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266,342 Results Found

  • Article
  • Open Access
7 Citations
12,822 Views
17 Pages

Early Outpatient Treatment of COVID-19: A Retrospective Analysis of 392 Cases in Italy

  • Marco Cosentino,
  • Veronica Vernocchi,
  • Stefano Martini,
  • Franca Marino,
  • Barbara Allasino,
  • Maria Antonietta Bàlzola,
  • Fabio Burigana,
  • Alberto Dallari,
  • Carlo Servo Florio Pagano and
  • Antonio Palma
  • + 2 authors

18 October 2022

COVID-19 was declared a pandemic in March 2020. The knowledge of COVID-19 pathophysiology soon provided a strong rationale for the early use of both anti-inflammatory and antithrombotic drugs; however, its evidence was slowly and partially incorporat...

  • Article
  • Open Access
3 Citations
5,181 Views
13 Pages

Preliminary Examination of an Appropriate Price Calculation Method and Medical Treatment Costs for Foreign Visitors in Japan

  • Tomoyuki Takura and
  • Study Group: Research on Appropriate Medical Treatment Prices for Foreigners Visiting Japan

This study proposes a method for calculating the appropriate medical treatment price level for foreign visitors (FVs) in Japan. Hospital management costs and foreign prices were analyzed from a market principles perspective to determine the medical t...

  • Opinion
  • Open Access
130 Citations
6,031 Views
7 Pages

National Institute for the Infectious Diseases “L. Spallanzani” IRCCS. Recommendations for COVID-19 Clinical Management

  • Emanuele Nicastri,
  • Nicola Petrosillo,
  • Tommaso Ascoli Bartoli,
  • Luciana Lepore,
  • Annalisa Mondi,
  • Fabrizio Palmieri,
  • Gianpiero D’Offizi,
  • Luisa Marchioni,
  • Silvia Murachelli and
  • Giuseppe Ippolito
  • + 1 author

On January 9th, 2020, the “World Health Organization” (WHO) declared the identification, by Chinese Health authorities, of a novel coronavirus, further classified as SARS-CoV-2 responsible of a diseases (COVID-19) ranging from asymptomatic cases to s...

  • Article
  • Open Access
6 Citations
2,845 Views
11 Pages

Correlation of Genotype and Perinatal Period, Time of Diagnosis and Anthropometric Data before Commencement of Recombinant Human Growth Hormone Treatment in Polish Patients with Prader–Willi Syndrome

  • Agnieszka Lecka-Ambroziak,
  • Marta Wysocka-Mincewicz,
  • Katarzyna Doleżal-Ołtarzewska,
  • Agata Zygmunt-Górska,
  • Teresa Żak,
  • Anna Noczyńska,
  • Dorota Birkholz-Walerzak,
  • Renata Stawerska,
  • Maciej Hilczer and
  • Monika Obara-Moszyńska
  • + 6 authors

Genotype–phenotype correlation in patients with Prader–Willi syndrome (PWS) has still not been fully described. We retrospectively analysed data of 147 patients and compared groups according to genetic diagnosis: paternal deletion of chromosome 15q11...

  • Article
  • Open Access
17 Citations
4,528 Views
19 Pages

Effects of Recombinant Human Growth Hormone Treatment, Depending on the Therapy Start in Different Nutritional Phases in Paediatric Patients with Prader–Willi Syndrome: A Polish Multicentre Study

  • Agnieszka Lecka-Ambroziak,
  • Marta Wysocka-Mincewicz,
  • Katarzyna Doleżal-Ołtarzewska,
  • Agata Zygmunt-Górska,
  • Anna Wędrychowicz,
  • Teresa Żak,
  • Anna Noczyńska,
  • Dorota Birkholz-Walerzak,
  • Renata Stawerska and
  • Maciej Hilczer
  • + 7 authors

19 July 2021

Recombinant human growth hormone (rhGH) treatment is an established management in patients with Prader–Willi syndrome (PWS), with growth promotion and improvement in body composition and possibly the metabolic state. We compared anthropometric charac...

