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12,200 Results Found

  • Article
  • Open Access
8 Citations
4,757 Views
19 Pages

17 November 2020

In the realm of new localism and collaboration, local educational policymakers are called upon for responsible community leadership. Given the conceptual continuum between new localism and transformational leadership, this study examines the relation...

  • Article
  • Open Access
7 Citations
5,510 Views
16 Pages

25 December 2021

Five principles for health promotion (HP) stand out in various forms, providing guidance for HP measures and policy implementation: (1) a broad and positive health concept, (2) participation and involvement of key stakeholders, (3) build action and a...

  • Article
  • Open Access
1 Citations
1,647 Views
10 Pages

Predictive Model of Paraaortic Lymph Node Involvement in cN0 Locally Advanced Cervical Cancers: PET/CT Technology Matters

  • Judicael Hotton,
  • Emilie Raimond,
  • Fabien Reyal,
  • Sophie Michel,
  • Vivien Ceccato,
  • Abdenasser Moubtakir,
  • Dimitri Papathanassiou and
  • David Morland

20 November 2024

Background: The aim is to propose a model for predicting occult paraaortic lymph node (PALN) involvement in locally advanced cervical cancer (LACC) patients by including parameters such as reconstruction detection technology (use of time-of-flight) a...

  • Article
  • Open Access
16 Citations
6,993 Views
21 Pages

22 July 2014

The last revision of the EMAS (Eco Management and Audit Scheme) Regulation encouraged a cluster approach to increase the participation of the organizations and to involve local stakeholders in the commitment to sustainability. Our research activity i...

  • Article
  • Open Access
8 Citations
4,241 Views
17 Pages

Pastoralism Partnerships: Recognizing the Value of Local Involvement in China’s Snow Leopard Conservation Efforts

  • Charlotte E. Hacker,
  • Jan E. Janecka,
  • Rodney M. Jackson,
  • Diqiang Li and
  • Yuguang Zhang

12 August 2020

Pastoralists are key stakeholders in environmental management decisions in China. Thus, their involvement in wildlife conservation and research is imperative for the success of long-term initiatives. Despite the many opportunities for herders to be i...

  • Article
  • Open Access
5 Citations
2,906 Views
20 Pages

According to the modern guidelines of the Smart City (SC) concept, smart cities are not only cities that are above average in terms of technology, but first and foremost are focused on the needs of their residents. A key need for quality of life is t...

  • Article
  • Open Access
10 Citations
5,083 Views
23 Pages

9 April 2020

Existing literature tends to treat enterprises as a whole when measuring government intervention. However, in Chinese region-specific institutional development, ultimate control (i.e., local government) tends to control multiple enterprises. This pap...

  • Article
  • Open Access
5 Citations
2,424 Views
20 Pages

17 July 2023

Entrepreneurship, as one of the key means of alleviating extreme poverty, is difficult to achieve among people experiencing poverty partly because their initiative is bound by long-term dependence and their entrepreneurial awareness is not strong. Ac...

  • Article
  • Open Access
15 Citations
5,979 Views
23 Pages

21 November 2023

Portugal has made investments in several regions within the country to promote the development of entrepreneurial ecosystems. The primary goal of these investments is to facilitate the foundation of new firms, drive economic growth, and encourage inn...

  • Article
  • Open Access
2 Citations
3,209 Views
19 Pages

The pandemic has resulted in a further reduction in travel distance, recreational radius of destinations and other levels of tourism activity, making “local people traveling locally” a new feature. From the perspective of localization of...

  • Article
  • Open Access
411 Views
15 Pages

6 December 2025

The purpose of this study is to clarify the impact of government embedment on villagers’ willingness to engage in mutual supervision of rural residential land utilization. It also examines the role of local elders’ involvement in this pro...

  • Article
  • Open Access
4 Citations
2,547 Views
15 Pages

11 November 2021

Finding the news of same case from the large numbers of case-involved news is an important basis for public opinion analysis. Existing text clustering methods usually based on topic models which only use topic and case infomation as the global featur...

