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86 Results Found

  • Article
  • Open Access
1,752 Views
14 Pages

14 January 2025

In this study, we conducted an exploration of blood collection, hematological and biochemical comparative analysis of the unique vitreous humor and blood of the celestial-eye goldfish (CE) (Carassius auratus), and obtained hematological and biochemic...

  • Article
  • Open Access
571 Views
19 Pages

31 October 2025

After intensive artificial selection, the development of celestial eyes in goldfish involves the eyeballs protuberating and turning upwards. Thus, the celestial eye goldfish is an excellent model for both evolutionary and human ocular disease studies...

  • Article
  • Open Access
4 Citations
2,625 Views
14 Pages

Full-Length RNA Sequencing Provides Insights into Goldfish Evolution under Artificial Selection

  • Xuedi Du,
  • Weiwei Zhang,
  • Jiali Wu,
  • Congyuan You and
  • Xiaojing Dong

1 February 2023

Goldfish Carassius auratus is an ideal model for exploring fish morphology evolution. Although genes underlying several ornamental traits have been identified, little is known about the effects of artificial selection on embryo gene expression. In th...

  • Article
  • Open Access
14 Citations
4,531 Views
13 Pages

Accumulation of C-CTX1 in Muscle Tissue of Goldfish (Carassius auratus) by Dietary Experience

  • Andres Sanchez-Henao,
  • Natalia García-Álvarez,
  • Daniel Padilla,
  • María Ramos-Sosa,
  • Freddy Silva Sergent,
  • Antonio Fernández,
  • Pablo Estévez,
  • Ana Gago-Martínez,
  • Jorge Diogène and
  • Fernando Real

19 January 2021

Ciguatoxins (CTXs) are produced by dinoflagellates usually present in tropical and subtropical waters. These toxins are bioaccumulated and transformed in fish causing ciguatera fish poisoning (CFP) in humans. Few trials have been performed to underst...

  • Article
  • Open Access
17 Citations
4,106 Views
11 Pages

3 September 2021

Cyprinid herpesvirus 2 (CyHV-2), a member of the Alloherpesviridae family belonging to the genus Cyprinivirus, is a fatal contagious aquatic pathogen that affects goldfish (Carassius auratus) and crucian carp (Carassius carassius). Although crucian c...

  • Article
  • Open Access
49 Citations
7,235 Views
14 Pages

Goldfish Leptin-AI and Leptin-AII: Function and Central Mechanism in Feeding Control

  • Ai-Fen Yan,
  • Ting Chen,
  • Shuang Chen,
  • Chun-Hua Ren,
  • Chao-Qun Hu,
  • Yi-Ming Cai,
  • Fang Liu and
  • Dong-Sheng Tang

In mammals, leptin is a peripheral satiety factor that inhibits feeding by regulating a variety of appetite-related hormones in the brain. However, most of the previous studies examining leptin in fish feeding were performed with mammalian leptins, w...

  • Article
  • Open Access
2 Citations
3,560 Views
24 Pages

Visual Perception of Photographs of Rotated 3D Objects in Goldfish (Carassius auratus)

  • Jessica J. Wegman,
  • Evan Morrison,
  • Kenneth Tyler Wilcox and
  • Caroline M. DeLong

13 July 2022

This study examined goldfishes’ ability to recognize photographs of rotated 3D objects. Six goldfish were presented with color photographs of a plastic model turtle and frog at 0° in a two-alternative forced-choice task. Fish were tested wi...

  • Article
  • Open Access
3 Citations
2,672 Views
13 Pages

Metabolic Hepatic Disorders Caused by Ciguatoxins in Goldfish (Carassius auratus)

  • María José Ramos-Sosa,
  • Víctor Hernández López,
  • Andres Sanchez-Henao,
  • Natalia García-Álvarez,
  • Ana R. Díaz-Marrero,
  • Inmaculada Rosario,
  • Fernando Real and
  • José J. Fernández

11 December 2022

Ciguatera poisoning (CP) is a foodborne disease known for centuries; however, little research has been conducted on the effects of ciguatoxins (CTXs) on fish metabolism. The main objective of this study was to assess different hepatic compounds obser...

