The laser cleaning process has the potential to become an alternative to the existing chemical-based cleaning process if integrated with an effective in-process monitoring system that could serve as a control mechanism over surface damages or contami...
Fused filament fabrication (FFF), an additive manufacturing technique, unlocks alternative possibilities for the production of complex geometries. In this process, the layer-by-layer deposition mechanism and several heat sources make it a thermally d...
Refolding is known as the bottleneck in inclusion body (IB) downstream processing in the pharmaceutical industry: high dilutions leading to large operating volumes, slow refolding kinetics and low refolding yields are only a few of the problems that...
This paper introduces a novel approach to in-process monitoring of the cutting temperature at the tool-chip interface (TCI). Currently, there are no tools available in the commercial market for measuring and monitoring cutting processes at the TCI re...
Currently, systems installed on large-scale aerospace structures are manually equipped by trained operators. To improve current methods, an automated system that ensures quality control and process adherence could be used. This work presents a mobile...
Additive manufacturing (AM) has emerged as a pivotal technology in component fabrication, renowned for its capabilities in freeform fabrication, material efficiency, and integrated design-to-manufacturing processes. As a critical branch of AM, metal...
The aim of manufacturing can be described as achieving the predefined high quality product in a short delivery time and at a competitive cost. However, it is unfortunately quite challenging and often difficult to ensure that certain quality character...
Heat generation is a critical issue in grinding. If the grinding point generates significant heat, dimensional and shape accuracy may decrease due to thermal deformation, and the machined surface may deteriorate due to grinding burn. Therefore, monit...
HPLC is established as a fast convenient analytical technology for characterizing the content of empty and full capsids in purified samples containing adeno-associated virus (AAV). UV-based monitoring unfortunately over-estimates the proportion of fu...
In the field of engineering, surface metrology is a valuable tool codified by international standards that enables the quantitative study of small-scale surface features. However, it is not recognized as a resource in the field of cultural heritage....
Wire arc additive manufacturing (WAAM) is an emerging and promising technology for producing medium-to-large-scale metallic components/structures for different industries, i.e., aerospace, automotive, shipbuilding, etc. It is now a feasible alternati...
The complexity of products increases considerably, and key functions can often only be realized by using high-precision components. Microgears have a particularly complex geometry and thus the manufacturing requirements often reach technological limi...
This study investigates the influence of resistive pre-heating of the feedstock wire (here called hot-wire) on the stability of laser-directed energy deposition of Duplex stainless steel. Data acquired online during depositions as well as metallograp...
Additive manufacturing workflows generate large amounts of data in each phase, which can be very useful for monitoring process performance and predicting the quality of the finished part if used correctly. In this paper, a framework is presented that...
Lack of fusion can often occur during ultra-thin sheets edge welding process, severely destroying joint quality and leading to seal failure. This paper presents a vision-based weld pool monitoring method for detecting a lack of fusion during micro pl...
Optical coherence tomography (OCT) is an inline process monitoring technology for laser welding with various applications in the pre-, in-, and post-process. In-process monitoring with OCT focuses on the measurement of weld depth by the placement of...
The acoustic emission (AE) technique is an effective method for monitoring grinding wheels, and numerous studies have been published on applying an AE to monitor grinding wheels. However, there are few studies on the effect of the location of the AE...
The aim of nuclear safeguards is to ensure that special nuclear material is used for peaceful purposes. Historically, nuclear material accounting (NMA) has provided the quantitative basis for monitoring for nuclear material loss or diversion, and pro...
Laser micro-welding manufacturers face substantial challenges in verifying weldment quality, as the industry and applications are requiring increasingly the miniaturization and compactness of products. The problem is compounded by new stringent deman...
The dispersion mechanisms in a clay-based polymer nanocomposite (CPNC) during twin-screw extrusion are studied by in-situ rheo-optical techniques, which relate the CPNC morphology with its viscosity. This methodology avoids the problems associated wi...
The mechanical energy resulting from cutting processes is turned almost completely in thermal energy, which encourages thermal procedures, such as diffusion, leading to higher wear in the cutting tool and thus to higher temperatures. Furthermore, hig...
Additive manufacturing is one of the rising manufacturing technologies in the future; however, due to its operational mechanism, printing failures are still prominent, leading to waste of both time and resources. The development of a real-time proces...
During the milling of thin-walled workpieces, the natural frequencies might change radically due to the material removal. To avoid resonant spindle speeds and chatter vibration, a precise knowledge of the instantaneous modal parameters is necessary....
With the increasing power and speed of laser welding, in-process monitoring has become even more crucial to ensure process stability and weld quality. Due to its low cost and installation flexibility, acoustic process monitoring is a promising method...
In this work, we combine some of the most relevant artificial intelligence (AI) techniques with a range-resolved interferometry (RRI) instrument applied to the maintenance of a wind turbine. This method of automatic and autonomous learning can identi...
