2,007 Results Found

Oligopeptidase B (OpB) is a two-domain, trypsin-like serine peptidase belonging to the S9 prolyloligopeptidase (POP) family. Two domains are linked by a hinge region that participates in the transition of the enzyme between two major states—closed an...

Multidrug resistance poses a major challenge to antibiotic therapy. A principal cause of antibiotic resistance is through active export by efflux pumps embedded in the bacterial membrane. Major facilitator superfamily (MFS) efflux pumps constitute a...

Laser pulses can be utilized to induce intermediate states of phase change materials between amorphous and crystalline phases, making phase change materials attractive and applicable for multi-level storage applications. In this paper, intermediate s...

Through a combination of comparative modeling, site-directed and classical random mutagenesis approaches, we previously identified critical residues for binding, recognition, and translocation of urea, and its inhibition by 2-thiourea and acetamide i...

Settlement control of existing stations has consistently been a key issue in tunnel construction. Intermediate soil has a significant influence on the settlement of the existing station as a connector between the new tunnel and the existing station w...

Bacteriorhodopsin (BR) functions as a light-driven proton pump that transitions between different states during the photocycle, such as all-trans (AT; BR568) and 13-cis, 15-syn (CS; BR548) state and K, L, M₁, M₂, N, and O intermediates. In this study...

As a member of the fatty acids transporter family, the heart fatty acid binding proteins (HFABPs) are responsible for many important biological activities. The binding mechanism of fatty acid with FABP is critical to the understanding of FABP functio...

Proteins are indispensable to cellular communication and metabolism. The structure on which cells and tissues are developed is deciphered from proteins. To perform functions, proteins fold into a three-dimensional structural design, which is specific...

Kinetic studies of the early events in cytochrome c folding are reviewed with a focus on the evidence for folding intermediates on the submillisecond timescale. Evidence from time-resolved absorption, circular dichroism, magnetic circular dichroism,...

We use molecular dynamics simulations of a full atomistic Gō model to explore the impact of selected DE-loop mutations (D59P and W60C) on the folding space of protein human β₂-microglobulin (Hβ₂m), the causing agent of dialysis-related amyloidosis, a...

Near-infrared fluorescent proteins (NIR FPs) based on the complexes of bacterial phytochromes with their natural biliverdin chromophore are widely used as genetically encoded optical probes for visualization of cellular processes and deep-tissue imag...

The interface models of diamond-coated WC-Co cemented carbide (DCCC) were constructed without intermediate layers and with different interface terminals, such as intermediate layers of TiC, TiN, CrN, and SiC. The adhesion work of the interface model...

Aspergillus oryzae has been used to ferment various cereal grains throughout history, as seen in the examples of sake, soy sauce, and miso. It is known that this fermentation enhances the nutritional quality of the raw materials by breaking down comp...

We review the current understanding of the time scale and mechanisms associated with the change in spin state in transition metal-based spin crossover (SCO) molecular complexes. Most time resolved experiments, performed by optical techniques, rely on...

Bromodomains (BRDs) are small protein interaction modules of about 110 amino acids that selectively recognize acetylated lysine in histones and other proteins. These domains have been identified in a variety of multi-domain proteins involved in trans...

Metalloporphyrins have attracted great attention in the potential application of biomimetic catalysis. Especially, they were widely investigated as green catalysts in the chemical oxidation of various hydrocarbons through the catalytic activation of...

To investigate the effect of C-terminal helix on the stability of the FF domain, we studied the native domain FF3-71 from human HYPA/FBP11 and the truncated version FF3-60 with C-terminal helix being deleted by molecular dynamics simulations with GRO...

As they are not subjected to natural selection process, de novo designed proteins usually fold in a manner different from natural proteins. Recently, a de novo designed mini-protein DS119, with a βαβ motif and 36 amino acids, has folded unusually slo...

We develop a cosmological model based on a quadratic equation of state \(p/c^2=-(\alpha+1){\rho^2}/{\rho_P}+\alpha\rho-(\alpha+1)\rho_ {\Lambda}\), where \(\rho_P\) is the Planck density and \(\rho_{\Lambda}\) the cosmological density, ``unifying'' v...

Singlet oxygen ene reactions produce 2-(tert-butyl)-4a-hydroperoxy-3-methyl-2,4a, 5,6,7,8-hexahydroquinazolin-4(3H)-one quantitatively during diffusion crystallization of 2-(tert-butyl)-3-methyl-2,3,5,6,7,8-hexahydroquinazolin-4(1H)-one in n-hexane/C...

The SARS-CoV-2 virus, commonly known as COVID-19, occurred in 2019. It is a highly contagious illness with effects ranging from mild symptoms to severe illness. It is also one of the best-known pathogens since more than 200,000 scientific papers occu...

Recently, metal nanoclusters (MNCs) emerged as a new class of luminescent materials and have attracted tremendous interest in the area of luminescence-related applications due to their excellent luminous properties (good photostability, large Stokes...

The low evaporation temperature and carcinogen classification of commonly used molybdenum trioxide (MoO₃) precursor render it unsuitable for the safe and practical synthesis of molybdenum disulfide (MoS₂). Furthermore, as evidenced by several experim...

A protein fold is defined as a structural arrangement of a secondary structure in a three-dimensional space. It would be interesting to know whether a particular fold can be assigned to certain features of the corresponding folding/unfolding transiti...