  • Article
  • Open Access
2 Citations
2,665 Views
12 Pages

1 September 2024

This study investigates the impact of different diets on fish growth and bacterial community structure present in the intestine of goldfish (Carassius auratus) and their aquaculture water under recirculating water conditions. We assumed that differen...

  • Article
  • Open Access
5 Citations
3,182 Views
11 Pages

21 December 2022

Skin color is an important phenotypic feature of vertebrate fitness under natural conditions. Celestial goldfish, a common goldfish breed in China, mainly shows three kinds of skin colors including white, yellow and brown. However, the molecular gene...

  • Article
  • Open Access
8 Citations
2,650 Views
15 Pages

17 July 2023

Imidacloprid (IMI) is the first-generation neonicotinoid insecticide. But, the long-term use of IMI as a pesticide has caused severe water pollution. Recently, the toxicity of IMI to aquatic organisms has received increasing attention. This study aim...

  • Article
  • Open Access
1 Citations
1,460 Views
19 Pages

Goldfish (Carassius auratus), subjected to millennia of artificial selection and breeding, have diversified into numerous ornamental varieties, such as the celestial-eye (CE) goldfish, noted for its unique dorsal eye rotation. Previous studies have p...

  • Article
  • Open Access
1,480 Views
13 Pages

1 May 2024

This study layed the groundwork for the creation of haploid and triploid celestial goldfish, presenting essential data derived from preliminary investigations. The research delved into three main areas: the short-term preservation of celestial goldfi...

  • Article
  • Open Access
662 Views
18 Pages

The migration of terrestrial microplastics (MPs) into aquatic environments is considered to have negatively affected aquatic ecosystems. However, quantifying terrestrial pathways is challenging because of the diverse sources of MPs. A poorly understo...

  • Article
  • Open Access
7 Citations
2,429 Views
11 Pages

9 May 2023

The aim of this study was to evaluate the potential effects of γ-irradiated date palm fruit (Phoenix dactylifera), which is rich in phenolic acids and has important and varied biological bioactivities, on growth performance, mucosal immunity an...

  • Article
  • Open Access
13 Citations
5,523 Views
21 Pages

Isolation of a Chinook Salmon Bafinivirus (CSBV) in Imported Goldfish Carassius auratus L. in the United Kingdom and Evaluation of Its Virulence in Resident Fish Species

  • Irene Cano,
  • David Stone,
  • Jacqueline Savage,
  • Gareth Wood,
  • Brian Mulhearn,
  • Joshua Gray,
  • Nick Stinton,
  • Stuart Ross,
  • Michaela Bonar and
  • Stephen W. Feist
  • + 1 author

25 May 2020

This is the first record of a fish nidovirus isolated from a consignment of goldfish at the United Kingdom (UK) border. The full-length viral genome was 25,985 nt, sharing a 97.9% nucleotide identity with the Chinook salmon bafinivirus (CSBV) NIDO wi...

  • Article
  • Open Access
2 Citations
2,507 Views
13 Pages

10 February 2023

Zinc (Zn), a heavy metal, is an essential element in fish; however, exposure to high concentrations causes oxidative stress. Water hardness reduces oxidative stress reactions caused by heavy metals. To confirm the effect of water hardness on oxidativ...

  • Article
  • Open Access
3 Citations
1,338 Views
12 Pages

16 April 2025

Background: Heavy metal interactions within aquatic ecosystems significantly affect fish physiology. This study evaluated the protective role of selenium against cadmium-induced hematological, biochemical, and electrophoretic alterations in goldfish....

  • Article
  • Open Access
4 Citations
2,755 Views
15 Pages

13 October 2022

Goldfish are one of the most popular models for studying the genetic diversity of skin color. Transcriptome sequencing (RNA-seq) and whole genome bisulfate sequencing (WGBS) of skin tissues from the third filial (F3) cyan (CN), black (BK), and white...

