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216 Results Found

  • Article
  • Open Access
5 Citations
2,967 Views
15 Pages

16 April 2023

This study has developed a production method for high-quality Genova tea with excellent antioxidant properties. The antioxidant properties of each part of the Genova basil plant (i.e., leaves, flowers, and stems) were determined; the leaves and flowe...

  • Article
  • Open Access
1 Citations
952 Views
49 Pages

19 March 2025

Generalizability theory (GT) provides an all-encompassing framework for estimating accuracy of scores and effects of multiple sources of measurement error when using measures intended for either norm- or criterion-referencing purposes. Structural equ...

  • Article
  • Open Access
1 Citations
5,358 Views
24 Pages

13 August 2020

In the waters of the Calabrian Ionian Sea, off Isola di Capo Rizzuto (Crotone, Italy) and at a depth of 26–29 m, lies the wreck of Bengala, an iron screw-steamer foundered in 1889. She was built and launched in 1871 in Sunderland (Great Britain...

  • Article
  • Open Access
3 Citations
3,725 Views
21 Pages

Assessing Climate Change Projections through High-Resolution Modelling: A Comparative Study of Three European Cities

  • Ana Ascenso,
  • Bruno Augusto,
  • Sílvia Coelho,
  • Isilda Menezes,
  • Alexandra Monteiro,
  • Sandra Rafael,
  • Joana Ferreira,
  • Carla Gama,
  • Peter Roebeling and
  • Ana Isabel Miranda

23 August 2024

Climate change is expected to influence urban living conditions, challenging cities to adopt mitigation and adaptation measures. This paper assesses climate change projections for different urban areas in Europe –Eindhoven (The Netherlands), Ge...

  • Article
  • Open Access
8 Citations
6,970 Views
20 Pages

15 April 2021

The introduction of ‘illegal’ migration in West African countries represented a major conceptual policy shift for societies that were historically characterized by intra-regional free movement. However, this transformation went along with severe alle...

  • Article
  • Open Access
15 Citations
3,678 Views
17 Pages

17 June 2021

In this work, we investigated the potential of PVA-borax hydrogel for cleaning limestones and the dependence of the cleaning on the porosity of the rock and on the action time of the hydrogel treatment. Towards this goal, we used a nuclear magnetic r...

  • Article
  • Open Access
12 Citations
3,150 Views
15 Pages

Capabilities of Double-Resonance LPG and SPR Methods for Hypersensitive Detection of SARS-CoV-2 Structural Proteins: A Comparative Study

  • Tinko Eftimov,
  • Petia Genova-Kalou,
  • Georgi Dyankov,
  • Wojtek J. Bock,
  • Vihar Mankov,
  • Sanaz Shoar Ghaffari,
  • Petar Veselinov,
  • Alla Arapova and
  • Somayeh Makouei

24 February 2023

The danger of the emergence of new viral diseases and their rapid spread demands apparatuses for continuous rapid monitoring in real time. This requires the creation of new bioanalytical methods that overcome the shortcomings of existing ones and are...

  • Feature Paper
  • Article
  • Open Access
10 Citations
3,323 Views
23 Pages

26 February 2023

Natural derivatives, such as essential oils, are presented as an alternative to classical biocides to the treatment of biocolonization. Thus, in this work, the cleaning and biocidal potential of some natural derivatives towards two natural biofilms&r...

  • Article
  • Open Access
1 Citations
2,627 Views
16 Pages

A Pilot Phase 2 Randomized Trial to Evaluate the Safety and Potential Efficacy of Etravirine in Friedreich Ataxia Patients

  • Gabriella Paparella,
  • Cristina Stragà,
  • Nicola Pesenti,
  • Valentina Dal Molin,
  • Gian Antonio Martorel,
  • Vasco Merotto,
  • Cristina Genova,
  • Arianna Piazza,
  • Giuseppe Piccoli and
  • Elena Panzeri
  • + 3 authors

9 August 2024

Background: A drug repositioning effort supported the possible use of the anti-HIV drug etravirine as a disease-modifying drug for Friedreich ataxia (FRDA). Etravirine increases frataxin protein and corrects the biochemical defects in cells derived f...

