Table of Contents
Int. J. Mol. Sci., Volume 18, Issue 10 (October 2017) – 210 articles
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Cover Story (view full-size image) A comprehensive screening effort was performed targeting the DNA damage-related kinase CK1. The [...] Read more. A comprehensive screening effort was performed targeting the DNA damage-related kinase CK1. The NCI/DTP diversity compound collection was evaluated in vitro and a selective inhibitor with the capacity to increase levels of the downstream p53 tumor suppressor was discovered. The systematic in vitro evaluation of the compound collection also enabled a retrospective analysis concerning the performance of commonly used virtual screening methods, affording a number of interesting observations. View this paper