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Platelets and Multi-Organ Failure in Sepsis

Department of Medical Science, University of Turin, 10126 Turin, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(10), 2200;
Received: 31 August 2017 / Revised: 13 October 2017 / Accepted: 17 October 2017 / Published: 20 October 2017
(This article belongs to the Special Issue Sepsis)
PDF [213 KB, uploaded 22 October 2017]


Platelets have received increasing attention for their role in the pathophysiology of infectious disease, inflammation, and immunity. In sepsis, a low platelet count is a well-known biomarker for disease severity and more recently authors have focused their attention on the active role of platelets in the pathogenesis of multi-organ failure. Septic shock is characterised by a dysregulated inflammatory response, which can impair the microcirculation and lead to organ injury. Being at the crossroads between the immune system, clotting cascade, and endothelial cells, platelets seem to be an appealing central mediator and possible therapeutic target in sepsis. This review focuses on the pathogenic role of platelets in septic organ dysfunction in humans and animal models. View Full-Text
Keywords: platelet; sepsis; multi-organ failure; thrombocytopenia; septic shock; antiplatelets; ARDS; AKI; DIC platelet; sepsis; multi-organ failure; thrombocytopenia; septic shock; antiplatelets; ARDS; AKI; DIC
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Greco, E.; Lupia, E.; Bosco, O.; Vizio, B.; Montrucchio, G. Platelets and Multi-Organ Failure in Sepsis. Int. J. Mol. Sci. 2017, 18, 2200.

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