  • Article
  • Open Access
15 Citations
7,566 Views
15 Pages

Leptin Stimulates Prolactin mRNA Expression in the Goldfish Pituitary through a Combination of the PI3K/Akt/mTOR, MKK3/6/p38MAPK and MEK1/2/ERK1/2 Signalling Pathways

  • Aifen Yan,
  • Yanfeng Chen,
  • Shuang Chen,
  • Shuisheng Li,
  • Yong Zhang,
  • Jirong Jia,
  • Hui Yu,
  • Lian Liu,
  • Fang Liu and
  • Ting Chen
  • + 1 author

20 December 2017

Leptin actions at the pituitary level have been extensively investigated in mammalian species, but remain insufficiently characterized in lower vertebrates, especially in teleost fish. Prolactin (PRL) is a pituitary hormone of central importance to o...

  • Article
  • Open Access
1 Citations
3,605 Views
12 Pages

Migration of Artificial Turf Fibers from Artificial Turf Sports Field and Their Ingestion by Goldfish

  • Kanoko Takahashi,
  • Ryosuke Fujinuma,
  • Tomoyasu Yoshitomi,
  • Yasuo Shimizu and
  • Makito Kobayashi

Various artificial materials and facilities are sources of microplastics, including artificial turf sports fields. In artificial turf fields, polyethylene fibers are attached to a basal cloth with adhesives. In the present study, we investigated whet...

  • Article
  • Open Access
19 Citations
5,366 Views
19 Pages

Optimizing the Growth, Health, Reproductive Performance, and Gonadal Histology of Broodstock Fantail Goldfish (Carassius auratus, L.) by Dietary Cacao Bean Meal

  • Hanan. S. Al-Khalaifah,
  • Shimaa A. Amer,
  • Dina M. M. Al-Sadek,
  • Alshimaa A. Khalil,
  • Eman M. Zaki and
  • Doaa A. El-Araby

5 October 2020

The potential effects of cacao bean meal, Theobroma cacao L., (CBM) on the growth, health status, blood biochemical parameters, antioxidant, immune status, physiological parameters, female reproductive performance, and gonadal histological features o...

  • Article
  • Open Access
5 Citations
4,182 Views
14 Pages

We investigated the changes in toxicity stress in goldfish, Carassius auratus, under exposure to different concentrations of Zn and water hardness for 14 days. We analyzed the changes in water hardness and Zn accumulation after exposure. To investiga...

  • Article
  • Open Access
692 Views
15 Pages

An Evaluation of the Anesthetic Properties and Serum Biochemical Response of Ocimum Essential Oil as a New Anesthetic Agent for Goldfish (Carassius auratus)

  • Taepin Junmahasathien,
  • Kantaporn Kheawfu,
  • Chuda Chittasupho,
  • Saransiri Nuanmanee,
  • Wasana Chaisri and
  • Surachai Pikulkaew

7 November 2025

The objective of this research was to investigate the anesthetic properties of essential oil from Ocimum tenuiflorum L. (OTO) and Ocimum basilicum L. (OBO), which belong to the Lamiaceae family. They are used as flavoring agents, food preservatives,...

  • Article
  • Open Access
9 Citations
3,765 Views
16 Pages

24 June 2016

Three new classes of N-body problems of goldfish type are identified, with N an arbitrary positive integer ( N ≥ 2 ). These models are characterized by nonlinear Newtonian (“accelerations equal forces”) equations of motion describing N equal po...

  • Article
  • Open Access
7 Citations
4,291 Views
17 Pages

The Biological Activity of Illicium verum (Star Anise) on Lernaea cyprinacea-Infested Carassius auratus (Goldfish): In Vivo Study

  • Marwa M. Attia,
  • Amal M. Alzahrani,
  • Magdy I. Hanna,
  • Heba M. Salem,
  • Mohammed A. S. Abourehab,
  • Mohamed T. El-Saadony and
  • Hasnaa Thabit

7 December 2022

Lernaea cyprinacea infestation is considered a serious economic problem in the fish market. An assessment to control this parasite is needed to manage this problem. The Illicium verum oil extract has considerable antioxidant activity and scavenges 96...

