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138 Results Found

  • Article
  • Open Access
2,869 Views
18 Pages

19 June 2023

In the present work, we investigate the possibility that long-range airborne transport of infectious aerosols could initiate an epidemic outbreak at distances downwind beyond one hundred kilometers. For this, we have developed a simple atmospheric tr...

  • Article
  • Open Access
6 Citations
1,963 Views
15 Pages

Due to the lack of timely protection measures against infectious diseases, or based on the particularity of the transmission of some infectious diseases and the time-varying connections between people, the transmission dynamics of infectious diseases...

  • Article
  • Open Access
102 Citations
10,684 Views
17 Pages

West Nile Virus Epidemic in Germany Triggered by Epizootic Emergence, 2019

  • Ute Ziegler,
  • Pauline Dianne Santos,
  • Martin H. Groschup,
  • Carolin Hattendorf,
  • Martin Eiden,
  • Dirk Höper,
  • Philip Eisermann,
  • Markus Keller,
  • Friederike Michel and
  • Robert Klopfleisch
  • + 16 authors

15 April 2020

One year after the first autochthonous transmission of West Nile virus (WNV) to birds and horses in Germany, an epizootic emergence of WNV was again observed in 2019. The number of infected birds and horses was considerably higher compared to 2018 (1...

  • Article
  • Open Access
2 Citations
3,433 Views
28 Pages

28 August 2023

Pandemic bonds can be used as an effective tool to mitigate the economic losses that governments face during pandemics and transfer them to the global capital market. Once considered as an “uninsurable” event, pandemic bonds caught the at...

  • Article
  • Open Access
1 Citations
1,317 Views
30 Pages

Epidemics spread through shipping networks and have dual characteristics as both biological sources of infection and triggers of cascading failures. However, existing resilience models fail to capture this dual and coupled dynamics. To minimize the c...

  • Review
  • Open Access
35 Citations
14,544 Views
13 Pages

A Review of the Environmental Trigger and Transmission Components for Prediction of Cholera

  • Moiz Usmani,
  • Kyle D. Brumfield,
  • Yusuf Jamal,
  • Anwar Huq,
  • Rita R. Colwell and
  • Antarpreet Jutla

Climate variables influence the occurrence, growth, and distribution of Vibrio cholerae in the aquatic environment. Together with socio-economic factors, these variables affect the incidence and intensity of cholera outbreaks. The current pandemic of...

  • Article
  • Open Access
1 Citations
3,012 Views
23 Pages

16 November 2023

This paper introduces the mathematical formalization of two probabilistic procedures for susceptible-infected-recovered (SIR) and susceptible-infected-susceptible (SIS) infectious diseases epidemic models, over Erdös-Rényi contact network...

  • Review
  • Open Access
12 Citations
3,912 Views
11 Pages

Mycoplasma pneumoniae (M. pneumoniae), a prevalent respiratory pathogen affecting children and adolescents, is known to trigger periodic global epidemics. The most recent significant outbreak commenced in the first half of 2023 and reached its peak g...

  • Article
  • Open Access
6 Citations
4,243 Views
17 Pages

Influence of COVID-19 Epidemic on Dark Web Contents

  • Abdul Razaque,
  • Bakhytzhan Valiyev,
  • Bandar Alotaibi,
  • Munif Alotaibi,
  • Saule Amanzholova and
  • Aziz Alotaibi

10 November 2021

The Dark Web is known as a place triggering a variety of criminal activities. Anonymization techniques enable illegal operations, leading to the loss of confidential information and its further use as bait, a trade product or even a crime tool. Despi...

  • Article
  • Open Access
8 Citations
2,721 Views
13 Pages

ETAS Space–Time Modeling of Chile Triggered Seismicity Using Covariates: Some Preliminary Results

  • Marcello Chiodi,
  • Orietta Nicolis,
  • Giada Adelfio,
  • Nicoletta D’Angelo and
  • Alex Gonzàlez

1 October 2021

Chilean seismic activity is one of the strongest in the world. As already shown in previous papers, seismic activity can be usefully described by a space–time branching process, such as the ETAS (Epidemic Type Aftershock Sequences) model, which is a...

  • Article
  • Open Access
1,019 Views
27 Pages

Distinct Virologic Properties of African and Epidemic Zika Virus Strains: The Role of the Envelope Protein in Viral Entry, Immune Activation, and Neuropathogenesis

  • Ashkan Roozitalab,
  • Chenyu Zhang,
  • Jiantao Zhang,
  • Ge Li,
  • Chengyu Yang,
  • Wangheng Hou,
  • Qiyi Tang and
  • Richard Y. Zhao

The 2016 Zika virus (ZIKV) epidemic has largely subsided, but a key question remains. How did ZIKV evolve to become a virulent human pathogen compared to the virus of its original discovery? What specific virologic and pathologic changes contributed...

