Announcements

1. “Glucagon-Like Peptide-1 Receptor Agonists for Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: An Updated Meta-Analysis of Randomized Controlled Trials”
   by Alessandro Mantovani, Graziana Petracca, Giorgia Beatrice, Alessandro Csermely, Amedeo Lonardo and Giovanni Targher
   Metabolites 2021, 11(2), 73; https://doi.org/10.3390/metabo11020073
   Available online: https://www.mdpi.com/2218-1989/11/2/73
   

2. “L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine”
   *Editor’s Choice Paper
   by Marc R. McCann, Mery Vet George De la Rosa, Gus R. Rosania and Kathleen A. Stringer
   Metabolites 2021, 11(1), 51; https://doi.org/10.3390/metabo11010051
   Available online: https://www.mdpi.com/2218-1989/11/1/51
   

3. “Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis”
   by Kenji Ohshima and Eiichi Morii
   Metabolites 2021, 11(1), 28; https://doi.org/10.3390/metabo11010028
   Available online: https://www.mdpi.com/2218-1989/11/1/28
   

4. “Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment”
   *Editor’s Choice Paper
   by Ligia J. Dominguez, Mario Farruggia, Nicola Veronese and Mario Barbagallo
   Metabolites 2021, 11(4), 255; https://doi.org/10.3390/metabo11040255
   Available online: https://www.mdpi.com/2218-1989/11/4/255
   

5. “Insulin Resistance across the Spectrum of Nonalcoholic Fatty Liver Disease”
   by Angelo Armandi, Chiara Rosso, Gian Paolo Caviglia and Elisabetta Bugianesi
   Metabolites 2021, 11(3), 155; https://doi.org/10.3390/metabo11030155
   Available online: https://www.mdpi.com/2218-1989/11/3/155
   

6. “Altered Ca²⁺ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease”
   by Antonio Michelucci, Chen Liang, Feliciano Protasi and Robert T. Dirksen
   Metabolites 2021, 11(7), 424; https://doi.org/10.3390/metabo11070424
   Available online: https://www.mdpi.com/2218-1989/11/7/424
   

7. “Effect of Exercise on Brain Health: The Potential Role of Lactate as a Myokine”
   by Takeshi Hashimoto, Hayato Tsukamoto, Soichi Ando and Shigehiko Ogoh
   Metabolites 2021, 11(12), 813; https://doi.org/10.3390/metabo11120813
   Available online: https://www.mdpi.com/2218-1989/11/12/813
   

8. “Sex Affects Human Premature Neonates’ Blood Metabolome According to Gestational Age, Parenteral Nutrition, and Caffeine Treatment”
   by Marianna Caterino, Margherita Ruoppolo, Michele Costanzo, Lucia Albano, Daniela Crisci, Giovanni Sotgiu, Laura Saderi, Andrea Montella, Flavia Franconi and Ilaria Campesi
   Metabolites 2021, 11(3), 158; https://doi.org/10.3390/metabo11030158
   Available online: https://www.mdpi.com/2218-1989/11/3/158
   

1. “The Role of AKR1B10 in Physiology and Pathophysiology”
   by Satoshi Endo, Toshiyuki Matsunaga and Toru Nishinaka
   Metabolites 2021, 11(6), 332; https://doi.org/10.3390/metabo11060332
   Available online: https://www.mdpi.com/2218-1989/11/6/332
   

2. “Dynamics in Anemia Development and Dysregulation of Iron Homeostasis in Hospitalized Patients with COVID-19”
   by Lukas Lanser, Francesco Robert Burkert, Rosa Bellmann-Weiler, Andrea Schroll, Sophie Wildner, Gernot Fritsche and Günter Weiss
   Metabolites 2021, 11(10), 653; https://doi.org/10.3390/metabo11100653
   Available online: https://www.mdpi.com/2218-1989/11/10/653
   