  • Article
  • Open Access
6 Citations
4,987 Views
23 Pages

9 June 2021

This study aims to examine the relationships between the experiential consumption, the social environment, and intention to revisit. The mediating role of involvement in the experience between experiential consumption and the intention to revisit and...

  • Article
  • Open Access
11 Citations
3,595 Views
25 Pages

Towards Solving the Beach Litter Problem: Ecosystem Service Assessments at North African Coasts

  • Esther Robbe,
  • Lilia Ben Abdallah,
  • Loubna El Fels,
  • Nour El Houda Chaher,
  • Mirco Haseler,
  • Fadhel Mhiri and
  • Gerald Schernewski

11 July 2024

Sandy beaches along the North African Mediterranean coast face significant challenges due to accumulating human-made debris (marine litter) and natural debris (beach wrack). Addressing these issues requires awareness of pollution and the ecological r...

  • Article
  • Open Access
24 Citations
9,935 Views
24 Pages

The Role of the Local Host Community’s Involvement in the Development of Tourism: A Case Study of the Residents’ Perceptions toward Tourism on the Route of Santiago de Compostela (Spain)

  • Jakson-Renner-Rodrigues Soares,
  • Maria-Francisca Casado-Claro,
  • María-Elvira Lezcano-González,
  • María-Dolores Sánchez-Fernández,
  • Larissa-Paola-Macedo-Castro Gabriel and
  • Maria Abríl-Sellarés

25 August 2021

As an economic, social, and cultural activity, tourism shapes the relationship between visitors and local communities in tourist destinations. While tourism generates economic growth and employment opportunities for residents, its benefits come with...

  • Review
  • Open Access
5 Citations
2,938 Views
14 Pages

Involvement of the Gut Microbiome in the Local and Systemic Immune Response to Pancreatic Ductal Adenocarcinoma

  • James M. Halle-Smith,
  • Hayden Pearce,
  • Samantha Nicol,
  • Lewis A. Hall,
  • Sarah F. Powell-Brett,
  • Andrew D. Beggs,
  • Tariq Iqbal,
  • Paul Moss and
  • Keith J. Roberts

29 February 2024

The systemic and local immunosuppression exhibited by pancreatic ductal adenocarcinoma (PDAC) contributes significantly to its aggressive nature. There is a need for a greater understanding of the mechanisms behind this profound immune evasion, which...

  • Article
  • Open Access
8 Citations
3,263 Views
16 Pages

Local Inflammatory Mediators Involved in Neuropathic Pain

  • Patricia García-Fernández,
  • Colette Reinhold,
  • Nurcan Üçeyler and
  • Claudia Sommer

Polyneuropathy (PNP) is a term to describe diseases of the peripheral nervous system, 50% of which present with neuropathic pain. In some types of PNP, pain is restricted to the skin distally in the leg, suggesting a local regulatory process leading...

  • Article
  • Open Access
1 Citations
3,737 Views
17 Pages

Challenges and Problems of Nature Conservation: A Case Study from Poland

  • Magdalena Kozera-Kowalska,
  • Anna Jęczmyk,
  • Magdalena Piekutowska,
  • Jarosław Uglis and
  • Gniewko Niedbała

29 June 2024

The article aims to show the attitudes and views of Polish residents on the problem of preserving the natural environment from the perspective of their place of residence. The need for research in this area stems from the insufficient number of avail...

  • Article
  • Open Access
2 Citations
3,120 Views
24 Pages

Developing a Participatory Process for Soil Fertility: A Case Study in an Urban Area of Italy

  • Laura Criscuolo,
  • Gloria Bordogna,
  • Lara Barbara,
  • Alice Benessia,
  • Caterina Bergami,
  • Elisa Calastri,
  • Valentina Capocefalo,
  • Andrea Caretto,
  • Chiara Cavallo and
  • Alba L’Astorina
  • + 20 authors

7 June 2024

Approaches that are transdisciplinary and participatory can help to address complex socio-ecological issues by integrating multiple disciplinary perspectives while taking into account the different needs and experiences of community members and other...