  • Article
  • Open Access
2 Citations
2,734 Views
14 Pages

Cholera remains a heavy burden worldwide, especially in Sub-Saharan African countries, which account for the majority of the reported cases on the continent. In this study, a 27-year retrospective analysis of cholera epidemics in Guinea-Bissau was pe...

  • Article
  • Open Access
5 Citations
3,393 Views
15 Pages

The outbreak of COVID-19 at the end of 2019 triggered more psychological problems than usual among the public. During this epidemic, the use of social media was very high, and several studies confirmed a positive correlation between social media use...

  • Article
  • Open Access
75 Citations
9,661 Views
16 Pages

Porcine Epidemic Diarrhea Virus Induces Autophagy to Benefit Its Replication

  • Xiaozhen Guo,
  • Mengjia Zhang,
  • Xiaoqian Zhang,
  • Xin Tan,
  • Hengke Guo,
  • Wei Zeng,
  • Guokai Yan,
  • Atta Muhammad Memon,
  • Zhonghua Li and
  • Yinxing Zhu
  • + 5 authors

19 March 2017

The new porcine epidemic diarrhea (PED) has caused devastating economic losses to the swine industry worldwide. Despite extensive research on the relationship between autophagy and virus infection, the concrete role of autophagy in porcine epidemic d...

  • Article
  • Open Access
3 Citations
1,566 Views
21 Pages

22 November 2022

Two new ecoepidemic models of predator–prey type are introduced. They feature prey that gather in herds. The specific novelty consists of the fact that the prey also has the ability to defend themselves if they are in large numbers. The two det...

  • Article
  • Open Access
16 Citations
2,135 Views
13 Pages

13 April 2023

The Epidemic Type Aftershock Sequence (ETAS) model is a widely used tool for cluster analysis and forecasting, owing to its ability to accurately predict aftershock occurrences. However, its capacity to explain the increase in seismic activity prior...

  • Review
  • Open Access
111 Citations
14,798 Views
12 Pages

Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis

  • Jung Min Shim,
  • Jinhee Kim,
  • Tanel Tenson,
  • Ji-Young Min and
  • Denis E. Kainov

12 August 2017

Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral outbreaks, new treatments are urgently needed. De...

  • Article
  • Open Access
14 Citations
4,140 Views
25 Pages

Negative online public sentiment generated by government mishandling of pandemics and other disasters can easily trigger widespread panic and distrust, causing great harm. It is important to understand the law of public sentiment dissemination and us...

  • Review
  • Open Access
68 Citations
9,566 Views
19 Pages

The Relationships between Gut Microbiota and Diabetes Mellitus, and Treatments for Diabetes Mellitus

  • Cristian-Ioan Craciun,
  • Maria-Adriana Neag,
  • Adrian Catinean,
  • Andrei-Otto Mitre,
  • Adriana Rusu,
  • Cornelia Bala,
  • Gabriela Roman,
  • Anca-Dana Buzoianu,
  • Dana-Maria Muntean and
  • Anca-Elena Craciun

Diabetes mellitus is considered to be a global epidemic. The combination of genetic susceptibility and an unhealthy lifestyle is considered to be the main trigger of this metabolic disorder. Recently, there has been increased interest in the roles of...

  • Article
  • Open Access
13 Citations
3,066 Views
18 Pages

Triggered by COVID-19, one of the most dramatic crashes in the stock market in history occurred in March 2020. The sharp reductions in NASDAQ insurance stock indexes were observed after the occurrence of COVID-19 and in March 2020. In this study, the...

  • Review
  • Open Access
42 Citations
15,223 Views
27 Pages

Frontal Fibrosing Alopecia: A Review

  • María Librada Porriño-Bustamante,
  • María Antonia Fernández-Pugnaire and
  • Salvador Arias-Santiago

21 April 2021

Frontal fibrosing alopecia is a scarring alopecia, the prevalence of which is increasing worldwide since its first description in 1994. The reason for this emerging epidemic may be a higher exposure to an unknown trigger, although its aethiology and...

  • Review
  • Open Access
14 Citations
3,928 Views
20 Pages

Metabolic Syndrome and Atrial Fibrillation: Different Entities or Combined Disorders

  • George E. Zakynthinos,
  • Vasiliki Tsolaki,
  • Evangelos Oikonomou,
  • Manolis Vavouranakis,
  • Gerasimos Siasos and
  • Epaminondas Zakynthinos

28 August 2023

Obesity, hypertension, insulin resistance, and dyslipidemia are all clusters of an entity called “Metabolic Syndrome”. The global trends of this syndrome’s incidence/prevalence continue to increase reciprocally, converting it into a...

