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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Post-transcriptional and Epigenetic Mechanisms Controlling Stem Cells Differentiation

edited by

Sorina Dinescu

submission deadline 29 Nov 2024 | 2 articles | Viewed by 1780

Keywords: stem cell differentiation; adipogenesis; neurogenesis; epigenetics; post-transcriptional modification; ncRNAs

(This special issue belongs to the Section Molecular Biology)

Mg2+ Transport and Mg Homeostasis: From Molecular Science to Clinical Praxis

edited by

Martin Kolisek

submission deadline 29 Nov 2024 | 1 articles | Viewed by 1671

Keywords: magnesium; Mg2+ transport; Mg homeostasis; Mg therapy; magnesiopathy; cellular energetics; biomedicine and translational medicine; human ailments; biochemistry; Mg in cellular regulation and signaling

(This special issue belongs to the Section Molecular Biology)

Research Advances in the Bioinformatics of Genome Editing and Gene Function Analysis

edited by

Hidemasa Bono

submission deadline 29 Nov 2024 | 1 articles | Viewed by 1444

Keywords: genome editing; functional genomics; genome analysis; transcriptome analysis; metagenome analysis; meta-analysis; bioinformatics; large language model (LLM); public databases

(This special issue belongs to the Section Molecular Informatics)

Effect of Plant Bioactives and Their Constituents on Human Cell Activity

edited by

Sung-Hoon Kim

submission deadline 29 Nov 2024 | 1 articles | Viewed by 1086

Keywords: oriental prescriptions; herbal extracts; natural compounds; inflammation; cancer; immune; thrombosis; biological activity

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Therapeutic Potential of Mesenchymal Stromal Cells

edited by Carlo Tremolada and

Dragan Primorac

submission deadline 29 Nov 2024 | Viewed by 347

Keywords: mesenchymal stromal cells; growth factor; immunomodulation; regenerative medicine; orthopaedics

(This special issue belongs to the Section Molecular Biology)

Lipid Droplet–Mitochondria Interactions in Health and Disease

edited by Anton Petcherski

submission deadline 29 Nov 2024 | Viewed by 334

Keywords: mitochondria; lipid droplets; metabolism; lipotoxicity; metabolically active tissue; triacylglycerides; fatty acid oxidation

(This special issue belongs to the Section Biochemistry)

How Aging Results in Cognitive Decline: Molecular Mechanisms

edited by Holly Christian Hunsberger

submission deadline 29 Nov 2024 | Viewed by 256

Keywords: aging; memory; hippocampus; neurodegeneration; sex; gender; exercise; synapses; metabolism; mitochondria

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Bacterial Epigenomics

edited by

Camilla Fagorzi

submission deadline 29 Nov 2024 | Viewed by 181

Keywords: bacterial epigenomics; DNA methylation; histone-like proteins; sRNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gut Microbiota in Human Disease and Health

edited by

Silvia Turroni

submission deadline 30 Nov 2024 | 4 articles | Viewed by 20006 | Submission Open

Keywords: gut microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation

(This special issue belongs to the Section Molecular Microbiology)

Immunopathogenesis and Novel Therapeutics Strategies of Systemic Lupus Erythematosus 2.0

edited by

Marzena Olesińska

and

Przemysław Kotyla

submission deadline 30 Nov 2024 | 7 articles | Viewed by 17253 | Submission Open

Keywords: systemic lupus erythematosus; SLE pathogenesis; the epigenetic regulation of lupus; the genetic background of SLE; interferon; cytokine networks; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Carbon–Multidisciplinary Investigations and Innovative Solutions

edited by

Magdalena Krystyjan

submission deadline 30 Nov 2024 | 8 articles | Viewed by 15545 | Submission Open

Keywords: carbons; innovative materials; green technology; carbon nanomaterials; carbon nanostructure

(This special issue belongs to the Section Materials Science)

Gene Mining and Germplasm Innovation for the Important Traits in Rice

edited by

Yongmei Bao

and

Shimin Zuo

submission deadline 30 Nov 2024 | 10 articles | Viewed by 13956 | Submission Open

Keywords: rice; gene mining; disease resistance; molecular design; gene editing; germplasm innovation

(This special issue belongs to the Section Molecular Plant Sciences)

Antioxidant, Anti-inflammatory, and Antiproliferative Activities of Natural Products—2nd Edition

edited by

Bruno Eto

submission deadline 30 Nov 2024 | 8 articles | Viewed by 12547 | Submission Open

Keywords: bioactive products; anti-infectives; antioxidants; anti-inflammatory; antiproliferative; clinical phytopharmacology; phytopharmacology; polyphytotherapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Protein Structure Research 2024

edited by

Istvan Simon

and

Csaba Magyar

submission deadline 30 Nov 2024 | 9 articles | Viewed by 12524 | Submission Open

Keywords: fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins

(This special issue belongs to the Section Molecular Biophysics)

