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30 Results Found

  • Brief Report
  • Open Access
3 Citations
3,590 Views
12 Pages

Functional MRI Lateralization [M1] of dlPFC and Implications for Transcranial Magnetic Stimulation (TMS) Targeting

  • Jean Rama Surya,
  • Barshen Habelhah,
  • Jonathan Haroon,
  • Kennedy Mahdavi and ,
  • Kaya Jordan,
  • Sergio Becerra,
  • Victoria Venkatraman,
  • Chloe Deveney,
  • Alexander Bystritsky and
  • Sheldon Jordan
  • + 6 authors+ 1 author

16 August 2023

The present study investigates a potential method of optimizing effective strategies for the functional lateralization of the dorsolateral prefrontal cortex (dlPFC) while in a scanner. Effective hemisphere lateralization of the dlPFC is crucial for l...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
14 Citations
10,706 Views
11 Pages

Generalized anxiety disorder (GAD) is marked by uncontrollable, persistent worry and exaggerated response to uncertainty. Here, we review and summarize the findings from the GAD literature that employs functional neuroimaging methods. In particular,...

(This article belongs to the Special Issue Neurobiological Mechanisms Implicated in Stress-Related Psychiatric Disorders)
  • Review
  • Open Access
16 Citations
4,130 Views
20 Pages

Detection and Mitigation of Neurovascular Uncoupling in Brain Gliomas

  • Shruti Agarwal,
  • Kirk M. Welker,
  • David F. Black,
  • Jason T. Little and ,
  • David R. DeLone,
  • Steven A. Messina,
  • Theodore J. Passe,
  • Chetan Bettegowda and
  • Jay J. Pillai
  • + 4 authors+ 0 author

8 September 2023

Functional magnetic resonance imaging (fMRI) with blood oxygen level-dependent (BOLD) technique is useful for preoperative mapping of brain functional networks in tumor patients, providing reliable in vivo detection of eloquent cortex to help reduce...

(This article belongs to the Section Methods and Technologies Development)
  • Communication
  • Open Access
3 Citations
2,336 Views
14 Pages

New Functional MRI Experiments Based on Fractional Diffusion Representation Show Independent and Complementary Contrast to Diffusion-Weighted and Blood-Oxygen-Level-Dependent Functional MRI

  • Alessandra Maiuro,
  • Marco Palombo,
  • Emiliano Macaluso,
  • Guglielmo Genovese and ,
  • Marco Bozzali,
  • Federico Giove and
  • Silvia Capuani
  • + 2 authors+ 0 author

29 April 2025

A fundamental limitation of fMRI based on the BOLD effect is its limited spatial specificity. This is because the BOLD signal reflects neurovascular coupling, leading to macrovascular changes that are not strictly limited to areas of increased neural...

(This article belongs to the Special Issue MR-Based Neuroimaging)
  • Review
  • Open Access
2 Citations
3,776 Views
27 Pages

Theoretical, Technical, and Analytical Foundations of Task-Based and Resting-State Functional Magnetic Resonance Imaging (fMRI)—A Narrative Review

  • Natalia Anna Koc,
  • Maurycy Rakowski,
  • Anna Dębska,
  • Bartosz Szmyd and ,
  • Agata Zawadzka,
  • Karol Zaczkowski,
  • Małgorzata Podstawka,
  • Dagmara Wilmańska,
  • Adam Dobek and
  • Karol Wiśniewski
  • + 7 authors+ 2 authors

Functional magnetic resonance imaging (fMRI) is a valuable tool for presurgical brain mapping, traditionally implemented with task-based paradigms (tb-fMRI) that measure blood oxygenation level-dependent (BOLD) signal changes during controlled motor...

(This article belongs to the Special Issue Nervous System Diseases: From Pathophysiology to Novel Therapeutic Approaches)
  • Article
  • Open Access
2 Citations
2,545 Views
11 Pages

Perceptual Pattern of Cleft-Related Speech: A Task-fMRI Study on Typical Mandarin-Speaking Adults

  • Yun Bai,
  • Shaowei Liu,
  • Mengxian Zhu,
  • Binbing Wang and ,
  • Sheng Li,
  • Liping Meng,
  • Xinghui Shi,
  • Fei Chen,
  • Hongbing Jiang and
  • Chenghui Jiang
  • + 5 authors+ 0 author

25 October 2023

Congenital cleft lip and palate is one of the common deformities in the craniomaxillofacial region. The current study aimed to explore the perceptual pattern of cleft-related speech produced by Mandarin-speaking patients with repaired cleft palate us...

