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Pediatric Reports
Volume 3
Issue 2
10.4081/pr.2011.e15
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Case Report

Effectiveness of Cyclosporine and Mycophenolate Mofetil in a Child with Refractory Evans Syndrome

by
Piero Farruggia
1,*,
Alessandra Macaluso
2,
Serena Tropia
1,
Selene Genova
2,
Olivia Paolicchi
3,
Floriana Di Marco
1 and
Paolo D'Angelo
1
1
Pediatric Hematology and Oncology Unit, G. Di Cristina Children’s Hospital, Palermo, Italy
2
Department of Pediatrics, G. Di Cristina Children’s Hospital, University of Palermo, Palermo, Italy
3
Department of Pediatric Hematology and Oncology, A.O.U. Meyer Children Hospital, Florence, Italy
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2011, 3(2), e15; https://doi.org/10.4081/pr.2011.e15
Submission received: 24 March 2011 / Accepted: 2 May 2011 / Published: 16 May 2011

Abstract

Evans Syndrome is a rare autoimmune disease consisting of hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. Its course can be extremely serious and, rarely, even life-threatening; thus it represents a excellent treatment challenge for the pediatric hematologist. First line treatment consists of steroids and/or immunoglobulin; further therapy with rituximab, vincristine, cyclophosphamide and other immunosuppressive drugs can be considered in unresponsive patients. We describe a baby with refractory Evans Syndrome that was cured by prolonged administration of mycophenolate mofetil and remained disease-free for 4 years after the discontinuation of treatment.
Keywords: evans’ syndrome; cyclosporine; mycophenolate mofetil; treatment; outcome evans’ syndrome; cyclosporine; mycophenolate mofetil; treatment; outcome

Share and Cite

MDPI and ACS Style

Farruggia, P.; Macaluso, A.; Tropia, S.; Genova, S.; Paolicchi, O.; Di Marco, F.; D'Angelo, P. Effectiveness of Cyclosporine and Mycophenolate Mofetil in a Child with Refractory Evans Syndrome. Pediatr. Rep. 2011, 3, e15. https://doi.org/10.4081/pr.2011.e15

AMA Style

Farruggia P, Macaluso A, Tropia S, Genova S, Paolicchi O, Di Marco F, D'Angelo P. Effectiveness of Cyclosporine and Mycophenolate Mofetil in a Child with Refractory Evans Syndrome. Pediatric Reports. 2011; 3(2):e15. https://doi.org/10.4081/pr.2011.e15

Chicago/Turabian Style

Farruggia, Piero, Alessandra Macaluso, Serena Tropia, Selene Genova, Olivia Paolicchi, Floriana Di Marco, and Paolo D'Angelo. 2011. "Effectiveness of Cyclosporine and Mycophenolate Mofetil in a Child with Refractory Evans Syndrome" Pediatric Reports 3, no. 2: e15. https://doi.org/10.4081/pr.2011.e15

APA Style

Farruggia, P., Macaluso, A., Tropia, S., Genova, S., Paolicchi, O., Di Marco, F., & D'Angelo, P. (2011). Effectiveness of Cyclosporine and Mycophenolate Mofetil in a Child with Refractory Evans Syndrome. Pediatric Reports, 3(2), e15. https://doi.org/10.4081/pr.2011.e15

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