  • Article
  • Open Access
2 Citations
3,117 Views
11 Pages

Evolution of the Surgical Management of Lung Cancer Invading the Spine: A Single Center Experience

  • Gabrielle Drevet,
  • Théo Broussolle,
  • Yanis Belaroussi,
  • Lucie Duponchelle,
  • Jean Michel Maury,
  • Renaud Grima,
  • Gualter Vaz,
  • Clément Silvestre and
  • François Tronc

26 April 2022

For patients with locally advanced non-small cell lung cancer invading the spine, induction chemoradiotherapy combined with radical en bloc resection is the key to obtaining long-term survival. With time, our operative technique evolved to a two-step...

  • Article
  • Open Access
8 Citations
2,259 Views
11 Pages

A Multicenter Retrospective Cohort Study on Superior Vena Cava Resection in Non-Small-Cell Lung Cancer Surgery

  • Andrea Dell’Amore,
  • Alessio Campisi,
  • Luca Bertolaccini,
  • Chunji Chen,
  • Piotr Gabryel,
  • Chunyu Ji,
  • Cezary Piwkowski,
  • Lorenzo Spaggiari,
  • Wentao Fang and
  • Federico Rea

13 December 2022

Background: Surgery for non-small-cell lung cancers (NSCLCs) invading the superior vena cava (SVC) is rarely performed due to surgical complexities and reported poor prognoses. Different methods have been described to reconstruct the SVC, such as dir...

  • Article
  • Open Access
7 Citations
7,893 Views
14 Pages

Active Coral Restoration to Preserve the Biodiversity of a Highly Impacted Reef in the Maldives

  • Irene Pancrazi,
  • Kayla Feairheller,
  • Hassan Ahmed,
  • Carolina di Napoli and
  • Monica Montefalcone

19 September 2023

Maldivian coral reefs have been experiencing significant degradation due to a combination of global climate change and local anthropogenic pressures. To enforce the conservation of coral reefs worldwide, coral restoration is becoming a popular tool t...

  • Article
  • Open Access
1 Citations
991 Views
16 Pages

Exploring Endovascular Photo-Activated Ablation (EPA) for Downstaging Locally Advanced Pancreatic Cancer: A Proof-of-Concept Study in the Normal Porcine Model

  • Alain García Vázquez,
  • Juan Manuel Verde,
  • Fanélie Wanert,
  • Irene Alexandra Spiridon,
  • Axel Schmid,
  • Tina Saeidi,
  • Lee L. Swanstrom,
  • Stephen G. Bown,
  • Lothar Lilge and
  • Arjen Bogaards

16 October 2025

Background: Pancreatic cancers can involve large blood vessels early, making complete resection technically challenging or impossible. A minimally invasive treatment that clears vessels from encasing tumours could potentially enable curative surgery....

  • Case Report
  • Open Access
1,370 Views
9 Pages

Leukemia Cutis, a Tricky Diagnosis: A Case Report and Literature Review

  • Valentina De Santis,
  • Sabrina Mariani,
  • Giulia Pileggi,
  • Federica Lubrano Lobianco,
  • Esmeralda Conte,
  • Gianluca Maiorana,
  • Chiara Togni,
  • Monica Piedimonte,
  • Arianna Di Napoli and
  • Agostino Tafuri
  • + 2 authors

21 October 2025

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy, typically presenting with systemic symptoms and mediastinal involvement. Leukemia cutis (LC) and renal infiltration are rare, especially at disease onset. A 27-year-...

  • Article
  • Open Access
3 Citations
2,412 Views
17 Pages

Exploring the Link Between Openness and Entrepreneurial Capacity in Young People: Building Resilient and Sustainable Rural Territories

  • Aleksandra S. Dragin,
  • Tamara Surla,
  • Maja Mijatov Ladičorbić,
  • Tamara Jovanović,
  • Zrinka Zadel,
  • Milena Nedeljković-Knežević,
  • Aleksandra Tešin,
  • Juan Manuel Amezcua-Ogáyar,
  • Alberto Calahorro-López and
  • Živorad Vasić
  • + 4 authors

3 November 2024

Youth migration has significant consequences that lead to depopulation and less sustainability of local business, which is particularly pronounced in rural areas. All of this contributes to the potential devastation of rural communities, an impact th...

