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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Molecular Insights to Novel Therapies: Neurological Diseases

edited by

Margarita Neganova

submission deadline 20 May 2026 | 19 articles | Viewed by 97652 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; epilepsy; mental illness; transgenic animal models; molecular pathways; metabolism disabilities; mitochondrial dysfunction; oxidative stress; disturbances in epigenetic regulation

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapy for Immune Diseases

edited by

Alexey Sarapultsev

submission deadline 20 May 2026 | 15 articles | Viewed by 58039 | Submission Open

Keywords: targeted therapy; immune diseases; biologics; immunotherapy; precision medicine; nanoparticles; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Fascial Anatomy and Histology: Advances in Molecular Biology

edited by

Carla Stecco

submission deadline 20 May 2026 | 7 articles | Viewed by 45767 | Submission Open

Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan

(This special issue belongs to the Section Molecular Biology)

Innovative Nanomaterials from Functional Molecules

edited by Xiaoming Zhang and

Yi Jia

submission deadline 20 May 2026 | 6 articles | Viewed by 39272 | Submission Open

Keywords: functional materials; molecular design; molecular assembly; medicine; catalysis; battery; supercapacitor; sensing

(This special issue belongs to the Section Molecular Nanoscience)

Plant Responses to Biotic and Abiotic Stresses

edited by

Shu Yuan

submission deadline 20 May 2026 | 24 articles | Viewed by 39222 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; stress response; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen response

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Anti-Inflammatory Activity of Natural Products of Plant Origin

edited by Radoslaw Zajdel

submission deadline 20 May 2026 | 2 articles | Viewed by 31300 | Submission Open

Keywords: anti-inflammatory; phytochemicals; natural products; medicinal plants; inflammation; cytokines; NF-κ B pathway; cyclooxygenase inhibitors; flavonoids; terpenoids; polyphenols; molecular mechanisms; drug discovery; ethnopharmacology; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Compounds in Cancer Therapy and Prevention, 2nd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 May 2026 | 7 articles | Viewed by 30983 | Submission Open

Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

Rare Genetic Diseases: From Molecular Mechanisms to Therapeutic Strategies

edited by

Maria Arnedo

submission deadline 20 May 2026 | 7 articles | Viewed by 28466 | Submission Open

Keywords: rare genetic disease; innate metabolic errors; neurodegenerative diseases; therapeutic; molecular diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Omics Science and Research in Human Health and Disease

edited by Elisa De Paolis

submission deadline 20 May 2026 | 8 articles | Viewed by 27978 | Submission Open

Keywords: genomics; transcriptomics; proteomics; metabolomics; single-cell analysis; spatial transcriptomics; bioinformatics; multi-omics

(This special issue belongs to the Section Molecular Biology)

Plant-Derived Bioactives: Antioxidant Mechanisms and Preventive Health Strategies

edited by

Charles Manful

submission deadline 20 May 2026 | 6 articles | Viewed by 27525 | Submission Open

Keywords: antioxidant; plant-derived bioactive compounds; flavonoids; oxidative stress; mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Skeletal Muscle Function and Metabolism: Molecular Mechanisms and Treatment—2nd Edition

edited by

Andrea Telek

submission deadline 20 May 2026 | 8 articles | Viewed by 24408 | Submission Open

Keywords: skeletal muscle; metabolism; mitochondria; epigenetics; exercise; signalization

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment

edited by Manuel Morales-Ruiz

submission deadline 20 May 2026 | 9 articles | Viewed by 21470 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways; diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling; cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

102nd Anniversary of Neurotransmitter Discovery: Cholinergic Pathways in Physiology and Pathophysiology

edited by

Sumonto Mitra

submission deadline 20 May 2026 | 7 articles | Viewed by 19123 | Submission Open

Keywords: acetylcholine; physiological functions; pathological alterations; cholinergic pathways

(This special issue belongs to the Section Biochemistry)

