Next Article in Journal
Growth Inhibition of Triple-Negative Breast Cancer: The Role of Spatiotemporal Delivery of Neoadjuvant Doxorubicin and Cisplatin
Previous Article in Journal
Development of a Topical Amphotericin B and Bursera graveolens Essential Oil-Loaded Gel for the Treatment of Dermal Candidiasis
Article

The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence

1
Department of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, Irvine, CA 92697, USA
2
Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan
3
Department of Anesthesiology and Perioperative Care, School of Medicine, University of California-Irvine, Irvine, CA 92697, USA
4
Department of Developmental and Cell Biology, School of Biological Sciences, University of California-Irvine, Irvine, CA 92697, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Thomas Efferth
Pharmaceuticals 2021, 14(10), 1034; https://doi.org/10.3390/ph14101034
Received: 18 September 2021 / Revised: 4 October 2021 / Accepted: 8 October 2021 / Published: 12 October 2021
(This article belongs to the Section Natural Products)
The opioid epidemic was triggered by an overprescription of opioid analgesics. In the treatment of chronic pain, repeated opioid administrations are required which ultimately lead to tolerance, physical dependence, and addiction. A possible way to overcome this conundrum consists of a co-medication that maintains the analgesic benefits of opioids while preventing their adverse liabilities. YHS, the extract of the plant Corydalis yanhusuo, has been used as analgesic in traditional Chinese medicine for centuries. More recently, it has been shown to promote analgesia in animal models of acute, inflammatory, and neuropathic pain. It acts, at least in part, by inhibiting the dopamine D2 receptor, suggesting that it may be advantageous to manage addiction. We first show that, in animals, YHS can increase the efficacy of morphine antinociceptive and, as such, decrease the need of the opioid. We then show that YHS, when coadministered with morphine, inhibits morphine tolerance, dependence, and addiction. Finally, we show that, in animals treated for several days with morphine, YHS can reverse morphine dependence and addiction. Together, these data indicate that YHS may be useful as a co-medication in morphine therapies to limit adverse morphine effects. Because YHS is readily available and safe, it may have an immediate positive impact to curb the opioid epidemic. View Full-Text
Keywords: opioid epidemic; addiction; dependence; medicinal plant; traditional medicine; Corydalis yanhusuo; antinociception opioid epidemic; addiction; dependence; medicinal plant; traditional medicine; Corydalis yanhusuo; antinociception
Show Figures

Figure 1

MDPI and ACS Style

Alhassen, L.; Nuseir, K.; Ha, A.; Phan, W.; Marmouzi, I.; Shah, S.; Civelli, O. The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence. Pharmaceuticals 2021, 14, 1034. https://doi.org/10.3390/ph14101034

AMA Style

Alhassen L, Nuseir K, Ha A, Phan W, Marmouzi I, Shah S, Civelli O. The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence. Pharmaceuticals. 2021; 14(10):1034. https://doi.org/10.3390/ph14101034

Chicago/Turabian Style

Alhassen, Lamees, Khawla Nuseir, Allyssa Ha, Warren Phan, Ilias Marmouzi, Shalini Shah, and Olivier Civelli. 2021. "The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence" Pharmaceuticals 14, no. 10: 1034. https://doi.org/10.3390/ph14101034

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop