Next Article in Journal
The Structure of Human Neuromuscular Junctions: Some Unanswered Molecular Questions
Next Article in Special Issue
Phospholamban Is Downregulated by pVHL-Mediated Degradation through Oxidative Stress in Failing Heart
Previous Article in Journal
Protective Effect of Argan and Olive Oils against LPS-Induced Oxidative Stress and Inflammation in Mice Livers
Previous Article in Special Issue
G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(10), 2188; https://doi.org/10.3390/ijms18102188

Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation

1
Université de Bourgogne Franche-Comté, LNC UMR1231, 21000 Dijon, France
2
Institut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, 21000 Dijon, France
Received: 15 September 2017 / Revised: 11 October 2017 / Accepted: 16 October 2017 / Published: 19 October 2017
(This article belongs to the Special Issue Ubiquitin System)
Full-Text   |   PDF [698 KB, uploaded 20 October 2017]   |  

Abstract

Ubiquitination is a post-translational modification that defines the cellular fate of intracellular proteins. It can modify their stability, their activity, their subcellular location, and even their interacting pattern. This modification is a reversible event whose implementation is easy and fast. It contributes to the rapid adaptation of the cells to physiological intracellular variations and to intracellular or environmental stresses. E2F1 (E2 promoter binding factor 1) transcription factor is a potent cell cycle regulator. It displays contradictory functions able to regulate both cell proliferation and cell death. Its expression and activity are tightly regulated over the course of the cell cycle progression and in response to genotoxic stress. I discuss here the most recent evidence demonstrating the role of ubiquitination in E2F1’s regulation. View Full-Text
Keywords: E2F1; ubiquitination; cell cycle; DNA damage E2F1; ubiquitination; cell cycle; DNA damage
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Dubrez, L. Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation. Int. J. Mol. Sci. 2017, 18, 2188.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top