The research on methods for monitoring sheet metal stamping is benefiting from the increased availability of enabling technologies such as sensors, data mining software, cloud computing, and artificial intelligence. The predictive maintenance policie...
In this study, silver (Ag) and silver–diamond (Ag-D) composites with varying diamond (D) content are fabricated using laser powder bed fusion (L-PBF) additive manufacturing (AM). The L-PBF process parameters and inert gas flow rate are optimise...
Virus-based biopharmaceutical products are used in clinical applications such as vaccines, gene therapy, and immunotherapy. However, their manufacturing remains a challenge, hampered by the lack of appropriate analytical tools for purification monito...
The technology of hairpin welding, which is frequently used in the automotive industry, entails high-quality requirements in the welding process. It can be difficult to trace the defect back to the affected weld if a non-functioning stator is detecte...
Rotavirus A infection is a global leading cause of severe acute gastroenteritis associated with life-threatening diarrheal episodes in infants and young children. The disease burden is being reduced, namely due to a wider access to rotavirus vaccines...
Residence-time-distribution (RTD)-based models are key to understanding the mixing dynamics of continuous manufacturing systems. Such models can allow for material traceability throughout the process and can provide the ability for removal of non-con...
Particularly for highly stressed components, it is important to have precise knowledge of the surface and subsurface properties and, thus, of the functional properties after final grinding at the end of a complex process chain in order to avoid rejec...
The present study introduces an AI (Artificial Intelligence) framework for surface roughness assessment in milling operations through sound signal processing. As industrial demands escalate for in-process quality control solutions, the proposed syste...
Metal additive manufacturing (AM) is a disruptive production technology, widely adopted in innovative industries that revolutionizes design and manufacturing. The interest in quality control of AM systems has grown substantially over the last decade,...
This study presents a real-time system for detecting sheath damage in multicore wire production, addressing the limitations of conventional high-voltage testing. After evaluating multiple sensing techniques, laser-diffused reflection emerged as the m...
Low-processed ready-to-eat (RTE) meat products are highly vulnerable to microbial contamination, yet data on in-process dynamics remain limited. This study investigated microbial dynamics and environmental hygiene during the production of vacuum-pack...
The paper presents a review of the research reports published in 2012–2022, dedicated to air gauging. Since most of the results are somehow related to Industry 4.0 concept, the review put the air gauging to the context of fourth industrial revo...
This study presents an intelligent machine developed for real-time quality monitoring during CNC turning, aimed at improving cutting efficiency and reducing production energy. A dynamometer integrated into the CNC machine captures decomposed cutting...
Liver transplantation (LT) is a complex surgical procedure requiring thorough pre- and post-operative planning and care. The nutritional status of the patient before, during, and after LT is crucial to surgical success and long-term prognosis. This r...
The future of the milling process is the fully autonomous operation of the machine tools. Developments in terms of automation and machine tool design are now enabling fully autonomous operation. However, the optimization and stability of the process...
Nickel-Titanium (Ni-Ti) alloys are very difficult-to-machine materials causing notable manufacturing problems due to their unique mechanical properties, including superelasticity, high ductility, and severe strain-hardening. In this framework, the ai...
In micro electrical discharge drilling, regression models are commonly used for predicting the material removal rate (MRR) and tool wear rate (TWR) from the applied processing parameters. However, these models can be inaccurate since the processing p...
With the increasing demand for high-performance ceramic guideways in precision industries, accurate flatness measurement of large-scale, rough ceramic surfaces remains challenging. This paper proposes a novel method combining oblique-incidence laser...
The increasing environmental pollution with particular reference to emerging contaminants, toxic heavy elements, and other hazardous agents is a serious concern worldwide. Considering this global issue, there is an urgent need to design and develop s...
Part quality monitoring and control in wire-based directed energy deposition additive manufacturing (w-DEDAM) processes has been garnering continuous interest from both the academic and industrial sectors. However, maintaining a consistent layer heig...
In-process penetration monitoring of the pulsed laser welding process remains a great challenge for achieving uniform and reproducible products due to the highly complex nature of the keyhole dynamics within the intense laser-metal interactions. The...
The digitalization of machining processes is increasingly recognized as essential for achieving higher productivity, reliability, and traceability. However, access to reliable in-process sensor data remains limited, particularly in multi-axis CNC mac...
The continuous manufacturing of biologics offers significant advantages in terms of reducing manufacturing costs and increasing capacity, but it is not yet widely implemented by the industry due to major challenges in the automation, scheduling, proc...
With the aim of increasing the efficiency of maintenance and fuel usage in airplanes, structural health monitoring (SHM) of critical composite structures is increasingly expected and required. The optimized usage of this concept is subject of intensi...
Vaccines undergo stringent batch-release testing, most often including in-vivo assays for potency. For combination vaccines, such as diphtheria-tetanus-pertussis (DTaP), chemical modification induced by formaldehyde inactivation, as well as adsorptio...
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