  • Article
  • Open Access
1,812 Views
18 Pages

Nonpharmaceutical policies for epidemic prevention and control have been extensively used since the outbreak of COVID-19. Policies ultimately work by limiting individual behavior. The aim of this paper is to evaluate the effectiveness of policies by...

  • Article
  • Open Access
2 Citations
3,097 Views
26 Pages

4 November 2023

Background: The COVID-19 pandemic has profoundly transformed the global scenario, marked by overwhelming infections, fatalities, overburdened healthcare infrastructures, economic upheavals, and significant lifestyle modifications. Concurrently, the R...

  • Article
  • Open Access
23 Citations
3,609 Views
18 Pages

The online public opinion is the sum of public views, attitudes and emotions spread on major public health emergencies through the Internet, which maps out the scope of influence and the disaster situation of public health events in real space. Based...

  • Article
  • Open Access
13 Citations
12,937 Views
11 Pages

The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence

  • Lamees Alhassen,
  • Khawla Nuseir,
  • Allyssa Ha,
  • Warren Phan,
  • Ilias Marmouzi,
  • Shalini Shah and
  • Olivier Civelli

12 October 2021

The opioid epidemic was triggered by an overprescription of opioid analgesics. In the treatment of chronic pain, repeated opioid administrations are required which ultimately lead to tolerance, physical dependence, and addiction. A possible way to ov...

  • Article
  • Open Access
1 Citations
3,545 Views
25 Pages

11 August 2020

We propose to view social conflicts in Africa as having similarities with earthquake occurrences and hence to consider the spatial-temporal Epidemic Type Aftershock Sequence (ETAS) model. The parameters of this highly parameterized model are estimate...

  • Review
  • Open Access
2 Citations
10,978 Views
23 Pages

Global Trends and Action Items for the Prevention and Control of Emerging and Re-Emerging Infectious Diseases

  • Silvia De Gaetano,
  • Elena Ponzo,
  • Angelina Midiri,
  • Giuseppe Mancuso,
  • Daniele Filippone,
  • Giovanni Infortuna,
  • Sebastiana Zummo and
  • Carmelo Biondo

In recent decades, the world has observed the emergence and re-emergence of a multitude of previously non-existent or re-emerging infectious diseases, for which there is a paucity of timely and effective preventative measures. The WHO has published a...

  • Article
  • Open Access
3 Citations
2,197 Views
20 Pages

Comparative Epidemiological Assessment of Monkeypox Infections on a Global and Continental Scale Using Logistic and Gompertz Mathematical Models

  • Obert Marín-Sánchez,
  • Pedro Pesantes-Grados,
  • Luis Pérez-Timaná,
  • Olegario Marín-Machuca,
  • Christian J. Sánchez-Llatas and
  • Ruy D. Chacón

27 November 2023

The monkeypox virus (MPXV) has caused an unusual epidemiological scenario—an epidemic within a pandemic (COVID-19). Despite the inherent evolutionary and adaptive capacity of poxviruses, one of the potential triggers for the emergence of this e...

  • Review
  • Open Access
4 Citations
5,835 Views
29 Pages

Microbial Translocation Disorders: Assigning an Etiology to Idiopathic Illnesses

  • Adonis Sfera,
  • Sabine Hazan,
  • Carolina Klein,
  • Carlos Manuel Zapata-Martín del Campo,
  • Sarvin Sasannia,
  • Johnathan J. Anton,
  • Leah Rahman,
  • Christina V. Andronescu,
  • Dan O. Sfera and
  • Zisis Kozlakidis
  • + 1 author

Gut microbes are immunologically tolerated in the gastrointestinal tract but trigger aggressive immune responses upon translocation across the gut barrier. Although oral tolerance, a physiological process that dampens immune responses to food protein...

  • Article
  • Open Access
1,811 Views
13 Pages

Viscoelastic Slider Blocks as a Model for a Seismogenic Fault

  • Charlotte A. Motuzas and
  • Robert Shcherbakov

6 October 2023

In this work, a model is proposed to examine the role of viscoelasticity in the generation of simulated earthquake-like events. This model serves to investigate how nonlinear processes in the Earth’s crust affect the triggering and decay patter...

