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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Autoimmune Disorders: Molecular Mechanisms and Therapeutic Strategies submission deadline 29 Nov 2025 | Viewed by 258
Keywords: molecular mechanisms; immune signaling pathways; targeted therapies; biomarkers; autoimmune pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research and Cellular Biology of Breast Cancer submission deadline 30 Nov 2025 | 11 articles | Viewed by 23968 | Submission Open
Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor immune responses; conventional and biological therapies; blood and tissue biomarkers
(This special issue belongs to the Section Molecular Oncology)
Plant Extracts and Bioactive Molecules with Potential Benefits for Human Health submission deadline 30 Nov 2025 | 8 articles | Viewed by 20233 | Submission Open
Keywords: medicinal plants; plant extracts; bioactive phytocompound identification and quantification; pharmacological activity; health benefits; phytotherapy; plant-based diet; functional foods
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms and Therapies of Pancreatic Cancer: 2nd Edition submission deadline 30 Nov 2025 | 10 articles | Viewed by 19941 | Submission Open
Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy
(This special issue belongs to the Section Molecular Oncology)
Medicinal Plants and Bioactive Compounds in Health and Disease submission deadline 30 Nov 2025 | 9 articles | Viewed by 19446 | Submission Open
Keywords: obesity; diabetes; metabolic syndrome; metabolic-associated fat liver disease; inflammatory processes; free radicals and oxidative stress; phyto-compounds; medicinal plants; nutrition; physical exercises
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Natural Compounds: Advances in Antimicrobial Activity submission deadline 30 Nov 2025 | 8 articles | Viewed by 19073 | Submission Open
Keywords: natural compounds; multidrug-resistant microorganisms; biofilm; synergistic effect; nanotechnologies; delivery systems; machine learning; clinical infections
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Molecular Mechanisms and Markers in Inflammatory Disorders, 3rd Edition
edited by
submission deadline 30 Nov 2025 | 8 articles | Viewed by 17277 | Submission Open
Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling
(This special issue belongs to the Section Molecular Immunology)
Role of Calprotectin in Human Health and Disease submission deadline 30 Nov 2025 | 4 articles | Viewed by 15858 | Submission Open
Keywords: acute phase reactants; analysis; bacterial infection; biomarker; calprotectin; critical care; inflammation; turbidimetric
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioinformatics and Machine Learning for Predicting Biological Processes
edited by Hao Lv
submission deadline 30 Nov 2025 | 1 articles | Viewed by 14586 | Submission Open
Keywords: bioinformatics; machine learning; multi-omics integration; gene regulation; biological processes; disease processes; data-driven discovery
(This special issue belongs to the Section Molecular Informatics)
Environmental Stress and Metabolic Responses in Plants
edited by
submission deadline 30 Nov 2025 | 5 articles | Viewed by 14350 | Submission Open
Keywords: abiotic stress; acclimation; biotic stress; climate change; light stresses; oxidative stress; photoinhibition; redox regulation; signalling; stress alleviation; stress detection in plants
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Diagnostics and Treatment of Inflammatory Bowel Disease submission deadline 30 Nov 2025 | 3 articles | Viewed by 13243 | Submission Open
Keywords: IBD molecular pathogenesis; intestinal mucosal healing; gut microbiota in IBD; fecal microbiota transplantation; target therapy in IBD; stem cell therapy; biologic agents; small molecules; adhesion antagonists; inflammatory cytokines; lymphocyte control
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanomaterials and Biomaterials in Biomedicine Application submission deadline 30 Nov 2025 | 6 articles | Viewed by 12851 | Submission Open
Keywords: nanomaterials; biomaterials; biomedicine; drug delivery; regenerative medicine; healthcare technologies; biocompatible platforms
(This special issue belongs to the Section Materials Science)
Molecular Dynamics Simulations and Structural Analysis of Protein Domains (2nd Edition) submission deadline 30 Nov 2025 | 7 articles | Viewed by 11264 | Submission Open
Keywords: protein structures; molecular dynamics; advanced molecular dynamics; variants; pathologies; drug design; allostery; protein domains; secondary structures; methodological development; protein design; ligands; normal mode analysis; machine learning
(This special issue belongs to the Section Molecular Informatics)
Latest Advances in Plant Abiotic Stress
edited by
submission deadline 30 Nov 2025 | 5 articles | Viewed by 9283 | Submission Open
Keywords: abiotic stress factors; priming effects; defense responses; biochemical pathway analyses; transcriptomics; plant conditioners; next-generation sequencing; genome-wide analyses
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Clinical Aspects of Migraine and Its Comorbidities: Epilepsy, Stroke, and Restless Leg Syndrome
edited by and Michał Fila
submission deadline 30 Nov 2025 | 2 articles | Viewed by 9023 | Submission Open
Keywords: migraine; genetics and epigenetics of migraine; migraine comorbidities; omics in migraine studies; stem cells in migraine studies; epilepsy; stroke; restless leg syndrome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Melatonin: Physiological Effects on Health and Diseases
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 8739 | Submission Open
Keywords: hormone melatonin; oxidative stress; sleep; metabolism; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Nuclear Receptors in Diseases
edited by Roberto Palacios-Ramirez