  • Article
  • Open Access
3 Citations
1,764 Views
15 Pages

Early Biological Response to Poly(ε-Caprolactone)/Alumina-Toughened Zirconia Composites Obtained by 3D Printing for Peri-Implant Application

  • Riccardo Pedraza,
  • Alessandro Mosca Balma,
  • Ilaria Roato,
  • Clarissa Orrico,
  • Tullio Genova,
  • Giacomo Baima,
  • Giovanni Nicolao Berta,
  • Andrea Giura,
  • Luigi Ribotta and
  • Donatella Duraccio
  • + 2 authors

5 September 2024

The improvement of the mucosal sealing around the implant represents a challenge, one that prompted research into novel materials. To this purpose, a printable poly(ε-caprolactone) (PCL)-based composite loaded with alumina-toughened zirconia...

  • Article
  • Open Access
3 Citations
2,186 Views
21 Pages

VEGF, but Not BDNF, Prevents the Downregulation of KCC2 Induced by Axotomy in Extraocular Motoneurons

  • Jaime Capilla-López,
  • Rosendo G. Hernández,
  • Génova Carrero-Rojas,
  • Paula M. Calvo,
  • Francisco J. Alvarez,
  • Rosa R. de la Cruz and
  • Angel M. Pastor

14 September 2024

The potassium–chloride cotransporter KCC2 is the main extruder of Cl- in neurons. It plays a fundamental role in the activity of the inhibitory neurotransmitters (GABA and glycine) since low levels of KCC2 promote intracellular Cl- accumulation...

  • Case Report
  • Open Access
2,796 Views
21 Pages

A Cautionary Tale of Hypertrophic Cardiomyopathy—From “Benign” Left Ventricular Hypertrophy to Stroke, Atrial Fibrillation, and Molecular Genetic Diagnostics: A Case Report and Review of Literature

  • Dolina Gencheva,
  • Petya Angelova,
  • Kameliya Genova,
  • Slavena Atemin,
  • Mila Sleptsova,
  • Tihomir Todorov,
  • Fedya Nikolov,
  • Donka Ruseva,
  • Vanyo Mitev and
  • Albena Todorova

29 August 2024

This case report concerns a 48-year-old man with a history of ischemic stroke at the age of 41 who reported cardiac hypertrophy, registered in his twenties when explained by increased physical activity. Family history was positive for a mother with p...

  • Article
  • Open Access
1 Citations
1,307 Views
15 Pages

Histopathological analysis is one of the primary pillars in clinical diagnostics. The efforts to implement optical techniques aim at alleviating the burden of delivering timely and accurate diagnoses. We have explored the potential application of uns...

  • Article
  • Open Access
6 Citations
1,911 Views
30 Pages

Influence of Deposition Temperature and WC Concentration on the Microstructure of Electroless Ni-P-WC Nanocomposite Coatings with Improved Hardness and Corrosion Resistance

  • Giulia Pedrizzetti,
  • Virgilio Genova,
  • Michelangelo Bellacci,
  • Erica Scrinzi,
  • Andrea Brotzu,
  • Francesco Marra and
  • Giovanni Pulci

This study aims to develop Ni-P coatings with high P content (≥11 wt.%) reinforced with WC nanoparticles on F22 steel substrates. The introduction of conductive WC in the plating solution dramatically increases reactivity of the plating solution,...

  • Article
  • Open Access
8 Citations
2,921 Views
24 Pages

Multi-Technique Assessment of Chelators-Loaded PVA-Borax Gel-like Systems Performance in Cleaning of Stone Contaminated with Copper Corrosion Products

  • Laura Giuliani,
  • Chiara Genova,
  • Valeria Stagno,
  • Luca Paoletti,
  • Andrea Louise Matulac,
  • Alessandro Ciccola,
  • Melania Di Fazio,
  • Silvia Capuani and
  • Gabriele Favero

11 July 2024

Currently, one of the most important challenges for the conservation of stone artworks is the removal of metal corrosion products on their surfaces. Traditional cleaning methods, which typically involve the application of aqueous solutions containing...

  • Article
  • Open Access
2 Citations
1,782 Views
11 Pages

Rapid On-Site Evaluation Performed by an Interventional Pulmonologist: A Single-Center Experience

  • Emanuela Barisione,
  • Carlo Genova,
  • Matteo Ferrando,
  • Maurizio Boggio,
  • Michele Paudice and
  • Elena Tagliabue

18 July 2024

Background: Rapid On-Site Evaluation (ROSE) during bronchoscopy allows us to assess sample adequacy for diagnosis and molecular analyses in the context of precision oncology. While extemporaneous smears are typically evaluated by pathologists, their...

