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Review

Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications

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Tumor Biology, Immunology, and Therapy Section, Immunology, Inflammation, and Metabolism Department, Division of Translational Medicine, Sidra Medical and Research Center, PO Box 26999 Doha, Qatar
2
Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
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Academic Medical Center Amsterdam, Center for Experimental Molecular Medicine, 1105AZ Amsterdam, The Netherlands
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Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, PO Box 5825 Doha, Qatar
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Office of the Chief Research Officer (CRO), Sidra Medical and Research Center, PO Box 26999 Doha, Qatar
*
Authors to whom correspondence should be addressed.
Current employer: Abbvie Biotherapeutics Corporation, 94063 Redwood City, CA, USA
These authors contributed equally to this work.
Int. J. Mol. Sci. 2017, 18(10), 2229; https://doi.org/10.3390/ijms18102229
Received: 11 September 2017 / Revised: 6 October 2017 / Accepted: 20 October 2017 / Published: 24 October 2017
The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) has led to the identification of favorable and unfavorable immunological attributes linked to clinical outcome. With the definition of consensus molecular subtypes (CMSs) based on transcriptomic profiles, multiple characteristics have been proposed to be responsible for the development of the tumor immune microenvironment and corresponding mechanisms of immune escape. In this review, a detailed description of proposed immune phenotypes as well as their interaction with different therapeutic modalities will be provided. Finally, possible strategies to shift the CRC immune phenotype towards a reactive, anti-tumor orientation are proposed per CMS. View Full-Text
Keywords: colorectal cancer; tumor microenvironment; immune contexture; immunologic constant of rejection; consensus molecular subtypes; immunotherapy; combination therapy colorectal cancer; tumor microenvironment; immune contexture; immunologic constant of rejection; consensus molecular subtypes; immunotherapy; combination therapy
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MDPI and ACS Style

Roelands, J.; Kuppen, P.J.K.; Vermeulen, L.; Maccalli, C.; Decock, J.; Wang, E.; Marincola, F.M.; Bedognetti, D.; Hendrickx, W. Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications. Int. J. Mol. Sci. 2017, 18, 2229. https://doi.org/10.3390/ijms18102229

AMA Style

Roelands J, Kuppen PJK, Vermeulen L, Maccalli C, Decock J, Wang E, Marincola FM, Bedognetti D, Hendrickx W. Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications. International Journal of Molecular Sciences. 2017; 18(10):2229. https://doi.org/10.3390/ijms18102229

Chicago/Turabian Style

Roelands, Jessica, Peter J.K. Kuppen, Louis Vermeulen, Cristina Maccalli, Julie Decock, Ena Wang, Francesco M. Marincola, Davide Bedognetti, and Wouter Hendrickx. 2017. "Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications" International Journal of Molecular Sciences 18, no. 10: 2229. https://doi.org/10.3390/ijms18102229

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