  • Article
  • Open Access
2 Citations
1,337 Views
18 Pages

27 October 2023

The average treatment effect is an important concept in causal inference. However, it fails to capture variation in response to treatment due to heterogeneity at many levels among patients in the target population. To study the heterogeneity in the t...

  • Article
  • Open Access
14 Citations
5,194 Views
16 Pages

Using the Personalized Advantage Index for Individual Treatment Allocation to Blended Treatment or Treatment as Usual for Depression in Secondary Care

  • Nadine Friedl,
  • Tobias Krieger,
  • Karine Chevreul,
  • Jean Baptiste Hazo,
  • Jérôme Holtzmann,
  • Mark Hoogendoorn,
  • Annet Kleiboer,
  • Kim Mathiasen,
  • Antoine Urech and
  • Heleen Riper
  • + 1 author

11 February 2020

A variety of effective psychotherapies for depression are available, but patients who suffer from depression vary in their treatment response. Combining face-to-face therapies with internet-based elements in the sense of blended treatment is a new ap...

  • Feature Paper
  • Article
  • Open Access
2,597 Views
17 Pages

18 April 2024

Machine learning for causal inference, particularly at the individual level, has attracted intense interest in many domains. Existing techniques focus on controlling differences in distribution between treatment groups in a data-driven manner, elimin...

  • Review
  • Open Access
2,559 Views
15 Pages

Personalized Treatment Modalities for Rectal Cancer: Advances in Neoadjuvant Treatment

  • Nussara Pakvisal,
  • Leontios Pappas,
  • Bennett A. Caughey,
  • Rocco Ricciardi and
  • Aparna Parikh

20 June 2025

Locally advanced rectal cancer treatment has shifted toward personalized, risk-adapted strategies that balance oncologic control with functional preservation while minimizing toxicity. A multidisciplinary team approach is essential, tailoring treatme...

  • Article
  • Open Access
1 Citations
2,972 Views
19 Pages

31 May 2025

Prostate cancer is the most common cancer in men in 112 countries, accounting for 1 in 14 diagnosed cancer cases worldwide. For this reason, the diagnosis and treatment of prostate cancer changed significantly, becoming a multidisciplinary process. S...

  • Review
  • Open Access
55 Citations
11,520 Views
14 Pages

Treatment of Sialolithiasis: What Has Changed? An Update of the Treatment Algorithms and a Review of the Literature

  • Michael Koch,
  • Konstantinos Mantsopoulos,
  • Sarina Müller,
  • Matti Sievert and
  • Heinrich Iro

31 December 2021

Treatment for sialolithiasis has undergone significant changes since the 1990s. Following the development of new minimally invasive and gland-preserving treatment modalities, a 40–50% rate of gland resection was reduced to less than 5%. Extraco...

  • Article
  • Open Access
1 Citations
1,510 Views
14 Pages

Background: An effective treatment for Opioid Use Disorder is Medication-Assisted Treatment (MAT). However, in the United States (US), this is still being underutilized by youth. Research indicates the need to develop strategies to reduce treatment b...

  • Article
  • Open Access
6 Citations
4,188 Views
12 Pages

28 March 2023

This retrospective real-world study aimed to evaluate the outcomes of clear aligner treatment (CAT) and patient demographics of patients seeking orthodontic re-treatment who had previously received orthodontic treatment in childhood or adolescence. T...

  • Review
  • Open Access
61 Citations
11,518 Views
13 Pages

The Treatment Gap in Osteoporosis

  • Nazia Ayub,
  • Malak Faraj,
  • Sam Ghatan,
  • Joannes A. A. Reijers,
  • Nicola Napoli and
  • Ling Oei

5 July 2021

Worldwide, there are millions of people who have been diagnosed with osteoporosis, a bone disease that increases the risk of fracture due to low bone mineral density and deterioration of bone architecture. In the US alone, there are approximately ten...

  • Article
  • Open Access
9 Citations
3,529 Views
18 Pages

This study explores the potential of storage lagoons as a quaternary treatment step in wastewater treatment plants (WWTPs), focusing on compliance with the recent European Urban Wastewater Treatment Directive (UWWTD), which mandates an 80% reduction...