  • Article
  • Open Access
6 Citations
3,007 Views
15 Pages

Prevalence of Gastrointestinal Parasites in Small Ruminant Farms in Southern Spain

  • Pablo José Rufino-Moya,
  • Rafael Zafra Leva,
  • Lilian Gonçalves Reis,
  • Isabel Acosta García,
  • Diego Ruiz Di Genova,
  • Almudena Sánchez Gómez,
  • Francisco García García and
  • Francisco J. Martínez-Moreno

3 June 2024

The primary population of small ruminants in Spain is concentrated in the southern region, a critical area for the country’s livestock production. Indirect economic losses can occur when this livestock is affected by gastrointestinal parasites....

  • Article
  • Open Access
1,987 Views
12 Pages

First Insight into the Prevalence of Coxiella burnetii Infection among Veterinary Medicine Students in Bulgaria

  • Petia Genova-Kalou,
  • Yordan Hodzhev,
  • Ilia Tsachev,
  • Roman Pepovich,
  • Stefan Panaiotov,
  • Veselin Dobrinov,
  • Stefka Krumova,
  • Betina Boneva-Marutsova,
  • Borislava Chakarova and
  • Keytlin Todorova
  • + 3 authors

26 August 2024

The aim of this study was to assess the prevalence of Coxiella burnetii infection among veterinary medicine students from two Bulgarian Universities, located in Sofia and Stara Zagora. Blood samples were collected from a total of 185 veterinary stude...

  • Article
  • Open Access
6 Citations
3,679 Views
20 Pages

The Serum ACE2, CTSL, AngII, and TNFα Levels after COVID-19 and mRNA Vaccines: The Molecular Basis

  • Mina Pencheva,
  • Martina Bozhkova,
  • Yordan Kalchev,
  • Steliyan Petrov,
  • Alexandra Baldzhieva,
  • Teodora Kalfova,
  • Valentin Dichev,
  • Donka Keskinova,
  • Silvia Genova and
  • Mariya Atanasova
  • + 1 author

27 November 2023

Background: The SARS-CoV-2 virus as well as the COVID-19 mRNA vaccines cause an increased production of proinflammatory cytokines. Aim: We investigated the relationship between ACE2, CTSL, AngII, TNFα and the serum levels of IL-6, IL-10, IL-33,...

  • Review
  • Open Access
24 Citations
9,171 Views
22 Pages

Carbohydrases and Phytase in Poultry and Pig Nutrition: A Review beyond the Nutrients and Energy Matrix

  • Dante Teixeira Valente Junior,
  • Jansller Luiz Genova,
  • Sung Woo Kim,
  • Alysson Saraiva and
  • Gabriel Cipriano Rocha

11 January 2024

This review aimed to clarify the mechanisms through which exogenous enzymes (carbohydrases and phytase) influence intestinal health, as well as their effects on the nutrients and energy matrix in diets fed to poultry and pigs reared under sanitary ch...

  • Article
  • Open Access
3 Citations
2,755 Views
13 Pages

Efficacy of a Solution Containing 33% Trichloroacetic Acid and Hydrogen Peroxide in Decontaminating Machined vs. Sand-Blasted Acid-Etched Titanium Surfaces

  • Giacomo Baima,
  • Federica Romano,
  • Ilaria Roato,
  • Alessandro Mosca Balma,
  • Riccardo Pedraza,
  • Maria Giulia Faga,
  • Federico Amoroso,
  • Clarissa Orrico,
  • Tullio Genova and
  • Mario Aimetti
  • + 1 author

This in vitro study assessed the efficacy of a solution containing 33% trichloroacetic acid (CCl3COOH; TCA) and hydrogen peroxide (H2O2) in decontaminating machined (MAC) and sand-blasted acid-etched (SBAE) titanium surfaces. A total of 80 titanium d...

  • Article
  • Open Access
9 Citations
3,886 Views
23 Pages

Investigating the Molecular Mechanisms Underlying Early Response to Inflammation and Helicobacter pylori Infection in Human Gastric Epithelial Cells

  • Giulia Martinelli,
  • Marco Fumagalli,
  • Stefano Piazza,
  • Nicole Maranta,
  • Francesca Genova,
  • Paola Sperandeo,
  • Enrico Sangiovanni,
  • Alessandra Polissi,
  • Mario Dell’Agli and
  • Emma De Fabiani

13 October 2023

Helicobacter pylori is a leading cause of chronic gastric inflammation, generally associated with gastritis and adenocarcinoma. Activation of the NF-κB pathway mainly contributes to the inflammatory phenotype observed in H. pylori infection in...

