20,368 Results Found

The U-box protein family of ubiquitin ligases is important in the biological processes of plant growth, development, and biotic and abiotic stress responses. Plants in the genus Zoysia are recognized as excellent warm-season turfgrass species with dr...

The Internet of Things is attracting attention as a solution to rural sustainability crises, such as slowing income, exports, and growth rates due to the aging of industries. To develop a high-performance IoT platform, we designed and implemented an...

The U-box E3 ubiquitin ligase (PUB) gene family plays an important role in regulating plant responses to abiotic stress. Poncirus trifoliata (trifoliate orange), a citrus rootstock with notable cold, drought, and salt tolerance, serves as an excellen...

AAA+ ATPase p97/valosin-containing protein (VCP)/Cdc48 is a key player in various cellular stress responses in which it unfolds ubiquitinated proteins to facilitate their degradation by the proteasome. P97 works in different cellular processes using...

This paper addresses the challenges of multicasting in Mobile Ad Hoc Networks (MANETs), where communication relies exclusively on direct interactions between mobile nodes without the support of fixed infrastructure. In such networks, efficient inform...

Plant U-box E3 ubiquitin ligase (PUB) is involved in various environmental stress conditions. However, the molecular mechanism of U-box proteins in response to abiotic stress in wheat remains unknown. In this study, two U-box E3 ligase genes (TaPUB2...

The ubiquitination and degradation of proteins are widely involved in plant biotic and abiotic stress responses. E3 ubiquitin ligases play an important role in the ubiquitination of specific proteins. In this study, we identified the function of a U-...

E3-ubiquitin ligases are known to confer abiotic stress responses in plants. In the present study, GmPUB21, a novel U-box E3-ubiquitin ligase-encoding gene, was isolated from soybean and functionally characterized. The expression of GmPUB21, which po...

Plants produce and accumulate stress-resistant substances when exposed to abiotic stress, which involves a protein conversion mechanism that breaks down stress-damaged proteins and supplies usable amino acids. Eukaryotic protein turnover is mostly dr...

Motivation: PubMed is a primary source of biomedical information comprising search tool function and the biomedical literature from MEDLINE which is the US National Library of Medicine premier bibliographic database, life science journals and online...

The [PSI+] nonsense-suppressor determinant of Saccharomyces cerevisiae is based on the formation of heritable amyloids of the Sup35 (eRF3) translation termination factor. [PSI+] amyloids have variants differing in amyloid structure and in the strengt...

Autoimmune diseases (AIDs) are often co-associated, and about 25% of patients with one AID tend to develop other comorbid AIDs. Here, we employ the power of datamining to predict the comorbidity of AIDs based on their normalized co-citation in PubMed...

Grain shape and size are key determinants of grain appearance quality and yield in rice. In our previous study, a grain shape QTL, qGS1-35.2, was fine-mapped using near-isogenic lines (NILs) derived from a cross between Zhenshan 97 (ZS97) and Milyang...

This paper proposes an innovative method that exploits a complex deep learning network architecture, called Hierarchical Deep Neural Network (HDNN), specifically developed for the eXtreme Multilabel Text Classification (XMTC) task, when the label set...

Grain weight, a crucial trait that determines the grain yield in rice, is influenced by grain size. Although a series of regulators that control grain size have been identified in rice, the mechanisms underlying grain development are not yet well und...

Ubiquitination plays a crucial role in regulating signal pathways during the post-translation stage of protein synthesis in response to various environmental stresses. E3 ubiquitin ligase has been discovered to ultimately control various intracellula...

With the rapidly increasing availability of High-Throughput Screening (HTS) data in the public domain, such as the PubChem database, methods for ligand-based computer-aided drug discovery (LB-CADD) have the potential to accelerate and reduce the cost...

The execution of scientific workflows is gaining importance as more computing resources are available in the form of grid environments. The Publish/Subscribe paradigm offers well-proven solutions for sustaining distributed scenarios while maintaining...

Drug-drug interaction (DDI) is becoming a serious issue in clinical pharmacy as the use of multiple medications is more common. The PubMed database is one of the biggest literature resources for DDI studies. It contains over 150,000 journal articles...

Developing realistic data sets for evaluating virtual screening methods is a task that has been tackled by the cheminformatics community for many years. Numerous artificially constructed data collections were developed, such as DUD, DUD-E, or DEKOIS....

Background. Retraction of problematic scientific articles after publication is one of the mechanisms for correcting the literature available to publishers. The market volume and the busi-ness model justify publishers’ ethical involvement in the...

Background: In recent years, there has been an exponential growth in global anti-cancer drug research, prompting the necessity for comprehensive analyses of publication output and thematic shifts. Methods: This study utilized a comprehensive set of P...

Background: Traditional Chinese medicine (TCM) may be understood as a system of sensations and findings designed to establish the functional vegetative state of the body. This state may be treated by several therapeutic methods such as acupuncture, C...

We present an automated journal recommendation pipeline designed to evaluate the performance of five Sentence Transformer models—all-mpnet-base-v2 (Mpnet), all-MiniLM-L6-v2 (Minilm-l6), all-MiniLM-L12-v2 (Minilm-l12), multi-qa-distilbert-cos-v1...

