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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Galectins (Gals), 2nd Edition
edited by
submission deadline 10 Aug 2025 | 5 articles | Viewed by 2881 | Submission Open
Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers
(This special issue belongs to the Section Molecular Biology)
Molecular Characterization and Applications of Nanomaterials in Nanomedicine and Cancer Therapy
edited by
submission deadline 15 Aug 2025 | 2 articles | Viewed by 1624 | Submission Open
Keywords: nanomaterials (preparation methods; characterization techniques; properties); theoretical studies of nanomaterials and computational simulations; biocompatibility and biofunctionalization; applications in nanomedicine; applications in cancer therapy; drug delivery; nanoparticle imaging; magnetic resonance imaging (MRI); contrast agents; nanotheranostics
(This special issue belongs to the Section Molecular Nanoscience)
Molecular and Cellular Therapies Barriers and Opportunities submission deadline 15 Aug 2025 | Viewed by 161 | Submission Open
Keywords: gene therapy; gene editing; RNA therapy; RNA editing; protein therapy; stem cells; cell therapy; genomics; proteomics; molecular pathology
(This special issue belongs to the Section Molecular Biology)
The Role of the Gut and Oral Microbiota in Neurodevelopment: Molecular Biological Insights
edited by Ioannis Alexandros Charitos
submission deadline 15 Aug 2025 | Viewed by 127 | Submission Open
Keywords: neuroscience; central nervous system; peripheral nervous system; human microbiota; metabolome; gut– oral-microbiota– brain axis; neurodevelopment disorders; cognitive modulation; neurodegenerative diseases; psychobiotics
(This special issue belongs to the Section Molecular Microbiology)
Novel Therapeutic Strategies for Gynecological Cancer
edited by
submission deadline 15 Aug 2025 | Viewed by 116 | Submission Open
Keywords: gynecological cancer; therapeutic strategies; genomic medicine; multimodality treatment; biomarker; molecular targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 37494 | Submission Open
Keywords: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); diagnosis; post-exertional malaise (PEM); comorbidity; biomarker; therapy; immunity; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Targeted Therapies of Breast Cancer
edited by , Karolina Jabłońska and
submission deadline 20 Aug 2025 | 9 articles | Viewed by 30459 | Submission Open
Keywords: breast cancer; cancer progression; cancer metastasis; tumor microenvironment; molecular mechanisms; molecular markers; epigenetics; genomics; transcriptomics; EMT; targeted therapies; signaling pathways; exosomes; EMT; hormonal regulation; drugs; apoptosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Bioactive Nutrients Promoting Human Health
edited by
submission deadline 20 Aug 2025 | 11 articles | Viewed by 22576 | Submission Open
Keywords: bioactive nutrients; antioxidants; anti-inflammatory; disease prevention; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Retinal Degenerative Diseases: 2nd Edition submission deadline 20 Aug 2025 | 6 articles | Viewed by 22570 | Submission Open
Keywords: retina; photoreceptor degenerative diseases; inherited retinal degenerations; glaucoma; retinal pigment epithelial cells; retinal ganglion cells (RGCs); neuronal degeneration; glial activation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Trace Elements in Nutrition and Health
edited by Jie Feng
submission deadline 20 Aug 2025 | 8 articles | Viewed by 20361 | Submission Open
Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Research of Skin Inflammation and Related Diseases submission deadline 20 Aug 2025 | 9 articles | Viewed by 20276 | Submission Open
Keywords: skin; inflammation; molecular target; inflammatory skin diseases; psoriasis; urticaria; atopic dermatitis; systemic sclerosis; skin fibrosis; immune system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites
edited by
