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  • Article
  • Open Access
7 Citations
3,910 Views
17 Pages

Deep Learning within a DICOM WSI Viewer for Histopathology

  • Noelia Vallez,
  • Jose Luis Espinosa-Aranda,
  • Anibal Pedraza,
  • Oscar Deniz and
  • Gloria Bueno

23 August 2023

Microscopy scanners and artificial intelligence (AI) techniques have facilitated remarkable advancements in biomedicine. Incorporating these advancements into clinical practice is, however, hampered by the variety of digital file formats used, which...

  • Article
  • Open Access
25 Citations
3,434 Views
29 Pages

Analysis of WSI Images by Hybrid Systems with Fusion Features for Early Diagnosis of Cervical Cancer

  • Mohammed Hamdi,
  • Ebrahim Mohammed Senan,
  • Bakri Awaji,
  • Fekry Olayah,
  • Mukti E. Jadhav and
  • Khaled M. Alalayah

Cervical cancer is one of the most common types of malignant tumors in women. In addition, it causes death in the latter stages. Squamous cell carcinoma is the most common and aggressive form of cervical cancer and must be diagnosed early before it p...

  • Article
  • Open Access
6 Citations
3,691 Views
17 Pages

The objective of this study is to determine the analytic expressions of the Helmholtz free energy, the equilibrium vacancy concentration, the melting temperature, the jumps of volume, enthalpy the mean nearest neighbor distance and entropy at melting...

  • Article
  • Open Access
5 Citations
3,562 Views
11 Pages

Diffusion Barrier Characteristics of WSiN Films

  • Yung-I Chen,
  • Kuo-Hong Yeh,
  • Tzu-Yu Ou and
  • Li-Chun Chang

10 June 2022

WSiN films were produced through hybrid pulse direct current/radio frequency magnetron co-sputtering and evaluated as diffusion barriers for Cu metallization. The Cu/WSiN/Si assemblies were annealed for 1 h in a vacuum at 500–900 °C. The st...

  • Feature Paper
  • Article
  • Open Access
6 Citations
5,657 Views
9 Pages

A WSi–WSiN–Pt Metallization Scheme for Silicon Carbide-Based High Temperature Microsystems

  • Ha-Duong Ngo,
  • Biswajit Mukhopadhyay,
  • Piotr Mackowiak,
  • Kevin Kröhnert,
  • Oswin Ehrmann and
  • Klaus-Dieter Lang

20 October 2016

In this paper, we present and discuss our new WSi–WSiN–Pt metallization scheme for SiC-based microsystems for applications in harsh environments. Stoichiometric material WSi was selected as contact material for SiC. The diffusion barrier material WSi...

  • Article
  • Open Access
1 Citations
1,366 Views
8 Pages

W/Si Multilayer Mirrors for Soft X-Ray Wavelengths < 2.4 nm

  • Denys Sevriukov,
  • Sergiy Yulin,
  • Sven Schröder and
  • Andreas Tünnermann

2 September 2025

W/Si multilayer mirrors are a promising candidate for soft X-ray applications at wavelengths below 2.4 nm. However, their optical performance is strongly affected by interface roughness and interlayer mixing, which limits reflectivity. One approach t...

  • Article
  • Open Access
8 Citations
2,790 Views
16 Pages

Reliability of T-WSI to Evaluate Neighborhoods Walkability and Its Changes over Time

  • Daniela D’Alessandro,
  • Diego Valeri and
  • Letizia Appolloni

More walkable neighborhoods are linked to increased physical activity. The Walking Suitability Index of the territory (T-WSI) is an easy method to evaluate walkability on the basis of direct observation. T-WSI provides 12 indicators divided into 4 ca...

  • Article
  • Open Access
524 Views
24 Pages

WSI-GT: Pseudo-Label Guided Graph Transformer for Whole-Slide Histology

  • Zhongao Sun,
  • Alexander Khvostikov,
  • Andrey Krylov,
  • Ilya Mikhailov and
  • Pavel Malkov

Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches...