  • Review
  • Open Access
232 Citations
54,066 Views
31 Pages

Electrocoagulation in Wastewater Treatment

  • Erick Butler,
  • Yung-Tse Hung,
  • Ruth Yu-Li Yeh and
  • Mohammed Suleiman Al Ahmad

6 April 2011

A review of the literature published in from 2008 to 2010 on topics related to electrochemical treatment within wastewater was presented. The review included several sections such as optimization, modeling, various wastewater treatment techniques, an...

  • Article
  • Open Access
24 Citations
5,972 Views
16 Pages

Treatment-Resistant Depression in Poland—Epidemiology and Treatment

  • Piotr Gałecki,
  • Jerzy Samochowiec,
  • Magdalena Mikułowska and
  • Agata Szulc

18 January 2022

(1) Background: Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders worldwide. Although several antidepressant drugs have been developed, up to 30% of patients fail to achieve remission, and acute remission rates decrea...

  • Article
  • Open Access
19 Citations
3,913 Views
6 Pages

3 March 2020

Background and Objectives: Demodex species are common obligatory parasites and normally present in low number in human beings. Immunosuppression was suggested to be associated with increased density of Demodex mites. Systemic glucocorticoids, cyclosp...

  • Article
  • Open Access
9 Citations
4,724 Views
14 Pages

The Global Initiative for Asthma (GINA) has presented a shift in pharmacological asthma treatment. The objective of this study was to explore factors influencing a successful switch to a new asthma treatment approach with a focus on asthma patients&r...

  • Article
  • Open Access
1,904 Views
15 Pages

Does the Modality of Dental Treatment Affect the Treatment Prognosis and the Necessity of Re-Treatments?

  • İrem Bağ,
  • Seçil Çalışkan,
  • Alaz Oya Erenel,
  • Kübra Nur Sevimli and
  • Merve Candan

19 October 2023

Background: The utilization of evidence-based approaches is crucial to achieving long-term positive outcomes for treatment performed chairside or under general anesthesia. The study aimed to evaluate if treatment modality (at the chairside or under g...

  • Review
  • Open Access
40 Citations
13,851 Views
12 Pages

Current and Prospective Treatment of Adenomyosis

  • Fady I. Sharara,
  • Mira H. Kheil,
  • Anis Feki,
  • Sara Rahman,
  • Jordan S. Klebanoff,
  • Jean Marc Ayoubi and
  • Gaby N. Moawad

30 July 2021

(1) Background: Adenomyosis is a poorly understood entity which makes it difficult to standardize treatment. In this paper we review and compare the currently approved medical and surgical treatments of adenomyosis and present the evidence behind the...

  • Article
  • Open Access
8 Citations
4,469 Views
15 Pages

Primary Treatment of Domestic Wastewater with the Use of Unmodified and Chemically Modified Drinking Water Treatment Sludge

  • Camilo C. Castro-Jiménez,
  • Julio C. Saldarriaga-Molina,
  • Edwin F. García and
  • Mauricio A. Correa-Ochoa

9 August 2022

Improved wastewater (WW) treatment contributes to preserving human life and aquatic ecosystems and acting on climate change. The use of drinking water treatment sludges (WTS) as coagulants in the primary treatment of WW contributes, in this regard, a...

  • Article
  • Open Access
12 Citations
7,821 Views
9 Pages

Ketamine as Add-On Treatment in Psychotic Treatment-Resistant Depression

  • Maria Gałuszko-Węgielnik,
  • Zuzanna Chmielewska,
  • Katarzyna Jakuszkowiak-Wojten,
  • Mariusz S. Wiglusz and
  • Wiesław J. Cubała

13 January 2023

Psychotic treatment-resistant depression is a complex and challenging manifestation of mood disorders in the clinical setting. Psychotic depression is a subtype of major depressive disorder characterized by mood-consistent hallucinations and/or delus...

  • Review
  • Open Access
8 Citations
2,541 Views
38 Pages

Locoregional Treatment in Intrahepatic Cholangiocarcinoma: Which Treatment for Which Patient?

