15,874 Results Found

This study presents a framework whereby cancer chemotherapy could be improved through collaboration between mathematicians and experimentalists. Following on from our recently published model, we use A20 murine leukemic cells transfected with monomer...

Large-format lithium-ion batteries (LIBs) suffer from problems in terms of their product life and capacity due to large temperature differences in LIB cells. This study analyzes the effect of design factors on temperature distribution using a 3D elec...

Centralised cell-based biomanufacturing severely limits applicability in low-resource and extreme environments, where a largely untreated human population is present. Cell-free protein synthesis (CFPS) can surpass many of these limitations, due to it...

Due to the complicated metabolism of mammalian cells, the corresponding dynamic mathematical models usually consist of large sets of differential and algebraic equations with a large number of parameters to be estimated. On the other hand, the measur...

In this methodological paper, lyophilized fibroin-coated alginate microcarriers (LFAMs) proposed as mesenchymal stem cells (MSCs) delivery systems and optimal MSCs seeding conditions for cell adhesion rate and cell arrangement, was defined by a Desig...

Cell signaling involves complex transduction mechanisms in which information released by nearby cells or extracellular cues are transmitted to the cell, regulating fundamental cellular activities. Understanding such mechanisms requires cell stimulati...

The investigation conducted is aimed at establishing the best operational conditions to obtain the best output of a 5-cell stack Proton Exchange Membrane fuel cell (PEMFC) with three different bipolar plate geometries. The work further explores the b...

An acoustofluidic trap is used for accurate 3D cell proliferation and cell function analysis in levitation. The prototype trap can be integrated with any microscope setup, allowing continuous perfusion experiments with temperature and flow control un...

Introduction: Allogeneic Stem Cell Transplantation (ASCT) and, consequently, the chronicity associated with this life event have a growing prevalence and a significant impact on the life and daily life of each person who experiences it. It is necessa...

In this work, we introduce the Architecture Tech for High-Pressure Experiments Net Assembly (ATHENA) package based on diamond anvil cells, combining both the deposition of specimens as well as the detection of probes on anvils layer by layer. The spe...

High-voltage spinel LiNi_0.5Mn_1.5O₄ (LNMO) is a promising candidate as a lithium-ion battery cathode material to fulfill the high-energy density demands of the electric vehicle industry. In this work, the design of the experiment’s methodology h...

Targeted therapies against specific driver gene mutations have become the standard first-line treatment for most patients with advanced non-small cell lung cancer (NSCLC). While these therapies significantly prolong survival, the entire cancer treatm...

Genome editing is currently widely used in biomedical research; however, the use of this method in the clinic is still limited because of its low efficiency and possible side effects. Moreover, the correction of mutations that cause diseases in human...

Sickle cell disease (SCD) affects millions globally, with approximately 0.26% of the Saudi population impacted. Despite standard treatments, patients frequently experience vaso-occlusive crises (VOCs). This retrospective observational study evaluated...

The effects of climate change are becoming increasingly clear, and the urgency of solving the energy and resource crisis has been recognized by politicians and society. One of the most important solutions is sustainable energy technologies. The probl...

Background: Cutaneous squamous cell carcinoma (cSCC) represents the second most common form of non-melanoma skin malignancy, and, when not amenable to curative surgery or radiotherapy, it is a life-threatening disease. The anti-PD-1 monoclonal antibo...

This study tested the effectiveness of using dynamic yield strength (DYS) and shear-cell experiments to calibrate the following discrete-element-method (DEM) parameters: surface energy, and the coefficients of sliding and rolling friction. These expe...

Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive mature T-cell malignancy caused by the human T lymphoma virus I (HTLV-I) affecting 3–5% of HTLV-1 carriers and is usually diagnosed in endemic regions. Romania is a region with high...

Gene expression profiling technologies have been used in various applications such as cancer biology. The development of gene expression profiling has expanded the scope of target discovery in transcriptomic studies, and each technology produces data...

Solid oxide fuel cell systems such as those presented in this paper are not only applicable for a pure supply with electric energy, they can typically also be used in decentralized power stations, i.e., as micro-cogeneration systems for houses, where...

Dietary polyphenols, which are present in Aronia melanocarpa, have been associated with various beneficial effects on human health including antioxidant, antiviral, and anti-inflammatory activities. We aimed to investigate the immunomodulatory effect...

The epidermal growth factor receptor (EGFR) is historically the prototypical receptor tyrosine kinase, being the first cloned and the first where the importance of ligand-induced dimer activation was ascertained. However, many years of structure dete...

Background: Quercetin (QCT) is a natural polyphenolic flavonoid showing great potential in the treatment of skin cancer. However, its use is limited owing to its poor water solubility, poor absorption, quick metabolism and excretion, as well as low s...

T cells play a pivotal role in cancer research, particularly in immunotherapy, which harnesses the immune system to target malignancies. However, conventional expansion methods face limitations such as high reagent consumption, contamination risks, a...

For practical use of pluripotent stem cells (PSCs) for disease modelling, drug screening, and regenerative medicine, the cell differentiation process needs to be properly refined to generate end products with consistent and high quality. To construct...

