Next Article in Journal
Understanding the Contribution of Zinc Transporters in the Function of the Early Secretory Pathway
Next Article in Special Issue
Regulation of E2F1 Transcription Factor by Ubiquitin Conjugation
Previous Article in Journal
Bone Marrow-Derived Stem Cell Populations Are Differentially Regulated by Thyroid or/and Ovarian Hormone Loss
Previous Article in Special Issue
Why Ubiquitin Has Not Evolved
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(10), 2180;

G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium

Department of Clinical and Biological Sciences, University of Turin, AOUS. Luigi, 10043 Orbassano TO, Italy
Department of Oncology, University of Turin, AOU S. Luigi, 10043 Orbassano TO, Italy
Author to whom correspondence should be addressed.
Received: 14 September 2017 / Revised: 12 October 2017 / Accepted: 16 October 2017 / Published: 19 October 2017
(This article belongs to the Special Issue Ubiquitin System)
PDF [1452 KB, uploaded 19 October 2017]


Signal transduction through G-protein-coupled receptors (GPCRs) is central for the regulation of virtually all cellular functions, and it has been widely implicated in human diseases. These receptors activate a common molecular switch that is represented by the heterotrimeric G-protein generating a number of second messengers (cAMP, cGMP, DAG, IP3, Ca2+ etc.), leading to a plethora of diverse cellular responses. Spatiotemporal regulation of signals generated by a given GPCR is crucial for proper signalling and is accomplished by a series of biochemical modifications. Over the past few years, it has become evident that many signalling proteins also undergo ubiquitination, a posttranslational modification that typically leads to protein degradation, but also mediates processes such as protein-protein interaction and protein subcellular localization. The social amoeba Dictyostelium discoideum has proven to be an excellent model to investigate signal transduction triggered by GPCR activation, as cAMP signalling via GPCR is a major regulator of chemotaxis, cell differentiation, and multicellular morphogenesis. Ubiquitin ligases have been recently involved in these processes. In the present review, we will summarize the most significant pathways activated upon GPCRs stimulation and discuss the role played by ubiquitination in Dictyostelium cells. View Full-Text
Keywords: signal transduction; GPCRs; ubiquitination; cAMP; HERC1; HECT; Dictyostelium discoideum; mammals; TORC2 signal transduction; GPCRs; ubiquitination; cAMP; HERC1; HECT; Dictyostelium discoideum; mammals; TORC2

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Pergolizzi, B.; Bozzaro, S.; Bracco, E. G-Protein Dependent Signal Transduction and Ubiquitination in Dictyostelium. Int. J. Mol. Sci. 2017, 18, 2180.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top