3. “Advances and Perspectives in Prostate Cancer Biomarker Discovery in the Last 5 Years through Tissue and Urine Metabolomics”
   *Feature Paper, Editor’s Choice Paper
   by Ana Rita Lima, Joana Pinto, Filipa Amaro, Maria de Lourdes Bastos, Márcia Carvalho and Paula Guedes de Pinho
   Metabolites 2021, 11(3), 181; https://doi.org/10.3390/metabo11030181
   Available online: https://www.mdpi.com/2218-1989/11/3/181
   

4. “Discovery of Volatile Biomarkers for Bladder Cancer Detection and Staging through Urine Metabolomics”
   by Joana Pinto, Ângela Carapito, Filipa Amaro, Ana Rita Lima, Carina Carvalho-Maia, Maria Conceição Martins, Carmen Jerónimo, Rui Henrique, Maria de Lourdes Bastos and Paula Guedes de Pinho
   Metabolites 2021, 11(4), 199; https://doi.org/10.3390/metabo11040199
   Available online: https://www.mdpi.com/2218-1989/11/4/199
   

5. “Physiological and Pathological Roles of Aldose Reductase”
   by Mahavir Singh, Aniruddh Kapoor and Aruni Bhatnagar
   Metabolites 2021, 11(10), 655; https://doi.org/10.3390/metabo11100655
   Available online: https://www.mdpi.com/2218-1989/11/10/655
   

6. “Reproducibility of Baseline Tumour Metabolic Volume Measurements in Diffuse Large B-Cell Lymphoma: Is There a Superior Method?”
   *Editor’s Choice Paper
   by Florian Eude, Mathieu Nessim Toledano, Pierre Vera, Hervé Tilly, Sorina-Dana Mihailescu and Stéphanie Becker
   Metabolites 2021, 11(2), 72; https://doi.org/10.3390/metabo11020072
   Available online: https://www.mdpi.com/2218-1989/11/2/72
   

7. “Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca²⁺ Leak during Early ER Stress”
   by Zhanat Koshenov, Furkan E. Oflaz, Martin Hirtl, Johannes Pilic, Olaf A. Bachkoenig, Benjamin Gottschalk, Corina T. Madreiter-Sokolowski, Rene Rost, Roland Malli and Wolfgang F. Graier
   Metabolites 2021, 11(7), 422; https://doi.org/10.3390/metabo11070422
   Available online: https://www.mdpi.com/2218-1989/11/7/422
   

8. “Iron-Bound Lipocalin-2 Protects Renal Cell Carcinoma from Ferroptosis”
   *Editor’s Choice Paper
   by Julia K. Meier, Matthias Schnetz, Susanne Beck, Tobias Schmid, Monica Dominguez, Sanela Kalinovic, Andreas Daiber, Bernhard Brüne and Michaela Jung
   Metabolites 2021, 11(5), 329; https://doi.org/10.3390/metabo11050329
   Available online: https://www.mdpi.com/2218-1989/11/5/329
   

1. “Approaches to Integrating Metabolomics and Multi-Omics Data: A Primer”
   by Takoua Jendoubi
   Metabolites 2021, 11(3), 184; https://doi.org/10.3390/metabo11030184
   Available online: https://www.mdpi.com/2218-1989/11/3/184
   

2. “Next-Generation Genome-Scale Metabolic Modeling through Integration of Regulatory Mechanisms”
   *Feature Paper
   by Carolina H. Chung, Da-Wei Lin, Alec Eames and Sriram Chandrasekaran
   Metabolites 2021, 11(9), 606; https://doi.org/10.3390/metabo11090606
   Available online: https://www.mdpi.com/2218-1989/11/9/606
   

3. “Amino Acid Metabolism in Apicomplexan Parasites”
   by Aarti Krishnan and Dominique Soldati-Favre
   Metabolites 2021, 11(2), 61; https://doi.org/10.3390/metabo11020061
   Available online: https://www.mdpi.com/2218-1989/11/2/61
   