  • Editorial
  • Open Access
140 Citations
14,689 Views
5 Pages

Searching for SARS-COV-2 on Particulate Matter: A Possible Early Indicator of COVID-19 Epidemic Recurrence

  • Leonardo Setti,
  • Fabrizio Passarini,
  • Gianluigi De Gennaro,
  • Pierluigi Barbieri,
  • Alberto Pallavicini,
  • Maurizio Ruscio,
  • Prisco Piscitelli,
  • Annamaria Colao and
  • Alessandro Miani

A number of nations were forced to declare a total shutdown due to COVID-19 infection, as extreme measure to cope with dramatic impact of the pandemic, with remarkable consequences both in terms of negative health outcomes and economic loses. However...

  • Article
  • Open Access
2 Citations
1,715 Views
13 Pages

Exploring Prehospital Data for Pandemic Preparedness: A Western Brazilian Amazon Case Study on COVID-19

  • Eduardo Fernandes,
  • Bernardo Maia da Silva,
  • Cássia da Luz Goulart,
  • Jefferson Valente,
  • Nádia Cubas-Vega,
  • Camila Sato,
  • Anna Gabriela Rezende,
  • Taynna Vernalha Rocha Almeida,
  • Robson Luís Oliveira de Amorim and
  • Jorge Luis Salinas
  • + 3 authors

Background: The timely management of rapidly evolving epidemiological scenarios caused by disease outbreaks is crucial to prevent devastating consequences. However, delayed laboratory diagnostics can hamper swift health policy and epidemic response,...

  • Article
  • Open Access
1,990 Views
23 Pages

29 October 2024

The coronavirus disease 2019 (COVID-19) pandemic, driven by the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been characterized by the virus’s ongoing evolution, leading to the appearance of more transmissible...

  • Article
  • Open Access
1 Citations
1,237 Views
31 Pages

Spatial Spillover Effects of Urban Gray–Green Space Form on COVID-19 Pandemic in China

  • Tingting Kang,
  • Yangyang Jiang,
  • Chuangeng Yang,
  • Yujie She,
  • Zixi Jiang and
  • Zeng Li

18 April 2025

Although the immediate impact of the COVID-19 pandemic has been alleviated, its long-term effects continue to shape global health and public safety. Policymakers should prepare for potential future health crises and direct urban planning toward more...

  • Article
  • Open Access
1 Citations
1,056 Views
25 Pages

17 February 2025

During a widespread epidemic, a large portion of the population faces an increased risk of contracting infectious diseases such as COVID-19, monkeypox, and pneumonia. These outbreaks often trigger cascading effects, significantly impacting society an...

  • Article
  • Open Access
26 Citations
6,436 Views
14 Pages

Immune Responses in Pregnant Sows Induced by Recombinant Lactobacillus johnsonii Expressing the COE Protein of Porcine Epidemic Diarrhea Virus Provide Protection for Piglets against PEDV Infection

  • Dianzhong Zheng,
  • Xiaona Wang,
  • Ning Ju,
  • Zhaorui Wang,
  • Ling Sui,
  • Li Wang,
  • Xinyuan Qiao,
  • Wen Cui,
  • Yanping Jiang and
  • Han Zhou
  • + 2 authors

21 December 2021

Porcine epidemic diarrhea (PED) induced by porcine epidemic diarrhea virus (PEDV) is an intestinal infectious disease in pigs that causes serious economic losses to the pig industry. To develop an effective oral vaccine against PEDV infection, we use...

  • Review
  • Open Access
12 Citations
9,262 Views
16 Pages

Universal Flu mRNA Vaccine: Promises, Prospects, and Problems

  • Andrei A. Deviatkin,
  • Ruslan A. Simonov,
  • Kseniya A. Trutneva,
  • Anna A. Maznina,
  • Elena M. Khavina and
  • Pavel Y. Volchkov

30 April 2022

The seasonal flu vaccine is, essentially, the only known way to prevent influenza epidemics. However, this approach has limited efficacy due to the high diversity of influenza viruses. Several techniques could potentially overcome this obstacle. A re...

  • Article
  • Open Access
2 Citations
1,562 Views
16 Pages

A Putative Effector Pst-18220, from Puccinia striiformis f. sp. tritici, Participates in Rust Pathogenicity and Plant Defense Suppression

  • Mengfan Tian,
  • Zhen Zhang,
  • Xiaorui Bi,
  • Yan Xue,
  • Jiahui Zhou,
  • Bo Yuan,
  • Zhaozhong Feng,
  • Lianwei Li and
  • Junjuan Wang

31 August 2024

Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), stands out as one of the most devastating epidemics impacting wheat production worldwide. Resistant wheat varieties had swiftly been overcome due to the emergence of new virulent Pst s...