Lipopolysaccharides 2.0

edited by

Satish Raina

and

Gracjana Klein

submission deadline 30 Nov 2024 | 6 articles | Viewed by 12221 | Submission Open

Keywords: lipid A and its biosynthesis; assembly and transport of LPS; regulation of the LpxC; chemical structure; regulated LPS modifications; LPS and virulence; recognition of LPS by immune system; antibiotic resistance; vaccines; envelope stress

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of the Thyroid Cancer and Thyroid Dysfunctions

edited by Vija Lavinia

submission deadline 30 Nov 2024 | 7 articles | Viewed by 11469 | Submission Open

Keywords: animal models; apoptosis; autophagy; cancer biomarker; cancer epidemiology; cancer prevention; cancer screening; cholesterol metabolism; clinical trial; DNA repair; epigenomics; genome instability; genomic database; genomics; invasion; metabolomics; metastasis; methylation; microarray; microRNA; molecular diagnostics; molecular tumor pathology; next-generation sequencing; noncoding RNA; omics; personalized medicine; prognosis; proteomics; radionuclide therapy; signaling pathway; SNP genotyping; targeted therapy; theranostics; thyroid cancer; hyperthyroidism; therapeutic targets; translational cancer research; treatment response; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

The Role of Natural Compounds in Cancer and Inflammation

edited by

Elia Ranzato

submission deadline 30 Nov 2024 | 7 articles | Viewed by 10929 | Submission Open

Keywords: natural compounds; oxidative stress; anti-cancer; anti-inflammatory; natural product synthesis and biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Dermatology: Advances in Pathophysiology and Therapies (2nd Edition)

edited by

Montserrat Fernández-Guarino

, Belén De la Hoz and

Javier Martínez-Botas

submission deadline 30 Nov 2024 | 5 articles | Viewed by 10228 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mixed Biofilms: Interbacterial Interactions and Antimicrobial Susceptibility

edited by

Airat Kayumov

submission deadline 30 Nov 2024 | 4 articles | Viewed by 9803 | Submission Open

Keywords: bacteria; micromycetes; biofilm; mixed biofilm; susceptibility to antimicrobials; synergy; molecular mechanisms of interbacterial interaction

(This special issue belongs to the Section Molecular Microbiology)

The Application of Biomaterials in Bone Tissue Repair and Regeneration

edited by

Jacek Matys

submission deadline 30 Nov 2024 | 4 articles | Viewed by 9636 | Submission Open

Keywords: allograft; autograft; autologous bone; bone; graft materials; mineral substitutes; regeneration

(This special issue belongs to the Section Materials Science)

Molecular Advances in Epilepsy and Seizures

edited by Sara Matricardi

submission deadline 30 Nov 2024 | 5 articles | Viewed by 9154 | Submission Open

(This special issue belongs to the Section Molecular Neurobiology)

Transcription Factors in Lung Cancer: Mechanisms and Future Perspectives

edited by

Kostas A. Papavassiliou

and

Athanasios G. Papavassiliou

submission deadline 30 Nov 2024 | 4 articles | Viewed by 9045 | Submission Open

Keywords: transcription factors; lung cancer; NSCLC SCLC; targeting; biomarkers; tumor suppressors; oncogenes; transcription factor network; computational models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Therapeutics for Diabetes and Related Complications

edited by

Kota V. Ramana

submission deadline 30 Nov 2024 | 8 articles | Viewed by 8987 | Submission Open

Keywords: diabetes; diabetes complications; molecular therapeutics; drug development; hyperglycemia; insulin resistance; cell signaling and oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Regenerative Medicine

edited by

Alberto Ruffilli

and

Cesare Faldini

submission deadline 30 Nov 2024 | 4 articles | Viewed by 8854 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Biostimulants

edited by

Michael Moustakas

and Julietta Moustaka

submission deadline 30 Nov 2024 | 5 articles | Viewed by 8835 | Submission Open

Keywords: biostimulants; abiotic stresses; biotic stresses; plant growth promoter; stress acclimation; oxidative damage; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Genome Editing

edited by Lei Gao

submission deadline 30 Nov 2024 | 5 articles | Viewed by 8790 | Submission Open

Keywords: plant genome editing; Cas9/Cas12a; CRISPR/CRISPRa/CRISPRi; anti-CRISPR; gene editing; off target impact; prime editing; bioinformatics/database

(This special issue belongs to the Section Molecular Plant Sciences)