  • Article
  • Open Access
2 Citations
1,464 Views
12 Pages

Impact of Assistant Experience on Perioperative Outcomes of Simple and Radical Laparoscopic Nephrectomy: Does It Really Matter?

  • Francesca Ambrosini,
  • Guglielmo Mantica,
  • Giovanni Marchi,
  • Enrico Vecchio,
  • Benedetta Col,
  • Luca Gaia Genova,
  • Giorgia Trani,
  • Arianna Ferrari and
  • Carlo Terrone

26 December 2023

Background and Objectives: While systematic reviews highlight the advantages of laparoscopic nephrectomy over traditional open surgery, the impact of an assistant’s experience on surgical outcomes remains unclear. This study aims to evaluate wh...

  • Review
  • Open Access
5 Citations
3,912 Views
18 Pages

Molecular and Genetic Advances in Small Cell Lung Cancer Landscape: From Homogeneity to Diversity

  • Lodovica Zullo,
  • Filippo Gustavo Dall’Olio,
  • Giovanni Rossi,
  • Chiara Dellepiane,
  • Giulia Barletta,
  • Elisa Bennicelli,
  • Marta Ingaliso,
  • Marco Tagliamento and
  • Carlo Genova

22 December 2023

Small cell lung cancer (SCLC) has been historically considered a homogeneous disease and thus approached as a single entity when it comes to clinical studies design and new treatments developments. However, increasing knowledge in the genetic and mol...

  • Article
  • Open Access
11 Citations
2,135 Views
16 Pages

Gold Nanoparticles-Functionalized Cotton as Promising Flexible and Green Substrate for Impedometric VOC Detection

  • Silvia Casalinuovo,
  • Daniela Caschera,
  • Simone Quaranta,
  • Virgilio Genova,
  • Alessio Buzzin,
  • Fulvio Federici,
  • Giampiero de Cesare,
  • Donatella Puglisi and
  • Domenico Caputo

25 August 2023

This work focuses on the possible application of gold nanoparticles on flexible cotton fabric as acetone- and ethanol-sensitive substrates by means of impedance measurements. Specifically, citrate- and polyvinylpyrrolidone (PVP)-functionalized gold n...

  • Article
  • Open Access
12 Citations
3,252 Views
15 Pages

Ytterbium Disilicate/Monosilicate Multilayer Environmental Barrier Coatings: Influence of Atmospheric Plasma Spray Parameters on Composition and Microstructure

  • Giulia Di Iorio,
  • Laura Paglia,
  • Giulia Pedrizzetti,
  • Virgilio Genova,
  • Francesco Marra,
  • Cecilia Bartuli and
  • Giovanni Pulci

13 September 2023

SiC/SiC ceramic matrix composites (SiCf/SiC CMCs) are regarded as the new materials for the hot-section components of aircraft gas turbine engines, since they have one-third of the density of metallic superalloys, a higher temperature capability, goo...

  • Article
  • Open Access
1 Citations
2,128 Views
14 Pages

11 December 2023

The identification of targets whose inactivation increases the activity of antibiotics helps to fight antibiotic resistance. Previous work showed that a transposon-insertion mutant in the gene PA14_27940 increases Pseudomonas aeruginosa susceptibilit...

  • Article
  • Open Access
11 Citations
4,688 Views
18 Pages

7 February 2024

The topic of food is one of the main terrains of the debate about sustainability, with reference to all the components of food systems. At present, a vast body of literature exists about what can be considered as sustainable food products, as well as...

  • Article
  • Open Access
15 Citations
5,078 Views
23 Pages

Medium and High Phosphorous Ni-P Coatings Obtained via an Electroless Approach: Optimization of Solution Formulation and Characterization of Coatings

  • Virgilio Genova,
  • Laura Paglia,
  • Giovanni Pulci,
  • Giulia Pedrizzetti,
  • Alice Pranzetti,
  • Marco Romanelli and
  • Francesco Marra

24 August 2023

A new lead-free electroless Ni-P plating solution was developed for the deposition of coatings with medium phosphorus content (MP, 6–9 wt%), and its composition was optimized to obtain deposits with high phosphorus (HP, 10–14 wt%). Cleani...

