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Volume 11
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Article

Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits

by
Ming Gao
1,
Abhichart Krissanaprasit
1,
Austin Miles
2,
Lilian C. Hsiao
3 and
Thomas H. LaBean
1,*
1
Department of Materials Science and Engineering, College of Engineering, North Carolina State University, Raleigh, NC 27695, USA
2
North Carolina School of Science and Mathematics, Durham, NC 27705, USA
3
Department of Chemical and Biomolecular Engineering, College of Engineering, North Carolina State University, Raleigh, NC 27695, USA
*
Author to whom correspondence should be addressed.
Appl. Sci. 2021, 11(5), 2245; https://doi.org/10.3390/app11052245
Submission received: 5 February 2021 / Revised: 23 February 2021 / Accepted: 24 February 2021 / Published: 3 March 2021
(This article belongs to the Special Issue Mechanical Design in DNA Nanotechnology)
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Abstract

Molecular self-assembly of DNA has been developed as an effective construction strategy for building complex materials. Among them, DNA hydrogels are known for their simple fabrication process and their tunable properties. In this study, we have engineered, built, and characterized a variety of pure DNA hydrogels using DNA tile-based crosslinkers and different sizes of linear DNA spacers, as well as DNA hydrogel/nanomaterial composites using DNA/nanomaterial conjugates with carbon nanotubes and gold nanoparticles as crosslinkers. We demonstrate the ability of this system to self-assemble into three-dimensional percolating networks when carbon nanotubes and gold nanoparticles are incorporated into the DNA hydrogel. These hydrogel composites showed interesting non-linear electrical properties. We also demonstrate the tuning of rheological properties of hydrogel-based composites using different types of crosslinkers and spacers. The viscoelasticity of DNA hydrogels is shown to dramatically increase by the use of a combination of interlocking DNA tiles and DNA/carbon nanotube crosslinkers. Finally, we present measurements and discuss electrically conductive nanomaterials for applications in nanoelectronics.
Keywords: DNA hydrogel; DNA hydrogel-based composites; self-assembly; biomaterials; DNA nanotechnology; carbon nanotubes; gold nanoparticles DNA hydrogel; DNA hydrogel-based composites; self-assembly; biomaterials; DNA nanotechnology; carbon nanotubes; gold nanoparticles

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MDPI and ACS Style

Gao, M.; Krissanaprasit, A.; Miles, A.; Hsiao, L.C.; LaBean, T.H. Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits. Appl. Sci. 2021, 11, 2245. https://doi.org/10.3390/app11052245

AMA Style

Gao M, Krissanaprasit A, Miles A, Hsiao LC, LaBean TH. Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits. Applied Sciences. 2021; 11(5):2245. https://doi.org/10.3390/app11052245

Chicago/Turabian Style

Gao, Ming, Abhichart Krissanaprasit, Austin Miles, Lilian C. Hsiao, and Thomas H. LaBean. 2021. "Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits" Applied Sciences 11, no. 5: 2245. https://doi.org/10.3390/app11052245

APA Style

Gao, M., Krissanaprasit, A., Miles, A., Hsiao, L. C., & LaBean, T. H. (2021). Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits. Applied Sciences, 11(5), 2245. https://doi.org/10.3390/app11052245

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