4. “Reconstruction of a Genome-Scale Metabolic Model of Streptomyces albus J1074: Improved Engineering Strategies in Natural Product Synthesis”
   *Feature Paper
   by Cheewin Kittikunapong, Suhui Ye, Patricia Magadán-Corpas, Álvaro Pérez-Valero, Claudio J. Villar, Felipe Lombó and Eduard J. Kerkhoven
   Metabolites 2021, 11(5), 304; https://doi.org/10.3390/metabo11050304
   Available online: https://www.mdpi.com/2218-1989/11/5/304
   

5. “Investigating Global Lipidome Alterations with the Lipid Network Explorer”
   by Nikolai Köhler, Tim Daniel Rose, Lisa Falk and Josch Konstantin Pauling
   Metabolites 2021, 11(8), 488; https://doi.org/10.3390/metabo11080488
   Available online: https://www.mdpi.com/2218-1989/11/8/488
   

6. “MSCAT: A Machine Learning Assisted Catalog of Metabolomics Software Tools”
   by Jonathan Dekermanjian, Wladimir Labeikovsky, Debashis Ghosh and Katerina Kechris
   Metabolites 2021, 11(10), 678; https://doi.org/10.3390/metabo11100678
   Available online: https://www.mdpi.com/2218-1989/11/10/678
   

7. “Diverse Taxonomies for Diverse Chemistries: Enhanced Representation of Natural Product Metabolism in UniProtKB”
   by Marc Feuermann, Emmanuel Boutet, Anne Morgat, Kristian B. Axelsen, Parit Bansal, Jerven Bolleman, Edouard de Castro, Elisabeth Coudert, Elisabeth Gasteiger, Sébastien Géhant et al.
   Metabolites 2021, 11(1), 48; https://doi.org/10.3390/metabo11010048
   Available online: https://www.mdpi.com/2218-1989/11/1/48
   

8. “Pathway Tools Visualization of Organism-Scale Metabolic Networks”
   by Suzanne Paley, Richard Billington, James Herson, Markus Krummenacker and Peter D. Karp
   Metabolites 2021, 11(2), 64; https://doi.org/10.3390/metabo11020064
   Available online: https://www.mdpi.com/2218-1989/11/2/64
   

1. “Uncoupling Thermotolerance and Growth Performance in Chinook Salmon: Blood Biochemistry and Immune Capacity”
   by Ronald Lulijwa, Tim Young, Jane E. Symonds, Seumas P. Walker, Natalí J. Delorme and Andrea C. Alfaro
   Metabolites 2021, 11(8), 547; https://doi.org/10.3390/metabo11080547
   Available online: https://www.mdpi.com/2218-1989/11/8/547
   

2. “Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice”
   by Sudip Paul, Aliki A. Rasmiena, Kevin Huynh, Adam Alexander T. Smith, Natalie A. Mellett, Karin Jandeleit-Dahm, Graeme I. Lancaster and Peter J. Meikle
   Metabolites 2021, 11(5), 299; https://doi.org/10.3390/metabo11050299
   Available online: https://www.mdpi.com/2218-1989/11/5/299
   

3. “Simultaneous Measurement of Amino Acid Enantiomers in Aged Mouse Brain Samples by LC/MS/MS Combined with Derivatization Using N^α-(5-Fluoro-2,4-dinitrophenyl)-l-leucinamide (l-FDLA)”
   by Taiji Yamamoto, Keisuke Yaku and Takashi Nakagawa
   Metabolites 2021, 11(1), 57; https://doi.org/10.3390/metabo11010057
   Available online: https://www.mdpi.com/2218-1989/11/1/57
   

4. “Correlation between Pre-Ovulatory Follicle Diameter and Follicular Fluid Metabolome Profiles in Lactating Beef Cows”
   by Casey C. Read, Lannett Edwards, Neal Schrick, Justin D. Rhinehart, Rebecca R. Payton, Shawn R. Campagna, Hector F. Castro, Jessica L. Klabnik, Emma J. Horn and Sarah E. Moorey
   Metabolites 2021, 11(9), 623; https://doi.org/10.3390/metabo11090623
   Available online: https://www.mdpi.com/2218-1989/11/9/623
   

