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Special Issue "Latest Advances in Colorectal Cancer Research: Molecular Mechanisms and Therapies"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2017).
Interests: colorectal cancer; tumor-immmune interactions; cancer genetics and epigenetics; immunotherapy; biomarkers
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Colorectal cancer (CRC) is the third most frequent cancer type, with approximately one million new cases per year world-wide, and more than half a million deaths annually. In the past few decades, important advances have been made in screening, staging, treatment, and molecular characterization of CRC. For non-metastasized CRC, surgery is the cornerstone for curative treatment. However, up to 50% of CRC patients show distant metastases, either at the time of diagnosis or during clinical follow-up. A major challenge in CRC is the development of curative treatment options for these patients. Recent advancements in molecular biological techniques and analyses have led to a much better understanding of the biology of CRC. Both genetic and epigenetic aberrations appear to be common in CRC. In addition, different subtypes of CRC have been defined, based on specific DNA mutations and on molecular pathways involved. Furthermore, accumulating evidence proved that the tumor microenvironment, including the immune system, plays an important role in CRC development. Traditionally, the treatment of choice for CRC is dependent on the tumor location (rectum vs. colon) and TNM classification. New treatment modalities become available that interfere in specific molecular pathways. Therefore, future treatment will be based on the underlying biology in specific cases of CRC. It has also become clear that therapeutic interventions can result in selective outgrowth of resistant subtypes. This is the result of tumor heterogeneity, with genetic and epigenetic instability as a driving force. Therefore, treatment outcome is the result of a competition between treatment efficacy and outgrowth of escape variants.
In this Special Issue of IJMS, the focus will be on this competition by considering the biology of CRC in relation with new treatment options.
Dr. Peter J.K. Kuppen
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- colorectal cancer
- molecular pathway
- tumor microenvironment