  • Review
  • Open Access
62 Citations
14,080 Views
32 Pages

24 April 2021

Genetically diverse influenza A viruses (IAVs) circulate in wild aquatic birds. From this reservoir, IAVs sporadically cause outbreaks, epidemics, and pandemics in wild and domestic avians, wild land and sea mammals, horses, canines, felines, swine,...

  • Review
  • Open Access
559 Views
26 Pages

Microbial Aerosols in Livestock Farming Environment: A Threat That Cannot Be Ignored

  • Hao Lu,
  • Yuqing Xie,
  • Longxin Chen,
  • Yue Song,
  • Limeng Zhang,
  • Runting Li,
  • Xiaoning Nie,
  • Yichen Liu,
  • Guoqiang Zhu and
  • Xueyan Ding
  • + 1 author

1 December 2025

Under modern intensive and large-scale animal farming practices, the high animal density and confined spaces have progressively elevated the risk of disease transmission while complicating epidemic prevention and control. Current estimates indicate t...

  • Review
  • Open Access
67 Citations
10,602 Views
24 Pages

Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity

  • Ziguo Song,
  • Yu Wang,
  • Fei Zhang,
  • Fangyao Yao and
  • Chao Sun

Nowadays, high epidemic obesity-triggered hypertension and diabetes seriously damage social public health. There is now a general consensus that the body’s fat content exceeding a certain threshold can lead to obesity. Calcium ion is one of the...

  • Case Report
  • Open Access
47 Citations
18,187 Views
7 Pages

Acute Transverse Myelitis Following COVID-19 Vaccination

  • Jhih-Jian Gao,
  • Hung-Pin Tseng,
  • Chun-Liang Lin,
  • Jr-Shiang Shiu,
  • Ming-Hsun Lee and
  • Ching-Hsiung Liu

10 September 2021

An increasing number of people are undergoing vaccination for COVID-19 because of the ongoing pandemic. The newly developed, genetically engineered mRNA vaccines are critical for controlling the epidemic disease. However, major adverse effects, inclu...

  • Review
  • Open Access
15 Citations
7,466 Views
17 Pages

28 August 2013

The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vac...

  • Article
  • Open Access
18 Citations
5,670 Views
13 Pages

The Relevance of Foreshocks in Earthquake Triggering: A Statistical Study

  • Eugenio Lippiello,
  • Cataldo Godano and
  • Lucilla de Arcangelis

13 February 2019

An increase of seismic activity is often observed before large earthquakes. Events responsible for this increase are usually named foreshock and their occurrence probably represents the most reliable precursory pattern. Many foreshocks statistical fe...

  • Article
  • Open Access
5 Citations
2,295 Views
19 Pages

9 March 2023

Pandemic outbreaks often determine swift global reaction, proven by for example the more recent COVID-19, H1N1, Ebola, or SARS outbreaks. Therefore, policy makers now rely more than ever on computational tools to establish various protection policies...

  • Article
  • Open Access
1,988 Views
21 Pages

A Data-Driven Pandemic Simulator with Reinforcement Learning

  • Yuting Zhang,
  • Biyang Ma,
  • Langcai Cao and
  • Yanyu Liu

After the coronavirus disease 2019 (COVID-19) outbreak erupted, it swiftly spread globally and triggered a severe public health crisis in 2019. To contain the virus’s spread, several countries implemented various lockdown measures. As the gover...

  • Article
  • Open Access
530 Views
13 Pages

21 November 2025

Background/Objectives: As of April 2025, La Réunion is facing a second major chikungunya virus (CHIKV) outbreak, following the 2005–2006 epidemic that infected nearly one-third of the population. IXCHIQ®, a live-attenuated, single-do...

  • Article
  • Open Access
11 Citations
6,328 Views
15 Pages

A Single V672F Substitution in the Spike Protein of Field-Isolated PEDV Promotes Cell–Cell Fusion and Replication in VeroE6 Cells

  • Asawin Wanitchang,
  • Janya Saenboonrueng,
  • Challika Kaewborisuth,
  • Kanjana Srisutthisamphan and
  • Anan Jongkaewwattana

20 March 2019

While porcine epidemic diarrhea virus (PEDV) infects and replicates in enterocytes lining villi of neonatal piglets with high efficiency, naturally isolated variants typically grow poorly in established cell lines, unless adapted by multiple passages...

  • Review
  • Open Access
3 Citations
2,588 Views
15 Pages

Coronaviruses (CoVs) are emerging pathogens with a significant potential to cause life-threatening harm to human health. Since the beginning of the 21st century, three highly pathogenic and transmissible human CoVs have emerged, triggering epidemics...

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