  • Article
  • Open Access
20 Citations
5,249 Views
16 Pages

The Hypoxia Tolerance of the Goldfish (Carassius auratus) Heart: The NOS/NO System and Beyond

  • Mariacristina Filice,
  • Rosa Mazza,
  • Serena Leo,
  • Alfonsina Gattuso,
  • Maria Carmela Cerra and
  • Sandra Imbrogno

The extraordinary capacity of the goldfish (Carassius auratus) to increase its cardiac performance under acute hypoxia is crucial in ensuring adequate oxygen supply to tissues and organs. However, the underlying physiological mechanisms are not yet c...

  • Article
  • Open Access
2 Citations
2,941 Views
13 Pages

23 September 2021

In this study, goldfish (Carassius auratus) were exposed to 0 (control group) and 0.81 mg/L TCCA for four consecutive days. The liver transcriptome, the molecular indices of oxidative stress, and gills histopathology were investigated. Kyoto Encyclop...

  • Article
  • Open Access
3 Citations
5,764 Views
18 Pages

Metabolic Rate of Goldfish (Carassius auratus) in the Face of Common Aquaculture Challenges

  • Lisbeth Herrera-Castillo,
  • Germán Vallejo-Palma,
  • Nuria Saiz,
  • Abel Sánchez-Jiménez,
  • Esther Isorna,
  • Ignacio Ruiz-Jarabo and
  • Nuria de Pedro

9 October 2024

This study examined the metabolic rate (MO2, oxygen consumption) of goldfish (Carassius auratus) under normal management conditions in aquaculture. Using an intermittent respirometry system, we assessed daily variations and the effects of feeding, ha...

  • Article
  • Open Access
12 Citations
3,909 Views
15 Pages

Assessment of the Effects of Bisphenol A on Dopamine Synthesis and Blood Vessels in the Goldfish Brain

  • Qing Wang,
  • Fangmei Lin,
  • Qi He,
  • Xiaochun Liu,
  • Shiqiang Xiao,
  • Leyun Zheng,
  • Huirong Yang and
  • Huihong Zhao

9 December 2019

Bisphenol A (BPA) is an abundant contaminant found in aquatic environments. While a large number of toxicological studies have investigated the effects of BPA, the potential effects of BPA exposure on fish brain have rarely been studied. To understan...

  • Article
  • Open Access
1 Citations
1,713 Views
31 Pages

Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression

  • Diego Madera,
  • Aitana Alonso-Gómez,
  • María Jesús Delgado,
  • Ana Isabel Valenciano and
  • Ángel Luis Alonso-Gómez

The aim of this work is the full characterization of all the nocturnin (noc) paralogues expressed in a teleost, the goldfish. An in silico analysis of the evolutive origin of noc in Osteichthyes is performed, including the splicing variants and new p...

  • Article
  • Open Access
5 Citations
2,703 Views
17 Pages

An ACE2-Alamandine Axis Modulates the Cardiac Performance of the Goldfish Carassius auratus via the NOS/NO System

  • Mariacristina Filice,
  • Rosa Mazza,
  • Sandra Imbrogno,
  • Olga Mileti,
  • Noemi Baldino,
  • Amilcare Barca,
  • Gianmarco Del Vecchio,
  • Tiziano Verri,
  • Alfonsina Gattuso and
  • Maria Carmela Cerra

Alamandine is a peptide of the Renin Angiotensin System (RAS), either generated from Angiotensin A via the Angiotensin Converting Enzyme 2 (ACE2), or directly from Ang-(1–7). In mammals, it elicits cardioprotection via Mas-related G-protein-cou...

  • Article
  • Open Access
2 Citations
2,167 Views
11 Pages

10 January 2025

In this study, the impact of leonardite as a feed additive in goldfish diets was examined, focusing on its potential to positively influence feed and water parameters, which are critical for achieving sustainable ornamental fish farming. In this stud...

  • Article
  • Open Access
8 Citations
9,696 Views
13 Pages

Effects of Aquatic Plants on Nutrient Concentration in Water and Growth Performance of Fantail Goldfish in an Aquaculture System

  • Mohd Naqib Azfar Mohd Roslan,
  • Abentin Estim,
  • Balu Alagar Venmathi Maran and
  • Saleem Mustafa

12 October 2021

The effects of two aquatic plants, duckweed (Lemna sp.) and azolla (Azolla sp.), on the growth performance of fantail goldfish (Carassius auratus) and dissolved nutrient concentrations were studied. The experiments were carried out in triplicate sets...