  • Article
  • Open Access
1 Citations
2,341 Views
19 Pages

WSI: A New Early Warning Water Survival Index for the Domestic Water Demand

  • Dong-Her Shih,
  • Ching-Hsien Liao,
  • Ting-Wei Wu,
  • Huan-Shuo Chang and
  • Ming-Hung Shih

27 November 2022

A reservoir is an integrated water resource management infrastructure that can be used for water storage, flood control, power generation, and recreational activities. Predicting reservoir levels is critical for water supply management and can influe...

  • Article
  • Open Access
13 Citations
4,406 Views
20 Pages

Computational Pipeline for Glomerular Segmentation and Association of the Quantified Regions with Prognosis of Kidney Function in IgA Nephropathy

  • Yoshimasa Kawazoe,
  • Kiminori Shimamoto,
  • Ryohei Yamaguchi,
  • Issei Nakamura,
  • Kota Yoneda,
  • Emiko Shinohara,
  • Yukako Shintani-Domoto,
  • Tetsuo Ushiku,
  • Tatsuo Tsukamoto and
  • Kazuhiko Ohe

25 November 2022

The histopathological findings of the glomeruli from whole slide images (WSIs) of a renal biopsy play an important role in diagnosing and grading kidney disease. This study aimed to develop an automated computational pipeline to detect glomeruli and...

  • Article
  • Open Access
10 Citations
3,753 Views
17 Pages

Water-Soluble Ions in Atmospheric Aerosol Measured in a Semi-Arid and Chemical-Industrialized City, Northwest China

  • Huimin Jiang,
  • Zhongqin Li,
  • Feiteng Wang,
  • Xi Zhou,
  • Fanglong Wang,
  • Shan Ma and
  • Xin Zhang

3 April 2021

We investigated water-soluble ions (WSIs) of aerosol samples collected from 2016 to 2017 in Lanzhou, a typical semi-arid and chemical-industrialized city in Northwest China. WSIs concentration was higher in the heating period (35.68 ± 19.17 μg/m3) an...

  • Article
  • Open Access
311 Views
14 Pages

Evaluation of the Influence of Bottle Type on the Acquisition of SORS Spectra of Extra Virgin and Virgin Olive Oils

  • Guillermo Jiménez-Hernández,
  • Fidel Ortega-Gavilán,
  • M. Gracia Bagur-González,
  • Jaime García-Mena,
  • Sandra Montoro-Alonso and
  • Antonio González-Casado

2 February 2026

The objective of this study was to evaluate the impact of the material (plastic or glass) and color (green or colorless) of extra virgin olive oil (EVOO) and virgin olive oil (VOO) bottles on the acquisition of SORS spectra using portable equipment....

  • Article
  • Open Access
12 Citations
9,308 Views
18 Pages

2 November 2020

Ki67 hot-spot detection and its evaluation in invasive breast cancer regions play a significant role in routine medical practice. The quantification of cellular proliferation assessed by Ki67 immunohistochemistry is an established prognostic and pred...

  • Article
  • Open Access
6,778 Views
18 Pages

13 November 2024

Conventional methods for tumor diagnosis suffer from two inherent limitations: they are time-consuming and subjective. Computer-aided diagnosis (CAD) is an important approach for addressing these limitations. Pathology whole-slide images (WSIs) are h...

  • Article
  • Open Access
6 Citations
5,551 Views
20 Pages

Automatic Feature Selection for Improved Interpretability on Whole Slide Imaging

  • Antoine Pirovano,
  • Hippolyte Heuberger,
  • Sylvain Berlemont,
  • SaÏd Ladjal and
  • Isabelle Bloch

Deep learning methods are widely used for medical applications to assist medical doctors in their daily routine. While performances reach expert’s level, interpretability (highlighting how and what a trained model learned and why it makes a specific...

  • Article
  • Open Access
3 Citations
1,603 Views
17 Pages

Variations in Water Stress and Its Driving Factors in the Yellow River Basin

  • Haodong Lyu,
  • Jianmin Qiao,
  • Gonghuan Fang,
  • Wenting Liang,
  • Zidong Tang,
  • Furong Lv,
  • Qin Zhang,
  • Zewei Qiu and
  • Gengning Huang

30 December 2024

As one of the most sensitive areas to climate change in China, the Yellow River Basin faces a significant water resource shortage, which severely restricts sustainable economic development in the region and has become the most prominent issue in the...