submission deadline 20 Aug 2025 | 12 articles | Viewed by 19150 | Submission Open
Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Neurodegenerative Diseases Research and Therapy—Third Edition
edited by
submission deadline 20 Aug 2025 | 8 articles | Viewed by 18049 | Submission Open
Keywords: neurodegenerative diseases; therapy; molecular mechanisms; neuron; astrocytes; microglia; inflammation; brain; drug delivery
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Skin Cancer Pathology: From Pathogenesis to Precision Therapies submission deadline 20 Aug 2025 | 4 articles | Viewed by 17666 | Submission Open
Keywords: skin cancer; melanoma; non-melanoma; immunotherapy; cutaneous malignancies; targeted therapy; early detection
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Diagnostics and Genomics of Tumors
edited by
submission deadline 20 Aug 2025 | 14 articles | Viewed by 16845 | Submission Open
Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Cytokines in Inflammatory Signaling: 2nd Edition submission deadline 20 Aug 2025 | 8 articles | Viewed by 16831 | Submission Open
Keywords: cytokines; inflammation; autoimmune diseases; immune homeostasis; signaling pathway; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Links between Sensory Nerves, Inflammation, and Pain 3.0 submission deadline 20 Aug 2025 | 5 articles | Viewed by 15278 | Submission Open
Keywords: sensory neuropeptides; inflammation; neurogenic inflammation; pain; arthritis; colitis; neuropathy; migraine; novel drug targets; TRP channels; neuroinflammation
(This special issue belongs to the Section Molecular Biology)
Photodynamic Therapy and Photodetection, 2nd Edition
edited by
submission deadline 20 Aug 2025 | 11 articles | Viewed by 14729 | Submission Open
Keywords: photodynamic therapy (PDT); photodetection (PD); photosensitiser; photochemical internalization (PCI); quantum dots; nanoparticles; nanotechnology; targeted therapy; immunotherapy; vaccines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Targeted Therapies and Drugs in Cancer submission deadline 20 Aug 2025 | 6 articles | Viewed by 14338 | Submission Open
Keywords: targeted therapies; genetic mutation; PARP inhibitors; immunotherapy; drug development; cancer molecular analysis; drug response; molecular-targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exercise and Health: Cellular and Molecular Perspectives
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 14016 | Submission Open
Keywords: promoting health; anti-inflammatory action; anti-ageing action; mental health; mitochondrial adaptation; cellular function; regulation of gene expression; metabolic response to exercise
(This special issue belongs to the Section Molecular Biology)
Neurodegenerative Disease: From Molecular Basis to Therapy, 3rd Edition
edited by
submission deadline 20 Aug 2025 | 7 articles | Viewed by 13881 | Submission Open
Keywords: neurodegenerative diseases; molecular biology; neurogenetics; pathogenesis; therapy; personalized medicine
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Pathophysiology of Lung Diseases
edited by and Brenda M. Juan-Guardela
submission deadline 20 Aug 2025 | 5 articles | Viewed by 13825 | Submission Open
Keywords: biomarkers; asthma; COPD; pulmonary fibrosis; post-COVID-19 interstitial lung disease; pathogenesis; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Responses to Abiotic and Biotic Stresses
edited by and
submission deadline 20 Aug 2025 | 15 articles | Viewed by 13446 | Submission Open
Keywords: climate change and crop production; abiotic stress; biotic stress; plant resistance to abiotic and biotic stresses; molecular mechanism; physiological responses; plant hormones; carbohydrate metabolism and transport; molecular signaling; reactive oxygen species (ROS); calcium ions; photosynthesis; respiration; energy metabolism
(This special issue belongs to the Section Molecular Plant Sciences)
Biomedical Applications of Mesenchymal Stem Cells submission deadline 20 Aug 2025 | 7 articles | Viewed by 13392 | Submission Open
Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Application of Mass Spectrometry and Chromatography in Biomedicine
edited by
submission deadline 20 Aug 2025 | 8 articles | Viewed by 13296 | Submission Open
Keywords: mass spectrometry; chromatography; LC-MS; GC-MS; biomarker discovery; pharmaceuticals; metabolimics; proteomics; lipidomics
(This special issue belongs to the Section Molecular Biophysics)
Computational Molecular Biology of Metabolic Pathways and Signal Transduction Pathways
edited by Ralf Herwig
submission deadline 20 Aug 2025 | 8 articles | Viewed by 13247 | Submission Open
Keywords: computational genomics; computational structural and molecular biology; molecular dynamics simulations; artificial intelligence; AI-driven drug design and development; molecular modeling; computer-aided drug design; computational proteomics; computational and theoretical chemistry
(This special issue belongs to the Section Molecular Biology)
Roles and Mechanisms of Non-Coding RNAs in Human Health and Disease submission deadline 20 Aug 2025 | 10 articles | Viewed by 13114 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; polymorphisms; cancer; degenerative diseases; therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Approach to Fern Development
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 12541 | Submission Open
Keywords: apomixis; apogamy; asexual reproduction; fern; proteomics; genomics; plant development; evo-devo; plant biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Viral Infection and Virology Methods
edited by
submission deadline 20 Aug 2025 | 6 articles | Viewed by 12471 | Submission Open
Keywords: acute and chronic viral infection; molecular mechanism; new methodologies; emerging disease; innate and adaptive immunity
(This special issue belongs to the Section Molecular Microbiology)
Novel Therapeutic Targets in Cancers: 3rd Edition
edited by
submission deadline 20 Aug 2025 | 6 articles | Viewed by 12461 | Submission Open
Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy
(This special issue belongs to the Section Molecular Oncology)
Innovative Strategies to Target Metabolism, Inflammation, and Oxidative Stress in Human Diseases
edited by
submission deadline 20 Aug 2025 | 11 articles | Viewed by 12030 | Submission Open
Keywords: metabolism; inflammation; oxidative stress; diabetes; aging; cardiovascular diseases; gene editing; stem cell therapy; next-generation sequencing; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Epigenetic Genes, Biomarkers and Immunotherapy in Cancers submission deadline 20 Aug 2025 | 5 articles | Viewed by 12021 | Submission Open
Keywords: epigenetics; epigenetic modifications; immunotherapies; immune checkpoint; DNA methylation; histone modifications; epigenetic biomarkers; epidrugs; endogenous retroviruses
(This special issue belongs to the Section Molecular Oncology)
Molecular and Cellular Advances in Endometriosis Research: 3rd Edition submission deadline 20 Aug 2025 | 3 articles | Viewed by 11879 | Submission Open
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms and Regulation in Chronic Kidney Diseases
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 11711 | Submission Open
Keywords: chronic kidney disease; pathophysiology; genetic and epigenetic factors; metabolic and inflammatory pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurological Disorders: Molecular Pathology and Therapeutic Approaches submission deadline 20 Aug 2025 | 4 articles | Viewed by 11661 | Submission Open
Keywords: The following topics are proposed for this SI:Intracellular signalling networks in neurological disorders.Identification of new therapeutic targets.Genetics of neurological disorders: identification and treatment of mutations.Mitochondrial diseases and neurodegeneration.Gene therapy in neurological diseases: recent advances.Neuroinflammation in autoimmune disorders of the central nervous system.Impact of the microbiome on neurological health.