  • Article
  • Open Access
5 Citations
3,049 Views
22 Pages

9 February 2022

Bacterial leaf scorch (BLS), caused by Xylella fastidiosa (Xf), is a prevalent disease of blueberries in the southeastern United States. Initially, this disease was reported to be caused by X. fastidiosa subsp. multiplex (Xfm). However, a recent surv...

  • Feature Paper
  • Review
  • Open Access
3,262 Views
15 Pages

Analysis of Renovation Works in Cappuccinelli Social Housing District in Trapani

  • Rossella Corrao,
  • Erica La Placa,
  • Enrico Genova and
  • Calogero Vinci

The refurbishment of public residential districts represents a current and complex problem. The Cappuccinelli Social Housing (SH) district in Trapani, designed in the late 1950s by Michele Valori and built during the 1960s, is emblematic of the archi...

  • Article
  • Open Access
3 Citations
2,337 Views
22 Pages

Mapping the Potential of High-Reflective Roof Coverings in Residential Buildings in Italy

  • Francesco Baldi,
  • Enrico Genova,
  • Alessandra Gugliandolo and
  • Maria-Anna Segreto

21 April 2022

The current warming trend of the earth’s climate is making it increasingly necessary to focus on solutions to improve indoor comfort while reducing energy demand for buildings during the hot season. The use of high-reflective products on the bu...

  • Review
  • Open Access
178 Citations
29,465 Views
25 Pages

Green Synthesis of Gold Nanoparticles: An Eco-Friendly Approach

  • Poornima Budime Santhosh,
  • Julia Genova and
  • Hassan Chamati

25 April 2022

By virtue of their unique physicochemical properties, gold nanoparticles (AuNPs) have gained significant interest in a broad range of biomedical applications such as sensors, diagnosis, and therapy. AuNPs are generally synthesized via different conve...

  • Article
  • Open Access
7 Citations
2,768 Views
16 Pages

Emotions, Stress and Coping among Healthcare Workers in a Reproductive Medicine Unit during the First and Second COVID-19 Lockdowns

  • Marcella Paterlini,
  • Erica Neri,
  • Alessia Nicoli,
  • Federica Genova,
  • Maria Teresa Villani,
  • Sara Santi and
  • Francesca Agostini

The impact of the COVID-19 pandemic on global healthcare workers’ (HCWs) mental health has been well documented in the last two years; however, little is known regarding HCWs working in specific healthcare fields. During two subsequent periods...

  • Article
  • Open Access
11 Citations
3,175 Views
12 Pages

Effects of Hydrophobic Gold Nanoparticles on Structure and Fluidity of SOPC Lipid Membranes

  • Poornima Budime Santhosh,
  • Tihomir Tenev,
  • Luka Šturm,
  • Nataša Poklar Ulrih and
  • Julia Genova

Gold nanoparticles (AuNPs) are promising candidates in various biomedical applications such as sensors, imaging, and cancer therapy. Understanding the influence of AuNPs on lipid membranes is important to assure their safety in the biological environ...

  • Article
  • Open Access
10 Citations
2,570 Views
18 Pages

Mechanical and Biological Characterization of PMMA/Al2O3 Composites for Dental Implant Abutments

  • Ilaria Roato,
  • Tullio Genova,
  • Donatella Duraccio,
  • Federico Alessandro Ruffinatti,
  • Diletta Zanin Venturini,
  • Mattia Di Maro,
  • Alessandro Mosca Balma,
  • Riccardo Pedraza,
  • Sara Petrillo and
  • Giorgia Chinigò
  • + 4 authors

27 July 2023

The mechanical and biological behaviors of PMMA/Al2O3 composites incorporating 30 wt.%, 40 wt.%, and 50 wt.% of Al2O3 were thoroughly characterized as regards to their possible application in implant-supported prostheses. The Al2O3 particles accounte...

  • Article
  • Open Access
7 Citations
2,403 Views
21 Pages

Transport of Pigs of Two Market Weights at Two Space Allowances: Effects on Behaviour, Blood Parameters, and Meat Quality under Summer and Winter Conditions

  • Jessica Gonçalves Vero,
  • Nicolas Devillers,
  • Ana Maria Bridi,
  • Kyle A. T. Moak,
  • Gizella Aboagye,
  • Guilherme Agostinis Ferreira,
  • Jansller Luiz Genova,
  • Sabine Conte and
  • Luigi Faucitano

30 August 2023

This study was carried out through two separate experiments aiming at evaluating the effects of two space allowances (0.54 and 0.62 m2/pig in summer and 0.44 m2/pig and 0.50 m2/pig in winter) on the behavioural and physiological response, and meat qu...