5. “Exploring the Lipids Involved in the Formation of Characteristic Lactones in Japanese Black Cattle”
   by Shuji Ueda, Ryo Sasaki, Rio Nakabayashi, Minoru Yamanoue, Yasuhito Sirai and Eiji Iwamoto
   Metabolites 2021, 11(4), 203; https://doi.org/10.3390/metabo11040203
   Available online: https://www.mdpi.com/2218-1989/11/4/203
   

6. “Metabolites Secreted by Bovine Embryos In Vitro Predict Pregnancies That the Recipient Plasma Metabolome Cannot, and Vice Versa”
   *Editor’s Choice Paper
   by Enrique Gomez, Nuria Canela, Pol Herrero, Adrià Cereto, Isabel Gimeno, Susana Carrocera, David Martin-Gonzalez, Antonio Murillo and Marta Muñoz
   Metabolites 2021, 11(3), 162; https://doi.org/10.3390/metabo11030162
   Available online: https://www.mdpi.com/2218-1989/11/3/162
   

7. “The Effects of Live Transport on Metabolism and Stress Responses of Abalone (Haliotis iris)”
   by Andrea C. Alfaro, Thao V. Nguyen, Leonie Venter, Jessica A. Ericson, Shaneel Sharma, Norman L. C. Ragg and Craig Mundy
   Metabolites 2021, 11(11), 748; https://doi.org/10.3390/metabo11110748
   Available online: https://www.mdpi.com/2218-1989/11/11/748
   

8. “High Throughput Procedure for Comparative Analysis of In Vivo Cardiac Glucose or Amino Acids Use in Cardiovascular Pathologies and Pharmacological Treatments”
   *Editor’s Choice Paper
   by Marta Tomczyk, Mariola Olkowicz, Ewa M. Slominska and Ryszard T. Smolenski
   Metabolites 2021, 11(8), 497; https://doi.org/10.3390/metabo11080497
   Available online: https://www.mdpi.com/2218-1989/11/8/497
   

As a leading open access publisher, MDPI provides scholars with a high-quality and rich academic exchange platform by continuously expanding into new and exciting research areas.

In December 2022, MDPI launched five new journals, covering multiple subjects such as life sciences, biology, medicine and pharmacology, social sciences and humanities. These new journals are being edited by established scholars across the world.

If you are interested in creating more open access journals with us to publish cutting-edge research, please send your journal proposal application to newjournal-committee@mdpi.com.

MDPI is pleased to announce that we now display the co-authors’ email addresses in addition to the corresponding author’s email address on the webpage of published papers, protected by Captcha. For more information about this change, please visit the journal’s instructions for authors page. 

We believe this change will facilitate academic discussions and advance our cause of open science and research. The corresponding authors are responsible for communicating with their co-authors and indicating in our system (https://susy.mdpi.com/) if co-authors would prefer for their email addresses not to be displayed.

On 9 February 2023, Clarivate, a global leader in providing trusted insights and analytics, added the Preprint Citation Index to the Web of Science platform, streamlining the research process by allowing researchers to locate and link to preprints alongside other trusted content in the database.

The Preprint Citation Index will act as a bridge to connect cutting-edge preprints with peer-reviewed journal articles published within the Web of Science Core Collection. Alerts can be easily set to monitor new research across several repositories and authors will also be able to include preprints on their Web of Science Research Profile to more accurately display their various research outputs.

As of its launch, the Preprint Citation Index will provide nearly two million preprints from various repositories, including MDPI’s own Preprints.org.

MDPI's Preprints Platform – Preprints.org

To advance Open Science and the fast dissemination of research, MDPI offers researchers a free multidisciplinary preprint platform. Preprints.org accepts submissions from all research areas and offers authors high visibility, permanent archiving, article-level Metrics and immediately citable content by assigning a Digital Object Identifier (DOI) to all preprints.