  • Review
  • Open Access
1 Citations
2,281 Views
14 Pages

Cryptococcosis in Pediatric Renal Transplant Recipients: Comparative Insights from Adult Cases

  • Guido Gembillo,
  • Chiara Terzo,
  • Salvatore Silipigni,
  • Luca Soraci,
  • Emmanuele Venanzi Rullo,
  • Ylenia Russotto,
  • Chiara Casuscelli,
  • Maria Elsa Gambuzza,
  • Maria Princiotto and
  • Domenico Santoro
  • + 3 authors

18 June 2025

Cryptococcosis, an opportunistic fungal infection predominantly caused by Cryptococcus neoformans, is the third most common invasive fungal disease in solid organ transplant recipients. While well-characterized in adult kidney transplant (KT) patient...

  • Article
  • Open Access
13 Citations
4,752 Views
17 Pages

23 January 2020

This paper focuses on the development of a participatory planning approach for local energy sustainability. The characteristics of a complex problem were reviewed to establish that the problem of sustainable energy at a local government level is comp...

  • Article
  • Open Access
386 Views
13 Pages

7 January 2026

Background: Surgical treatment of periprosthetic joint infection (PJI) after total hip arthroplasty (THA) remains challenging, with thorough debridement seen as critical for success. While revision THA is well documented as the standard treatment for...

  • Article
  • Open Access
828 Views
14 Pages

Revealing Microvascular Involvement in Pediatric Localized Scleroderma Through Nailfold Capillaroscopy

  • Sema Nur Taşkın,
  • Şeyda Doğantan,
  • Esra Esen,
  • Sümeyra Özdemir Çiçek,
  • Ayşenur Paç Kısaarslan and
  • Muammer Hakan Poyrazoğlu

17 September 2025

Background/Objectives: Juvenile localized scleroderma (jLoS) is a chronic inflammatory disorder with skin and subcutaneous tissue involvement. Microvascular alterations are thought to contribute to its pathogenesis. This study aimed to investigate mi...

  • Article
  • Open Access
1 Citations
2,196 Views
19 Pages

Local Existence and Blow-Up of Solutions for Wave Equation Involving the Fractional Laplacian with Nonlinear Source Term

  • Younes Bidi,
  • Abderrahmane Beniani,
  • Keltoum Bouhali,
  • Khaled Zennir,
  • Hatim M. ElKhair,
  • Eltegani I. Hassan and
  • Almonther Alarfaj

31 March 2023

The aim of this paper is to investigate the local weak existence and vacuum isolating of solutions, asymptotic behavior, and blow-up of the solutions for a wave equation involving the fractional Laplacian with nonlinear source. By means of the Galerk...

  • Article
  • Open Access
12 Citations
3,537 Views
15 Pages

2 June 2020

The paper focuses on Agro-food waste valorization conceived as a long-term, complex socio-technical process involving several different actors belonging to multiple levels. Although this process is typically affected by a series of uncertainties, the...

  • Review
  • Open Access
19 Citations
5,596 Views
28 Pages

Local Biomarkers Involved in the Interplay between Obesity and Breast Cancer

  • Jonas Busk Holm,
  • Ann H. Rosendahl and
  • Signe Borgquist

14 December 2021

Obesity is associated with an increased risk of breast cancer, which is the most common cancer in women worldwide (excluding non-melanoma skin cancer). Furthermore, breast cancer patients with obesity have an impaired prognosis. Adipose tissue is abu...

  • Article
  • Open Access
5 Citations
5,952 Views
31 Pages

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

  • Sandrine Baltzer,
  • Timur Bulatov,
  • Christopher Schmied,
  • Andreas Krämer,
  • Benedict-Tilman Berger,
  • Andreas Oder,
  • Ryan Walker-Gray,
  • Christin Kuschke,
  • Kerstin Zühlke and
  • Enno Klussmann
  • + 6 authors

The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis. However, the mechanisms controlling t...

