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Drugs and Drug Candidates, Volume 1, Issue 1

2022 December - 5 articles

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Article

2 Citations

3,231 Views

13 Pages

Synthesis, Characterization, and Activity of Hydroxymethylnitrofurazone Nanocrystals against Trypanosoma cruzi and Leishmania spp.

Cauê Benito Scarim,
Aline de Souza,
Débora Soares Souza Marins,
Elda Gonçalves dos Santos,
Lívia de Figueiredo Diniz Castro,
Ivo Santana Caldas,
Patrícia Ferreira Espuri,
Marcos José Marques,
Elizabeth Igne Ferreira and
Chung Man Chin
+ 1 author

Drugs Drug Candidates2022, 1(1), 43-55;https://doi.org/10.3390/ddc1010005

13 December 2022

Hydroxymethylnitrofurazone (NFOH) is a prodrug of nitrofurazone devoid of mutagenic toxicity, with in vitro and in vivo activity against Trypanosoma cruzi (T. cruzi) and in vitro activity against Leishmania. In this study, we aimed to increase the so...

(This article belongs to the Collection Anti-Parasite Drug Discovery)

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Article

10 Citations

4,054 Views

14 Pages

Xanthene Derivatives Targeting Bacterial Efflux Pumps, Quorum-Sensing, and Biofilm Formation

Miguel Maia,
Fernando Durães,
Diana I. S. P. Resende,
Nikoletta Szemerédi,
Luís Gales,
Paulo Martins-da-Costa,
Madalena Pinto,
Gabriella Spengler and
Emília Sousa

Drugs Drug Candidates2022, 1(1), 29-42;https://doi.org/10.3390/ddc1010004

6 December 2022

The rise of multidrug resistance (MDR) bacteria in nosocomial and health-care institutions is widespread and is currently recognized as a major medical challenge. Mechanisms of bacterial resistance, namely, quorum sensing (QS), biofilm formation, and...

(This article belongs to the Section Medicinal Chemistry and Preliminary Screening)

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Feature Paper
Opinion

3,272 Views

7 Pages

Failed Repurposing of Lysosomotropic Drugs for COVID-19 Treatment or Prevention

François Marceau

Drugs Drug Candidates2022, 1(1), 22-28;https://doi.org/10.3390/ddc1010003

2 December 2022

The hope for the rapid discovery of an effective drug therapy for COVID-19 has led to several efforts to repurpose drugs approved for other indications. Lysosomotropic drugs, organic amines such as chloroquine, hydroxychloroquine, amiodarone and many...

(This article belongs to the Special Issue Fighting SARS-CoV-2 and Related Viruses)

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Article

18 Citations

6,058 Views

19 Pages

Synthesis, Selective Cytotoxic Activity against Human Breast Cancer MCF7 Cell Line and Molecular Docking of Some Chalcone-Dihydropyrimidone Hybrids

Eduardo B. Mass,
Carolina A. de Lima,
Marcelo G. M. D’Oca,
Juliana M. Sciani,
Giovanna B. Longato and
Dennis Russowsky

Drugs Drug Candidates2022, 1(1), 3-21;https://doi.org/10.3390/ddc1010002

1 December 2022

Designed Chalcone-Dihydropyrimidinone hybrid compounds were synthesized expeditiously. The hybridization was performed through the Copper-catalyzed Alkyne-Azide Cycloaddition (CuAAC) from the propargyloxy chalcones and azido-dihydropyrimidinones. The...

(This article belongs to the Section Medicinal Chemistry and Preliminary Screening)

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