Exploring Cannabinoids: Molecular Mechanisms and Potential Therapeutic Applications

edited by

Grace Blest Hopley

submission deadline 20 May 2026 | 5 articles | Viewed by 18370 | Submission Open

Keywords: cannabinoids; endocannabinoid system; δ 9-tetrahydrocannabinol (THC); cannabidiol (CBD); inflammation; chronic pain; neurodegenerative disorders; epilepsy; psychosis; cancer-related symptoms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Oxidative Stress and Antioxidants in Human Disease

edited by

Federica Mannino

submission deadline 20 May 2026 | 7 articles | Viewed by 17913 | Submission Open

Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Melanoma and Skin Cancers: 2nd Edition

edited by

Domenico Mallardo

Debora Basile

and Maria Grazia Vitale

submission deadline 20 May 2026 | 6 articles | Viewed by 17762 | Submission Open

Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy

(This special issue belongs to the Section Molecular Oncology)

The Role of Natural Compounds in Cancer and Inflammation, 2nd Edition

edited by

Elia Ranzato

submission deadline 20 May 2026 | 7 articles | Viewed by 17580 | Submission Open

Keywords: natural compounds; oxidative stress; anti-cancer; anti-inflammatory; natural product synthesis; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genetic Engineering of Plants for Stress Tolerance, Second Edition

edited by

Moxian Chen

submission deadline 20 May 2026 | 8 articles | Viewed by 17482 | Submission Open

Keywords: CRISPR-Cas system; RNA interference; abiotic and biotic stresses; transcriptional regulation; post-transcriptional regulation; post-translational modification; genetic evolution; biotechnology; molecular mechanisms; regulatory circuits

(This special issue belongs to the Section Molecular Plant Sciences)

Antimicrobial and Antiviral Peptides: 2nd Edition

edited by

Tecla Ciociola

submission deadline 20 May 2026 | 4 articles | Viewed by 16655 | Submission Open

Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications

(This special issue belongs to the Section Biochemistry)

The Impact of Mitochondria on Human Disease and Health

edited by

Martina Semenzato

submission deadline 20 May 2026 | 5 articles | Viewed by 16463 | Submission Open

Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapies of Colorectal Cancer: 4th Edition

edited by

Donatella Delle Cave

submission deadline 20 May 2026 | 9 articles | Viewed by 16228 | Submission Open

Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine

(This special issue belongs to the Section Molecular Oncology)

Bioactive Compound Delivery Systems and Microbiome Interactions

edited by

Ramona Suharoschi

Adriana Fodor

and

Oana Lelia Pop

submission deadline 20 May 2026 | 2 articles | Viewed by 15875 | Submission Open

Keywords: bioactive compounds; delivery systems; gut microbiome; personalized nutrition; bioavailability; encapsulation technologies; microbiome– bioactive interactions; targeted delivery; precision nutrition; synergistic interactions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Cardiovascular Risk Factors: 2nd Edition

edited by

Antonio Barbato

submission deadline 20 May 2026 | 4 articles | Viewed by 15842 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Biology)

Advanced Perspectives on Virus–Host Interactions

edited by

Qibin Geng

submission deadline 20 May 2026 | 9 articles | Viewed by 15233 | Submission Open

Keywords: viral manipulation of host metabolics; virus– host interactions; host– pathogen co-evolution; susceptibility and resistance to viral infection; novel antiviral strategies

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights in Antivirals and Vaccines

edited by

Gergana Zahmanova

Ivan Minkov

and

Yoana Dimitrova Kiselova-Kaneva

submission deadline 20 May 2026 | 3 articles | Viewed by 15017 | Submission Open

Keywords: new vaccine platforms; cell cultures; plant molecular farming; vaccines and VLPs; nanoparticle vaccines; emerging viral diseases; novel therapeutics; biologics; antibodies; receptor modulators; plant-based compounds with antiviral activity; medicinal plant-derived products; bioactive proteins from plants

(This special issue belongs to the Section Molecular Microbiology)

Molecular Recognition and Biosensing

edited by

Longjiao Zhu

submission deadline 20 May 2026 | 5 articles | Viewed by 15001 | Submission Open

Keywords: molecular recognition; biosensor; nanomaterials; aptamer; nucleic acids; sensitivity

(This special issue belongs to the Section Biochemistry)