  • Héloïse Bourien,
  • Chiara Carlotta Pircher,
  • Boris Guiu,
  • Angela Lamarca,
  • Juan W Valle,
  • Monica Niger and
  • Julien Edeline

23 August 2023

For unresectable intrahepatic cholangiocarcinoma (iCC), different locoregional treatments (LRT) could be proposed to patients, including radiofrequency ablation (RFA) and microwave ablation (MWA), external beam radiotherapy (EBRT) or transarterial tr...

  • Article
  • Open Access
17 Citations
5,203 Views
16 Pages

Membrane Filtration as Post-Treatment of Rotating Biological Contactor for Wastewater Treatment

  • Sharjeel Waqas,
  • Muhammad Roil Bilad,
  • Nurul Huda,
  • Noorfidza Yub Harun,
  • Nik Abdul Hadi Md Nordin,
  • Norazanita Shamsuddin,
  • Yusuf Wibisono,
  • Asim Laeeq Khan and
  • Jumardi Roslan

29 June 2021

A rotating biological contactor (RBC) offers a low energy footprint but suffers from performance instability, making it less popular for domestic wastewater treatment. This paper presents a study on an RBC integrated with membrane technology in which...

  • Review
  • Open Access
7 Citations
8,558 Views
11 Pages

Whole Body Cryotherapy and Hyperbaric Oxygen Treatment: New Biological Treatment of Depression? A Systematic Review

  • Marek Krzystanek,
  • Monika Romańczyk,
  • Stanisław Surma and
  • Agnieszka Koźmin-Burzyńska

Treatment with antidepressants is often insufficiently effective, especially in treatment-resistant depression. In such a situation, it is possible to change the drug, add a second antidepressant, or use pharmacological and non-pharmacological method...

  • Article
  • Open Access
10 Citations
3,089 Views
16 Pages

13 September 2022

In order to improve the treatment processes of the drinking water treatment plant (DWTP) located near the Butoniga reservoir in Istria (Croatia), a prediction of the water quality index (WQI) was done. Based on parameters such as temperature, pH, tur...

  • Article
  • Open Access
7 Citations
3,380 Views
16 Pages

Cancer Treatment Patterns and Factors Affecting Receipt of Treatment in Older Adults: Results from the ASPREE Cancer Treatment Substudy (ACTS)

  • Jaidyn Muhandiramge,
  • Erica T. Warner,
  • John R. Zalcberg,
  • Andrew Haydon,
  • Galina Polekhina,
  • Gijsberta J. van Londen,
  • Peter Gibbs,
  • Wendy B. Bernstein,
  • Jeanne Tie and
  • Jeremy L. Millar
  • + 4 authors

5 February 2023

Introduction: Cancer treatment planning in older adults is complex and requires careful balancing of survival, quality of life benefits, and risk of treatment-related morbidity and toxicity. As a result, treatment selection in this cohort tends to di...

  • Article
  • Open Access
17 Citations
4,196 Views
13 Pages

Screening for Fabry Disease in Kidney Transplant Recipients: Experience of a Multidisciplinary Team

  • Massimiliano Veroux,
  • Ines P. Monte,
  • Margherita S. Rodolico,
  • Daniela Corona,
  • Rita Bella,
  • Antonio Basile,
  • Stefano Palmucci,
  • Maria L. Pistorio,
  • Giuseppe Lanza and
  • Concetta De Pasquale
  • + 2 authors

Fabry disease (FD) is a rare cause of end-stage renal disease requiring kidney transplantation. Data on the incidence of unrecognized FD in kidney transplant recipients are scarce and probably underestimated. This study evaluated the incidence of FD...

  • Concept Paper
  • Open Access
43 Citations
12,068 Views
17 Pages

8 December 2014

Patients with posttraumatic stress disorder (PTSD) who fail to respond to established treatments are at risk for chronic disability and distress. Although treatment-resistant PTSD (TR-PTSD) is a common clinical problem, there is currently no standar...