During submission to any MDPI journal, authors have the option to share their research as a preprint. After an initial screening, the manuscript is available online in 48 hours or less. Once online, preprints can be downloaded, shared, commented on, and cited, providing authors maximum visibility.

We invite you to join the ranks of the over 100k researchers using Preprints.org and share your research.

For more information, please visit Preprints.org.

Conference: 11th National Conference on Bioinformatics and Systems Biology
Date: 25–27 February 2023
Place: Guangzhou, China

MDPI will be attending the 11th National Conference on Bioinformatics and Systems Biology (CCBSB2023) as the exhibitor. The National Academic Conference on Bioinformatics and Systems Biology has been successfully held for ten sessions since its first session in 1998. It is a national event with the highest academic level and the greatest influence in the field of bioinformatics research in China. The theme of the conference is "The Latest Frontier Research of Bioinformatics and Systems Biology and Their Applications", and the topics cover translational informatics and data sharing security, biomedical data mining and computing, genome informatics, artificial intelligence and life sciences, group bioinformatics and integrated biology, non-coding RNA and RNA informatics, network biology, major disease omics informatics, biological macromolecular structure prediction and simulation, bioinformatics algorithm research, biological data resources, bioinformatics and drugs discovery, computational synthetic biology, agricultural and forestry informatics and other bioinformatics, and other frontier directions.

The following MDPI journals will be represented:

• Genes;
• JPM;
• Cardiogenetics;
• Bioengineering;
• Biomolecules;
• Metabolites;
• Cells;
• Symmetry;
• Biomedicines;
• Computers;
• COVID;
• Epigenomes.

If you are attending this conference, please feel free to start a conversation with us. Our delegates look forward to meeting you in person and answering any questions that you may have. For more information about the conference, please visit https://ccbsb2022.casconf.cn/.

It is our great honor to congratulate the publications that have been distinguished as highly cited papers by Clarivate^TM from 2020 to 2022, according to the Web of Science data. As of December 2022, these highly cited papers received enough citations to place them in the top 1% of the academic field of the “Biochemistry and Molecular Biology” category, based on a high citation threshold for the field and the publication year analyzed in the “Essential Science Indicators”, distinguishing them as hugely influential within their research areas.

1. “Major Nutritional Metabolic Alterations Influencing the Reproductive System of Postpartum Dairy Cows”
by Abdul Sammad, Muhammad Zahoor Khan, Zaheer Abbas, Lirong Hu, Qudrat Ullah, Yajing Wang, Huabin Zhu and Yachun Wang
Metabolites 2022, 12(1), 60; https://doi.org/10.3390/metabo12010060
Full text available online: https://www.mdpi.com/2218-1989/12/1/60

2. “Glucagon-Like Peptide-1 Receptor Agonists for Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: An Updated Meta-Analysis of Randomized Controlled Trials”
by Alessandro Mantovani, Graziana Petracca, Giorgia Beatrice, Alessandro Csermely, Amedeo Lonardo and Giovanni Targher
Metabolites 2021, 11(2), 73; https://doi.org/10.3390/metabo11020073
Full text available online: https://www.mdpi.com/2218-1989/11/2/73

3. “Comprehensive Meta-Analysis of COVID-19 Global Metabolomics Datasets”
by Zhiqiang Pang, Guangyan Zhou, Jasmine Chong and Jianguo Xia
Metabolites 2021, 11(1), 44; https://doi.org/10.3390/metabo11010044
Full text available online: https://www.mdpi.com/2218-1989/11/1/44

4. “The Potential of Metabolomics in Biomedical Applications”
by Vanessa Gonzalez-Covarrubias, Eduardo Martínez-Martínez and Laura del Bosque-Plata
Metabolites 2022, 12(2), 194; https://doi.org/10.3390/metabo12020194
Full text available online: https://www.mdpi.com/2218-1989/12/2/194

