
2,887 Views
8 Pages

5 February 2023

Alternative materials for postmortem diagnosis in the case of fatal poisonings are much needed when standard materials, such as blood and urine, are unavailable. The study presents a case of fatal mass methanol intoxication resulting from industrial...

(This article belongs to the Special Issue Advance in Forensic Toxicology)
  • Article
  • Open Access
33 Citations
8,138 Views
14 Pages

4 February 2023

Selective serotonin reuptake inhibitors (SSRIs) are currently the most prescribed class of psychotropic medications. Their increased global manufacture and use have become growing concerns for aquatic toxicologists and environmental biologists, who a...

  • Case Report
  • Open Access
15 Citations
3,999 Views
15 Pages

Distribution, Multi-Index Assessment, and Sources of Heavy Metals in Surface Sediments of Zhelin Bay, a Typical Mariculture Area in Southern China

  • Yan-Jie Han,
  • Rui-Ze Liang,
  • Hai-Song Li,
  • Yang-Guang Gu and ,
  • Shi-Jun Jiang and
  • Xiang-Tian Man
  • + 1 author+ 0 author

3 February 2023

The occurrence, multi-index assessment, and sources of heavy metals in surface sediments of Zhelin Bay were investigated. Average heavy metal concentrations (mg/kg) were 81.89 (Cr), 770.76 (Mn), 16.81 (Co), 62.25 (Ni), 96.30 (Cu), 162.04 (Zn), and 73...

(This article belongs to the Special Issue Occurrence, Fate and Transport of Marine Pollutants)
  • Article
  • Open Access
5 Citations
2,386 Views
16 Pages

Research on the Optimal Regulation of Sudden Water Pollution

  • Honglei Ren,
  • Fei Lin,
  • Yuezan Tao,
  • Ting Wei and ,
  • Bo Kang,
  • Yucheng Li and
  • Xian Li
  • + 2 authors+ 0 author

3 February 2023

For the needs of the whole region’s emergency regulation of the nullah sudden water pollution event, the emergency regulation strategy of the accident section and upstream and downstream of the sudden water pollution event is studied. For the a...

(This article belongs to the Special Issue Pollution Control in the Yellow River Basin: Monitoring, Restoration, and Management)

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Toxics - ISSN 2305-6304