submission deadline 30 Nov 2025 | 3 articles | Viewed by 8730 | Submission Open
Keywords: nuclear receptors; hormone receptors; orphan receptors; retinoid receptors; metabolic diseases; cancers; drug metabolism
(This special issue belongs to the Section Molecular Biology)
Molecular Progression of Genome-Related Diseases: 2nd Edition
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 8048 | Submission Open
Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health
(This special issue belongs to the Section Molecular Genetics and Genomics)
Multiple Sclerosis: The Latest Developments in Immunology and Therapy submission deadline 30 Nov 2025 | 4 articles | Viewed by 7924 | Submission Open
Keywords: multiple sclerosis; sensory disturbances; movement disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Renal Dysfunction, Uremic Compounds, and Other Factors (3rd Edition) submission deadline 30 Nov 2025 | 3 articles | Viewed by 7859 | Submission Open
Keywords: renal dysfunction; acute kidney disease; chronic kidney disease; soluble mediators; uremic toxins; disease progression; organ cross-talk; therapy; new techniques
(This special issue belongs to the Section Molecular Toxicology)
Role of NRF2 Pathway in Chronic Diseases submission deadline 30 Nov 2025 | 4 articles | Viewed by 6758 | Submission Open
Keywords: chronic diseases; NRF2; oxidative stress; inflammation; neurodegenerative diseases; cardiovascular disease; autoimmune diseases; chronic kidney diseases; liver disease
(This special issue belongs to the Section Biochemistry)
Mast Cells in Human Health and Diseases—3rd Edition
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 6038 | Submission Open
Keywords: mast cells; human diseases; pain; cardiovascular diseases; microbiome; food allergy; stress; cancer
(This special issue belongs to the Section Molecular Biology)
Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 5668 | Submission Open
Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’ s disease; therapeutics; healthy aging
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Microglia in Neurological Disorders: Potential Therapeutic Targets and Underlying Mechanisms
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 5486 | Submission Open
Keywords: cerebral amyloid angiopathy; Alzheimer's disease; amyloid-β fibril formation
(This special issue belongs to the Section Molecular Neurobiology)
Mitochondrial Biology and Reactive Oxygen Species submission deadline 30 Nov 2025 | 2 articles | Viewed by 5200 | Submission Open
Keywords: mitochondrial biology; mitochondrial dysfunction; mitochondrial coenzyme Q; metabolic homeostasis; oxidative stress; reactive oxygen species
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Soybean Molecular Breeding
edited by Dong Cao
submission deadline 30 Nov 2025 | 4 articles | Viewed by 5184 | Submission Open
Keywords: soybean; plant architecture; adaptation; yield improvement; molecular breeding; nutritional quality traits; stress tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Iron Metabolism, Ferritin and Hepcidin Research: 3rd Edition
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4580 | Submission Open
Keywords: iron; hepcidin; ferroportin; ferritin; regulation; anemia; therapies; cell signaling; inflammation; disorders
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Cardiovascular Diseases: Aging and Other Risk Factors
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 4215 | Submission Open
Keywords: aging; hypertension; endothelium; vascular smooth muscle cells; pulmonary hypertension; atherosclerosis; hyperlipidemia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Dermatology: Advances in Pathophysiology and Therapies (3rd Edition) submission deadline 30 Nov 2025 | 3 articles | Viewed by 4120 | Submission Open
Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immunophenotyping in Autoimmune Diseases and Cancer, 4th Edition submission deadline 30 Nov 2025 | 2 articles | Viewed by 3956 | Submission Open
Keywords: immunophenotyping; immune regulation; multiparameter cytometry; immuno-oncology; anti-tumor immunity; autoimmunity; cancer immunology; protein– protein interactions; structure/function relationships; sulfur amino acids
(This special issue belongs to the Section Molecular Immunology)
Exploring the Cytoskeleton and Its Regulators: From Structure to Function
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3841 | Submission Open
Keywords: cytoskeleton; cytoskeleton-binding protein; cytoskeletal protein; cell signaling; mechanotransduction; cell proliferation; cell migration; cellular motility; cell differentiation; structural biology
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Treatment of Retinal Diseases
edited by and
submission deadline 30 Nov 2025 | 3 articles | Viewed by 3826 | Submission Open
Keywords: nutritional supplementations; high myopia; optometry; cell therapy; drug delivery; age-related macular degeneration; glaucoma; retinal degeneration; choroidal thinning; scleral remodeling; light therapy; digital healthcare; prematurity of retionopathy; carotid artery occlusion; retinal ischemia; inflammation; eye drop
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Neurological and Psychiatric Disease, 2nd Edition
edited by and Maria Meringolo
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3547 | Submission Open
Keywords: Alzheimer's and Parkinson's diseases; epilepsy; migraine; essential tremors; stroke; depression; anxiety disorders; cognitive impairment
(This special issue belongs to the Section Molecular Neurobiology)
Translational Oncology: From Molecular Basis to Therapy
edited by and Gatti Veronica
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3524 | Submission Open
Keywords: cancer; therapy resistance; translational oncology; cancer stem cells; immunotherapy; cancer metabolism; OMICS; patient-derived-organoids; drug repositioning; TKI
(This special issue belongs to the Section Molecular Oncology)
