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Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity

College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
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Int. J. Mol. Sci. 2019, 20(11), 2768; https://doi.org/10.3390/ijms20112768
Received: 3 May 2019 / Revised: 29 May 2019 / Accepted: 31 May 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Molecular Control of Adipose Cell Fate and Energy Metabolism)
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Abstract

Nowadays, high epidemic obesity-triggered hypertension and diabetes seriously damage social public health. There is now a general consensus that the body’s fat content exceeding a certain threshold can lead to obesity. Calcium ion is one of the most abundant ions in the human body. A large number of studies have shown that calcium signaling could play a major role in increasing energy consumption by enhancing the metabolism and the differentiation of adipocytes and reducing food intake through regulating neuronal excitability, thereby effectively decreasing the occurrence of obesity. In this paper, we review multiple calcium signaling pathways, including the IP3 (inositol 1,4,5-trisphosphate)-Ca2+ (calcium ion) pathway, the p38-MAPK (mitogen-activated protein kinase) pathway, and the calmodulin binding pathway, which are involved in biological clock, intestinal microbial activity, and nerve excitability to regulate food intake, metabolism, and differentiation of adipocytes in mammals, resulting in the improvement of obesity. View Full-Text
Keywords: calcium signaling pathways; obesity; biological clock; intestinal microbial activity; nervous system excitability calcium signaling pathways; obesity; biological clock; intestinal microbial activity; nervous system excitability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Song, Z.; Wang, Y.; Zhang, F.; Yao, F.; Sun, C. Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity. Int. J. Mol. Sci. 2019, 20, 2768.

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