  • Review
  • Open Access
38 Citations
9,796 Views
19 Pages

Deep Brain Stimulation for Treatment-Resistant Depression: Towards a More Personalized Treatment Approach

  • Milaine Roet,
  • Jackson Boonstra,
  • Erdi Sahin,
  • Anne E.P. Mulders,
  • Albert F.G. Leentjens and
  • Ali Jahanshahi

24 August 2020

Major depressive disorder (MDD) affects approximately 4.4% of the world’s population. One third of MDD patients do not respond to routine psychotherapeutic and pharmacotherapeutic treatment and are said to suffer from treatment-resistant depres...

  • Review
  • Open Access
2,594 Views
11 Pages

10 February 2025

To treat early gastric cancer, one must choose between endoscopic treatment and surgical treatment. Endoscopic treatment has been developing significantly since the late 1990s and has made great progress up to the present. However, many patients with...

  • Article
  • Open Access
115 Citations
16,786 Views
21 Pages

5 March 2015

With rapid urbanization and infrastructure investment, wastewater treatment plants (WWTPs) in Chinese cities are putting increased pressure on energy consumption and exacerbating greenhouse gas (GHG) emissions. A carbon footprint is provided as a too...

  • Article
  • Open Access
2,186 Views
14 Pages

22 November 2023

This study investigated the impact of dynamic high-pressure (DHP) treatment on the ability of whey protein isolate (WPI) to form associative complexes with pectin and to form aggregate particles after their subsequent heat treatment. Light scattering...

  • Feature Paper
  • Article
  • Open Access
10 Citations
2,929 Views
11 Pages

UVA-LED Technology’s Treatment Efficiency and Cost in a Competitive Trial Applied to the Photo-Fenton Treatment of Landfill Leachate

  • Javier Tejera,
  • Antonio Gascó,
  • Daphne Hermosilla,
  • Víctor Alonso-Gomez,
  • Carlos Negro and
  • Ángeles Blanco

10 June 2021

The objective of this trial was to assess the application of UVA-LED technology as an alternative source of irradiation for photo-Fenton processes, aiming to reduce treatment costs and provide a feasible treatment for landfill leachate. An optimized...

  • Article
  • Open Access
13 Citations
5,189 Views
10 Pages

Characteristics of Previous Tuberculosis Treatment History in Patients with Treatment Failure and the Impact on Acquired Drug-Resistant Tuberculosis

  • Soedarsono Soedarsono,
  • Ni Made Mertaniasih,
  • Tutik Kusmiati,
  • Ariani Permatasari,
  • Wiwik Kurnia Ilahi and
  • Amelia Tantri Anggraeni

Tuberculosis (TB) treatment failure is a health burden, as the patient remains a source of infection and may lead to the development of multi-drug resistance (MDR). Information from cases of treatment failure that develop into MDR, which is related t...

  • Article
  • Open Access
67 Citations
15,942 Views
17 Pages

6 April 2011

Environmental policies at the European and global level support the diversion of wastes from landfills for their treatment in different facilities. Organic waste is mainly treated or valorized through composting, anaerobic digestion or a combination...

  • Article
  • Open Access
4 Citations
3,176 Views
15 Pages

13 December 2023

Therapist–client cognitive match upon key constructs such as treatment goals is purported to be an important component of culturally competent care. For adolescent clients, treatment may involve both youths and their parents, suggesting the nee...

  • Review
  • Open Access
23 Citations
9,161 Views
24 Pages

Batik Effluent Treatment and Decolorization—A Review

  • Nuriah Zakaria,
  • Rosiah Rohani,
  • Wan Hanna Melini Wan Mohtar,
  • Ronny Purwadi,
  • Giovanni Arneldi Sumampouw and
  • Antonius Indarto

29 March 2023

Batik is a piece of woven cloth decorated with beautiful patterns and designs and has become a signature product of the Malay Archipelago, including Malaysia and Indonesia. Batik industry consumes a large volume of water and produces a large amount o...

  • Review
  • Open Access
10 Citations
6,596 Views
23 Pages

Application of Decentralized Wastewater Treatment Technology in Rural Domestic Wastewater Treatment

  • Xinyu Li,
  • Xu Zhang,
  • Min Zhao,
  • Xiangyong Zheng,
  • Zhiquan Wang and
  • Chunzhen Fan

5 October 2024

The management of domestic wastewater in rural areas has always been challenging due to characteristics such as the wide distribution and dispersion of rural households. There are numerous domestic sewage discharge methods used in rural areas, and it...

