Special Issue "Risk Assessment of Food Contact Materials/Articles"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Risk Assessment and Management".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Isabelle Severin
E-Mail Website
Guest Editor
Universite Bourgogne Franche-Comte, UMR INSERM 1231, NUTox Team, Derttech “Packtox”, Dijon, France
Interests: In vitro bioassays; mixture assessment; genotoxicity, non-intentionally added substances

Special Issue Information

Dear Colleagues,

Food packaging is omnipresent in our daily life as most of the food distributed in developed countries is packed. Food contact articles (FCA), because of their technical functions, are barriers to preventing the chemical/microbiological contamination of food and to prolonging their shelf-life and maintaining the quality and safety of food. Their marketing roles make them a great source of innovation and information support for the consumer. Nevertheless, despite its many beneficial roles, food packaging safety is a major subject of concern for all the stakeholders. Indeed, there has been increased scientific, media, and public attention regarding packaging migrates as a source of food contamination.

Depending on food contact materials (FCM) physical/chemical parameters and FCM/food composition, FCM may interact with food and transfer some constituents by migration that induce low but measurable human exposure. Migration may cause a potential risk for human health that must be measured and controlled. In addition to starting substances, some non-intentionally added substances can also be found in food, and they could even represent a great part of migrating substances. Thus, FCM/FCA could be considered a complex mixture of chemicals whose risk is very difficult to assess as many substances are not well analytically identified, quantified, and toxicologically characterized.

The Special Issue aims to present recent research studies on the latest methods and approaches to better assess the risk of FCM and FCA, in terms of hazard identification, exposure characterization, and hazard assessment to ensure the safety of consumers. Studies may focus on but are not limited to migration modeling, improvement of food simulants, and conditions of contact, chemical analysis, toxicity assessment, in silico methods (TTC, QSAR, etc.), extraction protocols, in vitro bioassays (genotoxicity, endocrine disruption), and mixture effect. The contributions could also cover the risk assessment of new materials (bio-based, compostables) or the use of FCM in a closed-circuit loop (reuse or recycling).

We hope you find this hot topic of interest and look forward to receiving your proposals soon.

Dr. Isabelle Severin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food contact materials/articles
  • risk assessment
  • hazard assessment
  • migration
  • exposure
  • chemical analysis
  • in vitro bioassays
  • non-intentionally added substances
  • packaging safety mixture

Published Papers (1 paper)

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Research

Article
Direct Comparison of the Lowest Effect Concentrations of Mutagenic Reference Substances in Two Ames Test Formats
Toxics 2021, 9(7), 152; https://doi.org/10.3390/toxics9070152 - 29 Jun 2021
Viewed by 516
Abstract
The Ames assay is the standard assay for identifying DNA-reactive genotoxic substances. Multiple formats are available and the correct choice of an assay protocol is essential for achieving optimal performance, including fit for purpose detection limits and required screening capacity. In the present [...] Read more.
The Ames assay is the standard assay for identifying DNA-reactive genotoxic substances. Multiple formats are available and the correct choice of an assay protocol is essential for achieving optimal performance, including fit for purpose detection limits and required screening capacity. In the present study, a comparison of those parameters between two commonly used formats, the standard pre-incubation Ames test and the liquid-based Ames MPF™, was performed. For that purpose, twenty-one substances with various modes of action were chosen and tested for their lowest effect concentrations (LEC) with both tests. In addition, two sources of rat liver homogenate S9 fraction, Aroclor 1254-induced and phenobarbital/β-naphthoflavone induced, were compared in the Ames MPF™. Overall, the standard pre-incubation Ames and the Ames MPF™ assay showed high concordance (>90%) for mutagenic vs. non-mutagenic compound classification. The LEC values of the Ames MPF™ format were lower for 17 of the 21 of the selected test substances. The S9 source had no impact on the test results. This leads to the conclusion that the liquid-based Ames MPF™ assay format provides screening advantages when low concentrations are relevant, such as in the testing of complex mixtures. Full article
(This article belongs to the Special Issue Risk Assessment of Food Contact Materials/Articles)
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