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antioxidant, Anti-Inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights submission deadline 20 Aug 2025 | 3 articles | Viewed by 11630 | Submission Open
Keywords: phytochemicals; antioxidant activities; anti-inflammatory properties; antimicrobial effects; molecular mechanisms; clinical applications; traditional medicine; bioavailability; safety and toxicology and regulatory aspects of phytochemicals; pharmacological interaction
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of Glycosaminoglycans in Human Diseases
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 11614 | Submission Open
Keywords: glycosaminoglycans; inflammation; infectious disease; cancer
(This special issue belongs to the Section Biochemistry)
Molecular Research on Epigenetic Modifications
edited by , Mariella Cuomo and
submission deadline 20 Aug 2025 | 4 articles | Viewed by 11588 | Submission Open
Keywords: epigenetic modifications; chromatin remodeling; transcription factors; RNA modification; histones; methylation; diseases; epigenetic drugs development
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Insights into CKD and Age-Related Bone and Mineral Disorders submission deadline 20 Aug 2025 | 4 articles | Viewed by 11529 | Submission Open
Keywords: chronic kidney disease; CKD; CKD-MBD; mineral and bone disorder
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
State-of-the-Art Cancer Immunotherapies—2nd Edition submission deadline 20 Aug 2025 | 5 articles | Viewed by 11166 | Submission Open
Keywords: immune checkpoint inhibitors; antibody therapy; cytokines/chemokines; CAR-T and TCR-T cells; iPS cell-derived cells; dendritic cell therapy; vaccine; inflammation; mesenchymal stem cells; immunosuppressive tumor microenvironment
(This special issue belongs to the Section Molecular Immunology)
Novel Molecular Targets and Prognostic Markers Focused on Improving Quality in Healthcare
edited by
submission deadline 20 Aug 2025 | 6 articles | Viewed by 11096 | Submission Open
Keywords: prognostic markers; molecular targets; diagnostic tools
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Calcium Metabolism and Regulation
edited by Hermann Salmhofer and
submission deadline 20 Aug 2025 | 4 articles | Viewed by 10761 | Submission Open
Keywords: pathologic calcification; calcification inhibitors; calciprotein particles; Runx-2; apatite; matrix Gla protein; fetuin-A; vitamin D; parathyroid hormone
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advanced Research on Protein Structure and Protein Dynamics
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 10708 | Submission Open
Keywords: allostery; receptor; kinase; protein folding; simulations; X-ray crystallography; NMR; super-resolution imaging; fluorescence fluctuation techniques; thermodynamic; enzyme; catalysis; artificial intelligence
(This special issue belongs to the Section Molecular Biology)
Gastrointestinal Cancer: From Pathophysiology to Novel Therapeutic Approaches submission deadline 20 Aug 2025 | 4 articles | Viewed by 10542 | Submission Open
Keywords: gastrointestinal cancer; molecular pathology; innovative therapies; targeted therapy; immunotherapy; cancer resistance
(This special issue belongs to the Section Molecular Oncology)
Advances in Rare Diseases Biomarkers: 2nd Edition
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 10369 | Submission Open
Keywords: orphan diseases; rare diseases; inborn errors of metabolism; mitochondrial disorders; biomarker discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular and Cellular Research in Ophthalmology submission deadline 20 Aug 2025 | 5 articles | Viewed by 10279 | Submission Open
Keywords: eye disease; ophthalmology; molecular mechanisms; cellular mechanism; stem cell therapy; tissue engineering; gene therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Tendinopathy: Unraveling the Pathogenesis of Tendon Diseases
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 10128 | Submission Open
Keywords: tendinopathy; tendon pain; stiffness; physical disability; etiopathogenesis; molecular mechanisms; tendon reattachment; tendon repair; advanced molecular tools; omics techniques; biophysical therapies; novel biomaterials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Study and Treatment of Motor Neuron Diseases
edited by Simona Rossi and
submission deadline 20 Aug 2025 | 3 articles | Viewed by 9994 | Submission Open
Keywords: motor neuron; amyotrophic lateral sclerosis; neuronal degeneration; pathogenic mechanisms; molecular therapy
(This special issue belongs to the Section Molecular Neurobiology)
The Na, K-ATPase in Health and Disease
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 9955 | Submission Open
Keywords: Na+; K+-ATPase; α -subunit; β -subunit; γ   subunits; FXYD
(This special issue belongs to the Section Molecular Biology)
Advances in Immunology and Inflammation During and After Infectious Diseases
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 9893 | Submission Open
Keywords: bacterial infections; fungi infections; HIV; COVID-19; immune response; inflammation
(This special issue belongs to the Section Molecular Immunology)
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