  • Article
  • Open Access
64 Citations
9,253 Views
12 Pages

14 October 2016

In the United States, fuel reduction treatments are a standard land management tool to restore the structure and composition of forests that have been degraded by past management. Although treatments can have multiple purposes, their principal object...

  • Review
  • Open Access
9 Citations
5,274 Views
13 Pages

Minimally Invasive Spinal Treatment (MIST)—A New Concept in the Treatment of Spinal Diseases: A Narrative Review

  • Ken Ishii,
  • Goichi Watanabe,
  • Takashi Tomita,
  • Takuya Nikaido,
  • Tomohiro Hikata,
  • Akira Shinohara,
  • Masato Nakano,
  • Takanori Saito,
  • Kazuo Nakanishi and
  • Tadatsugu Morimoto
  • + 7 authors

18 August 2022

In the past two decades, minimally invasive spine surgery (MISS) techniques have been developed for spinal surgery. Historically, minimizing invasiveness in decompression surgery was initially reported as a MISS technique. In recent years, MISS techn...

  • Article
  • Open Access
3 Citations
2,065 Views
12 Pages

Delays in Treatment Initiation and Treatment Outcomes in Patients with Tuberculosis in the Kyrgyz Republic: Are There Differences between Migrants and Non-Migrants?

  • Kylychbek Istamov,
  • Mher Beglaryan,
  • Olga Goncharova,
  • Konushbek Sakmamatov,
  • Bolot Kyrbashov,
  • Mukadas Mamytova,
  • Indira Zairova,
  • Gulzat Alumkylova and
  • Divya Nair

Migrants are at increased risk of developing tuberculosis (TB) and have poor treatment outcomes. The National TB program (NTP) of the Kyrgyz Republic recognizes two types of migrants: internal (intra-country) and external (inter-country) migrants. Th...

  • Review
  • Open Access
1 Citations
1,597 Views
22 Pages

27 February 2025

This paper focuses on the microstructural characteristics of non-alloy structural steels with carbon contents below 0.3% (further—Low-Carbon Steel—LCS), as well as the possible structural transformations and the resultant mechanical prope...

  • Feature Paper
  • Article
  • Open Access
1 Citations
1,932 Views
14 Pages

11 November 2022

The impacts of dynamic high-pressure (DHP) pretreatment and post-treatment (100 MPa) on the physicochemical and functional properties of whey protein isolate (WPI) aggregates formed by thermal treatment were investigated in this study. When WPI aggre...

  • Review
  • Open Access
119 Citations
16,572 Views
20 Pages

Dye Waste Treatment

  • Siew-Teng Ong,
  • Pei-Sin Keng,
  • Weng-Nam Lee,
  • Sie-Tiong Ha and
  • Yung-Tse Hung

16 February 2011

Dye wastes represent one of the most problematic groups of pollutants because they can be easily identified by the human eye and are not easily biodegradable. This literature review paper highlights and provides an overview of dye waste treatments pe...

  • Review
  • Open Access
6 Citations
5,141 Views
27 Pages

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly NAFLD, is the most prevalent chronic liver disease worldwide. Strongly linked to obesity, type 2 diabetes, and metabolic syndrome, MASLD poses a growing health burden. Despite...

  • Review
  • Open Access
23 Citations
9,549 Views
22 Pages

23 December 2023

One of the most prevalent primary malignant brain tumors is glioblastoma (GB). About 6 incidents per 100,000 people are reported annually. Most frequently, these tumors are linked to a poor prognosis and poor quality of life. There has been little ad...

  • Review
  • Open Access
232 Citations
77,887 Views
20 Pages

Treatment Modalities for Acne

  • Lizelle Fox,
  • Candice Csongradi,
  • Marique Aucamp,
  • Jeanetta Du Plessis and
  • Minja Gerber

13 August 2016

Acne is a common inflammatory skin disease which affects the pilosebaceous units of the skin. It can have severe psychological effects and can leave the patient with severe skin scarring. There are four well-recognized pathological factors responsibl...

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