(This article belongs to the Section Craniofacial and Oral Neurosciences)
  • Article
  • Open Access
2 Citations
2,674 Views
16 Pages

Improving the Sensitivity of Task-Based Multi-Echo Functional Magnetic Resonance Imaging via T2* Mapping Using Synthetic Data-Driven Deep Learning

  • Yinghe Zhao,
  • Qinqin Yang,
  • Shiting Qian,
  • Jiyang Dong and ,
  • Shuhui Cai,
  • Zhong Chen and
  • Congbo Cai
  • + 2 authors+ 0 author

17 August 2024

(1) Background: Functional magnetic resonance imaging (fMRI) utilizing multi-echo gradient echo-planar imaging (ME-GE-EPI) has demonstrated higher sensitivity and stability compared to utilizing single-echo gradient echo-planar imaging (SE-GE-EPI). T...

(This article belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)
  • Article
  • Open Access
1,071 Views
20 Pages

Functional and Structural Connectivity in a Non-Transgenic Model of Alzheimer’s Disease

  • Peter Herman,
  • Maxime Parent,
  • Helen Wang,
  • Daniel Coman and ,
  • Vishaak Gangasandra,
  • Justus V. Verhagen,
  • Douglas L. Rothman,
  • Fahmeed Hyder and
  • Basavaraju G. Sanganahalli
  • + 4 authors+ 0 author

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline, reflecting widespread brain dysfunction across multiple neural systems. Early detection of pathological changes is cri...

  • Article
  • Open Access
19 Citations
5,650 Views
12 Pages

A CNN Deep Local and Global ASD Classification Approach with Continuous Wavelet Transform Using Task-Based FMRI

  • Reem Haweel,
  • Noha Seada,
  • Said Ghoniemy,
  • Norah Saleh Alghamdi and
  • Ayman El-Baz

29 August 2021

Autism spectrum disorder (ASD) is a neurodegenerative disorder characterized by lingual and social disabilities. The autism diagnostic observation schedule is the current gold standard for ASD diagnosis. Developing objective computer aided technologi...

(This article belongs to the Special Issue Computer Aided Diagnosis Sensors)
  • Article
  • Open Access
6 Citations
6,962 Views
21 Pages

3 July 2014

Blood-oxygen-level-dependent (BOLD) imaging is the most important noninvasive tool to map human brain function. It relies on local blood-flow changes controlled by neurovascular coupling effects, usually in response to some cognitive or perceptual ta...

(This article belongs to the Special Issue Entropy in Human Brain Networks)
  • Systematic Review
  • Open Access
3,030 Views
21 Pages

The Role of Blood Oxygen Level Dependent Signal Variability in Pediatric Neuroscience: A Systematic Review

  • Michael F. Dinatolo,
  • Daiana Roxana Pur,
  • Roy Eagleson and
  • Sandrine de Ribaupierre

19 July 2023

Background: As pediatric BOLD Signal Variability (SV) analysis is relatively novel, there is a need to provide a foundational framework that gives researchers an entry point into engaging with the topic. This begins with clarifying the definition of...

(This article belongs to the Special Issue Feature Paper in Physiology and Pathology)
  • Article
  • Open Access
614 Views
11 Pages

14 April 2026

Individual differences in second-language (L2) proficiency are expected to influence how listeners parse and represent continuous speech, yet their neural signatures under naturalistic conditions remain unclear. We investigated this question using ta...

  • Article
  • Open Access
68 Citations
5,607 Views
20 Pages

BOLD: Bio-Inspired Optimized Leader Election for Multiple Drones

  • Rajesh Ganesan,
  • X. Mercilin Raajini,
  • Anand Nayyar,
  • Padmanaban Sanjeevikumar and ,
  • Eklas Hossain and
  • Ahmet H. Ertas
  • + 1 author+ 0 author

1 June 2020

Over the past few years, unmanned aerial vehicles (UAV) or drones have been used for many applications. In certain applications like surveillance and emergency rescue operations, multiple drones work as a network to achieve the target in which any on...

