Hydrogel composites are pivotal in biomedical research, showing promise across various applications. This review aims to thoroughly examine their significance and versatile roles in regenerative medicine, tissue engineering, and drug delivery systems...
Articular cartilage defects remain a significant clinical challenge due to the limited intrinsic regenerative capacity of cartilage and the inability of many current therapeutic approaches to restore the structure and function of native hyaline tissu...
Hydrogels, renowned for their hydrophilic and viscoelastic properties, have emerged as key materials for flexible electronics, including electronic skins, wearable devices, and soft sensors. However, the application of pure double network hydrogel-ba...
Water pollution is caused by multiple factors, such as industrial dye wastewater. Dye-contaminated water can be treated using hydrogels as adsorbent materials. Recently, composite hydrogels containing metal oxide nanoparticles (MONPs) have been used...
The photoantibacterial properties of titania nanoparticles (TiO2NPs) are attracting much interest, but the separation of their suspension limits their application. In this study, the encapsulation of commercial TiO2NPs within self-assembling tripepti...
Anthropogenic phosphorus (P) release from human activities continues to degrade freshwater systems, underscoring the need for effective and sustainable approaches to P removal and management. This study investigates steel slag–chitosan–nanoclay hydro...
In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have been a recurrent solution in both cases, with some reaching already the market, even though their mechanical stabi...
Hydrogel composites can be prepared from cellulose-based materials and other gel materials, thus combining the advantages of both kinds of material. The aerogel, porous material formed after removing the water in the hydrogel, can maintain the networ...
Molecular self-assembly of DNA has been developed as an effective construction strategy for building complex materials. Among them, DNA hydrogels are known for their simple fabrication process and their tunable properties. In this study, we have engi...
The advancement of wearable sensing technologies has been pivotal in revolutionizing healthcare, environmental monitoring, and personal fitness. Among the diverse materials employed in these technologies, multifunctional hydrogel composites have emer...
The recognized antibacterial properties of silver nanoparticles (AgNPs) characterize them as attractive nanomaterials for developing new bioactive materials less prone to the development of antibiotic resistance. In this work, we developed new compos...
Dual-drug delivery systems using hydrogel–nanoparticle composites have emerged as a versatile platform for achieving controlled, targeted, and efficient delivery of two distinct therapeutic agents. This approach combines the high loading capaci...
The present paper investigated the synthesis of peptide-based hydrogel composites containing photo-generated silver nanoparticles (AgNPs) obtained in the presence and absence of honey as tensile strength enhancer and hydrogel stabilizer. Fmoc-Phe and...
Hydrogels with protein–polysaccharide combinations are widely used in the field of tissue engineering, as they can mimic the in vivo environments of native tissues, specifically the extracellular matrix (ECM). However, achieving stability and m...
Innovative materials and technologies capable of extraction and recovery of technologically relevant metal ions from various water sources, such as lakes, oceans, ponds, or wastewater reservoirs, are in great demand. Polymer beads are among the most...
Flexible materials that provide an electric, magnetic, or optic response upon deformation or tactile pressure could be important for the development of smart monitors, intelligent textiles, or in the development of robotic skins. In this work we demo...
3D bioprinting of hydrogel–cell composites requires simultaneous consideration of the biomechanical properties of the printed structures, the construct’s geometric stability, and conditions conducive to cell survival and function. Hydroge...
Chronic wounds constitute a major clinical and socioeconomic burden owing to prolonged inflammation, persistent bacterial infection, impaired angiogenesis, and defective extracellular matrix remodeling. Advanced wound dressings have traditionally bee...
We report on the synthesis and the mechanical characterization of an alginate-collagen fibril composite hydrogel. Native type I collagen fibrils were used to synthesize the fibrous composite hydrogel. We characterized the mechanical properties of th...
Nanocomposite hydrogels are highly porous colloidal structures with a high adsorption capacity, making them promising materials for wastewater treatment. In particular, magnetic nanoparticle (MNP) incorporated hydrogels are an excellent adsorbent for...
Stimuli-responsive hydrogels have emerged as a promising class of biomaterials for advanced wound healing applications, offering dynamic and controllable responses to the wound microenvironment. These hydrogels are designed to respond to specific sti...
Polymer hydrogels, including molecular hydrogels, are expected to become materials for healthcare and medical applications, but there is a need to create new functional molecular gels that can meet the required performance. In this paper, for creatin...
Hydrogels, electrospun fiber mats (EFMs), and their composites have been extensively studied for tissue engineering because of their physical and chemical similarity to native biological systems. However, while chemically similar, hydrogels and elect...
Electronic skins (E-skins) are the integration of intelligent wearable sensors that can collect human physiological, motion, or environmental parameters in real-time through flexible, sensitive materials. The performance of E-skins depends on the sel...
In this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogel...
Nowadays, as a result of the frequent occurrence of accidental injuries and traumas such as bone damage, the number of people causing bone injuries or fractures is increasing around the world. The design and fabrication of ideal bone tissue engineeri...
