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Volume 9
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10.3390/cells9061487
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Article

A Cellular Automaton Model as a First Model-Based Assessment of Interacting Mechanisms for Insulin Granule Transport in Beta Cells

by
Michael Müller
1,*,
Mathias Glombek
1,
Jeldrick Powitz
1,
Dennis Brüning
2 and
Ingo Rustenbeck
2,*
1
Institute of Dynamics and Vibrations, Technische Universität Braunschweig, D38106 Braunschweig, Germany
2
Institute of Pharmacology, Toxicology and Clinical Pharmacy, Technische Universität Braunschweig, D38106 Braunschweig, Germany
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(6), 1487; https://doi.org/10.3390/cells9061487
Submission received: 24 April 2020 / Revised: 16 June 2020 / Accepted: 17 June 2020 / Published: 18 June 2020
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Abstract

In this paper a first model is derived and applied which describes the transport of insulin granules through the cell interior and at the membrane of a beta cell. A special role is assigned to the actin network, which significantly influences the transport. For this purpose, microscopically measured actin networks are characterized and then further ones are artificially generated. In a Cellular Automaton model, phenomenological laws for granule movement are formulated and implemented. Simulation results are compared with experiments, primarily using TIRF images and secretion rates. In this respect, good similarities are already apparent. The model is a first useful approach to describe complex granule transport processes in beta cells, and offers great potential for future extensions. Furthermore, the model can be used as a tool to validate hypotheses and associated mechanisms regarding their effect on exocytosis or other processes. For this purpose, the source code for the model is provided online.
Keywords: simulations; cellular automaton; insulin secretion; beta cells; actin network; TIRF microscopy; experiments simulations; cellular automaton; insulin secretion; beta cells; actin network; TIRF microscopy; experiments
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MDPI and ACS Style

Müller, M.; Glombek, M.; Powitz, J.; Brüning, D.; Rustenbeck, I. A Cellular Automaton Model as a First Model-Based Assessment of Interacting Mechanisms for Insulin Granule Transport in Beta Cells. Cells 2020, 9, 1487. https://doi.org/10.3390/cells9061487

AMA Style

Müller M, Glombek M, Powitz J, Brüning D, Rustenbeck I. A Cellular Automaton Model as a First Model-Based Assessment of Interacting Mechanisms for Insulin Granule Transport in Beta Cells. Cells. 2020; 9(6):1487. https://doi.org/10.3390/cells9061487

Chicago/Turabian Style

Müller, Michael, Mathias Glombek, Jeldrick Powitz, Dennis Brüning, and Ingo Rustenbeck. 2020. "A Cellular Automaton Model as a First Model-Based Assessment of Interacting Mechanisms for Insulin Granule Transport in Beta Cells" Cells 9, no. 6: 1487. https://doi.org/10.3390/cells9061487

APA Style

Müller, M., Glombek, M., Powitz, J., Brüning, D., & Rustenbeck, I. (2020). A Cellular Automaton Model as a First Model-Based Assessment of Interacting Mechanisms for Insulin Granule Transport in Beta Cells. Cells, 9(6), 1487. https://doi.org/10.3390/cells9061487

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