The Molecular Basis of Plant–Microbe Interactions

edited by

Stephan Pollmann

Luis Morales-Quintana

and

Patricio Ramos

submission deadline 20 May 2026 | 5 articles | Viewed by 14906 | Submission Open

Keywords: plant immune and defense responses; microbe and microbiome function; microbial biodiversity; abiotic and biotic stress mitigation; gene regulatory mechanisms; plant hormones in plant– microbe interactions; molecular mechanisms of plant growth and microbe interactions; chemical communication in plant– microbe interactions; microbe effects on fruit quality; OMICs approaches (metagenomics; metatranscriptomics; epigenomics; transcriptomics; metabolomics); bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration

edited by

Sara Cruciani

submission deadline 20 May 2026 | 6 articles | Viewed by 14842 | Submission Open

Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Pathogenesis and Novel Therapeutic Approaches for Sarcomas

edited by Francisco Giner

submission deadline 20 May 2026 | 5 articles | Viewed by 14599 | Submission Open

Keywords: soft tissue tumors; bone tumors; molecular biology; target therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bile Acids and Bile Acid Modifications in Health and Disease

edited by

Francisco J. Osuna-Prieto

submission deadline 20 May 2026 | 4 articles | Viewed by 14177 | Submission Open

Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders

(This special issue belongs to the Section Molecular Microbiology)

The Roles of Photodynamic Therapy in Tumors and Cancers

edited by Jianyong Liu

submission deadline 20 May 2026 | 4 articles | Viewed by 14091 | Submission Open

Keywords: photodynamic therapy; PDT; photodetection; photosensitizers; photosensitizing agents; reactive oxygen species; molecular mechanisms; cell necrosis; apoptosis; singlet oxygen; synergetic therapy; combination therapy; delivery vehicles; immunophototherapy; nano-photosensitizer

(This special issue belongs to the Section Molecular Oncology)

Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine

edited by

Ramya Lakshmi Rajendran

and

Prakash Gangadaran

submission deadline 20 May 2026 | 5 articles | Viewed by 14049 | Submission Open

Keywords: regenerative medicine; pluripotent stem cells; cell differentiation; tissue engineering; gene editing; therapeutic potential; clinical applications; neurodegenerative disorders; disease modeling

(This special issue belongs to the Section Molecular Biology)

Cutting-Edge Methods for Exploiting Bioactive Compounds in Biomasses: From the Plant Matrix to Molecular Function

edited by Chiara Magni

submission deadline 20 May 2026 | 7 articles | Viewed by 13811 | Submission Open

Keywords: plant matrix; agri-food biomasses; biochemistry; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy

edited by

Tetiana Zaǐchuk

submission deadline 20 May 2026 | 6 articles | Viewed by 13449 | Submission Open

Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution

(This special issue belongs to the Section Molecular Oncology)

Amyotrophic Lateral Sclerosis (ALS): Pathogenesis and Treatments

edited by

Monica Consonni

and

Stefania Marcuzzo

submission deadline 20 May 2026 | 3 articles | Viewed by 13340 | Submission Open

Keywords: amyotrophic lateral sclerosis; therapeutic applications; extracellular-vesicles; gene variants; RNA metabolism; mitochondrial dysfunction; oxidative stress; neuroinflammation; protein misfolding; muscle impariment

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Biological and Molecular Targets in Schizophrenia

edited by Jacopo Sapienza

submission deadline 20 May 2026 | 4 articles | Viewed by 13251 | Submission Open

Keywords: schizophrenia; cognition; negative symptoms; synapses; kynurenine pathway; TAAR1; psychedelics; new treatments

(This special issue belongs to the Section Molecular Neurobiology)

Advancing Molecular Science Through Reproducible qPCR: MIQE Guidelines and Beyond

edited by

Stephen Bustin

submission deadline 20 May 2026 | 6 articles | Viewed by 13196 | Submission Open

Keywords: MIQE; qPCR; reverse transcription

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Ecology, Physiology and Biochemistry of Insects, 5th Edition

edited by

Klaus H. Hoffmann

submission deadline 20 May 2026 | 6 articles | Viewed by 13017 | Submission Open

Keywords: insect development and reproduction; molecular endocrinology/neuropeptides; insect immunity; photoperiodism; cold hardiness; global climate change; insect aging; insect– plant interactions; molecular interactions of insects with microorganisms; chemical communication; biochemistry of insect venoms; insect genomics and proteomics; genetic engineering; molecular; volution/population genetics; insect biotechnology