  • Article
  • Open Access
12 Citations
4,268 Views
14 Pages

Analysis of Antibody Neutralisation Activity against SARS-CoV-2 Variants and Seasonal Human Coronaviruses NL63, HKU1, and 229E Induced by Three Different COVID-19 Vaccine Platforms

  • Diego Cantoni,
  • Gabriel Siracusano,
  • Martin Mayora-Neto,
  • Claudia Pastori,
  • Tobia Fantoni,
  • Spyros Lytras,
  • Cecilia Di Genova,
  • Joseph Hughes,
  • on behalf of the Ambulatorio Medico San Luca Villanuova Group and
  • Lucia Lopalco
  • + 1 author

27 December 2022

Coronaviruses infections, culminating in the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic beginning in 2019, have highlighted the importance of effective vaccines to induce an antibody response with cross-neutralizing...

  • Article
  • Open Access
7 Citations
3,125 Views
21 Pages

10 January 2023

Chemosensory pathways and two-component systems are important bacterial signal transduction systems. In the human pathogen Pseudomonas aeruginosa, these systems control many virulence traits. Previous studies showed that inorganic phosphate (Pi) defi...

  • Article
  • Open Access
8 Citations
3,095 Views
12 Pages

Four-Line C2*/CH* Optical Sensor for Chemiluminescence Based Imaging of Flame Stoichiometry

  • Michael E. Tonarely,
  • Tommy Genova,
  • Anthony J. Morales,
  • Daniel Micka,
  • Darin Knaus and
  • Kareem A. Ahmed

28 July 2022

In the present work, an optical sensor was developed and calibrated for the purpose of non-intrusive equivalence ratio measurements in combustion systems. The sensor incorporates a unique four-line, single-sensor chemiluminescence imaging-based appro...

  • Article
  • Open Access
33 Citations
4,616 Views
22 Pages

10 November 2020

Cognitive fatigue is common and debilitating among persons with multiple sclerosis (pwMS). Neural mechanisms underlying fatigue are not well understood, which results in lack of adequate treatment. The current study examined cognitive fatigue-related...

  • Review
  • Open Access
40 Citations
7,030 Views
21 Pages

A Smart and Sustainable Future for Viticulture Is Rooted in Soil: How to Face Cu Toxicity

  • Stefano Cesco,
  • Youry Pii,
  • Luigimaria Borruso,
  • Guido Orzes,
  • Paolo Lugli,
  • Fabrizio Mazzetto,
  • Giulio Genova,
  • Marco Signorini,
  • Gustavo Brunetto and
  • Roberto Terzano
  • + 2 authors

20 January 2021

In recent decades, agriculture has faced the fundamental challenge of needing to increase food production and quality in order to meet the requirements of a growing global population. Similarly, viticulture has also been undergoing change. Several co...

  • Article
  • Open Access
14 Citations
3,511 Views
18 Pages

Comparative Evaluation of Different Chitosan Species and Derivatives as Candidate Biomaterials for Oxygen-Loaded Nanodroplet Formulations to Treat Chronic Wounds

  • Monica Argenziano,
  • Bruno Bressan,
  • Anna Luganini,
  • Nicole Finesso,
  • Tullio Genova,
  • Adriano Troia,
  • Giuliana Giribaldi,
  • Giuliana Banche,
  • Narcisa Mandras and
  • Anna Maria Cuffini
  • + 2 authors

15 February 2021

Persistent hypoxia is a main clinical feature of chronic wounds. Intriguingly, oxygen-loaded nanodroplets (OLNDs), filled with oxygen-solving 2H,3H-decafluoropentane and shelled with polysaccharides, have been proposed as a promising tool to countera...

  • Review
  • Open Access
127 Citations
10,638 Views
28 Pages

Advances on Bone Substitutes through 3D Bioprinting

  • Tullio Genova,
  • Ilaria Roato,
  • Massimo Carossa,
  • Chiara Motta,
  • Davide Cavagnetto and
  • Federico Mussano

23 September 2020

Reconstruction of bony defects is challenging when conventional grafting methods are used because of their intrinsic limitations (biological cost and/or biological properties). Bone regeneration techniques are rapidly evolving since the introduction...