Both biosystems and engineering fields demand advanced friction-reducing and lubricating materials. Due to their hydrophilicity and tissue-mimicking properties, hydrogels are ideal candidates for use as lubricants in water-based environments. They ar...
Numerous innovative advancements in dressing technology for wound healing have emerged. Among the various types of wound dressings available, hydrogel dressings, structured with a three-dimensional network and composed of predominantly hydrophilic co...
Hydrogel dressings are critical in biomedical applications. However, developing multifunctional hydrogel dressings that combine antibacterial action, strong interfacial adhesion, and anti-inflammatory regulation remains a significant challenge. This...
The development of biomaterials for the restoration of the normal tissue structure–function relationship in pathological conditions as well as acute and chronic injury is an area of intense investigation. More recently, the use of tailored or c...
Uveal melanoma (UM) is the most common primary intraocular tumor in adults with high mortality. In order to improve prognosis and survival of UM patients, it is critical to inhibit tumor progression and metastasis as early as possible after the initi...
Hydrogel/electrospun polymer nanofiber composites (HENC) integrate the advantages of both components. Hydrogels provide high water content, biocompatibility, and tunable drug release, while electrospun nanofibers offer a high surface area, loading ca...
The precise management of chronic wounds poses a global medical challenge, owing to their complex and dynamically shifting pathological microenvironment, coupled with their inherent difficulty in healing. Traditional dressings, which lack capabilitie...
Layered composite hydrogels have been considered attractive materials for use in osteochondral repair and regeneration. These hydrogel materials should be mechanically strong, elastic, and tough besides fulfilling some basic requirements such as bioc...
We report the feasibility of using gelatin hydrogel networks as the host for the in situ, environmentally friendly formation of well-dispersed zinc oxide nanoparticles (ZnONPs) and the evaluation of the antibacterial activity of the as-prepared compo...
This study aims to address the poor extensibility, brittleness, and limited hydration stability of pure sodium alginate (SA) hydrogels, which hinder their use in flexible, skin-adherent applications such as facial masks, by developing bio-based compo...
Hydrogels consist of three-dimensionally crosslinked polymeric chains, are hydrophilic, have the ability to absorb other molecules in their structure and are relatively easy to obtain. However, in order to improve some of their properties, usually me...
Composite hydrogels with electrospun nanofibers (NFs) have recently been used to mimic the native extracellular matrix. In this study, composite hydrogels of methacrylated hyaluronic acid containing fragmented polycaprolactone NFs were used for bone...
Rapid new microvascular network induction was critical for bone regeneration, which required the spatiotemporal delivery of growth factors and transplantation of endothelial cells. In this study, the linear poly(d,l-lactic-co-glycolic acid)-b-methoxy...
We investigated the mechanical properties of corn starch (CS)/poly(vinyl alcohol) (PVA)/borax hydrogels reinforced by clay platelets, silica (SiO2) nanospheres, or cellulose nanofibers (CNFs). The effects of these reinforcing agents on the tensile pr...
Wound healing is a complex physiological process involving multiple stages, including hemostasis, inflammation, proliferation, and remodeling, which imposes high demands on the functionality and adaptability of wound repair materials. Hydrogels, as a...
Polysaccharide–protein composite hydrogels have demonstrated remarkable potential in targeted gastrointestinal delivery owing to their excellent biocompatibility, adjustable physicochemical characteristics, and intelligent responsiveness. This...
Bone tissue engineering has gained attention recently as a method for regenerating bone critical-size defects. This work aims to synthesize a hydrogel based on gelatin, di-amine polyethylene glycol, Polyethylene Glycol-Polypropylene Glycol-Polyethyle...
It is well known that elastic instabilities induce pattern transformations when a soft cellular structure is compressed beyond critical limits. The nonlinear phenomena of pattern transformations make them a prime candidate for controlling macroscopic...
In this work, novel hydrogel composites membranes comprising [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide as monomer, N,N-methylene bisacrylamide as cross-linker, and 1-butyl-3-methylimidazolium hexafluorophosphate as ionic li...
Novel composite hydrogels based on the combination of alginate (Alg), soy protein isolate (SPI) and bioactive glass (BG) nanoparticles were developed for soft tissue engineering. Human umbilical vein endothelial cells (HUVEC) and normal human dermal...
To enhance the mechanical strength and cell adhesion of alginate hydrogel, making it satisfy the requirements of an ideal tissue engineering scaffold, the grafting of Arg-Gly-Asp (RGD) polypeptide sequence onto the alginate molecular chain was conduc...
Controlling the balance between mechanical characteristics and sorption–diffusion properties remains one of the main challenges in the development of hydrogel materials. In this work, a method for obtaining composite copolymers of polyvinylpyrr...
The three-dimensional network and ample pore structure of novel hydrogel materials enable outstanding adsorption performance for pollutants such as methylene blue (MB) and Cr6+ ions in wastewater. In order to develop an environmentally friendly hydro...
In this study, a series of gelatin/silver nanoparticles (AgNPs) composite hydrogels are prepared for the first time through the facile in situ formation of AgNPs. AgNPs, which are formed by reducing Ag+ using dopamine-conjugated gelatins. These can s...
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