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1,244 Results Found

  • Article
  • Open Access
829 Views
20 Pages

14 November 2025

Urban fragmentation has emerged as a central issue in the study of socio-spatial dynamics in contemporary cities, reflecting processes of inequality, segregation, and spatial discontinuities. This article introduces a new methodological approach to m...

  • Article
  • Open Access
2,301 Views
19 Pages

Spatial Barriers to Improved Water and Sanitation in Rural Zambia

  • Sarah L. Smiley,
  • Angela G. Subulwa and
  • Sav Herald

18 July 2025

The Sustainable Development Goals seek to achieve universal, adequate, and equitable access to drinking water and sanitation by the year 2030. Yet, significant and persistent disparities in water and sanitation access exist, with rural and low-income...

  • Article
  • Open Access
4 Citations
3,077 Views
22 Pages

24 April 2024

In the past five decades, global food systems have undergone a notable transition, moving from predominantly rural settings to increasingly urban and industrialized environments, largely driven by processes of globalization and supply chain integrati...

  • Article
  • Open Access
24 Citations
7,067 Views
18 Pages

14 April 2021

Decision support systems (DSSs) are increasingly common in forest and wildfire planning and management in the United States. Recent policy direction and frameworks call for collaborative assessment of wildfire risk to inform fuels treatment prioritiz...

  • Article
  • Open Access
1,449 Views
22 Pages

4 April 2025

China’s rapidly aging population has intensified demand for long-term services and supports (LTSSs), yet geographic disparities in accessibility persist despite policy reforms like long-term care insurance (LTCI). This study evaluates spatial i...

  • Article
  • Open Access
5 Citations
4,454 Views
22 Pages

The aim of this study was to modify an algorithm for mapping service areas, also known as access areas. The algorithm is widely applied in network analyses. Service areas are generated based on features such as road networks and base points represent...

  • Article
  • Open Access
2 Citations
2,697 Views
29 Pages

26 September 2025

Healthcare access is a fundamental human right, yet barriers often negatively impact health, particularly in developing countries like Pakistan, where maternal mortality remains a crisis. This study aimed to identify factors influencing healthcare ac...

  • Article
  • Open Access
15 Citations
5,373 Views
13 Pages

Wildlife–vehicle collisions (WVCs) cause significant road mortality of wildlife and have led to the installation of protective measures along streets. Until now, it has been difficult to determine the impact of roadside infrastructure that migh...

  • Article
  • Open Access
6 Citations
2,700 Views
21 Pages

14 November 2023

As cities expand, residents are experiencing increasing commuting distances and a growing trend of job–housing separation, which is often associated with traffic congestion, inefficiency in commuting, and air pollution. In the process of studyi...

  • Article
  • Open Access
110 Citations
12,002 Views
17 Pages

3 December 2015

The high importance of bathymetric character for many processes on reefs means that high-resolution bathymetric models are commonly needed by marine scientists and coastal managers. Empirical and optimisation methods provide two approaches for derivi...

  • Article
  • Open Access
2 Citations
1,400 Views
26 Pages

15 July 2024

The stability of energy generation is crucial for the functioning of every country. Currently, the EU policy is moving towards becoming independent of fossil energy sources, which can be replaced with sources that are not exhaustible, for example, en...

  • Article
  • Open Access
2 Citations
3,287 Views
13 Pages

1 April 2023

Carnivores with large home ranges are especially vulnerable to habitat fragmentation. As coyotes (Canis latrans) are often found living in highly modified landscapes, it is unclear how urban and suburban development impact gene flow between their pop...

  • Article
  • Open Access
1 Citations
603 Views
25 Pages

Eurotium cristatum-Fermented White Tea Ameliorates DSS-Induced Colitis by Multi-Scale

  • Huini Wu,
  • Xiangrui Kong,
  • Ruiyang Shan,
  • Song Peng,
  • Mengshi Zhao,
  • Wenquan Yu,
  • Changsong Chen,
  • Xiuping Wang and
  • Zhaolong Li

25 December 2025

Eurotium cristatum-Fermented White Tea (FWT) significantly alters white tea (WT) composition, increasing caffeine while decreasing polyphenols and amino acids. FWT effectively ameliorated dextran sulfate sodium (DSS)-induced murine colitis symptoms (...