  • Article
  • Open Access
2 Citations
2,652 Views
22 Pages

14 December 2023

The scientific literature shows some attributes of neighborhood built environments that can contribute to promoting physical activity, thereby encouraging older adults to take outdoor walks. The aim of this study was to measure the walkability of 20...

  • Article
  • Open Access
14 Citations
3,606 Views
12 Pages

Computer-Aided Assessment of Melanocytic Lesions by Means of a Mitosis Algorithm

  • Bart Sturm,
  • David Creytens,
  • Jan Smits,
  • Ariadne H. A. G. Ooms,
  • Erik Eijken,
  • Eline Kurpershoek,
  • Heidi V. N. Küsters-Vandevelde,
  • Carla Wauters,
  • Willeke A. M. Blokx and
  • Jeroen A. W. M. van der Laak

An increasing number of pathology laboratories are now fully digitised, using whole slide imaging (WSI) for routine diagnostics. WSI paves the road to use artificial intelligence (AI) that will play an increasing role in computer-aided diagnosis (CAD...

  • Article
  • Open Access
2 Citations
2,320 Views
19 Pages

1 August 2022

Current studies neglect how virtual water transfer (VWT) between countries within a drainage basin affects water stress and then yields an invisible effect on the water quantity conflict in transboundary rivers, which would further make management po...

  • Article
  • Open Access
1 Citations
2,708 Views
13 Pages

Accurate segmentation of cellular structures in whole slide images (WSIs) is essential for quantitative analysis in computational pathology. However, the complexity and scale of WSIs present significant challenges for conventional segmentation method...

  • Article
  • Open Access
2,370 Views
15 Pages

27 June 2024

Microscopic and digital whole-slide images (WSIs) often suffer from limited spatial resolution, hindering accurate pathological analysis and cancer diagnosis. Improving the spatial resolution of these pathology images is crucial, as it can enhance th...

  • Article
  • Open Access
17 Citations
9,610 Views
25 Pages

Subsurface Event Detection and Classification Using Wireless Signal Networks

  • Suk-Un Yoon,
  • Ehsan Ghazanfari,
  • Liang Cheng,
  • Sibel Pamukcu and
  • Muhannad T. Suleiman

5 November 2012

Subsurface environment sensing and monitoring applications such as detection of water intrusion or a landslide, which could significantly change the physical properties of the host soil, can be accomplished using a novel concept, Wireless Signal Netw...

  • Article
  • Open Access
53 Citations
5,669 Views
19 Pages

A Survival Guide for the Rapid Transition to a Fully Digital Workflow: The “Caltagirone Example”

  • Filippo Fraggetta,
  • Alessandro Caputo,
  • Rosa Guglielmino,
  • Maria Giovanna Pellegrino,
  • Giampaolo Runza and
  • Vincenzo L'Imperio

16 October 2021

Digital pathology for the routine assessment of cases for primary diagnosis has been implemented by few laboratories worldwide. The Gravina Hospital in Caltagirone (Sicily, Italy), which collects cases from 7 different hospitals distributed in the Ca...

  • Article
  • Open Access
4 Citations
1,777 Views
16 Pages

Mechanical Properties and Oxidation Behavior of TaWSiN Films

  • Chin-Han Tzeng,
  • Li-Chun Chang and
  • Yung-I Chen

17 November 2022

This study explored the structural characteristics, mechanical properties, and oxidation behavior of W-enriched TaWSiN films prepared through co-sputtering. The atomic ratios [W/(W + Ta)] of the as-deposited films maintained a range of 0.77–0.8...

  • Article
  • Open Access
3 Citations
2,280 Views
15 Pages

16 March 2023

Groundwater depletion caused by agricultural irrigation is a worldwide problem. Digital technology has the potential to mitigate the groundwater over-exploitation problem by precisely restricting agriculture groundwater withdrawal and borewell constr...

  • Article
  • Open Access
552 Views
19 Pages

Low-Cost Lung Cancer Classification in WSIs Using a Foundation Model and Evolving Prototypes

  • Soroush Oskouei,
  • André Pedersen,
  • Marit Valla,
  • Vibeke Grotnes Dale,
  • Sissel Gyrid Freim Wahl,
  • Mats Dehli Haugum,
  • Borgny Ytterhus,
  • Maria Paula Ramnefjell,
  • Lars Andreas Akslen and
  • Hanne Sorger
  • + 1 author

6 December 2025

Whole slide imaging has transformed the field of pathology by enabling high-resolution digitization of histopathological slides. However, the large image size and variability in morphology, tissue processing, and imaging can pose challenges for robus...