Molecular Cages: Design, Synthesis, and Applications submission deadline 30 Nov 2025 | 1 articles | Viewed by 2905 | Submission Open
Keywords: molecular cages; supramolecular chemistry; synthetic chemistry; self-assembly; molecular design; host– guest chemistry; biological applications
(This special issue belongs to the Section Macromolecules)
Pancreatic Disease: From Molecular Basis to Novel Therapies—2nd Edition submission deadline 30 Nov 2025 | 3 articles | Viewed by 2830 | Submission Open
Keywords: pancreatitis; acinar-to-ductal neoplasia; early pancreatic neoplasia; fibroinflammatory disease; pancreatic cancer; diabetes Mellitus
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Natural Compounds in Immune-Inflammatory Regulation: Mechanisms and Therapeutics
edited by Dae-Hun Park, Chun-Sik Bae and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2810 | Submission Open
Keywords: natural compound; immune-inflammatory regulation; mechanism; cytokine; NF-κ B/COX-2; PGE2
(This special issue belongs to the Section Molecular Immunology)
Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI
edited by and
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2686 | Submission Open
Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant– pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants
(This special issue belongs to the Section Molecular Informatics)
Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications submission deadline 30 Nov 2025 | 2 articles | Viewed by 2586 | Submission Open
Keywords: oncogenes; tumor suppressors; cancer biology; molecular mechanisms; tumor microenvironment; biomarkers; targeted cancer therapy; cancer initiation and progression
(This special issue belongs to the Section Molecular Oncology)
Steroids in Human Disease and Health
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2523 | Submission Open
Keywords: steroid metabolism; steroids and endocrinopathies; steroids and inflammation; corticosteroids; mineralocorticoids; neuroactive steroids; steroids and neuropsychiatric diseases; steroids and reproduction; steroidomics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Bioinformatics of Gene Regulations and Structure–2025 submission deadline 30 Nov 2025 | 4 articles | Viewed by 2399 | Submission Open
Keywords: gene expression regulation; bioinformatics and systems biology; NGS data analysis of gene expression; ncRNA networks; computer genomics of model organisms; fundamental biomedicine model; regulatory gene networks; AI tools in bioinformatics
(This special issue belongs to the Section Molecular Informatics)
Impact of Circulatory and Blood Clotting Dysfunctions in Infectious Diseases
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2379 | Submission Open
Keywords: infectious diseases; circulatory dysfunction; coagulation disorders; endothelial activation; platelet aggregation; anticoagulant therapy; diagnostic biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Study on Organellar Genomes of Vascular Plants submission deadline 30 Nov 2025 | 3 articles | Viewed by 2292 | Submission Open
Keywords: mitochondrial DNA (mtDNA); chloroplast DNA (cpDNA); plant evolution; plant organellar genome; genomics
(This special issue belongs to the Section Molecular Plant Sciences)
The Innate Immune System in Renal Diseases
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 2285 | Submission Open
Keywords: innate immune system; acquired immunity; complement system; dendritic cells; monocyte/macrophages (Mϕ); polymorphonuclear leukocytes; NK/NKT cells; innate lymphoid cells (ILCs); AKI; CKD
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Venom and Antivenom
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2008 | Submission Open
Keywords: venom; antivenom; mass spectroscopy; spectrophotometry; thromboelastography; coagulation; neuromuscular junction
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence
edited by and Inês Bártolo
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1917 | Submission Open
Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus– host interactions; HIV eradication strategies
(This special issue belongs to the Section Molecular Biology)
State-of-the-Art Molecular Genetics and Genomics in Poland: 3rd Edition submission deadline 30 Nov 2025 | 2 articles | Viewed by 1890 | Submission Open
Keywords: RNA; DNA; DNA structure; damage; and repair; post-translational modifications; autophagy; cell cycle; gene expression; functions and therapy; mutation; nuclear organization; polymerase; nucleic acid– protein interactions; molecular clone; sequencing analysis; epigenetics; transcriptomics; genetics of aging; genetic disorders; SNP; etc
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cellular and Molecular Mechanisms of Blood–Brain Barrier (BBB) Dysfunction and Dementia
edited by Mark Slevin
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1861 | Submission Open
Keywords: blood– brain barrier; Alzheimer’ s disease; endothelial dysfunction; amyloid beta; tau; neuroinflammation; oxidative stress; aging; gut– brain axis; therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Micro-RNA in Gastrointestinal Cancers—from Molecules to Novel Therapies
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1830 | Submission Open
Keywords: micro-RNA; gastrointestinal cancer; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; neuroendocrine tumor; esophageal cancer; gallbladder cancer; rectal cancer
(This special issue belongs to the Section Molecular Oncology)
Enhancing Stem Cell Grafting in Tissue Regeneration and Repair
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1789 | Submission Open
Keywords: stem cell therapy; tissue regeneration; graft enhancement; molecular mechanisms; engraftment; biomaterials; immunomodulation
(This special issue belongs to the Section Molecular Biology)
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