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Review

Whole Body Cryotherapy and Hyperbaric Oxygen Treatment: New Biological Treatment of Depression? A Systematic Review

1
Clinic of Psychiatric Rehabilitation, Department of Psychiatry and Psychotherapy, Faculty of Medical Sciences, Medical University of Silesia in Katowice, Ziołowa 45/47, 40-635 Katowice, Poland
2
Clinic of Psychiatric Rehabilitation, Leszek Giec Upper-Silesian Medical Centre of the Medical University of Silesia in Katowice, Ziołowa 45/47, 40-635 Katowice, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Lusine Danielyan and Huu Phuc Nguyen
Pharmaceuticals 2021, 14(6), 595; https://doi.org/10.3390/ph14060595
Received: 31 May 2021 / Revised: 18 June 2021 / Accepted: 19 June 2021 / Published: 21 June 2021
(This article belongs to the Special Issue New Drugs and Biologics For Treatment of Central Nervous Dysfunction)
Treatment with antidepressants is often insufficiently effective, especially in treatment-resistant depression. In such a situation, it is possible to change the drug, add a second antidepressant, or use pharmacological and non-pharmacological methods of augmenting the effect of pharmacotherapy. New methods that may fall into the scope of multi-module depression treatment as an augmentation of depression treatment are whole body cryotherapy (WBC) and hyperbaric oxygen treatment (HBOT). 545 records were selected and analyzed for these two treatments and finally three clinical trials were selected for analysis. The review also includes data on the possibility of using WBC and HBOT in somatic indications and in organic mental syndromes. Despite the small number of studies on the effectiveness of WBC or HBOT in depression, the current data show that both methods may be effective in the treatment of depression. WBC may be effective in the augmentation of antidepressants, and additionally, it is a method in which a quick antidepressant effect is obtained. HBOT may be effective in endogenous depression, just as it is effective in the treatment of somatic depression symptoms. The results are very preliminary, but if confirmed in subsequent studies, both WBC and HBOT may become new treatment options in treating depression. The authors point to the need and directions for further research into these treatment methods as an augmentation strategy for pharmacological treatment of depression. View Full-Text
Keywords: whole body cryotherapy; WBC; hyperbaric oxygen treatment; HBOT; depression; pharmacotherapy; augmentation; treatment resistant depression whole body cryotherapy; WBC; hyperbaric oxygen treatment; HBOT; depression; pharmacotherapy; augmentation; treatment resistant depression
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MDPI and ACS Style

Krzystanek, M.; Romańczyk, M.; Surma, S.; Koźmin-Burzyńska, A. Whole Body Cryotherapy and Hyperbaric Oxygen Treatment: New Biological Treatment of Depression? A Systematic Review. Pharmaceuticals 2021, 14, 595. https://doi.org/10.3390/ph14060595

AMA Style

Krzystanek M, Romańczyk M, Surma S, Koźmin-Burzyńska A. Whole Body Cryotherapy and Hyperbaric Oxygen Treatment: New Biological Treatment of Depression? A Systematic Review. Pharmaceuticals. 2021; 14(6):595. https://doi.org/10.3390/ph14060595

Chicago/Turabian Style

Krzystanek, Marek, Monika Romańczyk, Stanisław Surma, and Agnieszka Koźmin-Burzyńska. 2021. "Whole Body Cryotherapy and Hyperbaric Oxygen Treatment: New Biological Treatment of Depression? A Systematic Review" Pharmaceuticals 14, no. 6: 595. https://doi.org/10.3390/ph14060595

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