Antimicrobial Peptides: Structure and Mechanism of Biological Activity: 3rd Edition

edited by

Juan Borrero

submission deadline 30 Nov 2024 | 5 articles | Viewed by 8668 | Submission Open

Keywords: antimicrobial peptides; mechanism of biological activity; functional diversity of peptides; structural analysis of peptides; dynamic conformation of peptides; lipid composition of the cell membrane; peptide– lipid interactions; peptide self-association; peptide-lipid complex formation; peptide– intracellular receptor interaction; peptide translocation through membrane; cell morphology; peptide interaction with infectious agents; surface properties of the cell; peptide interaction with the cell in vivo

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellar Research of Spine and Spinal Cord Injury

edited by

Javad Tavakoli

and Joanne Tipper

submission deadline 30 Nov 2024 | 3 articles | Viewed by 8640 | Submission Open

Keywords: pine; spinal cord; intervertebral disc; tissue engineering; regenerative medicine; cell therapy; molecular therapy; injury models; organ-on-a-chip and microfluidic systems for cell therapy; mechanobiology; spinal implants wear particle; safety and efficacy

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Plant Virus Diseases and Virus-Induced Resistance

edited by

Pedro Martínez-Gómez

and Muqing Zhang

submission deadline 30 Nov 2024 | 6 articles | Viewed by 7924 | Submission Open

Keywords: virus detection; virus characterization; virus resistance; gene silencing; epigenetic regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Sphingolipids

edited by

Elisabetta Meacci

submission deadline 30 Nov 2024 | 4 articles | Viewed by 7537 | Submission Open

Keywords: sphingolipids; ceramide; sphingosine; sphingosine 1-phosphate; ceramide 1-phosphate; glycosphingolipids; diabetes; insulin resistance; beta-cell failure; NAFLD; cardiovascular disease; metabolic dysfunction

(This special issue belongs to the Section Molecular Biology)

Molecular Perspective of Cardiovascular Diseases

edited by

Silvia S. Barbieri

submission deadline 30 Nov 2024 | 6 articles | Viewed by 7083 | Submission Open

Keywords: cardiovascular diseases; cardiology; inflammation; atherosclerosis; cardiomyopathy; endothelial cell

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Development, Characterization and Applications of Novel Polymeric Materials and Composites

edited by

Daniel Dumitru Banciu

and

Xiao Hu

submission deadline 30 Nov 2024 | 5 articles | Viewed by 7065 | Submission Open

Keywords: diagnosis; therapy; polymers; composite materials; theoretical model

(This special issue belongs to the Section Macromolecules)

New Insights into Gut Microbiota and Immunity

edited by

Maria Pascual

submission deadline 30 Nov 2024 | 5 articles | Viewed by 6978 | Submission Open

Keywords: gut; microbiota; immune response; infectious disease; cancer; brain function; metabolism; endocrine signaling; pathological conditions; therapy

(This special issue belongs to the Section Molecular Immunology)

The Role of Cytokines in Diseases

edited by

Svetlana Khaiboullina

submission deadline 30 Nov 2024 | 4 articles | Viewed by 6853 | Submission Open

Keywords: cytokines; inflammation; immune response; genetics; epigenetics; disease; infection; pathogen-associated molecular patterns; damage-associated molecular patterns; pattern-recognizing receptors; treatment

(This special issue belongs to the Section Biochemistry)

The Role of Bioactive Compounds in Human Health and Disease: 2nd Edition

edited by

Guan-Jhong Huang

submission deadline 30 Nov 2024 | 6 articles | Viewed by 6844 | Submission Open

Keywords: cancer; inflammation; cardiovascular diseases; plants; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Nanoparticles in Nanobiotechnology and Nanomedicine: 2nd Edition

edited by

Costica Caizer

submission deadline 30 Nov 2024 | 4 articles | Viewed by 6786 | Submission Open

Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology

(This special issue belongs to the Section Molecular Nanoscience)

New Insights into Antimicrobial Nanoparticles: From Mechanisms to Applications

edited by

Evgenii Plotnikov

submission deadline 30 Nov 2024 | 3 articles | Viewed by 6545 | Submission Open

Keywords: antimicrobial nanoparticles; alternative to antibiotics; physical and chemical activation of nanoparticles; multi-drug resistance; mechanisms of anti-infective action

(This special issue belongs to the Section Molecular Nanoscience)

Innovative In Vitro Model for Medical, Pharmaceutical and Diagnostic Applications

edited by

Barbara Tomasello

Rosaria Acquaviva

and

Jean Viallet

submission deadline 30 Nov 2024 | 4 articles | Viewed by 6165 | Submission Open

Keywords: in vitro 3D models; organoids; drug and nutraceutical screening; preclinical imaging; tissue engineering; precision and regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