  • Article
  • Open Access
3 Citations
2,953 Views
23 Pages

Evaluating AI-Based Mitosis Detection for Breast Carcinoma in Digital Pathology: A Clinical Study on Routine Practice Integration

  • Clara Simmat,
  • Loris Guichard,
  • Stéphane Sockeel,
  • Nicolas Pozin,
  • Rémy Peyret,
  • Magali Lacroix-Triki,
  • Catherine Miquel,
  • Arnaud Gauthier,
  • Marie Sockeel and
  • Sophie Prévot

Background/Objectives: An accurate assessment of mitotic activity is crucial in the histopathological diagnosis of invasive breast carcinoma. However, this task is time-consuming and labor-intensive, and suffers from high variability between patholog...

  • Article
  • Open Access
37 Citations
8,166 Views
16 Pages

Analysis of Cytology Pap Smear Images Based on Ensemble Deep Learning Approach

  • Mohammed Alsalatie,
  • Hiam Alquran,
  • Wan Azani Mustafa,
  • Yasmin Mohd Yacob and
  • Asia Ali Alayed

10 November 2022

The fourth most prevalent cancer in women is cervical cancer, and early detection is crucial for effective treatment and prognostic prediction. Conventional cervical cancer screening and classifying methods are less reliable and accurate as they heav...

  • Article
  • Open Access
16 Citations
3,450 Views
25 Pages

GIS-Based Spatial Modeling of Soil Erosion and Wildfire Susceptibility Using VIIRS and Sentinel-2 Data: A Case Study of Šar Mountains National Park, Serbia

  • Uroš Durlević,
  • Tanja Srejić,
  • Aleksandar Valjarević,
  • Bojana Aleksova,
  • Vojislav Deđanski,
  • Filip Vujović and
  • Tin Lukić

10 March 2025

Soil erosion and wildfires are frequent natural disasters that threaten the environment. Identifying and zoning susceptible areas are crucial for the implementation of preventive measures. The Šar Mountains are a national park with rich biodiv...

  • Article
  • Open Access
4 Citations
2,169 Views
14 Pages

Janus MoSH/WSi2N4 van der Waals Heterostructure: Two-Dimensional Metal/Semiconductor Contact

  • Yongdan Wang,
  • Xiangjiu Zhu,
  • Hengshuo Zhang,
  • Shitong He,
  • Ying Liu,
  • Wenshi Zhao,
  • Huilian Liu and
  • Xin Qu

28 July 2024

Constructing heterostructures from already synthesized two-dimensional materials is of significant importance. We performed a first-principles study to investigate the electronic properties and interfacial characteristics of Janus MoSH/WSi2N4 van der...

  • Proceeding Paper
  • Open Access
1,526 Views
3 Pages

The water soluble ionic species (WSIS) i.e., NH4+, SO42−, NO3 and Cl of PM2.5 and trace gases (NH3, NO, NO2, SO2, HNO3) were measured to study the relationship of ambient NH3 in the formation of secondary inorganic aerosols in Del...

  • Article
  • Open Access
2 Citations
2,864 Views
15 Pages

Advancing Content-Based Histopathological Image Retrieval Pre-Processing: A Comparative Analysis of the Effects of Color Normalization Techniques

  • Zahra Tabatabaei,
  • Fernando Pérez Bueno,
  • Adrián Colomer,
  • Javier Oliver Moll,
  • Rafael Molina and
  • Valery Naranjo

1 March 2024

Content-Based Histopathological Image Retrieval (CBHIR) is a search technique based on the visual content and histopathological features of whole-slide images (WSIs). CBHIR tools assist pathologists to obtain a faster and more accurate cancer diagnos...

  • Review
  • Open Access
2 Citations
4,377 Views
21 Pages

5 September 2025

The integration of generative artificial intelligence (generative AI) into library systems is transforming the global information society, offering new possibilities for improving information access, management, and dissemination. However, these adva...