  • Feature Paper
  • Article
  • Open Access
1 Citations
1,260 Views
18 Pages

18 January 2025

The aim of this paper is to demonstrate the existence of a unique positive solution to non-local fractional p-Laplacian equations of the Brézis–Oswald type involving Hardy potentials. The main feature of this paper is solving the difficu...

  • Article
  • Open Access
10 Citations
4,458 Views
19 Pages

25 April 2021

Plants live in ever-changing environments, facing adverse environmental conditions including pathogen infection, herbivore attack, drought, high temperature, low temperature, nutrient deficiency, toxic metal soil contamination, high salt, and osmotic...

  • Article
  • Open Access
14 Citations
4,528 Views
13 Pages

Testis-Specific SEPT12 Expression Affects SUN Protein Localization and is Involved in Mammalian Spermiogenesis

  • Chung-Hsin Yeh,
  • Ya-Yun Wang,
  • Shi-Kae Wee,
  • Mei-Feng Chen,
  • Han-Sun Chiang,
  • Pao-Lin Kuo and
  • Ying-Hung Lin

Male infertility is observed in approximately 50% of all couples with infertility. Intracytoplasmic sperm injection (ICSI), a conventional artificial reproductive technique for treating male infertility, may fail because of a severe low sperm count,...

  • Article
  • Open Access
11 Citations
3,076 Views
15 Pages

The identification and characterization of new proteins involved in spermatogenesis is fundamental, considering that good-quality gametes are basic in ensuring proper reproduction. Here, we further analyzed the temporal and spatial localization durin...

  • Review
  • Open Access
10 Citations
4,007 Views
22 Pages

Multimodality Treatment including Surgery Related to the Type of N2 Involvement in Locally Advanced Non-Small Cell Lung Cancer

  • Toon Allaeys,
  • Lawek Berzenji,
  • Patrick Lauwers,
  • Suresh Krishan Yogeswaran,
  • Jeroen M. H. Hendriks,
  • Charlotte Billiet,
  • Charlotte De Bondt and
  • Paul E. Van Schil

25 March 2022

For patients with locally advanced non-small cell lung cancer (NSCLC) or positive N1 nodes, multimodality treatment is indicated. However, the optimal management of patients presenting with ipsilateral positive mediastinal nodes (N2 disease) has not...

  • Article
  • Open Access
18 Citations
1,668 Views
13 Pages

12 March 2023

In the present work, we introduce two new local fractional integral operators involving Mittag–Leffler kernel on Yang’s fractal sets. Then, we study the related generalized Hermite–Hadamard-type inequality using generalized (E,h)-co...

  • Article
  • Open Access
3 Citations
2,409 Views
18 Pages

Local Magnetic Hyperthermia and Systemic Gemcitabine/Paclitaxel Chemotherapy Triggers Neo-Angiogenesis in Orthotopic Pancreatic Tumors without Involvement of Auto/Paracrine Tumor Cell VEGF Signaling and Hypoxia

  • Wisdom O. Maduabuchi,
  • Felista L. Tansi,
  • Bernd Faenger,
  • Paul Southern,
  • Quentin A. Pankhurst,
  • Frank Steiniger,
  • Martin Westermann and
  • Ingrid Hilger

20 December 2023

There is a growing interest in exploring the therapeutically mediated modulation of tumor vascularization of pancreatic cancer, which is known for its poorly perfused tumor microenvironment limiting the delivery of therapeutic agents to the tumor sit...

  • Article
  • Open Access
18 Citations
7,377 Views
30 Pages

Co-Designing the User Experience of Location-Based Games for a Network of Museums: Involving Cultural Heritage Professionals and Local Communities

  • Panayiotis Koutsabasis,
  • Konstantinos Partheniadis,
  • Anna Gardeli,
  • Panagiotis Vogiatzidakis,
  • Vasiliki Nikolakopoulou,
  • Pavlos Chatzigrigoriou,
  • Spyros Vosinakis and
  • Despina Elizabeth Filippidou

The design of location-based games (LBGs) for cultural heritage should ensure the active participation and contribution of local communities and heritage professionals to achieve contextual relevance, importance, and content validity. This paper pres...