External Stimuli-Responsive Nanomaterials for Diagnosis and Treatment

edited by

Loredana Ricciardi

submission deadline 30 Nov 2024 | 2 articles | Viewed by 6053 | Submission Open

Keywords: nanotechnology; external stimuli-responsive nanomaterials; nanotheranostic systems; biodetection; bioimaging; plasmonics

(This special issue belongs to the Section Molecular Nanoscience)

Autophagy, Cellular Senescence and Oxidative Stress in Ageing and Age-Related Diseases

edited by

Varvara Trachana

submission deadline 30 Nov 2024 | 3 articles | Viewed by 5987 | Submission Open

Keywords: autophagy; oxidative stress; antioxidants; homeostasis; senescence; ageing; age-related diseases; reactive oxygen species; macromolecular damage; cytotoxic stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stress, Immunity, and Tissue Microenvironment: 2nd Edition

edited by

Massimo Conese

and

Arcangelo Liso

submission deadline 30 Nov 2024 | 3 articles | Viewed by 5749 | Submission Open

(This special issue belongs to the Section Molecular Immunology)

Novel Insight into Epigenomic Studies of Human Disease

edited by

Mitsuko Masutani

and Takashi Ito

submission deadline 30 Nov 2024 | 5 articles | Viewed by 5303 | Submission Open

Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cellular and Molecular Biology of Mitochondria in Human Health and Diseases

edited by

Satoshi Gojo

submission deadline 30 Nov 2024 | 3 articles | Viewed by 5197 | Submission Open

Keywords: mitochondria; mitophagy; oxidative phosphorylation; apoptosis; integrated stress response; heteroplasmy; calcium dynamics; reactive oxygen species; fusion/fission; mitochondrial quality control

(This special issue belongs to the Section Molecular Biology)

Gene Transfer in Brain Disorders

edited by

Tam Thanh Quach

, Lluís Samaranch and Anne-Marie Duchemin

submission deadline 30 Nov 2024 | 1 articles | Viewed by 4860 | Submission Open

Keywords: intellectual disability; neurodegenerative disorders; psychiatric diseases; gene transfer; AAV

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Translational Research in Cardiovascular Endocrinology, Cardio-Metabolic Diseases and Non-alcoholic Fatty Liver Disease (NAFLD): 2nd Edition

edited by

Eva Kassi

Ioannis Kyrou

and

Harpal S. Randeva

submission deadline 30 Nov 2024 | 5 articles | Viewed by 4762 | Submission Open

Keywords: cardiovascular endocrinology; atherosclerosis; coronary artery disease; endocrine hypertension; non-alcoholic fatty liver disease (NAFLD); diabetes mellitus and obesity; metabolic syndrome; endothelial cells; vascular inflammation; antidiabetic drugs; antihypertensive treatments; lipid lowering treatments; lifestyle interventions; molecular targeted therapies; heart failure; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targets in Skin Diseases

edited by Hanna Mys̈liwiec

submission deadline 30 Nov 2024 | 3 articles | Viewed by 4751 | Submission Open

Keywords: inflammatory skin diseases; systemic inflammation; infectious skin diseases; comorbidity; pathogenesis; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Helicobacter pylori Infections and Treatments

edited by

Dmitry Bordin

submission deadline 30 Nov 2024 | 3 articles | Viewed by 4481 | Submission Open

Keywords: H. pylori; gastritis; carcinogenesis; mechanisms of pathogenicity; molecular pathology; molecular genetics; microbiome modulation; antibiotic resistance; eradication

(This special issue belongs to the Section Molecular Microbiology)

Serotonin in Health and Diseases

edited by

Elena E. Voronezhskaya

submission deadline 30 Nov 2024 | 3 articles | Viewed by 4408 | Submission Open

Keywords: components of serotonergic system; serotonin targets; related systems; serotonergic mechanisms; experimental models

(This special issue belongs to the Section Biochemistry)

Computational Approaches in Drug Design: Novel Methodologies and Applications

edited by

Serena Vittorio

submission deadline 30 Nov 2024 | 3 articles | Viewed by 4407 | Submission Open

Keywords: drug design; computational approaches; molecular docking; molecular dynamics; pharmacophore modeling; homology modeling; computer aided drug design; ADME/Tox predictions; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

Emerging Biotechnological Approaches for Natural Antiviral Molecules Discovery

edited by

Rosamaria Pennisi

Maria Teresa Sciortino

and

Giuseppina Mandalari

submission deadline 30 Nov 2024 | 2 articles | Viewed by 4344 | Submission Open

Keywords: natural antivirals; biotechnology; viruses; cellular signalling; natural bioactive compounds; viral infections; antiviral therapeutics; virus inhibition assays

(This special issue belongs to the Section Molecular Microbiology)

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