(This special issue belongs to the Section Molecular Immunology)

New Insights in Plant Cell Biology

edited by

Jacek Z. Kubiak

and

Malgorzata Kloc

submission deadline 20 May 2026 | 4 articles | Viewed by 12721 | Submission Open

Keywords: chloroplasts; cell wall; vacuoles; microtubule cytoskeleton; plant-cell-specific structures

(This special issue belongs to the Section Molecular Plant Sciences)

Effects of Stressors During Pregnancy and Breastfeeding on the Child: Molecular Perspectives

edited by

Anna Weronika Sobańska

submission deadline 20 May 2026 | 1 articles | Viewed by 12669 | Submission Open

Keywords: xenobiotics; drugs; gestation; breastfeeding; fetus; placenta; child’ s development; teratogenicity; central nervous system

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Antioxidant Activity

edited by Demetrios Kouretas and

Fotios Tekos

submission deadline 20 May 2026 | 7 articles | Viewed by 12645 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

Exploring the Molecular Mechanisms of Chronic Kidney Disease

edited by

Juan Miguel Diaz-Tocados

submission deadline 20 May 2026 | 5 articles | Viewed by 12533 | Submission Open

Keywords: chronic kidney disease; hereditary renal disease; renal hypertension; diabetic nephropathy; secondary hyperparathyroidism; cardiovascular disease; renal osteodystrophy; peritoneal dialysis; hemodialysis; anemia; metabolic acidosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regulatory Mechanisms of Development and Abiotic Stress Response by Transcriptional Regulators in Plants: 2nd Edition

edited by

Yong-Hwan Moon

submission deadline 20 May 2026 | 6 articles | Viewed by 12084 | Submission Open

Keywords: transcriptional regulator; transcription activation; transcription factor; transcription repression; plant development; abiotic stress response; epigenetic regulation; genome-wide analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Computational Studies in Drug Design and Discovery

edited by

Elena Cichero

submission deadline 20 May 2026 | 5 articles | Viewed by 11760 | Submission Open

Keywords: molecular docking; homology modeling; repositioning; virtual screening; QSAR; molecular dynamics; ADME prediction

(This special issue belongs to the Section Molecular Informatics)

The Function of Glial Cells in the Nervous System: 2nd Edition

edited by Krista Minéia Wartchow

submission deadline 20 May 2026 | 4 articles | Viewed by 11736 | Submission Open

Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches

(This special issue belongs to the Section Molecular Neurobiology)

Endometriosis and Infertility

edited by Ludwig Kiesel

submission deadline 20 May 2026 | 4 articles | Viewed by 11668 | Submission Open

Keywords: endometriosis; infertility; subfertility; physiological mechanisms; treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioprinting: Progress and Challenges

edited by

Rui Vitorino

submission deadline 20 May 2026 | 3 articles | Viewed by 11593 | Submission Open

Keywords: advances in 3D bioprinting technologies; biomaterials for bioprinting; bioprinting applications in tissue engineering and regenerative medicine; cellular and molecular interactions in bioprinted constructs; bio-printed organ and tissue models for disease research

(This special issue belongs to the Section Materials Science)

Macrophages and Inflammation

edited by

Julia Kzhyshkowska

submission deadline 20 May 2026 | 2 articles | Viewed by 11390 | Submission Open

Keywords: innate immunity; transcriptional programs; epigenetics; immunometabolism; receptors; scavenging; cytokines; ROS

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals

edited by

Roberta Macri

submission deadline 20 May 2026 | 3 articles | Viewed by 11320 | Submission Open

Keywords: cardiovascular disease; drugs; nutrients

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Microbiome Connections in Age-Related Diseases

edited by Shalini Jain

submission deadline 20 May 2026 | 3 articles | Viewed by 11219 | Submission Open

Keywords: microbiome; aging; age-related diseases; Alzheimer’ s; dementia

(This special issue belongs to the Section Molecular Microbiology)

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