  • Article
  • Open Access
2,244 Views
14 Pages

5 September 2022

Muscarinic acetylcholine receptors (mAChRs) play a central role in learning and memory in mammals as in honeybees. The results obtained in the honeybee Apis mellifera are based on the detrimental effects of the mAChR antagonists, atropine and scopola...

  • Article
  • Open Access
296 Views
17 Pages

The Role of a “Conservative” Resection Strategy After Neoadjuvant Treatment for Borderline/Locally Advanced PDAC with Arterial Involvement: A Single-Centre Retrospective Observational Study

  • Roberta Vella,
  • Elisa Bannone,
  • Alessandro Giardino,
  • Isabella Frigerio,
  • Martina Guerra,
  • Erica Pizzocaro,
  • Laura Bignotto,
  • Filippo Scopelliti,
  • Paolo Regi and
  • Giovanni Butturini
  • + 5 authors

4 March 2026

Background: Recent advances in multimodal therapies have increased the potential for resectability of borderline resectable and locally advanced pancreatic ductal adenocarcinoma (PDAC). We herein describe the conservative resection strategy adopted a...

  • Article
  • Open Access
3,497 Views
29 Pages

15 July 2025

Creating shared spaces is a key part of making extended reality (XR) and Internet of Things (IoT) technology more interactive and collaborative. Currently, one system which stands out in achieving this end commercially involves spatial anchors. Due t...

  • Article
  • Open Access
6 Citations
3,440 Views
13 Pages

24 January 2021

Pigment epithelium derived factor (PEDF) is a multifunctional secretory soluble glycoprotein that belongs to the serine protease inhibitor (serpin) family. It was reported to have neurotrophic, anti-angiogenic and anti-tumorigenic activity. Recently,...

  • Case Report
  • Open Access
1,294 Views
15 Pages

Psychological Involvement in the Journey of a Patient with Localized Prostate Cancer—From Diagnosis to Treatment

  • Daniela Mihalcia Ailene,
  • Gabriela Rahnea-Nita,
  • Alexandru Nechifor,
  • Liliana Florina Andronache,
  • Mihaela Emilia Dumitru,
  • Alexandru-Mihai Rebegea,
  • Cristina Stefanescu,
  • Roxana-Andreea Rahnea-Nita and
  • Laura-Florentina Rebegea

1 October 2025

Introduction: Prostate cancer is one of the most common neoplasia in men, and its clinical evolution is highly influenced by psycho-emotional factors, especially in elderly patients. Comorbidities, the perception of one’s identity and its impac...

  • Article
  • Open Access
10 Citations
8,540 Views
16 Pages

17 October 2014

Voluntary cooperation and the support of stakeholders carry a major importance in the development of Model Forests. The identification of the support level of local organizations as stakeholders in the Bucak Model Forest initiative, located in the Me...

  • Article
  • Open Access
12 Citations
3,244 Views
11 Pages

31 August 2022

Prothymosin α (PTMA) is a phylogenetically conserved polypeptide in male gonads of Vertebrates. In Mammals, it is a ubiquitous protein, and, possessing a random-coil structure, it interacts with many other partners, in both cytoplasmic and nucl...

  • Article
  • Open Access
1 Citations
4,611 Views
17 Pages

Examining the Factors Influencing Tsunami Evacuation Action Selection in Thailand: A Comprehensive Study Involving Local Residents, Non-Local Workers, and Travelers

  • Naphat Mahittikul,
  • Nawat Wancham,
  • Wanit Treeranurat,
  • Kumpol Saengtabtim,
  • Ampan Laosunthara,
  • Jing Tang and
  • Natt Leelawat

29 February 2024

Tsunamis are a substantial natural threat in Thailand, as evidenced by the 2004 Indian Ocean tsunami. Effective evacuation is vital to reduce casualties and property damage. However, despite improved warning systems, high death tolls still occur, ind...

  • Article
  • Open Access
3 Citations
2,237 Views
17 Pages

19 January 2023

Research in this paper aims to explore the concept of generalized exponentially (s,m)-convex functions, and to determine some properties of these functions. In addition, we look at some interactions between generalized exponentially (s,m)-convex func...

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