  • Systematic Review
  • Open Access
2 Citations
2,592 Views
24 Pages

Background: Breast cancer is one of the leading causes of death among women worldwide. Accurate early detection of lymphocytes and molecular biomarkers is essential for improving diagnostic precision and patient prognosis. Whole slide images (WSIs) a...

  • Article
  • Open Access
32 Citations
6,806 Views
10 Pages

Digital Pathology Implementation in Private Practice: Specific Challenges and Opportunities

  • Diana Montezuma,
  • Ana Monteiro,
  • João Fraga,
  • Liliana Ribeiro,
  • Sofia Gonçalves,
  • André Tavares,
  • João Monteiro and
  • Isabel Macedo-Pinto

18 February 2022

Digital pathology (DP) is being deployed in many pathology laboratories, but most reported experiences refer to public health facilities. In this paper, we report our experience in DP transition at a high-volume private laboratory, addressing the mai...

  • Article
  • Open Access
15 Citations
3,417 Views
19 Pages

WWFedCBMIR: World-Wide Federated Content-Based Medical Image Retrieval

  • Zahra Tabatabaei,
  • Yuandou Wang,
  • Adrián Colomer,
  • Javier Oliver Moll,
  • Zhiming Zhao and
  • Valery Naranjo

The paper proposes a federated content-based medical image retrieval (FedCBMIR) tool that utilizes federated learning (FL) to address the challenges of acquiring a diverse medical data set for training CBMIR models. CBMIR is a tool to find the most s...

  • Article
  • Open Access
16 Citations
11,125 Views
23 Pages

10 October 2023

Matcha is a powdered green tea obtained from the Camellia sinensis L. plant intended for both “hot” and “cold” consumption. It is a rich source of bioactive ingredients, thanks to which it has strong antioxidant properties. In...

  • Article
  • Open Access
8 Citations
2,839 Views
18 Pages

5 April 2023

The diagnosis of different pathologies and stages of cancer using whole histopathology slide images (WSI) is the gold standard for determining the degree of tissue metastasis. The use of deep learning systems in the field of medical images, especiall...

  • Article
  • Open Access
11 Citations
4,968 Views
11 Pages

Since conventional culture-based antibiotic susceptibility testing (AST) methods are too time-consuming (typically 24–72 h), rapid AST is urgently needed for preventing the increasing emergence and spread of antibiotic resistant infections. Alt...

  • Article
  • Open Access
3 Citations
1,408 Views
18 Pages

24 September 2023

CrWSiN films were prepared through the co-sputtering technique, and the process variables were substrate bias voltage and temperature. The mechanical properties of hardness and elastic modulus of the CrWSiN films were dominantly affected by their ave...

  • Article
  • Open Access
13 Citations
3,843 Views
17 Pages

15 December 2018

We applied first-principles electronic structure calculations to study structural, thermodynamic and elastic properties of nanocomposites exhibiting nearly perfect match of constituting phases. In particular, two combinations of transition-metal disi...

  • Review
  • Open Access
32 Citations
5,747 Views
15 Pages

Digital Pathology for Better Clinical Practice

  • Assia Hijazi,
  • Carlo Bifulco,
  • Pamela Baldin and
  • Jérôme Galon

26 April 2024

(1) Background: Digital pathology (DP) is transforming the landscape of clinical practice, offering a revolutionary approach to traditional pathology analysis and diagnosis. (2) Methods: This innovative technology involves the digitization of traditi...

  • Article
  • Open Access
31 Citations
3,220 Views
23 Pages

Hybrid Techniques for Diagnosis with WSIs for Early Detection of Cervical Cancer Based on Fusion Features

  • Badiea Abdulkarem Mohammed,
  • Ebrahim Mohammed Senan,
  • Zeyad Ghaleb Al-Mekhlafi,
  • Meshari Alazmi,
  • Abdulaziz M. Alayba,
  • Adwan Alownie Alanazi,
  • Abdulrahman Alreshidi and
  • Mona Alshahrani

2 September 2022

Cervical cancer is a global health problem that threatens the lives of women. Liquid-based cytology (LBC) is one of the most used techniques for diagnosing cervical cancer; converting from vitreous slides to whole-slide images (WSIs) allows images to...