For the research and development of new battery materials, achieving high reproducibility of the performance parameters in the laboratory test cells is of great importance. Therefore, in the present work, three typical small-format lithium-ion cells...

Due to the simple structure and the possibility of manual production, coin cells enable fast and, compared to larger cell formats, an inexpensive examination option in battery research. The comparability and traceability of coin cell structures in li...

Proton exchange membrane fuel cell (PEMFC) has become one of the new energy vehicle powertrains due to its special advantages, such as no pollution to the environment, high energy efficiency and power density. In order to improve the performance, a t...

Several studies have been conducted on the interaction between three-dimensional scaffolds and mesenchymal stem cells for the regeneration of damaged tissues. Considering that stem cells do not survive for sufficient time to directly sustain tissue r...

The operating conditions can have uncontrolled effects on the voltage of a High-Temperature Proton Exchange Membrane Fuel Cell (HT-PEMFC). For instance, the HT-PEMFC can be used at ambient pressure, i.e., without having a back pressure regulator. In...

The article describes the possibilities of using Peltier cells as an energy source to power the telemetry units, which are used in large-scale monitoring systems as central units, ensuring the collection of data from sensors, processing, and sending...

Hydrogel microbeads hold great promise for immune-protective cell transplants and in vitro studies. Millifluidic generation of hydrogel microbeads is a highly efficient and reproducible approach enabling a mass production. This paper illustrates the...

In manufacturing-cell-formation research, a major concern is to make groups of machines into machine cells and parts into part families. Extensive work has been carried out in this area using various models and techniques. Regarding these ideas, in t...

Large animal experiments are important for preclinical studies of regenerative stem cell transplantation therapy. Therefore, we investigated the differentiation capacity of pig skeletal muscle-derived stem cells (Sk-MSCs) as an intermediate model bet...

As one of the medicinal and edible resources, Gastrodia elata (GE) is considered to hold potential in alleviating alcoholic liver injury, yet its mechanism needs further elucidation. To explore the molecular mechanisms of GE against alcoholic liver i...

Cell-free systems are particularly attractive for screening applications and the production of difficult-to-express proteins. However, the production of cell lysates is difficult to implement on a larger scale due to large time requirements, cultivat...

Cell injection therapy is emerging as an alternative to treat corneal endothelial dysfunction (CED) and to avoid corneal scarring due to bullous keratopathy. However, establishing a standardized culture procedure that provides appropriate cell yield...

In this paper a first model is derived and applied which describes the transport of insulin granules through the cell interior and at the membrane of a beta cell. A special role is assigned to the actin network, which significantly influences the tra...

Background: Most hemodialysis patients may experience physiological and psychological stress. Exposure to nature has been reported to reduce psychological and physiological stress levels and improve immune function. This study aimed to investigate ps...

Hydrogen, which has a high energy density and does not emit pollutants, is considered an alternative energy source to replace fossil fuels. Herein, we report an experimental study on hydrogen leaks and ventilation methods for preventing damage caused...

In recent years, mathematical models have developed into an important tool for cancer research, combining quantitative analysis and natural processes. We have focused on Chronic Lymphocytic Leukemia (CLL), since it is one of the most common adult leu...

Knowledge of the susceptibility of proteins to endolysosomal proteases provides valuable information on immunogenicity. Though Ole e 1-like proteins are considered relevant allergens, little is known about their immunogenic properties and T cell epit...

This paper reviews the available methods to study thermal applications with open-cell metal foam. Both experimental and numerical work are discussed. For experimental research, the focus of this review is on the repeatability of the results. This is...

Background: Colorectal cancer is the third most common cancer worldwide, accounting for about 10% of all cancer cases. There is an urgent need to improve treatment outcomes and survival rates for colorectal cancer. Juglone is an anthraquinone with an...

This study aimed to estimate the bioelectricity production process using a vinasse solution through the application of Plackett–Burman and Box–Behnken designs. An electrochemical cell was constructed using Arduino to measure the potential...

The development of therapies to prevent or treat salivary gland dysfunction has been limited by a lack of functional in vitro models. Specifically, critical markers of salivary gland secretory phenotype downregulate rapidly ex vivo. Here, we utilize...

Background: The hedgehog inhibitors vismodegib and sonidegib are approved for the treatment of advanced basal cell carcinoma. This study reports the experiences with these therapies in a tertiary skin referral center in daily practice. Methods: A ret...

The performance of proton exchange membrane fuel cells (PEMFCs) is greatly affected by their operating parameters, especially at high current densities. An advanced concentration loss model is proposed to improve a semi-empirical model describing PEM...

It is proposed that the primary living cells (“probionts”) cannot emerge of organic substance simply by continuous chemical complication of prebiotic macromolecules and microsystems. The complication must be accompanied by the radical the...

Mixtures of hydrogen with common hydrocarbon fuels are considered viable for reducing carbon footprint in modern industry, power production, and transportation. The addition of hydrogen alters the kinetics and thermophysical properties of the mixture...