(This article belongs to the Section Intelligent Sensors)
  • Article
  • Open Access
2 Citations
1,785 Views
26 Pages

Interpreting fMRI Studies in Populations with Cerebrovascular Risk: The Use of a Subject-Specific Hemodynamic Response Function

  • Ian M. McDonough,
  • Andrew R. Bender,
  • Lawrence Patihis,
  • Elizabeth A. Stinson and ,
  • Sarah K. Letang and
  • William S. Miller
  • + 1 author+ 0 author

26 October 2025

Functional magnetic resonance imaging (fMRI) is commonly used to investigate the neural bases of aging and psychological disorders. However, the BOLD signal captured by fMRI is affected by many factors that are non-neural in origin. We tested how vas...

(This article belongs to the Special Issue Diet, Lifestyle and Neurobehaviors)
  • Article
  • Open Access
2 Citations
2,338 Views
11 Pages

25 January 2024

It is imperative to study individual brain functioning toward understanding the neural bases responsible for individual behavioral and clinical traits. The complex and dynamic brain activity varies from area to area and from time to time across the e...

(This article belongs to the Special Issue Advances of AI in Neuroimaging)
  • Article
  • Open Access
2 Citations
3,377 Views
19 Pages

6 November 2021

Pavlovian-to-instrumental transfer (PIT) refers to a phenomenon whereby a classically conditioned stimulus (CS) impacts the motivational salience of instrumental behavior. We examined behavioral response patterns and functional magnetic resonance ima...

(This article belongs to the Section Systems Neuroscience)
  • Article
  • Open Access
3 Citations
6,031 Views
16 Pages

4 October 2023

Neuroimaging holds an essential position in global healthcare, as brain-related disorders are a substantial and growing burden. Non-degenerative disorders such as stress, depression and anxiety share common function related traits of diffuse and fluc...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
685 Views
42 Pages

10 June 2026

Grounded in the Cognitive Theory of Multimedia Learning and Cognitive Load Theory, this study examined how cue-based instructional support relates to L2 Chinese vocabulary processing and immediate learning outcomes. Forty intermediate-to-advanced lea...

(This article belongs to the Section Educational Psychology)
  • Article
  • Open Access
37 Citations
9,533 Views
16 Pages

Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study

  • Catherine M. Mewborn,
  • Cutter A. Lindbergh,
  • Talia L. Robinson,
  • Marissa A. Gogniat and ,
  • Douglas P. Terry,
  • Kharine R. Jean,
  • Billy Randy Hammond,
  • Lisa M. Renzi-Hammond and
  • Lloyd Stephen Miller
  • + 4 authors+ 0 author

7 April 2018

Lutein (L) and zeaxanthin (Z) are two xanthophyll carotenoids that have antioxidant and anti-inflammatory properties. Previous work has demonstrated their importance for eye health and preventing diseases such as age-related macular degeneration. An...

(This article belongs to the Special Issue Nutrition and the Function of the Central Nervous System)
  • Article
  • Open Access
2 Citations
3,429 Views
19 Pages

Convolutional Neural Networks to Assess Steno-Occlusive Disease Using Cerebrovascular Reactivity

  • Yashesh Dasari,
  • James Duffin,
  • Ece Su Sayin,
  • Harrison T. Levine and ,
  • Julien Poublanc,
  • Andrea E. Para,
  • David J. Mikulis,
  • Joseph A. Fisher,
  • Olivia Sobczyk and
  • Mir Behrad Khamesee
  • + 5 authors+ 0 author

8 August 2023

Cerebrovascular Reactivity (CVR) is a provocative test used with Blood oxygenation level-dependent (BOLD) Magnetic Resonance Imaging (MRI) studies, where a vasoactive stimulus is applied and the corresponding changes in the cerebral blood flow (CBF)...

(This article belongs to the Special Issue Artificial Intelligence Applications in Medicine)
  • Article
  • Open Access
21 Citations
6,872 Views
16 Pages

DNA Barcoding for Delimitation of Putative Mexican Marine Nematodes Species

  • Arely Martínez-Arce,
  • Alberto De Jesús-Navarrete and
  • Francesca Leasi

19 March 2020

Nematode biodiversity is mostly unknown; while about 20,000 nematode species have been described, estimates for species diversity range from 0.1 to 100 million. The study of nematode diversity, like that of meiofaunal organisms in general, has been m...

(This article belongs to the Special Issue Meiofauna Biodiversity and Ecology)
  • Article
  • Open Access
1 Citations
2,319 Views
21 Pages

10 June 2025

The issue of environmental protection and nature conservation has gained global importance, and its solution requires not only scientific and technological efforts but also the education of an environmentally conscious and active young generation. Ch...