Remarkable structural homologies between the main proteases of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the avian infectious bronchitis virus (IBV) were revealed by comparative amino-acid sequence and 3D structural alignme...

Salient segmentation is a critical step in biomedical image analysis, aiming to cut out regions that are most interesting to humans. Recently, supervised methods have achieved promising results in biomedical areas, but they depend on annotated traini...

In the Industry 4.0 era, with the continuous integration of industrial field systems and upper-layer facilities, interconnection between industrial wireless sensor networks (IWSNs) and industrial Internet networks is becoming increasingly pivotal. Ho...

Ubiquitination is a kind of post-translational modification of proteins that plays an important role in plant response to biotic and abiotic stress. The response of soybean GmPUB genes to soybean cyst nematode (SCN, Heterodera glycines) infection is...

E3 ubiquitin ligases known as plant U-box (PUB) proteins regulate a variety of aspects of plant growth, development, and stress response. However, the functions and characteristics of the PUB gene family in alfalfa remain unclear. This work involved...

The U-box E3 (PUB) family genes encode the E3 ubiquitin ligase enzyme, which determines substrate specific recognition during protein ubiquitination. They are widespread in plants and are critical for plant growth, development, and response to extern...

AXL kinase is a promising target in novel drug discovery for cancer. A ligand-based pharmacophore model was generated with the Pharmit web server. Its inbuilt PubChem molecule database was screened and led to 408 candidate molecules. Docking of the A...

Proteins encoded by U-box type ubiquitin ligase (PUB) genes in rice are known to play an important role in plant responses to abiotic and biotic stresses. Functional analysis has revealed a detailed molecular mechanism involving PUB proteins in relat...

The ubiquitin-proteasome system (UPS) is a key protein degradation pathway in eukaryotes, in which E3 ubiquitin ligases mediate protein ubiquitination, directly or indirectly targeting substrate proteins to regulate various biological processes, incl...

Plant U-box E3 ubiquitin ligases (PUBs) play an important role in growth, development, and stress responses in many species. However, the characteristics of U-box E3 ubiquitin ligase genes in cabbage (Brassica oleracea var. capitata) are still unclea...

Computing services for the Internet-of-Things (IoT) play a vital role for widespread IoT deployment. A hierarchy of Edge-Cloud publish/subscribe (pub/sub) broker overlay networks that support latency-sensitive IoT applications in a scalable manner is...

Plant U-box E3 ubiquitin ligases (PUBs) serve as crucial regulators of protein degradation and are fundamentally involved in plant developmental processes and stress response mechanisms. Despite their well-characterized roles in model plant species,...

The body of scientific literature continues to grow annually. Over 1.5 million abstracts of biomedical publications were added to the PubMed database in 2021. Therefore, developing cognitive systems that provide a specialized search for information i...

Public utility bus (PUB) systems and passenger behaviors drastically changed during the COVID-19 pandemic. This study assessed the clustered behavior of 505 PUB passengers using feature selection, K-means clustering, and particle swarm optimization (...

It is with great pleasure and proud that we can announce that Diagnostics is now indexed and searchable in PubMed.[...]

Purple urine bag syndrome (PUBS) is a rare condition characterized by purple discoloration of urine and urine bags. Although it is benign, it represents an alarming symptom to the patients and their relatives because of purple discoloration. We have...

Cabbage (Brassica oleracea var. capitata) is a biennial plant. Gene editing technology has not been extensively studied in this species. In this study, we report the induction of highly efficient and heritable transgenic roots in cabbage using the CR...

Predictions in ungauged basins (PUB) has been always a focus of hydrological research. The problem presented by ungauged basins is how to reasonably estimate water resource availability. To solve the issues of data scale, this study combines field ex...

Background: Health policy, systems and services research (HPSSR) is increasingly needed to enable better access to, and value of, rehabilitation services worldwide. We aim to quantify the growth of Rehabilitation HPSSR publications since 1990, compar...

In the Internet-of-Things (IoT) environments, the publish (pub)/subscribe (sub)-operated communication is widely employed. The use of pub/sub operation as a lightweight communication protocol facilitates communication among IoTs. The protocol consist...

Recent advancements in generative AI have fostered the development of highly adept Large Language Models (LLMs) that integrate diverse data types to empower decision-making. Among these, multimodal retrieval-augmented generation (RAG) applications ar...

Drought causes osmotic stress and rapidly triggers abscisic acid (ABA) accumulation in plants. The roles of various ABA receptors in drought tolerance and molecular mechanisms regulating ABA receptor stability needs to be elucidated. Here, we report...

A better understanding of the clinical characteristics of coronavirus disease 2019 (COVID-19) is urgently required to address this health crisis. Numerous researchers and pharmaceutical companies are working on developing vaccines and treatments; how...

Accessible health information is essential to promote patient engagement and informed participation in clinical research. Brief summaries on ClinicalTrials.gov are indented for lay people; however they are often written at a reading level that is too...

Stream temperature (Ts) is an important water quality parameter that affects ecosystem health and human water use for beneficial purposes. Accurate Ts predictions at different spatial and temporal scales can inform water management decisions that acc...

Chloroplasts are ancient organelles responsible for photosynthesis and various biosynthetic functions essential to most life on Earth. Many of these functions require tightly controlled regulatory processes to maintain homeostasis at the protein leve...