  • Article
  • Open Access
3,805 Views
11 Pages

5 March 2023

Endolimax is a genus of intestinal amoebae which stands among the least known human protists. Previous studies on amoebic systemic granulomatosis of a marine fish (Solea senegalensis) resulted in the unexpected characterization of a new organism whic...

  • Article
  • Open Access
2 Citations
2,002 Views
18 Pages

22 April 2023

Nesfatin-1 and nesfatin-1-like peptide (Nlp) are derived from precursors nucleobindin-2 and -1, two calcium and DNA binding proteins, respectively. Both peptides exhibit hormone-like actions in mammals and fish. These functions include insulinotropic...

  • Brief Report
  • Open Access
17 Citations
3,861 Views
8 Pages

In Vitro Assessment of Berberine against Ichthyophthirius multifiliis in Goldfish

  • Ke Huang,
  • Guangran Hu,
  • Runqiu Wang,
  • Qingwen Zeng,
  • Wenxiang Li,
  • Hong Zou,
  • Shangong Wu,
  • Guitang Wang and
  • Ming Li

20 October 2022

Ichthyophthirius multifiliis is a pathogenic ciliate parasite, which infects almost all freshwater teleost fish and leads to significant economic losses. The present study aimed to evaluate the acute toxicity of berberine to the free-living stages of...

  • Article
  • Open Access
2 Citations
2,585 Views
13 Pages

1 October 2020

Goldfish (Carassius aurautus), which is a middle size cyprinid, widely distribute throughout Eurasia. Phylogeographic studies using mtDNA markers have revealed several divergent lineages within goldfish. In this study, mtDNA variations were determine...

  • Article
  • Open Access
2 Citations
1,913 Views
12 Pages

The spleen plays a critical role in the immune and hematopoietic systems of teleost fish, functioning as a major secondary lymphoid organ. This study provides a detailed morphological and ultrastructural assessment of the spleen in goldfish (Carassiu...

  • Feature Paper
  • Article
  • Open Access
41 Citations
7,905 Views
17 Pages

Goldfish Response to Chronic Hypoxia: Mitochondrial Respiration, Fuel Preference and Energy Metabolism

  • Elie Farhat,
  • Hang Cheng,
  • Caroline Romestaing,
  • Matthew Pamenter and
  • Jean-Michel Weber

22 March 2021

Hypometabolism is a hallmark strategy of hypoxia tolerance. To identify potential mechanisms of metabolic suppression, we have used the goldfish to quantify the effects of chronically low oxygen (4 weeks; 10% air saturation) on mitochondrial respirat...

  • Article
  • Open Access
3 Citations
1,160 Views
18 Pages

Serotonin Signaling and Macrophage Subsets in Goldfish Gills: Unraveling the Neuroimmune Network for Gill Homeostasis

  • Manal T. Hussein,
  • Giacomo Zaccone,
  • Marco Albano,
  • Alessio Alesci,
  • Sebastian Marino,
  • Rasha Alonaizan and
  • Doaa M. Mokhtar

7 May 2025

Goldfish (Carassius auratus) gills function as both respiratory and immune-regulatory organs, integrating neuroendocrine and immune responses to environmental stimuli. This study explores the spatial organization and interaction of neuroendocrine cel...

  • Article
  • Open Access
9 Citations
5,821 Views
19 Pages

Peripheral Nerve Sheath Tumors Resembling Human Atypical Neurofibroma in Goldfish (Carassius auratus, Linnaeus, 1758)

  • Federico Armando,
  • Claudio Pigoli,
  • Matteo Gambini,
  • Andrea Ghidelli,
  • Gabriele Ghisleni,
  • Attilio Corradi,
  • Benedetta Passeri,
  • Mario Caniatti,
  • Valeria Grieco and
  • Christina Puff

7 September 2021

Skin spindle cell tumors (SSTs) frequently occur in fishes, with peripheral nerve sheath tumors (PNSTs) being the most commonly reported neoplasms in goldfish. However, distinguishing PNSTs from other SCTs is not always possible when relying exclusiv...