(This article belongs to the Special Issue Eco-Rebels with a Cause: Representations and Explorations of Politics and Activism in Children's and YA Literature)
  • Article
  • Open Access
21 Citations
5,886 Views
20 Pages

12 May 2023

To date, a rather large set of both mathematical theories for species delimitation, based on single-locus genetic data, and their implementations as software products, has been accumulated. Comparison of the efficiencies of different delineation meth...

(This article belongs to the Special Issue Biogeography and Speciation of Aquatic Organisms)
  • Article
  • Open Access
413 Views
15 Pages

Sex Differences in Aggressive Traits and Superior Temporal Cortical Responses to Monetary Loss

  • Guangfei Li,
  • Yingjie Cao,
  • Yongxiu Yang,
  • Xinyu Zhang and ,
  • Bao Li,
  • Hao Sun,
  • Suqin Huang,
  • Mengdi Gao,
  • Guangyu Bin and
  • Chiang-Shan R. Li
  • + 5 authors+ 0 author

29 September 2026

Background: Individuals vary in aggression traits. Here, we investigated how individual aggression is associated with altered reward and punishment processing in the brain and the neural bases of sex differences. Methods: Aggression was assessed by t...

(This article belongs to the Section Experimental and Clinical Neurosciences)
  • Article
  • Open Access
7 Citations
3,107 Views
19 Pages

Explainable Multimodal Graph Isomorphism Network for Interpreting Sex Differences in Adolescent Neurodevelopment

  • Binish Patel,
  • Anton Orlichenko,
  • Adnan Patel,
  • Gang Qu and ,
  • Tony W. Wilson,
  • Julia M. Stephen,
  • Vince D. Calhoun and
  • Yu-Ping Wang
  • + 3 authors+ 0 author

14 May 2024

Background: A fundamental grasp of the variability observed in healthy individuals holds paramount importance in the investigation of neuropsychiatric conditions characterized by sex-related phenotypic distinctions. Functional magnetic resonance imag...

(This article belongs to the Special Issue Applications of Artificial Intelligence in Biomedical Data Analysis)
  • Article
  • Open Access
2 Citations
2,575 Views
24 Pages

Functional Connectome Fingerprinting Through Tucker Tensor Decomposition

  • Vitor Carvalho,
  • Mintao Liu,
  • Jaroslaw Harezlak,
  • Ana María Estrada Gómez and
  • Joaquín Goñi

26 April 2025

The human functional connectome (FC) is a representation of the functional couplings between brain regions derived from blood oxygen level-dependent (BOLD) signals. Over the past decade, studies related to FC fingerprinting have sought to uncover fun...

(This article belongs to the Special Issue Brain Functional Connectivity: Prediction, Dynamics, and Modeling)
  • Systematic Review
  • Open Access
6 Citations
4,806 Views
23 Pages

23 November 2022

Real-time functional magnetic resonance imaging neurofeedback (rt-fMRI-nf) training is an emerging intervention for neurorehabilitation. However, its translation into clinical use on participants with clinical depression is unclear, the effect estima...

(This article belongs to the Section Clinical Neurology)
  • Review
  • Open Access
10 Citations
6,619 Views
13 Pages

Neuroimaging in the Rare Sleep Disorder of Kleine–Levin Syndrome: A Systematic Review

  • Juan Fernando Ortiz,
  • Jennifer M. Argudo,
  • Mario Yépez,
  • Juan Andrés Moncayo and ,
  • Hyder Tamton,
  • Alex S. Aguirre,
  • Ghanshyam Patel,
  • Meghdeep Sen,
  • Ayushi Mistry and
  • Samir Ruxmohan
  • + 8 authors+ 3 authors

Kleine–Levin syndrome (KLS) is characterized by episodes of hypersomnia. Additionally, these patients can present with hyperphagia, hypersexuality, abnormal behavior, and cognitive dysfunction. Functional neuroimaging studies such as fMRI-BOLD,...

(This article belongs to the Section Human Basic Research & Neuroimaging)
  • Review
  • Open Access
25 Citations
16,143 Views
15 Pages

12 January 2024

The inspirational paper by Ash, Dowler, and Varsi in 1978, proposing to utilize in situ resources on Mars (ISRU) rather than bringing them from Earth, originated the field of Mars ISRU that has been the subject of research ever since. In this paper,...

  • Article
  • Open Access
838 Views
5 Pages

Recent technical developments and increased affordability of high-speed eye tracking devices have brought microsaccades to the forefront of research in many areas of sensory, perceptual, and cognitive processes. The present thematic issue on “Microsa...