Geometric and electronic structure changes in the copper (Cu) centers in bilirubin oxidase (BOD) upon a four-electron reduction were investigated by quantum mechanics/molecular mechanics (QM/MM) calculations. For the QM region, the unrestricted densi...

Oligopeptidase B (OPB) is the least studied group from the prolyl oligopeptidase family. OPBs are found in bacteria and parasitic protozoa and represent pathogenesis factors of the corresponding infections. OPBs consist of two domains connected by a...

Biomphalaria pfeifferi snails serve as the major intermediate host for intestinal schistosomiasis in Sudan. The genetic structure and infection status of 163 B. pfeifferi collected from six localities in Gezira State, Sudan (East Gezira, Greater Wadm...

A covalent serine protease inhibitor—Na-p-Tosyl-Lysyl Chloromethylketone (TCK) is a modified lysine residue tosylated at the N-terminus and chloromethylated at the C-terminus, one molecule of which is capable of forming two covalent bonds with both S...

The human Vitamin K Epoxide Reductase Complex (hVKORC1), a key enzyme that converts vitamin K into the form necessary for blood clotting, requires for its activation the reducing equivalents supplied by its redox partner through thiol–disulphid...

Intermediate-temperature (IT) proton-exchange membranes (PEMs) play vital roles in hydrogen and direct liquid fuel cells, electrolyzers, and other electrochemical membrane reactors at elevated temperatures of higher than 150 °C. This article repo...

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal degenerative lung disease of unknown etiology. Although in its final stages it implicates, in a reactive manner, all lung cell types, the initial damage involves the alveolar epithelial c...

This paper presents the state of the art distributed sensing systems, based on optical fibres, developed and qualified for the French Cigéo project, the underground repository for high level and intermediate level long-lived radioactive wastes. Four...

This paper proposes a novel system-wide multi-state framework to model state occupations and the transitions among current, delinquency, default, prepayment, repurchase, short sale and foreclosure on mortgage loans. The approach allows for the modell...

Research on microglia in Down syndrome (DS) has shown that microglial activation, increased inflammatory gene expression, and oxidative stress occur at different ages in DS brains. However, most studies resulted in simplistic definitions of microglia...

Two different conformational isoforms or amyloid strains of insulin with different cytotoxic capacity have been described previously. Herein these filamentous and fibrillar amyloid states of insulin were investigated using biophysical and spectroscop...

Herein, the collective effects of spin polarization in a degenerate electron gas of an arbitrary space dimension are discussed. We consider these low-dimensional systems in light of potential wells (rectangular or cylindrical), and as a two- or one-d...

Human β2-microglobulin (b2m) protein is classically associated with dialysis-related amyloidosis (DRA). Recently, the single point mutant D76N was identified as the causative agent of a hereditary systemic amyloidosis affecting visceral organs....

We consider a boundary control problem for the equation of string vibration with given initial and final conditions, given the deflection form at an intermediate moment of time. The control is carried out by displacement of one end with the other end...

Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) are derived from pre- and post-implantation embryos, representing the initial “naïve” and final “primed” states of pluripotency, respectively. In this stu...

TAR DNA-binding protein 43 (TDP-43) is a 414-residue long nuclear protein whose deposition into intraneuronal insoluble inclusions has been associated with the onset of amyotrophic lateral sclerosis (ALS) and other diseases. This protein is physiolog...

Local food has been the subject of federal, state, and local government policies in recent years throughout the United States as consumer demand has grown. Local foods have been linked to several government priorities—including enhancing the rural ec...

We perform precise measurements of the ⁸⁷Rb Rydberg excitation spectrum by using electromagnetically induced transparency (EIT) in a ladder system. We utilize a two-photon excitation configuration with the probe and control lasers at 420 nm and 1013...

When coherent detection occurs, the polarization mismatch between signal light and local oscillator light can reduce the efficiency of coherent detection. This article combines the principle of optical mixers to derive the relationship between the po...

Experimental data on the folding and unfolding of small globular proteins are often well described assuming a two-state equilibrium process. It means that after careful analysis by a combination of experimental techniques, only folded and unfolded st...

Conventional economic growth models treat production/consumption as abstractions linked only by money flows, disregarding their connection to the physical world. Nevertheless, the existing literature suggests that energy flows can influence productio...

Integrin LFA-1 plays a critical role in T-cell migration and in the formation of immunological synapses. LFA-1 functions through interacting with its ligands with differing affinities: low, intermediate, and high. Most prior research has studied how...

How do transformers model physics? Do transformers model systems with interpretable analytical solutions or do they create an “alien physics” that is difficult for humans to decipher? We have taken a step towards demystifying this larger...

A power-down system has an on-state, an off-state, and a finite or infinite number of intermediate states. In the off-state, the system uses no energy and in the on-state energy it is used fully. Intermediate states consume only some fraction of ener...

SrVO₂H, obtained by a topochemical reaction of SrVO₃ perovskite using CaH₂, is an anion-ordered phase with hydride anions exclusively at the apical site. In this study, we conducted a CaH₂ reduction of SrVO₃ thin films epitaxially grown on KTaO₃ (KTO...

Our previous study reported that operation in multiple steady states contributes to an improvement in reaction conversion, making it possible to reduce the energy consumption of the reactive distillation process for tert-amyl methyl ether (TAME) synt...