  • Article
  • Open Access
4 Citations
6,244 Views
20 Pages

Although sea turtles are formidable prey as adults, their nests are highly vulnerable to terrestrial predation. Along the Southeastern coast of the United States, a primary predator of sea turtle nests is the red fox (Vulpes vulpes). Examining the re...

  • Article
  • Open Access
6 Citations
4,083 Views
12 Pages

13 February 2023

Historically, public policies in Brazil and many developing countries have prioritized individual motorized modes of transport. The urban space of Brazilian cities has been repeatedly remodeled, often to meet the demands of vehicle flow, to the detri...

  • Review
  • Open Access
1,138 Views
17 Pages

Rat Calvarial Guided Bone Regeneration Model: Preclinical Insights into Biomaterials, Barrier Design, and Systemic Modulators

  • Akira Hasuike,
  • Taito Watanabe,
  • Shin Wakuda,
  • Tomoe Suzuki,
  • Shuto Kikuchi,
  • Seiko Min,
  • Yoshinori Arai and
  • Shuichi Sato

25 November 2025

Guided bone regeneration (GBR) plays a key role in alveolar ridge augmentation and implant therapy, but the biological mechanisms governing its outcomes are not fully understood. Preclinical animal models provide critical insights that cannot be obta...

  • Article
  • Open Access
26 Citations
9,355 Views
14 Pages

Diversity and Structure of Parrotfish Assemblages across the Northern Great Barrier Reef

  • Garrett B. Johnson,
  • Brett M. Taylor,
  • William D. Robbins,
  • Erik C. Franklin,
  • Rob Toonen,
  • Brian Bowen and
  • J. Howard Choat

18 January 2019

The structure and dynamics of coral reef environments vary across a range of spatial scales, with patterns of associated faunal assemblages often reflecting this variability. However, delineating drivers of biological variability in such complex envi...

  • Article
  • Open Access
3,469 Views
21 Pages

A Community-Based Intervention Proposal for Municipal Solid Waste Management: Analyzing Willingness, Barriers and Spatial Strategies

  • Jose Alejandro Aristizábal Cuellar,
  • Elkin Puerto-Rojas,
  • Sharon Naomi Correa-Galindo and
  • Myriam Carmenza Sierra Puentes

7 July 2025

Municipal Solid Waste (MSW) management programs can help to mitigate the triple planetary crises of climate change, biodiversity loss and pollution. However, their success largely depends on the public willingness to engage in the pro-environmental s...

  • Editorial
  • Open Access
12 Citations
5,101 Views
9 Pages

22 October 2021

The article provides an overview of the legal and administrative aspects of spatial governance and planning and of the related challenges. The legal dimension of spatial planning, administrative spatial planning traditions, as well as different frame...

  • Article
  • Open Access
6 Citations
3,863 Views
21 Pages

24 July 2025

This paper critically examines the persistent limitations of spatial planning reforms in China in addressing urban–rural integration, despite significant and successive legislative and planning reforms. Through a historically grounded and insti...

  • Article
  • Open Access
10 Citations
3,866 Views
16 Pages

Hypertension is associated with blood-brain barrier alteration and brain function decline. Previously, we established the 2-kidney,1-clip (2K1C) hypertensive mice model by renin-angiotensin system (RAS) stimulating. We found that 2K1C-induced hyperte...

  • Article
  • Open Access
1 Citations
609 Views
20 Pages

20 October 2025

Water and soil resources (WSRs) determine the healthy development of the socio-economic systems. This research seeks to clarify the spatiotemporal evolution characteristics, spatial spillover effects, and key constraint factors influencing the compre...

  • Article
  • Open Access
8 Citations
4,979 Views
11 Pages

Spatial and Temporal Variation in Fecundity of Acropora spp. in the Northern Great Barrier Reef

  • Morgan S. Pratchett,
  • Andrew S. Hoey,
  • Chun-Hong Tan,
  • Chao-Yang Kuo,
  • Andrew G. Bauman,
  • Rajani Kumaraswamy and
  • Andrew H. Baird

16 April 2019

The amount of energy invested in sexual reproduction by scleractinian corals depends on their life history strategies (i.e., allocation of energy between growth, reproduction, and maintenance). However, energy allocated to reproduction will also be a...