5. “Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson's Disease”
by Peipei Li, Bryan A. Killinger, Elizabeth Ensink, Ian Beddows, Ali Yilmaz, Noah Lubben, Jared Lamp, Meghan Schilthuis, Irving E. Vega and Randy Woltjer et al.
Metabolites 2021, 11(1), 29; https://doi.org/10.3390/metabo11010029
Full text available online: https://www.mdpi.com/2218-1989/11/1/29

6. “L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine”
by Marc R. McCann, Mery Vet George De la Rosa, Gus R. Rosania and Kathleen A. Stringer
Metabolites 2021, 11(1), 51; https://doi.org/10.3390/metabo11010051
Full text available online: https://www.mdpi.com/2218-1989/11/1/51

7. “MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics”
by Zhiqiang Pang, Jasmine Chong, Shuzhao Li and Jianguo Xia
Metabolites 2020, 10(5), 186; https://doi.org/10.3390/metabo10050186
Full text available online: https://www.mdpi.com/2218-1989/10/5/186

8. “Gut Microbiota Metabolites in Major Depressive Disorder-Deep Insights into Their Pathophysiological Role and Potential Translational Applications”
by Miguel A. Ortega, Miguel Angel Alvarez-Mon, Cielo García-Montero, Oscar Fraile-Martinez, Luis G. Guijarro, Guillermo Lahera, Jorge Monserrat, Paula Valls, Fernando Mora and Roberto Rodríguez-Jiménez et al.
Metabolites 2022, 12(1), 50; https://doi.org/10.3390/metabo12010050
Full text available online: https://www.mdpi.com/2218-1989/12/1/50

9. “The Role of Fructose as a Cardiovascular Risk Factor: An Update”
by Stefan-Sebastian Busnatu, Teodor Salmen, Maria-Alexandra Pana, Manfredi Rizzo, Tiziana Stallone, Nikolaos Papanas, Djordje Popovic, Denisa Tanasescu, Dragos Serban and Anca Pantea Stoian
Metabolites 2022, 12(1), 67; https://doi.org/10.3390/metabo12010067
Full text available online: https://www.mdpi.com/2218-1989/12/1/67

We are pleased to announce the launch of a new initiative—the MDPI Special Issue Mentor Program.

This program will enable early career researchers (who must hold a Ph.D. in a related field) to experience editing a Special Issue in MDPI journals, under the mentorship of our experienced Editorial Board Members or other experienced scientists. The mentor program will provide an excellent opportunity for early career scientists to gain editorial experience, and to cultivate their ability to edit scientific research.

The mentee’s responsibilities include:

• Proposing a Special Issue title and assisting the mentor in preparing a summary (around 200–400 words) and 3–10 keywords describing the background, importance, and goal of the Issue;
• Writing a brief promotion plan for the Special Issue;
• Preparing a list of scholars who may be interested in the Issue and personally e-mailing invitations on behalf of Guest Editors;
• Writing an editorial for the online Special Issue together with the mentor.

The mentor’s responsibilities include:

• Conducting a final check before the Special Issue is published online;
• Performing editorial control of the Special Issue and quality control of the publications, both of which must be carried out in a timely manner;
• Providing suggestions to younger scholars if they have any doubts or concerns regarding submissions;
• Organizing video calls with young scholars and the Editorial Office regularly to discuss problems and improvement suggestions for the Special Issue;
• Making and submitting decisions regarding submissions with the assistance of mentees.

Certificates and awards:
After the Special Issue closes, the Editorial Office will provide official certificates for all the mentors and early career researchers.

If you are interested in this opportunity, please send your Special Issue proposal to the Editorial Office of a journal you choose, and we will discuss the process (i.e., mentor collaboration, Special Issue topic feasibility analysis, etc.) in further detail. The full list of MDPI journals is as follows: https://www.mdpi.com/about/journals.

In addition to the new Special Issue Mentor Program, we will continue to welcome all Special Issue proposals focusing on hot research topics.