  • Article
  • Open Access
6 Citations
2,719 Views
18 Pages

Assessing Chronodisruption Distress in Goldfish: The Importance of Multimodal Approaches

  • Nuria Saiz,
  • Lisbeth Herrera-Castillo,
  • Nuria de Pedro,
  • María Jesús Delgado,
  • Sven David Arvidsson,
  • Miguel Ángel Marugal-López and
  • Esther Isorna

1 August 2023

Chronodisruption caused by factors such as light at night and mistimed meals has been linked to numerous physiological alterations in vertebrates and may be an anxiogenic factor affecting welfare. This study aims to investigate whether chronodisrupti...

  • Article
  • Open Access
2 Citations
3,253 Views
15 Pages

Hormone-Driven Temperature Optimization for Elevated Reproduction in Goldfish (Carassius auratus) under Laboratory Conditions

  • Zeynab Taheri-Khas,
  • Ahmad Gharzi,
  • Somaye Vaissi,
  • Pouria Heshmatzad and
  • Zahra Kalhori

18 September 2024

This study investigates the efficacy of hormone-induced artificial reproduction in goldfish (Carassius auratus) under controlled temperatures. Ovaprim injections significantly enhanced ovulation and sperm production compared to controls. Medium tempe...

  • Article
  • Open Access
12 Citations
4,293 Views
13 Pages

Polylactic Acid-Based Microplastic Particles Induced Oxidative Damage in Brain and Gills of Goldfish Carassius auratus

  • Alla Khosrovyan,
  • Hranush Melkonyan,
  • Lilit Rshtuni,
  • Bardukh Gabrielyan and
  • Anne Kahru

4 June 2023

The effect of 96 h exposure of the goldfish Carassius auratus to two different types of bioplastic particles, originating from commercial shopping bag (Bag, ~5 mm) and polylactic acid-based (PLA) cup (Cup, ≤5 mm), and petroleum-based polyamide par...

  • Article
  • Open Access
969 Views
18 Pages

In this study, we demonstrated that lrp6a, a co-receptor in the Wnt signaling pathway, is essential for proper median fin formation and somitogenesis in goldfish. We analyzed the gene’s sequence features and expression patterns in both wen-type...

  • Article
  • Open Access
2 Citations
2,837 Views
13 Pages

Exploring Cellular Dynamics in the Goldfish Bulbus Arteriosus: A Multifaceted Perspective

  • Doaa M. Mokhtar,
  • Enas A. Abd-Elhafez,
  • Marco Albano,
  • Giacomo Zaccone and
  • Manal T. Hussein

29 May 2024

The bulbus arteriosus of goldfish, Carassius auratus, possesses unique structural features. The wall of the bulbus arteriosus is exceptionally thick, with an inner surface characterized by longitudinally arranged finger-like ridges, resulting in an u...

  • Article
  • Open Access
2,034 Views
15 Pages

19 June 2025

This preclinical study investigated the efficacy and safety of fenbendazole, a broad-spectrum benzimidazole anthelmintic, for the treatment of Gyrodactylus kobayashii in goldfish (Carassius auratus). In vivo bath treatments demonstrated potent, dose-...

  • Article
  • Open Access
3,426 Views
12 Pages

12 August 2019

It is now widely accepted that allele-specific DNA methylation (ASM) commonly occurs at non-imprinted loci. Most of the non-imprinted ASM regions observed both within and outside of the CpG island show a strong correlation with DNA polymorphisms. How...

  • Article
  • Open Access
7 Citations
2,721 Views
20 Pages

Daily Rhythms in the IGF-1 System in the Liver of Goldfish and Their Synchronization to Light/Dark Cycle and Feeding Time

  • Aitana Alonso-Gómez,
  • Diego Madera,
  • Ángel Luis Alonso-Gómez,
  • Ana Isabel Valenciano and
  • María Jesús Delgado

30 November 2022

The relevance of the insulin-like growth factor-1 (IGF-1) system in several physiological processes is well-known in vertebrates, although little information about their temporal organization is available. This work aims to investigate the possible r...

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