  • Article
  • Open Access
1 Citations
458 Views
22 Pages

Subcellular Localization Dictates Therapeutic Function: Spatially Targeted Delivery of Amuc_1100 by Engineered Lacticaseibacillus paracasei L9 Enhances Intestinal Barrier in Colitis

  • Xinrui Dong,
  • Li Lin,
  • Weina Miao,
  • Zhengyuan Zhai,
  • Yanling Hao,
  • Ming Zhang,
  • Ran Wang,
  • Shaoyang Ge,
  • Hao Zhang and
  • Liang Zhao
  • + 1 author

30 December 2025

Background/Objectives: Impaired intestinal barrier function is a hallmark of inflammatory bowel disease (IBD). Akkermansia muciniphila and its outer membrane protein Amuc_1100 can enhance this barrier, but the clinical application of Amuc_1100 is lim...

  • Article
  • Open Access
1 Citations
934 Views
23 Pages

25 March 2025

Rural modernization constitutes a crucial aspect in the modernization of socialism with Chinese characteristics. This paper assesses the level of rural modernization in China and investigates its spatiotemporal evolution characteristics and restricti...

  • Article
  • Open Access
1,160 Views
19 Pages

Territorial Context and Spatial Interactions: A Case Study on the Erasmus K1 Mobility Datasets

  • Alexandru Rusu,
  • Octavian Groza,
  • Nicolae Popa and
  • Anita Denisa Caizer

This study evaluates the impact of different territorial contexts on academic mobility within the framework of the Erasmus Programme, using data on Key Action 1 exchanges between 2015 and 2023. Using official EU datasets and a gravity model framework...

  • Article
  • Open Access
19 Citations
3,418 Views
17 Pages

County Ecosystem Health Assessment Based on the VORS Model: A Case Study of 183 Counties in Sichuan Province, China

  • Rong He,
  • Xintong Huang,
  • Xiaoying Ye,
  • Zhe Pan,
  • Heng Wang,
  • Bin Luo,
  • Dongmei Liu and
  • Xinxin Hu

15 September 2022

The scientific assessment of the health level of county ecosystems is the basis for formulating county-based sustainable development strategies. In this paper, we take the county areas of Sichuan Province as the evaluation objects and combine the SDG...

  • Article
  • Open Access
1,205 Views
19 Pages

Background: Previous studies have suggested that electromagnetic pulse (EMP) can induce openings in the blood–brain barrier (BBB). However, the temporal variation and spatial distribution of BBB permeability after EMP radiation are difficult to...

  • Article
  • Open Access
3 Citations
2,191 Views
17 Pages

In this paper, we propose an extension to the barrier model, i.e., the Multi-Barriers Model, which could characterize an area of interest with different types of obstacles. In the proposed model, the area of interest is divided into two or more areas...

  • Article
  • Open Access
1,922 Views
29 Pages

Modeling Hydraulic Fracture Entering Stress Barrier: Theory and Practical Recommendations

  • Aleksandr Linkov,
  • Liliana Rybarska-Rusinek and
  • Ewa Rejwer-Kosińska

12 November 2024

Numerical modeling of hydraulic fracturing is complicated when a fracture reaches a stress barrier. For high barriers, it may require changing the computational scheme. In view of the strong influence of stress barriers on the final footprint and ope...

  • Article
  • Open Access
14 Citations
2,794 Views
18 Pages

4 September 2019

The multi-functionality of land as the basis of land use and utilization is under increasing investigation. This study assesses the spatiotemporal dynamic multi-functionality of land use and analyzes the obstacle indicators in Xiangxi using two metho...

  • Article
  • Open Access
51 Citations
4,278 Views
22 Pages

Ecological Security Patterns at Different Spatial Scales on the Loess Plateau

  • Liangguo Lin,
  • Xindong Wei,
  • Pingping Luo,
  • Shaini Wang,
  • Dehao Kong and
  • Jie Yang

12 February 2023

The study of ecological security patterns (ESPs) is of great significance for improving the value of ecosystem services and promoting both ecological protection and high-quality socio-economic development. As an important part of the “Loss Plat...