  • Case Report
  • Open Access
11 Citations
2 Views
2 Pages

Effectiveness of Cyclosporine and Mycophenolate Mofetil in a Child with Refractory Evans Syndrome

  • Piero Farruggia,
  • Alessandra Macaluso,
  • Serena Tropia,
  • Selene Genova,
  • Olivia Paolicchi,
  • Floriana Di Marco and
  • Paolo D'Angelo

Evans Syndrome is a rare autoimmune disease consisting of hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. Its course can be extremely serious and, rarely, even life-th...

  • Case Report
  • Open Access
7 Citations
915 Views
3 Pages

Acute Respiratory Distress Syndrome Associated with Tumor Lysis Syndrome in a Child with Acute Lymphoblastic Leukemia

  • Alessandra Macaluso,
  • Selene Genova,
  • Silvio Maringhini,
  • Giancarlo Coffaro,
  • Ottavio Ziino and
  • Paolo D'Angelo

27 March 2015

Tumor lysis syndrome is a serious and dangerous complication usually associated with antiblastic treatment in some malignancies characterized by high cell turn-over. Mild or severe electrolyte abnormalities including high serum levels of uric acid, p...

  • Review
  • Open Access
57 Citations
7,469 Views
30 Pages

Precision Medicine for NSCLC in the Era of Immunotherapy: New Biomarkers to Select the Most Suitable Treatment or the Most Suitable Patient

  • Giovanni Rossi,
  • Alessandro Russo,
  • Marco Tagliamento,
  • Alessandro Tuzi,
  • Olga Nigro,
  • Giacomo Vallome,
  • Claudio Sini,
  • Massimiliano Grassi,
  • Maria Giovanna Dal Bello and
  • Simona Coco
  • + 6 authors

30 April 2020

In recent years, the evolution of treatments has made it possible to significantly improve the outcomes of patients with non-small cell lung cancer (NSCLC). In particular, while molecular targeted therapies are effective in specific patient sub-group...

  • Article
  • Open Access
27 Citations
4,515 Views
19 Pages

Correlation between B7-H4 and Survival of Non-Small-Cell Lung Cancer Patients Treated with Nivolumab

  • Carlo Genova,
  • Simona Boccardo,
  • Marco Mora,
  • Erika Rijavec,
  • Federica Biello,
  • Giovanni Rossi,
  • Marco Tagliamento,
  • Maria Giovanna Dal Bello,
  • Simona Coco and
  • Angela Alama
  • + 6 authors

1 October 2019

Reliable predictors of benefit from immune checkpoint inhibitors in non-small-cell lung cancer (NSCLC) are still limited. We aimed to evaluate the association between the expression of selected molecules involved in immune response and clinical outco...

  • Article
  • Open Access
19 Citations
5,387 Views
29 Pages

Physical-Chemical Characterization of Different Carbon-Based Sorbents for Environmental Applications

  • Simone Marzeddu,
  • María Alejandra Décima,
  • Luca Camilli,
  • Maria Paola Bracciale,
  • Virgilio Genova,
  • Laura Paglia,
  • Francesco Marra,
  • Martina Damizia,
  • Marco Stoller and
  • Agostina Chiavola
  • + 1 author

14 October 2022

Biochar has been used in various applications, e.g., as a soil conditioner and in remediation of contaminated water, wastewater, and gaseous emissions. In the latter application, biochar was shown to be a suitable alternative to activated carbon, pro...

  • Review
  • Open Access
15 Citations
3,720 Views
17 Pages

Immune Checkpoint Blockade: A Strategy to Unleash the Potential of Natural Killer Cells in the Anti-Cancer Therapy

  • Melania Grottoli,
  • Paolo Carrega,
  • Lodovica Zullo,
  • Chiara Dellepiane,
  • Giovanni Rossi,
  • Francesca Parisi,
  • Giulia Barletta,
  • Linda Zinoli,
  • Simona Coco and
  • Angela Alama
  • + 9 authors

14 October 2022

Immune checkpoint inhibitors (ICIs) immunotherapy has represented a breakthrough in cancer treatment. Clinical use of ICIs has shown an acceptable safety profile and promising antitumor activity. Nevertheless, some patients do not obtain clinical ben...

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