  • Article
  • Open Access
14 Citations
4,068 Views
13 Pages

5 February 2020

Many water-saving techniques have been developed for rice production in response to irrigation water scarcity. The selection of the water-saving methods and the optimum thresholds for obtaining maximum benefits of these regimes are largely site-speci...

  • Review
  • Open Access
1 Citations
1,954 Views
17 Pages

Deep Learning Image Processing Models in Dermatopathology

  • Apoorva Mehta,
  • Mateen Motavaf,
  • Danyal Raza,
  • Neil Jairath,
  • Akshay Pulavarty,
  • Ziyang Xu,
  • Michael A. Occidental,
  • Alejandro A. Gru and
  • Alexandra Flamm

4 October 2025

Dermatopathology has rapidly advanced due to the implementation of deep learning models and artificial intelligence (AI). From convolutional neural networks (CNNs) to transformer-based foundation models, these systems are now capable of accurate whol...

  • Article
  • Open Access
437 Views
21 Pages

Integrated Transcriptomic and Histological Analysis of TP53/CTNNB1 Mutations and Microvascular Invasion in Hepatocellular Carcinoma

  • Ignacio Garach,
  • Nerea Hernandez,
  • Luis J. Herrera,
  • Francisco M. Ortuño and
  • Ignacio Rojas

3 February 2026

Background/Objectives: Hepatocellular carcinoma (HCC) shows marked molecular and histopathological heterogeneity. Among the alterations most strongly associated with clinical outcome are mutations in TP53 and CTNNB1, as well as the presence of microv...

  • Review
  • Open Access
105 Citations
13,293 Views
20 Pages

Recent Advances of Deep Learning for Computational Histopathology: Principles and Applications

  • Yawen Wu,
  • Michael Cheng,
  • Shuo Huang,
  • Zongxiang Pei,
  • Yingli Zuo,
  • Jianxin Liu,
  • Kai Yang,
  • Qi Zhu,
  • Jie Zhang and
  • Wei Shao
  • + 4 authors

25 February 2022

With the remarkable success of digital histopathology, we have witnessed a rapid expansion of the use of computational methods for the analysis of digital pathology and biopsy image patches. However, the unprecedented scale and heterogeneous patterns...

  • Article
  • Open Access
10 Citations
3,267 Views
19 Pages

Prior to Implementation of Digital Pathology—Assessment of Expectations among Staff by Means of Normalization Process Theory

  • Minne L. N. Mikkelsen,
  • Marianne H. Frederiksen,
  • Niels Marcussen,
  • Bethany Williams and
  • Kristian Kidholm

The Region of Southern Denmark is the first in Denmark to implement digital pathology (DIPA), starting at the end of 2020. The DIPA process involves changes in workflow, and the pathologist will have to diagnose based on digital whole slide imaging i...

  • Review
  • Open Access
8 Citations
12,182 Views
24 Pages

Digital Pathology: A Comprehensive Review of Open-Source Histological Segmentation Software

  • Anna Maria Pavone,
  • Antonino Giulio Giannone,
  • Daniela Cabibi,
  • Simona D’Aprile,
  • Simona Denaro,
  • Giuseppe Salvaggio,
  • Rosalba Parenti,
  • Anthony Yezzi and
  • Albert Comelli

In the era of digitalization, the biomedical sector has been affected by the spread of artificial intelligence. In recent years, the possibility of using deep and machine learning methods for clinical diagnostic and therapeutic interventions has been...

  • Article
  • Open Access
3 Citations
3,516 Views
22 Pages

Artificial Intelligence Reveals Distinct Prognostic Subgroups of Muscle-Invasive Bladder Cancer on Histology Images

  • Okyaz Eminaga,
  • Sami-Ramzi Leyh-Bannurah,
  • Shahrokh F. Shariat,
  • Laura-Maria Krabbe,
  • Hubert Lau,
  • Lei Xing and
  • Mahmoud Abbas

16 October 2023

Muscle-invasive bladder cancer (MIBC) is a highly heterogeneous and costly disease with significant morbidity and mortality. Understanding tumor histopathology leads to tailored therapies and improved outcomes. In this study, we employed a weakly sup...

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