  • Article
  • Open Access
16 Citations
5,649 Views
15 Pages

Inhibition of Protein Prenylation of GTPases Alters Endothelial Barrier Function

  • Muhammad Aslam,
  • Christian Troidl,
  • Christian Tanislav,
  • Susanne Rohrbach,
  • Dursun Gündüz and
  • Christian W. Hamm

The members of Rho family of GTPases, RhoA and Rac1 regulate endothelial cytoskeleton dynamics and hence barrier integrity. The spatial activities of these GTPases are regulated by post-translational prenylation. In the present study, we investigated...

  • Article
  • Open Access
120 Citations
17,035 Views
25 Pages

Comparison of Bayesian Clustering and Edge Detection Methods for Inferring Boundaries in Landscape Genetics

  • Toni Safner,
  • Mark P. Miller,
  • Brad H. McRae,
  • Marie-Josée Fortin and
  • Stéphanie Manel

25 January 2011

Recently, techniques available for identifying clusters of individuals or boundaries between clusters using genetic data from natural populations have expanded rapidly. Consequently, there is a need to evaluate these different techniques. We used spa...

  • Article
  • Open Access
4 Citations
3,960 Views
13 Pages

5 June 2019

Spatial mapping of remote sensing data tends to be used less when valuing coastal ecosystem services than in other ecosystems. This research project aimed to understand obstacles to the use of remote sensing data in coastal ecosystem valuations, and...

  • Article
  • Open Access
17 Citations
3,999 Views
15 Pages

7 April 2021

Thermal barrier coatings (TBCs) have been investigated both experimentally and through simulation for mixing controlled combustion (MCC) concepts as a method for reducing heat transfer losses and increasing cycle efficiency, but it is still a very ac...

  • Article
  • Open Access
5 Citations
4,544 Views
19 Pages

Investigating Controls on Barrier Island Overwash and Evolution during Extreme Storms

  • Jesse N. Beckman,
  • Joseph W. Long,
  • Andrea D. Hawkes,
  • Lynn A. Leonard and
  • Eman Ghoneim

12 October 2021

Over short periods of time, extreme storms can significantly alter barrier island morphology, increasing the vulnerability of coastal habitats and communities relative to future storms. These impacts are complex and the result of interactions between...

  • Article
  • Open Access
3 Citations
3,519 Views
14 Pages

Genetic Structure of the Root Vole Microtus oeconomus: Resistance of the Habitat Specialist to the Natural Fragmentation of Preferred Moist Habitats

  • Rafał Łopucki,
  • Iwona Mróz,
  • Zuzanna Nowak-Życzyńska,
  • Magdalena Perlińska-Teresiak,
  • Edyta Owadowska-Cornil and
  • Daniel Klich

27 February 2022

Climate-related changes have a severe impact on wetland ecosystems and pose a serious challenge for wetland-dependent animals as their preferred habitats decline, lose spatial continuity, and appear as isolated islands in the landscape. In this paper...

  • Article
  • Open Access
5 Citations
1,986 Views
16 Pages

3 October 2022

The article proposes methods by which an in-depth analysis of the factors determining the planning activity of municipalities for renewable energy sources can be carried out. The article aims to determine the relationship between the number of local...

  • Article
  • Open Access
10 Citations
4,228 Views
14 Pages

9 November 2022

The crucial barrier properties of the stratum corneum (SC) depend critically on the design and integrity of its layered molecular structure. However, analysis methods capable of spatially resolved molecular characterization of the SC are scarce and f...

  • Article
  • Open Access
2,605 Views
25 Pages

30 September 2025

Against a global backdrop of industrialization and urbanization, precise measurement of multifactor flows and systematic identification of barriers and drivers are critical for optimizing resource allocation in smart regional development. This study...

  • Article
  • Open Access
1,117 Views
26 Pages

10 July 2025

As a crucial ecological barrier in China, the Greater Khingan Mountains play a vital role in global ecological security. Investigating the spatiotemporal variations in fractional vegetation cover (FVC) and the driving mechanisms behind its spatial di...

  • Article
  • Open Access
28 Citations
7,631 Views
17 Pages

Spatial and Temporal Variability of Open-Ocean Barrier Islands along the Indus Delta Region

  • Muhammad Waqas,
  • Majid Nazeer,
  • Muhammad Imran Shahzad and
  • Ibrahim Zia

20 February 2019

Barrier islands (BIs) have been designated as the first line of defense for coastal human assets against rising sea level. Global mean sea level may rise from 0.21 to 0.83 m by the end of 21st century as predicted by the Intergovernmental Panel on Cl...

  • Article
  • Open Access
6 Citations
3,814 Views
10 Pages

Investigation of Barrier Layer Effect on Switching Uniformity and Synaptic Plasticity of AlN Based Conductive Bridge Random Access Memory

  • Srikant Kumar Mohanty,
  • Kuppam Poshan Kumar Reddy,
  • Chien-Hung Wu,
  • Po-Tsung Lee,
  • Kow-Ming Chang,
  • Prabhakar Busa and
  • Yaswanth Kuthati

23 October 2022

In this work, we investigated the effect of the tungsten nitride (WNx) diffusion barrier layer on the resistive switching operation of the aluminum nitride (AlN) based conductive bridge random access memory. The WNx barrier layer limits the diffusion...

  • Article
  • Open Access
12 Citations
3,140 Views
26 Pages

The assessment of the carrying capacity and suitability of spatial resources and the environment can provide effective guidance for regional planning and make vital contributions to the high-quality advancement of society and the economy. Additionall...

  • Communication
  • Open Access
5 Citations
2,231 Views
9 Pages

Barrier Height, Ideality Factor and Role of Inhomogeneities at the AlGaN/GaN Interface in GaN Nanowire Wrap-Gate Transistor

  • Siva Pratap Reddy Mallem,
  • Peddathimula Puneetha,
  • Yeojin Choi,
  • Seung Mun Baek,
  • Dong-Yeon Lee,
  • Ki-Sik Im and
  • Sung Jin An

17 December 2023

It is essential to understand the barrier height, ideality factor, and role of inhomogeneities at the metal/semiconductor interfaces in nanowires for the development of next generation nanoscale devices. Here, we investigate the drain current (Ids)&n...

  • Article
  • Open Access
17 Citations
4,336 Views
15 Pages

Discharge Regimes Transition and Characteristics Evolution of Nanosecond Pulsed Dielectric Barrier Discharge

  • Li Zhang,
  • Dezheng Yang,
  • Sen Wang,
  • Zixian Jia,
  • Hao Yuan,
  • Zilu Zhao and
  • Wenchun Wang

26 September 2019

Discharge regime transition in a single pulse can present the breakdown mechanism of nanosecond pulsed dielectric barrier discharge. In this paper, regime transitions between streamer, diffuse, and surface discharges in nanosecond pulsed dielectric b...

  • Article
  • Open Access
11 Citations
3,389 Views
15 Pages

30 July 2021

This conceptual paper aims to expand the notion of “farming newcomers” in Europe by also including those that we label “involuntary newcomers”, who correspond to the workforce coming unwillingly to farming for reasons associated with spatial (im)mobi...

  • Article
  • Open Access
36 Citations
8,486 Views
24 Pages

16 January 2021

The growing concern for sustainability in agri-food systems and the parallel decrease in the number of people engaged in agriculture, especially in the Global North, is starting to draw attention to new entrant farmers from non-farming backgrounds (&...

  • Article
  • Open Access
15 Citations
5,682 Views
15 Pages

An Experimental Workflow for Studying Barrier Integrity, Permeability, and Tight Junction Composition and Localization in a Single Endothelial Cell Monolayer: Proof of Concept

  • Maria Bartosova,
  • David Ridinger,
  • Iva Marinovic,
  • Jana Heigwer,
  • Conghui Zhang,
  • Eszter Levai,
  • Jens H. Westhoff,
  • Franz Schaefer,
  • Stefan Terjung and
  • Sotirios G. Zarogiannis
  • + 5 authors

Endothelial and epithelial barrier function is crucial for the maintenance of physiological processes. The barrier paracellular permeability depends on the composition and spatial distribution of the cell-to-cell tight junctions (TJ). Here, we provid...

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